Telomere-independent reduction of human B lymphocyte: Proliferation during long-term culture

Immunological Investigations

Volumn 30, Issue 2, 2001, Pages 157-168

  Jung, Daniel ^a   Néron, Sonia ^a   Lemieux, Réal ^a   Roy, Annie ^a   Richard, Martine ^a  

^a HÉMA QUÉBEC   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; LYMPHOCYTE ANTIGEN; TELOMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL AGING; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

ANIMALS; ANTIGENS, CD19; ANTIGENS, CD40; B-LYMPHOCYTES; CD40 LIGAND; CELL AGING; CELL CULTURE TECHNIQUES; CELL DIVISION; CELLS, CULTURED; HUMANS; INTERLEUKIN-4; L CELLS (CELL LINE); MICE; TELOMERASE; TELOMERE; TIME FACTORS;

EID: 0034947321     PISSN: 08820139     EISSN: None     Source Type: Journal    
DOI: 10.1081/IMM-100104023     Document Type: Article

References (25)

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6. Telomere length predicts replicative capacity of human fibroblasts
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8. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
9. Extension of life-span by introduction of telomerase into normal human cells
10. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
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12. Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro
13. Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor
14. Long-term human B cell lines dependent on interleukin-4 and antibody to CD40
15. Induction of LFA-1 independent human B cell proliferation and differentiation by binding of CD40 with its ligand
16. Generation of memory B cells and plasma cells in vitro
17. Specific association of human telomerase activity with immortal cells and cancer
18. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
19. Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit
20. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
21. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function
22. Down-modulation of C-Myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion
23. Myc activates telomerase
24. Direct activation of TERT transcription by C-MYC
25. Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8(+) tlymphocyte immortalization