Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor1 (CRF1) receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2083-2086

  Huang, Charles Q ^a   Grigoriadis, Dimitri E ^a   Liu, Zhengyu ^a   McCarthy, James R ^a   Ramphal, John ^a   Webb, Thomas ^a   Whitten, Jeffrey P ^a   Xie, Michael Y ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PYRIMIDINE ANTAGONIST;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN RELEASE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION;

ANIMALS; CHO CELLS; CRICETINAE; DRUG DESIGN; PYRIMIDINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842690649     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.053     Document Type: Article

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