4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1- (3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): A potent and selective corticotrophin-releasing factor1 receptor antagonist. I. Biochemical and pharmacological characterization

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 322-332

  Gully, Danielle ^a   Geslin, Michel ^a   Serva, Laurence ^a   Fontaine, Evelyne ^a   Roger, Pierre ^a   Lair, Christine ^a   Darre, Valerie ^a   Marcy, Claudine ^a   Rouby, Pierre Eric ^a   Simiand, Jacques ^a   Guitard, Josette ^a   Gout, Georgette ^a   Steinberg, Regis ^b   Rodier, Daniel ^b   Griebel, Guy ^b   Soubrie, Philippe ^b   Pascal, Marc ^a   Pruss, Rebecca ^b   Scatton, Bernard ^a   Maffrand, Jean Pierre ^a   Le Fur, Gerard ^a   more..

^a SANOFI   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; 4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 1,3 THIAZOL 2 AMINE; 4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 2 THIAZOLAMINE; ACETYLCHOLINE; ANTALARMIN; ANTISAUVAGINE 30; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR 2ALPHA RECEPTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR BINDING PROTEIN; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; HORMONE BINDING PROTEIN; SAUVAGINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CHO CELL; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; GERBIL; HIPPOCAMPUS; IMMOBILIZATION STRESS; ISOTOPE LABELING; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 18344362026     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.322     Document Type: Article

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