Potent and selective thrombin inhibitors incorporating the constrained arginine mimic L-3-piperidyl(N-guanidino)alanine at P1

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4527-4530

  Levy, O E ^a   Semple, J E ^a   Lim, M L ^a   Reiner, J ^a   Rote, W E ^a   Dempsey, E ^a   Richard, B M ^a   Zhang, E ^a   Tulinsky, A ^a   Ripka, W C ^a   Nutt, R F ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; CVS 1123; CVS 1578; CVS 1778; LACTAM DERIVATIVE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICOAGULANT THERAPY; ARTERY THROMBOSIS; ARTICLE; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITHROMBINS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUANIDINES; HUMANS; PIPERIDINES; RATS; STEREOISOMERISM; THROMBIN;

EID: 0029850330     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960607j     Document Type: Article

References (0)