Cutting edge: Induction of antigen-specific hyporesponsiveness by transplantation of hemopoietic cells containing an MHC class I transgene regulated by a lymphocyte-specific promoter

Journal of Immunology

Volumn 161, Issue 3, 1998, Pages 1063-1068

  Hansal, Susan A ^a   Morris, Diane I ^a   Sechler, Joan M G ^a   Love, Paul E ^b   Rosenberg, Amy S ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; COMPLEMENTARY DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; EPITOPE; H2 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN H 2D(B); HISTOCOMPATIBILITY ANTIGEN H-2D(B);

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW TRANSPLANTATION; CELL SPECIFICITY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; GENE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE STRAIN; RADIATION CHIMERA; SKIN TRANSPLANTATION; T LYMPHOCYTE; THYMECTOMY;

ANIMALS; ANTIGENS, CD2; B-LYMPHOCYTES; BONE MARROW TRANSPLANTATION; EPITOPES; GENE EXPRESSION REGULATION; GENES, MHC CLASS I; H-2 ANTIGENS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNE TOLERANCE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RADIATION CHIMERA; SKIN TRANSPLANTATION; T-LYMPHOCYTES; THYMECTOMY; TRANSGENES;

EID: 0032134124     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sykes, M. 1996. Chimerism and central tolerance. Curr. Opin. Immunol. 8:694.
2. Wood, K., and D. H. Sachs. 1996. Chimerism and transplantation tolerance: cause and effect. Immunol. Today 17:584.
3. Sharabi, Y., and D. H. Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J. Exp. Med. 169:493.
4. Bachar-Lustig, E., N. Rachamim, H. W. Li, F. Lan, and Y. Reisner. 1995. Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nat. Med. 1:1268.
5. Sykes, M., G. L. Szot, K. A. Swenson, and D. A. Pearson. 1997. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat. Med. 3:783.
6. Fink, P. J., R. P. Shimonkevitz, and M. J. Bevan. 1988. Veto cells. Annu. Rev. Immunol. 6:115.
7. Hiruma, K., H. Nakamura, P. A. Henkart, and R. E. Gress. 1992. Clonal deletion of postthymic T cells: veto cells kill precursor CTL. J. Exp. Med. 175:863.
8. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.
9. Eynon, E. E., and D. C. Parker. 1993. Parameters of tolerance induction by antigen targeted to B lymphocytes. J. Immunol. 151:2958.
10. Cobbold, S. P., E. Adams, S. E. Marshall, J. D. Davies, and H. Waldmann. 1996. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol. Rev. 149:5.
11. Streilein, J. W., B. R. Ksander, and A. W. Taylor. 1997. Immune deviation in relation to ocular immune privilege. J. Immunol. 158:3557.
12. Rocken, M., and E. M. Shevach. 1996. Immune deviation: the third dimension of nondeletional T cell tolerance. Immunol. Rev. 149:175.
13. Chambers, C. A., and J. P. Allison. 1997. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:396.
14. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
15. Grewal, I. S., and R. A. Flavell. 1996. The role of CD40 ligand in costimulation and T-cell activation. Immunol. Rev. 153:85.
16. Larsen, C. P., E. T. Elwood, D. Z. Alexander, S. C. Ritchie, R. Hendrix, C. Tucker-Burden, H. R. Cho, A. Aruffo, D. Hollenbaugh, and P. S. Linsley. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 381:434.
17. Kirk, A. D., D. M. Harlan, N. N. Armstrong, T. A. Davis, Y. Dong, G. S. Gray, X. Hong, D. Thomas, J. H. Fechner, Jr., and S. J. Knechtle. 1997. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc. Natl. Acad. Sci. USA 94:8789.
18. Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 56:979.
19. Love, P. E., E. W. Shores, E. J. Lee, A. Grinberg, T. I. Munitz, H. Westphal, and A. Singer. 1994. Differential effects of ζ and η transgenes on early α/β T cell development. J. Exp. Med. 179:1485.
20. Evans, G. A., D. H. Margulies, B. Shykind, J. G. Seidman, and K. Ozato. 1982. Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Nature 300:755.
21. Hogan, B., F. Costantini, and E. Lacy. 1986. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
22. Norbury, C. C., B. J. Chambers, A. R. Prescott, H. G. Ljunggren, and C. Watts. 1997. Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells. Eur. J. Immunol. 27:280.
23. Rosenberg, A. S. 1994. Skin allograft rejection. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, p. 4.4.
24. Manickan, E., S. Kanangat, R. J. Rouse, Z. Yu, and B. T. Rouse. 1997. Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. J. Leukocyte Biol. 61:125.
25. + cells in mediating skin graft rejection against different amounts of transgenic H-2Kb antigen. J. Exp. Med. 173:261.
26. Rosenberg, A. S. 1993. The T cell populations mediating rejection of MHC class I disparate skin grafts in mice. Transpl. Immunol. 1:93.
27. + T cells. Bone Marrow Transplant. 18:285.
28. Young, F., B. Ardman, Y. Shinkai, R. Lansford, T. K. Blackwell, M. Mendelsohn, A. Rolink, F. Melchers, and F. W. Alt. 1994. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation [published erratum appears in Genes Dev. 1995. 9:3190] Genes Dev. 8:1043.
29. Duplay, P., D. Lancki, and J. P. Allison. 1989. Distribution and ontogeny of CD2 expression by murine T cells. J. Immunol. 142:2998.
30. Yagita, H., J. Asakawa, S. Tansyo, T. Nakamura, S. Habu, and K. Okumura. 1989. Expression and function of CD2 during murine thymocyte ontogeny. Eur. J. Immunol. 19:2211.
31. Nakamura, H., and R. E. Gress. 1990. Graft rejection by cytolytic T cells: specificity of the effector mechanism in the rejection of allogeneic marrow. Transplantation. 49:453.
32. + T cell compartment. J. Exp. Med. 184:1573.
33. Jones, N. D., N. C. Fluck, D. L. Roelen, A. L. Mellor, P. J. Morris, and K. J. Wood. 1997. Deletion of alloantigen-reactive thymocytes as a mechanism of adult tolerance induction following intrathymic antigen administration. Eur. J. Immunol. 27:1591.
34. Hayashi, H., R. S. Mayfield, T. Sawada, S. Germana, M. Sykes, J. Iacomini, D. H. Sachs, and C. LeGuern. 1997. Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene. Transplant. Proc. 29:1133.