Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesions

Brain Research Bulletin

Volumn 57, Issue 5, 2002, Pages 587-594

  Kadish, Inga ^a   Pradier, Laurent ^b   Van Groen, Thomas ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b SANOFI   (France)

Author keywords

Alzheimer's disease; Entorhinal cortex; Hippocampus; Mouse; Plasticity; Presenilin; Sprouting

Indexed keywords

IBOTENIC ACID; PRESENILIN 1; SYNAPTOPHYSIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DENTATE GYRUS; ENTORHINAL CORTEX; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NERVE CELL PLASTICITY; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; DENERVATION; DENTATE GYRUS; DISEASE MODELS, ANIMAL; ENTORHINAL CORTEX; GROWTH CONES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONAL PLASTICITY; PERFORANT PATHWAY; PRESENILIN-1; SYNAPTOPHYSIN;

EID: 0037086435     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00751-1     Document Type: Article

References (51)

1. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
2. Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
3. Comparative evaluation of synaptophysin-based methods for quantification of synapses
4. Proteolytical processing of mutated human amyloid precursor protein in transgenic mice
5. Presenilins and Alzheimer's disease; Biological functions and pathogenic mechanisms
6. Lesion-induced plasticity of central neurons; Sprouting of single fibers in the rat hippocampus after unilateral entorhinal cortex lesions
7. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
8. Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations
9. The septohippocampal pathway; Structure and function of a central cholinergic system
10. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
11. Cholinergic sprouting in the rat fascia dentata after entorhinal lesion is not linked to early changes in neurotrophin messenger RNA expression
12. Proliferative and migratory activity of glial cells in the partially deafferented hippocampus
13. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice
14. Presenilins; Genes for life and death
15. Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells
16. Microglial and astroglial reactions to anterograde axonal degeneration; A histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions
17. Differences in entorhinal cortex lesion-induced sprouting in the hippocampus between rats and mice
18. Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations
19. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
20. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
21. Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions
22. An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration
23. An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts
24. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
25. Cell and molecular neurobiology of presenilins; A role for the endoplasmatic reticulum in the pathogenesis of Alzheimer's disease?
26. Terminal proliferation in the partially deafferented dentate gyrus; Time course for the appearance and removal of degeneration and the replacement of lost terminals
27. Neuroplasticity failure in Alzheimer's disease; Bridging the gap between plaques and tangles
28. High-level neuronal expression of abeta 1-42 in wild-type human amyloid precursor protein precursor transgenic mice; Synaptotoxicity without plaque formation
29. Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions
30. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin-1
31. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phsophorylation
32. Mutant genes in familial Alzheimer's disease and transgenic models
33. Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions
34. The function of presenilin-1 in amyloid β-peptide generation and brain development
35. Ibotenic acid-induced neuronal degeneration; A morphological and neurochemical study
36. Transgenic animals relevant to Alzheimer's disease
37. Notch and presenilins in vertebrates and invertebrates; Implications for neuronal development and degeneration
38. The distribution of the commissural-associational afferents of the dentate gyrus after perforant path lesions in one-day-old rats
39. Growth of a new fiber projection in the brain of adult rats; Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions
40. The process of reinnervation in the dentate gyrus of the adult rat; A quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis
41. Synapse replacement on cortical neurons following denervation
42. Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism; Implications for Alzheimer's disease
43. The amyloid precursor protein of Alzheimer's disease and the Aβ peptide
44. Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia
45. Projections from the anterodorsal and anteroventral nuclei of the thalamus to the limbic cortex in the rat
46. The projections from the entorhinal cortex to the hippocampus in the mouse
47. Entorhinal lesions result in shrinkage of the outer molecular layer of rat dentate gyrus leading subsequently to an apparent increase of glutamate decarboxylase and cytochrome oxidase activities
48. Cholinergic and non-cholinergic septohippocampal pathways
49. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1