Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release

Biochemical and Biophysical Research Communications

Volumn 303, Issue 4, 2003, Pages 1073-1079

  Bae, Jae Hoon ^a   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

Author keywords

Apoptosis; Ca2+ uptake; Curcumin; Mitochondrial uniporter; Ruthenium red

Indexed keywords

ALKENE DERIVATIVE; CALCIUM ION; CASPASE 3; CURCUMIN; CYCLOPIAZONIC ACID; CYTOCHROME C; DANTOLENE; PROTEIN BCL XL; RUTHENIUM RED; THAPSIGARGIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; PRIORITY JOURNAL;

CURCUMA;

EID: 0037453223     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00479-0     Document Type: Article

References (20)

1. Ammon H.P., Wahl M.A. Phamacology of Curcuma longa. Planta Med. 57:1991;1-7.
2. Huang M.T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:1988;5941-5946.
3. Huang M.T., Newmark H.L., Frenkel K. Inhibitory effects of curcumin on tumorigenesis in mice. J. Cell Biochem. Suppl. 27:1997;26-34.
4. Mehta K., Pantazis P., McQueen T., Aggarwal B.B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs. 8:1997;470-481.
5. Huang M.T., Lou Y.R., Ma W., Newmark H.L., Reuhl K.R., Conney A.H. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. 54:1994;5841-5847.
6. Kelloff G.J., Boone C.W., Crowell J.A., Steele V.E., Lubet R., Sigman C.C. Chemopreventive drug development: perspectives and progress. Cancer Epidemiol. Biomarkers Prev. 3:1994;85-98.
7. Gunter T.E., Buntinas L., Sparagna G., Eliseev R., Gunter K. Mitochondrial calcium transport: mechanisms and functions. Cell Calcium. 28:2000;285-296.
8. Kruman I.I., Mattson M.P. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J. Neurochem. 72:1999;529-540.
9. Johnson E.M. Jr., Koike T., Franklin J. A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor. Exp. Neurol. 115:1992;163-166.
10. Berridge M.J., Lipp P., Bootmanm M.D. The versatility and universality of calcium signaling. Nat. Rev. Mol. Cell. Biol. 1:2000;11-21.
11. Berridge M.J., Bootman M.D., Lipp P. Calcium - a life and death signal. Nature. 395:1998;645-648.
12. McLarnon J.G., Franciosi S., Wang X., Bae J.H., Choi H.B., Kim S.U. Acute actions of tumor necrosis factor-alpha on intracellular Ca(2+) and K(+) currents in human microglia. Neuroscience. 104:2001;1175-1184.
13. Bae J.H., Mun K.C., Park W.K., Lee S.R., Baek W.K., Yim M.B., Kwon T.K., Song D.K. EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons. Biochem. Biophys. Res. Commun. 290:2002;1506-1512.
14. Desagher S., Osen-Sand A., Nichols A., Eskes R., Montessuit S., Lauper S., Maundrell K., Antonsson B., Martinou J.C. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biol. 144:1999;891-901.
15. Deveraux Q.L., Reed J.C. IAP family proteins: suppressors of apoptosis. Genes Dev. 13:1999;239-252.
16. Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16:1997;6914-6925.
17. Deveraux Q.L., Leo E., Stennicke H.R., Welsh K., Salvesen G.S., Reed J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 18:1999;5242-5251.
18. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
19. Gunter T.E., Pfeiffer D.R. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258:1990;C755-C786.
20. Duchen M.R. Mitochondria and calcium: from cell signalling to cell death. J. Physiol. 529:2000;57-68.