The contested role of uracil DNA glycosylase in immunoglobulin gene diversification

Trends in Genetics

Volumn 21, Issue 5, 2005, Pages 253-256

  Longerich, Simonne ^a   Storb, Ursula ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE DEAMINASE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; INHIBITOR PROTEIN; MUTANT PROTEIN; UNCLASSIFIED DRUG; URACIL; URACIL DNA GLYCOSYLASE INHIBITOR PROTEIN; URACIL DNA GLYCOSYLTRANSFERASE;

DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INACTIVATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SOMATIC HYPERMUTATION;

EID: 17644403462     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2005.02.013     Document Type: Short Survey

References (19)

1. U. Storb, and J. Stavnezer Immunoglobulin genes: generating diversity with AID and UNG Curr. Biol. 12 2002 R725 R727
2. K. Imai Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination Nat. Immunol. 4 2003 1023 1028
3. C. Rada Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice Curr. Biol. 12 2002 1748 1755
4. N.A. Begum Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch Science 305 2004 1160 1163
5. C. Redon Histone H2A variants H2AX and H2AZ Curr. Opin. Genet. Dev. 12 2002 162 169
6. S. Petersen AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching Nature 414 2001 660 665
7. N.A. Begum De novo protein synthesis is required for activationinduced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination Proc. Natl. Acad. Sci. U. S. A. 101 2004 13003 13007
8. I.M. Ward, and J. Chen Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress J. Biol. Chem. 276 2001 47759 47762
9. O. Fernandez-Capetillo H2AX: the histone guardian of the genome DNA Repair (Amst.) 3 2004 959 967
10. L. Zou, and S.J. Elledge Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science 300 2003 1542 1548
11. J. Chaudhuri Replication protein A interacts with AID to promote deamination of somatic hypermutation targets Nature 430 2004 992 998
12. C.D. Mol Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis Cell 80 1995 869 878
13. H. Nilsen Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication Mol. Cell 5 2000 1059 1065
14. C. Rada Mismatch recognition and uracil-excision provide complementary paths to both immunoglobulin switching and the second (dA:dT-focussed) phase of somatic mutation Mol. Cell 16 2004 163 171
15. P.D. Bardwell The G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination J. Immunol. 170 2003 1620 1624
16. M. Ehrenstein, and M. Neuberger Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation EMBO J. 18 1999 3484 3490
17. Z. Li Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification J. Exp. Med. 200 2004 47 59
18. R.D. Kolodner, and G.T. Marsischky Eukaryotic DNA mismatch repair Curr. Opin. Genet. Dev. 9 1999 89 96
19. N. Sugawara Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination Proc. Natl. Acad. Sci. U. S. A. 94 1997 9214 9219