메뉴 건너뛰기




Volumn 115, Issue 1, 2005, Pages 65-73

Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells

Author keywords

Apoptosis; Melanoma; Ras; RNAi; Signal transduction

Indexed keywords

ADENINE; CYCLIN D1; CYTOSINE; GLUTAMIC ACID; GLUTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; VALINE;

EID: 17644383337     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20873     Document Type: Article
Times cited : (86)

References (43)
  • 1
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 2
    • 0035964458 scopus 로고    scopus 로고
    • Ras and Rho regulation of the cell cycle and oncogenesis
    • Pruitt K, Der CJ. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 2001;171:1-10.
    • (2001) Cancer Lett , vol.171 , pp. 1-10
    • Pruitt, K.1    Der, C.J.2
  • 3
    • 0033793874 scopus 로고    scopus 로고
    • Ras proteins in the control of the cell cycle and cell differentiation
    • Crespo P, Leon J. Ras proteins in the control of the cell cycle and cell differentiation. Cell Mol Life Sci 2000;57:1613-36.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1613-1636
    • Crespo, P.1    Leon, J.2
  • 4
    • 0031936353 scopus 로고    scopus 로고
    • Ras signalling and apoptosis
    • Downward J. Ras signalling and apoptosis. Curr Opin Genet Dev 1998;8:49-54.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 49-54
    • Downward, J.1
  • 5
    • 0036725771 scopus 로고    scopus 로고
    • Blocking oncogenes in malignant cells by RNA interference-new hope for a highly specific cancer treatment?
    • Borkhardt A. Blocking oncogenes in malignant cells by RNA interference-new hope for a highly specific cancer treatment? Cancer Cell 2002;2:167-8.
    • (2002) Cancer Cell , vol.2 , pp. 167-168
    • Borkhardt, A.1
  • 6
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic Ras signaling for cancer therapy
    • Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001;93:1062-74.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1062-1074
    • Adjei, A.A.1
  • 8
    • 0036983115 scopus 로고    scopus 로고
    • The Ras-Raf-MEK-ERK pathway in the treatment of cancer
    • Hilger RA, Scheulen ME, Strumberg D. The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Onkologie 2002;25:511-8.
    • (2002) Onkologie , vol.25 , pp. 511-518
    • Hilger, R.A.1    Scheulen, M.E.2    Strumberg, D.3
  • 11
    • 0036850146 scopus 로고    scopus 로고
    • Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: Mutations occur early and persist throughout tumor progression
    • Omholt K, Karsberg S, Platz A, Kanter L, Ringborg U, Hansson J. Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res 2002;8:3468-74.
    • (2002) Clin Cancer Res , vol.8 , pp. 3468-3474
    • Omholt, K.1    Karsberg, S.2    Platz, A.3    Kanter, L.4    Ringborg, U.5    Hansson, J.6
  • 13
    • 0031738326 scopus 로고    scopus 로고
    • N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
    • Jiveskog S, Ragnarsson-Olding B, Platz A, Ringborg U. N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J Invest Dermatol 1998;111:757-61.
    • (1998) J Invest Dermatol , vol.111 , pp. 757-761
    • Jiveskog, S.1    Ragnarsson-Olding, B.2    Platz, A.3    Ringborg, U.4
  • 15
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999;18:664-74.
    • (1999) EMBO J , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouyssegur, J.6
  • 17
    • 0037115394 scopus 로고    scopus 로고
    • Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression
    • Dhawan P, Singh AB, Ellis DL, Richmond A. Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res 2002;62:7335-42.
    • (2002) Cancer Res , vol.62 , pp. 7335-7342
    • Dhawan, P.1    Singh, A.B.2    Ellis, D.L.3    Richmond, A.4
  • 18
    • 85047698904 scopus 로고    scopus 로고
    • Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation
    • Dajee M, Tarutani M, Deng H, Cai T, Khavari PA. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002;21:1527-38.
    • (2002) Oncogene , vol.21 , pp. 1527-1538
    • Dajee, M.1    Tarutani, M.2    Deng, H.3    Cai, T.4    Khavari, P.A.5
  • 19
    • 0032480885 scopus 로고    scopus 로고
    • Signal transduction. New exchange, new target
    • Downward J. Signal transduction. New exchange, new target. Nature 1998;396:416-7.
    • (1998) Nature , vol.396 , pp. 416-417
    • Downward, J.1
  • 20
    • 0037007119 scopus 로고    scopus 로고
    • Cell signaling: Life or death decisions of ras proteins
    • Feig LA, Buchsbaum RJ. Cell signaling: life or death decisions of ras proteins. Curr Biol 2002;12:R259-61.
    • (2002) Curr Biol , vol.12
    • Feig, L.A.1    Buchsbaum, R.J.2
  • 22
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- und 22-nucleotide RNAs
    • Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- und 22-nucleotide RNAs. Genes Dev 2001;15:188-200.
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 23
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference - 2001
    • Sharp PA. RNA interference - 2001. Genes Dev 2001;15:485-90.
    • (2001) Genes Dev , vol.15 , pp. 485-490
    • Sharp, P.A.1
  • 24
    • 0037400975 scopus 로고    scopus 로고
    • A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
    • Smalley KS. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003;104:527-32.
    • (2003) Int J Cancer , vol.104 , pp. 527-532
    • Smalley, K.S.1
  • 26
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
    • Marte BM, Downward J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 1997;22:355-8.
    • (1997) Trends Biochem Sci , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, J.2
  • 27
    • 0032803236 scopus 로고    scopus 로고
    • Suppression of Ras-induced apoptosis by the Rac GTPase
    • Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol 1999;19:5892-901.
    • (1999) Mol Cell Biol , vol.19 , pp. 5892-5901
    • Joneson, T.1    Bar-Sagi, D.2
  • 28
    • 0038311995 scopus 로고    scopus 로고
    • Ras family signaling: Therapeutic targeting
    • Cox AD, Der CJ. Ras family signaling: therapeutic targeting. Cancer Biol Ther 2002;1:599-606.
    • (2002) Cancer Biol Ther , vol.1 , pp. 599-606
    • Cox, A.D.1    Der, C.J.2
  • 30
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 2003;4:457-67.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 33
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002;2:243-7.
    • (2002) Cancer Cell , vol.2 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 34
    • 0041335551 scopus 로고    scopus 로고
    • Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer
    • Yang G, Thompson JA, Fang B, Liu J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene 2003;22:5694-701.
    • (2003) Oncogene , vol.22 , pp. 5694-5701
    • Yang, G.1    Thompson, J.A.2    Fang, B.3    Liu, J.4
  • 36
    • 4444240325 scopus 로고    scopus 로고
    • Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
    • Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A. Taira K, Kawakami Y. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 2004;23:6031-9.
    • (2004) Oncogene , vol.23 , pp. 6031-6039
    • Sumimoto, H.1    Miyagishi, M.2    Miyoshi, H.3    Yamagata, S.4    Shimizu, A.5    Taira, K.6    Kawakami, Y.7
  • 37
    • 0031038131 scopus 로고    scopus 로고
    • R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
    • Marte BM, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr Biol 1997;7:63-70.
    • (1997) Curr Biol , vol.7 , pp. 63-70
    • Marte, B.M.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 39
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 40
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockei J, Boise LH, Thompson CB, Korsmeyer SJ. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995;80:285-91.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockei, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 42
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999;401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.