-
1
-
-
0024376173
-
ras oncogenes in human cancer: A review
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
2
-
-
0035964458
-
Ras and Rho regulation of the cell cycle and oncogenesis
-
Pruitt K, Der CJ. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 2001;171:1-10.
-
(2001)
Cancer Lett
, vol.171
, pp. 1-10
-
-
Pruitt, K.1
Der, C.J.2
-
3
-
-
0033793874
-
Ras proteins in the control of the cell cycle and cell differentiation
-
Crespo P, Leon J. Ras proteins in the control of the cell cycle and cell differentiation. Cell Mol Life Sci 2000;57:1613-36.
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 1613-1636
-
-
Crespo, P.1
Leon, J.2
-
4
-
-
0031936353
-
Ras signalling and apoptosis
-
Downward J. Ras signalling and apoptosis. Curr Opin Genet Dev 1998;8:49-54.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
5
-
-
0036725771
-
Blocking oncogenes in malignant cells by RNA interference-new hope for a highly specific cancer treatment?
-
Borkhardt A. Blocking oncogenes in malignant cells by RNA interference-new hope for a highly specific cancer treatment? Cancer Cell 2002;2:167-8.
-
(2002)
Cancer Cell
, vol.2
, pp. 167-168
-
-
Borkhardt, A.1
-
6
-
-
0035908493
-
Blocking oncogenic Ras signaling for cancer therapy
-
Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001;93:1062-74.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1062-1074
-
-
Adjei, A.A.1
-
8
-
-
0036983115
-
The Ras-Raf-MEK-ERK pathway in the treatment of cancer
-
Hilger RA, Scheulen ME, Strumberg D. The Ras-Raf-MEK-ERK pathway in the treatment of cancer. Onkologie 2002;25:511-8.
-
(2002)
Onkologie
, vol.25
, pp. 511-518
-
-
Hilger, R.A.1
Scheulen, M.E.2
Strumberg, D.3
-
9
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen O, O'Hagan R, Pantginis I, Zhou H, Horner IW 2nd, Cardon-Cardo C, et al. Essential role for oncogenic Ras in tumour maintenance. Nature 1999;400:468-72.
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, O.7
O'Hagan, R.8
Pantginis, I.9
Zhou, H.10
Horner II, I.W.11
Cardon-Cardo, C.12
-
10
-
-
0038128356
-
Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations
-
Eskandarpour M, Hashemi J, Kanter L, Ringborg U, Platz A, Hansson J. Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations. J Natl Cancer Inst 2003;95:790-8.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 790-798
-
-
Eskandarpour, M.1
Hashemi, J.2
Kanter, L.3
Ringborg, U.4
Platz, A.5
Hansson, J.6
-
11
-
-
0036850146
-
Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: Mutations occur early and persist throughout tumor progression
-
Omholt K, Karsberg S, Platz A, Kanter L, Ringborg U, Hansson J. Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res 2002;8:3468-74.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3468-3474
-
-
Omholt, K.1
Karsberg, S.2
Platz, A.3
Kanter, L.4
Ringborg, U.5
Hansson, J.6
-
12
-
-
0028178840
-
Ras mutations in human melanoma: A marker of malignant progression
-
Ball NJ, Yohn JJ, Morelli JG, Norris DA, Golitz LE, Hoeffler JP. Ras mutations in human melanoma: a marker of malignant progression. J Invest Dermatol 1994;102:285-90.
-
(1994)
J Invest Dermatol
, vol.102
, pp. 285-290
-
-
Ball, N.J.1
Yohn, J.J.2
Morelli, J.G.3
Norris, D.A.4
Golitz, L.E.5
Hoeffler, J.P.6
-
13
-
-
0031738326
-
N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin
-
Jiveskog S, Ragnarsson-Olding B, Platz A, Ringborg U. N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J Invest Dermatol 1998;111:757-61.
-
(1998)
J Invest Dermatol
, vol.111
, pp. 757-761
-
-
Jiveskog, S.1
Ragnarsson-Olding, B.2
Platz, A.3
Ringborg, U.4
-
14
-
-
0029781017
-
Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma
-
van Elsas A, Zerp SF, van der Flier S, Kruse KM, Aarnoudse C, Hayward NK, Ruiter DI, Schrier PI. Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma. Am J Pathol 1996;149:883-93.
-
(1996)
Am J Pathol
, vol.149
, pp. 883-893
-
-
Van Elsas, A.1
Zerp, S.F.2
Van Der Flier, S.3
Kruse, K.M.4
Aarnoudse, C.5
Hayward, N.K.6
Ruiter, D.I.7
Schrier, P.I.8
-
15
-
-
0033081066
-
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
-
Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999;18:664-74.
-
(1999)
EMBO J
, vol.18
, pp. 664-674
-
-
Brunet, A.1
Roux, D.2
Lenormand, P.3
Dowd, S.4
Keyse, S.5
Pouyssegur, J.6
-
16
-
-
0034175984
-
Understanding Ras: 'It ain't over 'til it's over'
-
Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol 2000;10:147-54.
-
(2000)
Trends Cell Biol
, vol.10
, pp. 147-154
-
-
Shields, J.M.1
Pruitt, K.2
McFall, A.3
Shaub, A.4
Der, C.J.5
-
17
-
-
0037115394
-
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression
-
Dhawan P, Singh AB, Ellis DL, Richmond A. Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res 2002;62:7335-42.
-
(2002)
Cancer Res
, vol.62
, pp. 7335-7342
-
-
Dhawan, P.1
Singh, A.B.2
Ellis, D.L.3
Richmond, A.4
-
18
-
-
85047698904
-
Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation
-
Dajee M, Tarutani M, Deng H, Cai T, Khavari PA. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002;21:1527-38.
-
(2002)
Oncogene
, vol.21
, pp. 1527-1538
-
-
Dajee, M.1
Tarutani, M.2
Deng, H.3
Cai, T.4
Khavari, P.A.5
-
19
-
-
0032480885
-
Signal transduction. New exchange, new target
-
Downward J. Signal transduction. New exchange, new target. Nature 1998;396:416-7.
-
(1998)
Nature
, vol.396
, pp. 416-417
-
-
Downward, J.1
-
20
-
-
0037007119
-
Cell signaling: Life or death decisions of ras proteins
-
Feig LA, Buchsbaum RJ. Cell signaling: life or death decisions of ras proteins. Curr Biol 2002;12:R259-61.
-
(2002)
Curr Biol
, vol.12
-
-
Feig, L.A.1
Buchsbaum, R.J.2
-
21
-
-
0036303748
-
Ras family genes: An interesting link between cell cycle and cancer
-
Macaluso M, Russo G, Cinti C, Bazan V, Gebbia N, Russo A. Ras family genes: an interesting link between cell cycle and cancer. J Cell Physiol 2002;192:125-30.
-
(2002)
J Cell Physiol
, vol.192
, pp. 125-130
-
-
Macaluso, M.1
Russo, G.2
Cinti, C.3
Bazan, V.4
Gebbia, N.5
Russo, A.6
-
22
-
-
0035863097
-
RNA interference is mediated by 21- und 22-nucleotide RNAs
-
Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- und 22-nucleotide RNAs. Genes Dev 2001;15:188-200.
-
(2001)
Genes Dev
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
23
-
-
0035281741
-
RNA interference - 2001
-
Sharp PA. RNA interference - 2001. Genes Dev 2001;15:485-90.
-
(2001)
Genes Dev
, vol.15
, pp. 485-490
-
-
Sharp, P.A.1
-
24
-
-
0037400975
-
A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
-
Smalley KS. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003;104:527-32.
-
(2003)
Int J Cancer
, vol.104
, pp. 527-532
-
-
Smalley, K.S.1
-
25
-
-
0035736485
-
Timing of cyclin D1 expression within G1 phase is controlled by Rho
-
Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001;3:950-7.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 950-957
-
-
Welsh, C.F.1
Roovers, K.2
Villanueva, J.3
Liu, Y.4
Schwartz, M.A.5
Assoian, R.K.6
-
26
-
-
0030884103
-
PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
-
Marte BM, Downward J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 1997;22:355-8.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 355-358
-
-
Marte, B.M.1
Downward, J.2
-
27
-
-
0032803236
-
Suppression of Ras-induced apoptosis by the Rac GTPase
-
Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol 1999;19:5892-901.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5892-5901
-
-
Joneson, T.1
Bar-Sagi, D.2
-
28
-
-
0038311995
-
Ras family signaling: Therapeutic targeting
-
Cox AD, Der CJ. Ras family signaling: therapeutic targeting. Cancer Biol Ther 2002;1:599-606.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 599-606
-
-
Cox, A.D.1
Der, C.J.2
-
29
-
-
0035670803
-
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma
-
Demunter A, Stas M, Degreef H, De Wolf-Peelers C, van den Oord JJ. Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma. J Invest Dermatol 2001;117:1483-9.
-
(2001)
J Invest Dermatol
, vol.117
, pp. 1483-1489
-
-
Demunter, A.1
Stas, M.2
Degreef, H.3
De Wolf-Peelers, C.4
Van Den Oord, J.J.5
-
31
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-7.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
32
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 2001;15:3249-62.
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
Lenczowski, J.M.4
Tichelaar, J.W.5
Lizak, M.J.6
Whitsett, J.A.7
Koretsky, A.8
Varmus, H.E.9
-
33
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002;2:243-7.
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
34
-
-
0041335551
-
Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer
-
Yang G, Thompson JA, Fang B, Liu J. Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumor growth in a model of human ovarian cancer. Oncogene 2003;22:5694-701.
-
(2003)
Oncogene
, vol.22
, pp. 5694-5701
-
-
Yang, G.1
Thompson, J.A.2
Fang, B.3
Liu, J.4
-
35
-
-
0141816881
-
Suppression of BRAF(V599E) in human melanoma abrogates transformation
-
Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M, Tuveson DA. Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res 2003;63:5198-202.
-
(2003)
Cancer Res
, vol.63
, pp. 5198-5202
-
-
Hingorani, S.R.1
Jacobetz, M.A.2
Robertson, G.P.3
Herlyn, M.4
Tuveson, D.A.5
-
36
-
-
4444240325
-
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
-
Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A. Taira K, Kawakami Y. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 2004;23:6031-9.
-
(2004)
Oncogene
, vol.23
, pp. 6031-6039
-
-
Sumimoto, H.1
Miyagishi, M.2
Miyoshi, H.3
Yamagata, S.4
Shimizu, A.5
Taira, K.6
Kawakami, Y.7
-
37
-
-
0031038131
-
R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
-
Marte BM, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr Biol 1997;7:63-70.
-
(1997)
Curr Biol
, vol.7
, pp. 63-70
-
-
Marte, B.M.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
38
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed IC. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998;282:1318-21.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, I.C.8
-
39
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
40
-
-
0028809209
-
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
-
Yang E, Zha J, Jockei J, Boise LH, Thompson CB, Korsmeyer SJ. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995;80:285-91.
-
(1995)
Cell
, vol.80
, pp. 285-291
-
-
Yang, E.1
Zha, J.2
Jockei, J.3
Boise, L.H.4
Thompson, C.B.5
Korsmeyer, S.J.6
-
41
-
-
0030612937
-
Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras
-
Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, Der CJ, Baldwin AS Jr. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 1997;278:1812-5.
-
(1997)
Science
, vol.278
, pp. 1812-1815
-
-
Mayo, M.W.1
Wang, C.Y.2
Cogswell, P.C.3
Rogers-Graham, K.S.4
Lowe, S.W.5
Der, C.J.6
Baldwin Jr., A.S.7
-
42
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999;401:86-90.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
43
-
-
0027170451
-
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
-
Pages G, Lenormand P, L'Allemain G, Chambard JC, Meloche S, Pouyssegur J. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 1993;90:8319-23.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8319-8323
-
-
Pages, G.1
Lenormand, P.2
L'Allemain, G.3
Chambard, J.C.4
Meloche, S.5
Pouyssegur, J.6
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