Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test

European Journal of Pharmacology

Volumn 512, Issue 2-3, 2005, Pages 121-127

  Ambriz Tututi, Mónica ^a   Velázquez Zamora, Dulce A ^a   Urquiza Marín, Héctor ^a   Granados Soto, Vinicio ^a,b  

^a UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Cyclic GMP; K+ channel; Peripheral processing; Protein kinase G; Sildenafil

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ADENOSINE TRIPHOSPHATE; APAMIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; CHARYBDOTOXIN; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; GUANYLATE CYCLASE INHIBITOR; POTASSIUM CHANNEL BLOCKING AGENT; SILDENAFIL; TETRYLAMMONIUM; TOLBUTAMIDE;

ANTINOCICEPTION; ARTICLE; CALCIUM CONDUCTANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 17444426707     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.01.055     Document Type: Article

References (50)

1. P. Aguirre-Bañuelos, and V. Granados-Soto Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test Eur. J. Pharmacol. 395 2000 9 13
2. + channels activation Life Sci. 74 2004 2577 2591
3. + channel by cGMP-dependent protein kinase Proc. Natl. Acad. Sci. U. S. A. 91 1994 7583 7587
4. R. Asomoza-Espinosa, R. Alonso-López, T. Mixcoatl-Zecuatl, P. Aguirre-Bañuelos, J.E. Torres-López, and V. Granados-Soto Sildenafil increases diclofenac antinociception in the formalin test Eur. J. Pharmacol. 418 2001 195 200
5. J.A. Beavo Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms Physiol. Rev. 75 1995 725 745
6. V.M. Bolotina, S. Najibi, J.J. Palacino, P.J. Pagano, and R.A. Cohen Nitric oxide directly activates calcium dependent potassium channels in vascular smooth muscle Nature 368 1994 850 853
7. F. Capone, and A.M. Aloisi Refinement of pain evaluation techniques. The formalin test Ann. Ist. Super. Sanita 40 2004 223 229
8. + channels Am. J. Physiol. 273 1997 H76 H83
9. N.S. Cook, and U. Quast Potassium channel pharmacology N.S. Cook Potassium Channels: Structure, Classification, Function and Therapeutic Potential 1990 Ellis Horwood Limited Chichester 181 255
10. I.D.G. Duarte, B.B. Lorenzetti, and S.H. Ferreira Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway Eur. J. Pharmacol. 186 1990 289 293
11. I.D.G. Duarte, I.R. Santos, B.B. Lorenzetti, and S.H. Ferreira Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway Eur. J. Pharmacol. 217 1992 225 227
12. D. Dubuisson, and S.G. Dennis The formalin test: a quantitative study of the analgesic effect of morphine, meperidine, and brain stem stimulation in rats and cats Pain 4 1977 161 174
13. + channels Annu. Rev. Pharmacol. Toxicol. 33 1993 597 637
14. S.H. Ferreira, I.D.G. Duarte, and B.B. Lorenzetti The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release Eur. J. Pharmacol. 201 1991 121 122
15. I. Gaumond, P. Arsenault, and S. Marchand The role of sex hormones on formalin-induced nociceptive responses Brain Res. 958 2002 139 145
16. D.B. Glass Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors Biochem. J. 213 1983 159 164
17. V. Granados-Soto, F.J. Flores-Murrieta, G. Castañeda- Hernández, and F.J. López-Muñoz Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac in the rat Eur. J. Pharmacol. 277 1995 281 284
18. V. Hampl, J.M. Huang, R.K. Weir, and S.L. Archer Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels Physiol. Res. 44 1995 39 44
19. M. Islas-Cadena, P. Aguirre-Bañuelos, and V. Granados-Soto Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive effect of nimesulide J. Pharmacol. Toxicol. Methods 42 1999 87 92
20. N.K. Jain, C.S. Patil, A. Singh, and S.K. Kulkarni Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway Brain Res. 909 2001 170 178
21. N.K. Jain, C.S. Patil, A. Singh, and S.K. Kulkarni Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine Pharmacology 67 2003 150 156
22. H.D. Langtry, and A. Markham Sildenafil: a review of its use in erectile dysfunction Drugs 57 1999 967 989
23. + channel pathway in the antinociceptive action of ketorolac Eur. J. Pharmacol. 426 2001 39 44
24. K.A. Lucas, G.M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K.P. Chepenik, and S.A. Waldman Guanylyl cyclases and signaling by cyclic GMP Pharmacol. Rev. 52 2000 375 414
25. T. Mixcoatl-Zecuatl, P. Aguirre-Bañuelos, and V. Granados-Soto Sildenafil produces antinociception and increases morphine antinociception in the formalin test Eur. J. Pharmacol. 400 2000 81 87
26. R.B. Moreland, I. Goldstein, N.N. Kim, and A. Traish Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: research and clinical implications in erectile dysfunction Trends Endocrinol. Metab. 10 1999 97 104
27. M.A. Moro, R.J. Russel, S. Cellek, I. Lizasoain, Y. Su, V.M. Darley-Usmar, M.W. Radomski, and S. Moncada cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase Proc. Natl. Acad. Sci. U. S. A. 93 1996 1480 1485
28. M. Narita, K. Takamori, N. Kawashima, M. Funada, J. Kamei, T. Suzuki, M. Misawa, and H. Nagase Activation of central ATP-sensitive potassium channels produces antinociception and spinal noradrenaline turnover-enhancing effect in mice Psychopharmacology 113 1993 11 14
29. M. Ocana, E. Del Pozo, M. Barrios, L.I. Robles, and J.M. Baeyens An ATP-dependent potassium channel blocker antagonizes morphine analgesia Eur. J. Pharmacol. 186 1990 377 378
30. + channels by diclofenac Eur. J. Pharmacol. 438 2002 85 91
31. + channels Pharmacol. Biochem. Behav. 74 2003 465 470
32. + channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin Pharmacol. Biochem. Behav. 76 2003 187 195
33. H. Ouadid-Ahidouch, F.V. Coppenolle, X.L. Bourhis, A. Belhaj, and N. Prevarskaya Potassium channels in rat prostate epithelial cells FEBS Lett. 459 1999 15 21
34. C.S. Patil, N.K. Jain, A. Singh, and S.K. Kulkarni Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception Pharmacology 69 2003 183 189
35. C.A. Porro, and M. Cavazzuti Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model Prog. Neurobiol. 41 1993 565 607
36. M. Price, S.C. Lee, and C. Deutsch Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes Proc. Natl. Acad. Sci. U. S. A. 86 1989 10171 10175
37. + channels Br. J. Pharmacol. 129 2000 110 114
38. + channels J. Physiol. 79 1984 259 264
39. + channel pathway Proc. Natl. Acad. Sci. U. S. A. 101 2004 3680 3685
40. 2-induced hyperalgesic paw Br. J. Pharmacol. 134 2001 127 131
41. + channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside Eur. J. Pharmacol. 400 2000 67 71
42. D. Stretton, M. Miura, M.G. Bevisi, and P.J. Barnes Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves Proc. Natl. Acad. Sci. U. S. A. 9 1992 1325 1329
43. Y. Tanaka, M. Aida, H. Tanaka, K. Shigenobu, and L. Toro Involvement of maxi-K (Ca) channel activation in atrial natriuretic peptide-induced vasorelaxation Naunyn-Schmiedeberg's Arch. pharmacol. 357 1998 705 708
44. I. Tegeder, A. Schmidtko, E. Niederberger, P. Ruth, and G. Geisslinger Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats Neurosci. Lett. 332 2002 146 150
45. N.K. Terrett, A.S. Bell, D. Brown, and P. Ellis Sildenafil (Viagra™), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction Bioorg. Med. Chem. Lett. 6 1996 1819 1824
46. Ca channels Pediatr. Res. 52 2002 19 24
47. C.R. Tonussi, and S.H. Ferreira Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization Eur. J. Pharmacol. 251 1994 173 179
48. H. Wheeler-Aceto, and A. Cowan Standardization of the rat paw formalin test for the evaluation of analgesics Psychopharmacology 104 1991 35 44
49. I. Yamazumi, T. Okuda, and Y. Koga Involvement of potassium channels in spinal antinociception induced by fentanyl, clonidine and bethanechol in rats Jpn. J. Pharmacol. 87 2001 268 276
50. M. Zimmermann Ethical guidelines for investigations on experimental pain in conscious animals Pain 16 1983 109 110