Participation of the nitric oxide-cyclic GMP-ATP-sensitive K+ channel pathway in the antinociceptive action of ketorolac

European Journal of Pharmacology

Volumn 426, Issue 1-2, 2001, Pages 39-44

  Lázaro Ibáez, Guadalupe G ^a,c   Torres López, Jorge E ^a,b   Granados Soto, Vinicio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD JUÁREZ AUTÓNOMA DE TABASCO   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

1H (1,2,4) oxadiazolo(4,2 a)quinoxalin 1 one (ODQ); cGMP; Glibenclamide; Ketorolac; NG L nitro arginine methyl ester (L NAME); Nitric oxide (NO); S nitroso N acetylpenicillamine (SNAP)

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ADENOSINE TRIPHOSPHATE; CYCLIC GMP; GLIBENCLAMIDE; KETOROLAC; N ACETYL S NITROSOPENICILLAMINE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CHANNEL; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GLYBURIDE; GUANYLATE CYCLASE; KETOROLAC; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PAIN; PAIN MEASUREMENT; PENICILLAMINE; POTASSIUM CHANNELS; QUINOXALINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 0035943412     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01206-7     Document Type: Article

References (40)

1. Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone
2. Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test
3. + channels
4. + channels in cGMP-mediated pial artery vasodilatation
5. Ketorolac tromethamine: An experimental study of its analgesic effects in the rat
6. + channels
7. + channels of muscle cells - Their properties, regulation, and functions
8. Characterization of the analgesic activity of ketorolac in mice
9. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway
10. Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway
11. + channels
12. Pharmacologic properties of ketorolac tromethamine: A potent analgesic drug
13. Ketorolac: A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management
14. Evidence against the participation of μ- and κ-opioid receptors in the analgesic activity of ketorolac in rats
15. Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac in the rat
16. Evidence for the involvement of nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test
17. Ethical guidelines for investigations on experimental pain in conscious animals
18. Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive effect of nimesulide
19. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat
20. + channels in the mediation of carbachol-induced antinociception at the spinal level: A behavioral study in rats
21. + channels are involved in the mediation of intrathecal norepinephrine-or morphine-induced antinociception at the spinal level: A study using EMG planimetry of flexor reflex in rats
22. Lack of addictive potential of ketorolac tromethamine
23. Activation of the arginine-nitric oxide pathway in primary sensory neurons contributes to dipyrone-induced spinal and peripheral analgesia
24. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
25. cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase
26. The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation
27. + channel blocker antagonizes morphine analgesia
28. + channel-acting drugs
29. Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo
30. + channels
31. The "glibenclamide-shift" of centrally-acting antinociceptive agents in mice
32. + channels
33. The analgesic and anti-inflammatory profile of (±)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619)
34. + channels: Mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside
35. Efficacy and safety of single doses of intramuscular ketorolac tromethamine compared with meperidine for postoperative pain
36. 3 opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilatation
37. Mechanism of diclofenac analgesia: Direct blockade of inflammatory sensitization
38. Antinociceptive activity of intrathecal ketorolac is blocked by the κ-opioid antagonist, nor-binaltorphimine
39. Standardization of the rat paw formalin test for evaluation of analgesics
40. Ketorolac tromethamine is a new analgesic comparable to morphine that does not bind to opioid receptors and has a low addictive potential