The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin

Pharmacology Biochemistry and Behavior

Volumn 76, Issue 1, 2003, Pages 187-195

  Ortiz, Mario I ^a,b   Granados Soto, Vinicio ^a,c   Castañeda Hernández, Gilberto ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO   (Mexico)

^c UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO   (Mexico)

Author keywords

Antinociception; Area under the curve; Atrial natriuretic peptide; AUC; CGMP; Cyclic GMP; Cyclic guanosine monophosphate; Diclofenac; Indomethacin; L NAME; NG L nitro arginine methyl ester; Nitric oxide; NO; Pinacidil; Potassium channels

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ANALGESIC AGENT; APAMIN; ATRIAL NATRIURETIC FACTOR; CHARYBDOTOXIN; CYCLIC GMP; DICLOFENAC; FORMALDEHYDE; GLIBENCLAMIDE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FEMALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANALGESICS; ANIMALS; CYCLIC GMP; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOMETHACIN; NITRIC OXIDE; PAIN MEASUREMENT; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 1642304125     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(03)00214-4     Document Type: Article

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