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Volumn 10, Issue 3, 1999, Pages 97-104

Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: Research and clinical implications in erectile dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIC GMP; GUANYLATE CYCLASE; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL;

EID: 0033013460     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00127-1     Document Type: Review
Times cited : (123)

References (51)
  • 1
    • 0002429437 scopus 로고
    • In the physiology of erection, signposts to impotence
    • Saenz de Tejada I. In the physiology of erection, signposts to impotence. Contemp. Urol. 7:1992;52-68.
    • (1992) Contemp. Urol. , vol.7 , pp. 52-68
    • Saenz De Tejada, I.1
  • 4
    • 0028036149 scopus 로고
    • Impotence and its medical and psychosocial correlates: Results of the Massachusetts male aging study
    • Feldman H.A., Goldstein I., Hatzichristou D.G., Krane R.J., McKinlay J.B. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J. Urol. 151:1994;54-61.
    • (1994) J. Urol. , vol.151 , pp. 54-61
    • Feldman, H.A.1    Goldstein, I.2    Hatzichristou, D.G.3    Krane, R.J.4    McKinlay, J.B.5
  • 5
  • 6
    • 0030071844 scopus 로고    scopus 로고
    • The rationale for prostaglandin E1 in erectile failure: A survey of worldwide experience
    • Porst H. The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. J. Urol. 155:1996;802-815.
    • (1996) J. Urol. , vol.155 , pp. 802-815
    • Porst, H.1
  • 7
    • 0031845244 scopus 로고    scopus 로고
    • New developments in self-injection therapy for erectile dysfunction
    • Gingell J.C. New developments in self-injection therapy for erectile dysfunction. Br. J. Urol. 81:1998;599-603.
    • (1998) Br. J. Urol. , vol.81 , pp. 599-603
    • Gingell, J.C.1
  • 8
    • 0031060411 scopus 로고    scopus 로고
    • Nitric oxide in the penis: Physiology and pathology
    • Burnett A. Nitric oxide in the penis: physiology and pathology. J. Urol. 157:1997;320-324.
    • (1997) J. Urol. , vol.157 , pp. 320-324
    • Burnett, A.1
  • 9
    • 0030640206 scopus 로고    scopus 로고
    • Signal transduction in cavernous smooth muscle
    • Stief C.G., Noack T., Andersson K-E. Signal transduction in cavernous smooth muscle. World J. Urol. 15:1997;27-31.
    • (1997) World J. Urol. , vol.15 , pp. 27-31
    • Stief, C.G.1    Noack, T.2    Andersson, K.-E.3
  • 10
    • 0026634314 scopus 로고
    • Regulation of contraction and relaxation of arterial smooth muscle
    • Rembold C.M. Regulation of contraction and relaxation of arterial smooth muscle. Hypertension. 20:1991;129-137.
    • (1991) Hypertension , vol.20 , pp. 129-137
    • Rembold, C.M.1
  • 11
    • 0031057516 scopus 로고    scopus 로고
    • 2+ desensitization in vascular smooth muscle by activating myosin light chain phosphatase
    • 2+ desensitization in vascular smooth muscle by activating myosin light chain phosphatase. J. Biol. Chem. 272:1997;5063-5068.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5063-5068
    • Lee, M.R.1    Li, L.2    Kitazawa, T.3
  • 12
    • 0032323162 scopus 로고    scopus 로고
    • Sildenafil, a type 5 c-GMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro
    • Chuang A.T., Strauss J.D., Murphy R.A., Steers W.D. Sildenafil, a type 5 c-GMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro. J. Urol. 160:1998;257-261.
    • (1998) J. Urol. , vol.160 , pp. 257-261
    • Chuang, A.T.1    Strauss, J.D.2    Murphy, R.A.3    Steers, W.D.4
  • 13
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo J.A. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75:1995;725-745.
    • (1995) Physiol. Rev. , vol.75 , pp. 725-745
    • Beavo, J.A.1
  • 14
    • 0029942933 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases and vascular smooth muscle
    • Polson J.B., Strada S.J. Cyclic nucleotide phosphodiesterases and vascular smooth muscle. Annu. Rev. Pharmacol. Toxicol. 36:1996;403-427.
    • (1996) Annu. Rev. Pharmacol. Toxicol. , vol.36 , pp. 403-427
    • Polson, J.B.1    Strada, S.J.2
  • 16
    • 0030637901 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases in human cavernous smooth muscle
    • Taher A., Meyer M., Stief C.G., Jonas U., Forssman W.G. Cyclic nucleotide phosphodiesterases in human cavernous smooth muscle. World J. Urol. 15:1997;32-35.
    • (1997) World J. Urol. , vol.15 , pp. 32-35
    • Taher, A.1    Meyer, M.2    Stief, C.G.3    Jonas, U.4    Forssman, W.G.5
  • 17
    • 0032546779 scopus 로고    scopus 로고
    • Isolation and characterization of PDE9A, a novel cGMP-specific phosphodiesterase
    • Fischer D.A., Smith J.F., Pillar J.S., St. Denis S.H., Cheng J.B. Isolation and characterization of PDE9A, a novel cGMP-specific phosphodiesterase. J. Biol. Chem. 273:1998;15559-15564.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15559-15564
    • Fischer, D.A.1    Smith, J.F.2    Pillar, J.S.3    St. Denis, S.H.4    Cheng, J.B.5
  • 18
    • 0032546924 scopus 로고    scopus 로고
    • Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases
    • Sonderling S.H., Bayuga S.J., Beavo J.A. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J. Biol. Chem. 273:1998;15553-15558.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15553-15558
    • Sonderling, S.H.1    Bayuga, S.J.2    Beavo, J.A.3
  • 19
    • 0032445219 scopus 로고    scopus 로고
    • Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
    • Ballard S.A., Gingell C.J., Tang K., Turner L.A., Price M.E., Naylor A.M. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol. 159:1998;2164-2171.
    • (1998) J. Urol. , vol.159 , pp. 2164-2171
    • Ballard, S.A.1    Gingell, C.J.2    Tang, K.3    Turner, L.A.4    Price, M.E.5    Naylor, A.M.6
  • 20
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • Boolell M.et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int. J. Impot. Res. 8:1996;47-52.
    • (1996) Int. J. Impot. Res. , vol.8 , pp. 47-52
    • Boolell, M.1
  • 21
    • 0032502708 scopus 로고    scopus 로고
    • Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum
    • Moreland R.B., Goldstein I., Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum. Life Sci. 62:1998;PL309-PL318.
    • (1998) Life Sci. , vol.62 , pp. 309-PL318
    • Moreland, R.B.1    Goldstein, I.2    Traish, A.3
  • 22
    • 0018871466 scopus 로고
    • Characterization of a novel cGMP binding protein from rat lung
    • Francis S.H., Lincoln T.M., Corbin J.D. Characterization of a novel cGMP binding protein from rat lung. J. Biol. Chem. 255:1980;620-626.
    • (1980) J. Biol. Chem. , vol.255 , pp. 620-626
    • Francis, S.H.1    Lincoln, T.M.2    Corbin, J.D.3
  • 23
    • 0025041146 scopus 로고
    • Characterization of a purified bovine lung cGMP-binding, c-GMP-specific phosphodiesterase
    • Thomas M.K., Francis S.H., Corbin J.D. Characterization of a purified bovine lung cGMP-binding, c-GMP-specific phosphodiesterase. J. Biol. Chem. 265:1990;14964-14970.
    • (1990) J. Biol. Chem. , vol.265 , pp. 14964-14970
    • Thomas, M.K.1    Francis, S.H.2    Corbin, J.D.3
  • 24
    • 0027486271 scopus 로고
    • The structure of a bovine lung cGMP-bind-ing site of cGMP-binding, c-GMP- specific phosphodiesterase deduced from a cDNA clone
    • McAllister-Lucas L.M.et al. The structure of a bovine lung cGMP-bind-ing site of cGMP-binding, c-GMP- specific phosphodiesterase deduced from a cDNA clone. J. Biol. Chem. 268:1993;22863-22873.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22863-22873
    • McAllister-Lucas, L.M.1
  • 25
    • 0028070403 scopus 로고
    • Zinc interactions and conserved motifs of the cGMP-binding, c-GMP-specific phosphodiesterase suggest that it is a zinc hydrolase
    • Francis S.H., Colbran J.L., McAllister-Lucas L.M., Corbin J.D. Zinc interactions and conserved motifs of the cGMP-binding, c-GMP-specific phosphodiesterase suggest that it is a zinc hydrolase. J. Biol. Chem. 269:1994;22477-22480.
    • (1994) J. Biol. Chem. , vol.269 , pp. 22477-22480
    • Francis, S.H.1    Colbran, J.L.2    McAllister-Lucas, L.M.3    Corbin, J.D.4
  • 26
    • 0032543366 scopus 로고    scopus 로고
    • Molecular cloning and expression of human cGMP- binding cGMP-specific phosphodiesterase (PDE5)
    • Stacey P., Rulten S., Dapling A., Phillips S.C. Molecular cloning and expression of human cGMP- binding cGMP-specific phosphodiesterase (PDE5). Biochem. Biophys. Res. Commun. 247:1998;249-254.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 249-254
    • Stacey, P.1    Rulten, S.2    Dapling, A.3    Phillips, S.C.4
  • 27
    • 0029786581 scopus 로고    scopus 로고
    • Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding c-GMP-specific phosphodiesterase
    • Turko I.V., Haik T.L., McAllister-Lucas L.M., Burns F., Francis S.H., Corbin J.D. Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding c-GMP-specific phosphodiesterase. J. Biol. Chem. 271:1996;22240-22244.
    • (1996) J. Biol. Chem. , vol.271 , pp. 22240-22244
    • Turko, I.V.1    Haik, T.L.2    McAllister-Lucas, L.M.3    Burns, F.4    Francis, S.H.5    Corbin, J.D.6
  • 28
    • 0032008128 scopus 로고    scopus 로고
    • Binding of cGMP to both allosteric sites of cGMP-binding c-GMP-specific phosphodiesterase (PDE 5) is required for its phosphorylation
    • Turko I.V., Francis S.H., Corbin J.D. Binding of cGMP to both allosteric sites of cGMP-binding c-GMP-specific phosphodiesterase (PDE 5) is required for its phosphorylation. Biochem. J. 329:1998;505-510.
    • (1998) Biochem. J. , vol.329 , pp. 505-510
    • Turko, I.V.1    Francis, S.H.2    Corbin, J.D.3
  • 29
    • 18144445994 scopus 로고
    • The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases
    • Beltman J., Sonnenberg W.K., Beavo J.A. The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol. Cell. Biochem. 128:1993;239-253.
    • (1993) Mol. Cell. Biochem. , vol.128 , pp. 239-253
    • Beltman, J.1    Sonnenberg, W.K.2    Beavo, J.A.3
  • 30
    • 0031938315 scopus 로고    scopus 로고
    • ANF elicits phosphorylation of the cGMP phosphodi-esterase in vascular smooth muscle cells
    • Wyatt T.A., Naftilan A.J., Francis S., Corbin J.D. ANF elicits phosphorylation of the cGMP phosphodi-esterase in vascular smooth muscle cells. Am. J. Physiol. 274:1998;H448-H455.
    • (1998) Am. J. Physiol. , vol.274 , pp. 448-H455
    • Wyatt, T.A.1    Naftilan, A.J.2    Francis, S.3    Corbin, J.D.4
  • 31
    • 0000247159 scopus 로고    scopus 로고
    • Hydropathic analysis and mutagenesis of the catalytic domain of the cGMP-binding c-GMP-specific phosphodiesterase (PDE5) cGMP versus cAMP substrate selectivity
    • Turko I.V., Francis S.H., Corbin J.D. Hydropathic analysis and mutagenesis of the catalytic domain of the cGMP-binding c-GMP-specific phosphodiesterase (PDE5) cGMP versus cAMP substrate selectivity. Biochemistry. 37:1998;4200-4205.
    • (1998) Biochemistry , vol.37 , pp. 4200-4205
    • Turko, I.V.1    Francis, S.H.2    Corbin, J.D.3
  • 32
    • 0032513145 scopus 로고    scopus 로고
    • Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding c-GMP-specific phosphodiesterase
    • Turko I.V., Francis S.H., Corbin J.D. Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding c-GMP-specific phosphodiesterase. J. Biol. Chem. 273:1998;6460-6466.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6460-6466
    • Turko, I.V.1    Francis, S.H.2    Corbin, J.D.3
  • 33
    • 0344050149 scopus 로고    scopus 로고
    • Isolation of a human phosphodiesterase 5 cDNA and in situ analysis of its expression in human corpus cavernosum
    • (abstr. 351)
    • Rulten S.L.et al. Isolation of a human phosphodiesterase 5 cDNA and in situ analysis of its expression in human corpus cavernosum. J. Urol. 159:1998;92. (abstr. 351).
    • (1998) J. Urol. , vol.159 , pp. 92
    • Rulten, S.L.1
  • 34
    • 0031951754 scopus 로고    scopus 로고
    • Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development
    • Sanchez L.S., de la Monte S.M., Filippov G., Jones R.C., Zapol W.M., Bloch K.D. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr. Res. 43:1998;163-168.
    • (1998) Pediatr. Res. , vol.43 , pp. 163-168
    • Sanchez, L.S.1    De La Monte, S.M.2    Filippov, G.3    Jones, R.C.4    Zapol, W.M.5    Bloch, K.D.6
  • 35
    • 0030725663 scopus 로고    scopus 로고
    • Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development
    • Kotera J.et al. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development. Eur. J. Biochem. 249:1997;434-442.
    • (1997) Eur. J. Biochem. , vol.249 , pp. 434-442
    • Kotera, J.1
  • 36
    • 0000141954 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of sildenafil (Viagra™) in the treatment of severe erectile dysfunction
    • (abstr. 910)
    • Steers W.D. Meta-analysis of the efficacy of sildenafil (Viagra™) in the treatment of severe erectile dysfunction. J. Urol. 159:1998;238. (abstr. 910).
    • (1998) J. Urol. , vol.159 , pp. 238
    • Steers, W.D.1
  • 37
    • 0000141954 scopus 로고    scopus 로고
    • Analysis of the efficacy of sildenafil (Viagra™) in the treatment of male erectile dysfunction in elderly patients
    • (abstr. 912)
    • Wagner G. Analysis of the efficacy of sildenafil (Viagra™) in the treatment of male erectile dysfunction in elderly patients. J. Urol. 159:1998;239. (abstr. 912).
    • (1998) J. Urol. , vol.159 , pp. 239
    • Wagner, G.1
  • 38
    • 0031920611 scopus 로고    scopus 로고
    • The effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo
    • Stief C.G., Uckert S., Becker A.J., Truss M.C., Jonas U. The effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo. J. Urol. 159:1998;1390-1395.
    • (1998) J. Urol. , vol.159 , pp. 1390-1395
    • Stief, C.G.1    Uckert, S.2    Becker, A.J.3    Truss, M.C.4    Jonas, U.5
  • 39
    • 0031403328 scopus 로고    scopus 로고
    • Effects of sildenafil. A type 5 cGMP phosphodiesterase inhibitor and papverine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro
    • Jeremy J.Y., Ballard S.A., Naylor A.M., Miller M.A., Angelini G.D. Effects of sildenafil. A type 5 cGMP phosphodiesterase inhibitor and papverine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitro. Br. J. Urol. 79:1997;958-963.
    • (1997) Br. J. Urol. , vol.79 , pp. 958-963
    • Jeremy, J.Y.1    Ballard, S.A.2    Naylor, A.M.3    Miller, M.A.4    Angelini, G.D.5
  • 40
    • 0031861609 scopus 로고    scopus 로고
    • Clinical safety of oral sildenafil citrate (Viagra™) in the treatment of erectile dysfunction
    • Morales A., Gingell C., Collins M., Wicker P.A., Osterloh I.H. Clinical safety of oral sildenafil citrate (Viagra™) in the treatment of erectile dysfunction. Int. J. Impot. Res. 10:1998;69-74.
    • (1998) Int. J. Impot. Res. , vol.10 , pp. 69-74
    • Morales, A.1    Gingell, C.2    Collins, M.3    Wicker, P.A.4    Osterloh, I.H.5
  • 41
    • 0032323503 scopus 로고    scopus 로고
    • Effect of the selective phosphodiesterase type 5 inhibitor on erectile function on the anesthetized dog
    • Carter A.J., Ballard S.A., Naylor A.M. Effect of the selective phosphodiesterase type 5 inhibitor on erectile function on the anesthetized dog. J. Urol. 160:1998;242-246.
    • (1998) J. Urol. , vol.160 , pp. 242-246
    • Carter, A.J.1    Ballard, S.A.2    Naylor, A.M.3
  • 42
    • 0030780668 scopus 로고    scopus 로고
    • Development of an assay for simultaneous determination of sildenafil (Viagra™) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high performance liquid chroma- tography
    • Cooper J.D., Muirhead D.C., Taylor J.E., Baker P.R. Development of an assay for simultaneous determination of sildenafil (Viagra™) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high performance liquid chroma- tography. J. Chromatogr. B Biomed. Appl. 701:1997;87-95.
    • (1997) J. Chromatogr. B Biomed. Appl. , vol.701 , pp. 87-95
    • Cooper, J.D.1    Muirhead, D.C.2    Taylor, J.E.3    Baker, P.R.4
  • 43
    • 0030964555 scopus 로고    scopus 로고
    • Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure
    • Fox D.A., Campbell M.L., Blocker Y.S. Functional alterations and apoptotic cell death in the retina following developmental or adult lead exposure. Neurotoxicology. 18:1997;645-664.
    • (1997) Neurotoxicology , vol.18 , pp. 645-664
    • Fox, D.A.1    Campbell, M.L.2    Blocker, Y.S.3
  • 44
    • 0030842912 scopus 로고    scopus 로고
    • Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype
    • Boerth N.J., Dey N.B., Cornwell T.L., Lincoln T.M. Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype. J. Vasc. Res. 34:1997;245-249.
    • (1997) J. Vasc. Res. , vol.34 , pp. 245-249
    • Boerth, N.J.1    Dey, N.B.2    Cornwell, T.L.3    Lincoln, T.M.4
  • 45
    • 9544258245 scopus 로고    scopus 로고
    • Mechanisms of venous leakage: A prospective clinicopathological correlation of corporeal function and structure
    • Nehra A.et al. Mechanisms of venous leakage: a prospective clinicopathological correlation of corporeal function and structure. J. Urol. 156:1996;1320-1329.
    • (1996) J. Urol. , vol.156 , pp. 1320-1329
    • Nehra, A.1
  • 46
    • 0031805037 scopus 로고    scopus 로고
    • Is there a role of hypoxemia in penile fibrosis?
    • Moreland R.B. Is there a role of hypoxemia in penile fibrosis? Int. J. Impot. Res. 10:1998;113-120.
    • (1998) Int. J. Impot. Res. , vol.10 , pp. 113-120
    • Moreland, R.B.1
  • 48
    • 0031805041 scopus 로고    scopus 로고
    • Vasculogenic female sexual dysfunction: Vaginal engorgement and clitoral erectile insufficiency syndromes
    • Goldstein I., Berman J.R. Vasculogenic female sexual dysfunction: vaginal engorgement and clitoral erectile insufficiency syndromes. Int. J. Impot. Res. 10(Suppl. 2):1998;84-90.
    • (1998) Int. J. Impot. Res. , vol.10 , Issue.SUPPL. 2 , pp. 84-90
    • Goldstein, I.1    Berman, J.R.2
  • 49
    • 0031805345 scopus 로고    scopus 로고
    • Physiological measures of vaginal vasocongestion
    • Laan E., Everaerd W. Physiological measures of vaginal vasocongestion. Int. J. Impot. Res. 10(Suppl. 2):1998;S107-S110.
    • (1998) Int. J. Impot. Res. , vol.10 , Issue.SUPPL. 2 , pp. 107-S110
    • Laan, E.1    Everaerd, W.2
  • 50
    • 0030903202 scopus 로고    scopus 로고
    • Vasculogenic female sexual dysfunction: The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency
    • Park K., Goldstein I., Andry C., Siroky M.B., Krane R.J., Azadzoi K.M. Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int. J. Impot. Res. 9:1997;27-37.
    • (1997) Int. J. Impot. Res. , vol.9 , pp. 27-37
    • Park, K.1    Goldstein, I.2    Andry, C.3    Siroky, M.B.4    Krane, R.J.5    Azadzoi, K.M.6
  • 51
    • 0032575623 scopus 로고    scopus 로고
    • Characterization of phosphodiesterase activity in human clitoral corpus cavernosum smooth muscle cells in culture
    • Park K., Moreland R.B., Atala A., Goldstein I., Traish A.M. Characterization of phosphodiesterase activity in human clitoral corpus cavernosum smooth muscle cells in culture. Biochem. Biophys. Res. Commun. 249:1998;612-617.
    • (1998) Biochem. Biophys. Res. Commun. , vol.249 , pp. 612-617
    • Park, K.1    Moreland, R.B.2    Atala, A.3    Goldstein, I.4    Traish, A.M.5


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