Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test

European Journal of Pharmacology

Volumn 395, Issue 1, 2000, Pages 9-13

  Aguirre Bañuelos, Patricia ^a   Granados Soto, Vinicio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

cGMP; Meloxicam; N(G) L nitro arginine methyl ester (L NAME); Nitric oxide (NO); ODQ (1H (1,2,4) oxadiazolo(4,2 a)quinoxalin 1 one)

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; CYCLOOXYGENASE 2 INHIBITOR; FORMALDEHYDE; MELOXICAM; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; HYPERALGESIA; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, NON-NARCOTIC; ANIMALS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FORMALDEHYDE; GUANYLATE CYCLASE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PAIN; PAIN MEASUREMENT; QUINOXALINES; RATS; RATS, WISTAR; THIAZINES; THIAZOLES;

EID: 0343729518     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00157-6     Document Type: Article

References (34)

1. Aguirre-Bañuelos P., Castañeda-Hernández G., López-Muñoz F.J., Granados-Soto V. Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia. Eur. J. Pharmacol. 377:1999;175-182.
2. Aley K.O., Levine J.D. Role of protein kinase A in the maintenance of inflammatory pain. J. Neurosci. 19:1999;2181-2186.
3. Aley K.O., McCarter G., Levine J.D. Nitric oxide signaling in pain and nociceptor sensitization in the rat. J. Neurosci. 18:1998;7008-7014.
4. Cunha F.Q., Texeira M.M., Ferreira S.H. Pharmacological modulation of secondary mediator systems - cyclic AMP and cyclic GMP - on inflammatory hyperalgesia. Br. J. Pharmacol. 127:1999;671-678.
5. 2 release. Eur. J. Pharmacol. 331:1997;155-160.
6. Duarte I.D.G., Lorenzetti B.B., Ferreira S.H. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur. J. Pharmacol. 186:1990;289-293.
7. Duarte I.D.G., Santos I.R., Lorenzetti B.B., Ferreira S.H. Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway. Eur. J. Pharmacol. 217:1992;225-227.
8. Euchenhofer C., Maihofner C., Brune K., Tegeder I., Geisslinger G. Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat. Neurosci. Lett. 248:1998;25-28.
9. Ferreira S.H., Duarte I.D.G., Lorenzetti B.B. The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release. Eur. J. Pharmacol. 201:1991;121-122.
10. 2+ dependent process. Prostaglandins. 18:1979;179-190.
11. 2-induced sensitization of rat sensory neurons in vitro. J. Neurosci. 18:1998;10345-10355.
12. Granados-Soto V., Flores-Murrieta F.J., Castañeda-Hernández G., López-Muñoz F.J. Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac in the rat. Eur. J. Pharmacol. 277:1995;281-284.
13. Granados-Soto V., Rufino M.O., Gomes Lopes L.D., Ferreira S.H. Evidence for the involvement of nitric oxide-cGMP pathway in the antinociception of morphine in the formalin test. Eur. J. Pharmacol. 287:1997;281-284.
14. Haley J.E., Dickenson A.H., Schachter M. Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat. Neuropharmacology. 31:1992;251-258.
15. Hill R.G. Peripheral analgesic pharmacology - An update. Max M. Pain 1999 - An Updated Review. Refresher Course Syllabus. IASP Scientific Program Committee. International Association for the Study of Pain. 1999;391-395 IASP Press, Seattle.
16. Ethical guidelines for investigations on experimental pain in conscious animals. Pain. 16:1983;109-110.
17. Kawabata A., Manabe S., Manabe Y., Takagi H. Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. Br. J. Pharmacol. 112:1994;547-550.
18. Laird J.M.A., Herrero J.F., Garcia de la Rubia P., Cervero F. Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: central and peripheral components. Inflammation Res. 46:1997;203-210.
19. López-Garcia J.A., Laird J.M.A. Central antinociceptive effects of meloxicam on rat spinal cord in vitro. NeuroReport. 9:1998;647-651.
20. López-Muñoz F.J., Castañeda-Hernández G., Flores-Murrieta F.J., Granados-Soto V. Effect of caffeine coadministration and nitric oxide synthesis inhibition on the antinociceptive action of ketorolac. Eur. J. Pharmacol. 308:1996;275-277.
21. López-Muñoz F.J., Castañeda-Hernández G., Torres-López J.E., Picazo Y.F., Flores-Murrieta F.J., Granados-Soto V. Differences in the mechanism of antinociceptive action of non-steroidal anti-inflammatory drugs in the rat. Pharm. Sci. 2:1996;189-190.
22. Lorenzetti B.B., Ferreira S.H. Activation of the arginine-nitric oxide pathway in primary sensory neurons contributes to dipyrone-induced spinal and peripheral analgesia. Inflammation Res. 45:1996;308-311.
23. Malmberg A.B., Yaksh T.L. Antinociceptive actions of spinal non-steroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 263:1992;136-146.
24. Malmberg A.B., Yaksh T.L. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test. Pain. 54:1993;291-300.
25. Moro M.A., Russel R.J., Cellek S., Lizasoain I., Su Y., Darley-Usmar V.M., Radomski M.W., Moncada S. cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc. Natl. Acad. Sci. U. S. A. 93:1996;1480-1485.
26. Namba T., Oida H., Sugimoto Y., Kakizuka A., Negishi M., Ichikawa A., Narumiya S. cDNA cloning of a mouse prostacyclin receptor. J. Biol. Chem. 269:1994;9986-9992.
27. Nozaki-Taguchi N., Yamamoto T. The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation. Anesth. Analg. 86:1998;367-373.
28. 2-induced mechanical hyperalgesia in the rat. Neuroscience. 64:1995;769-776.
29. Pairet M., van Ryn J., Schierok H., Mauz A., Trummlitz G., Engelhardt G. Differential inhibition of cyclooxygenase-1 and -2 by meloxicam and its 4′-isomer. Inflammation Res. 47:1998;270-276.
30. Sluka K.A., Rees H., Chen P.S., Tsurouka M., Willis W.D. Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor. Brain Res. 772:1997;82-86.
31. Smith J.A.M., Amagasu S.M., Eglen R.M., Hunter J.C., Bley K.R. Characterization of prostanoid receptor-evoked responses in rat sensory neurons. Br. J. Pharmacol. 124:1998;513-523.
32. Taiwo Y.O., Levine J.D. Further confirmation of the role of adenylyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience. 44:1991;131-135.
33. Tonussi C.R., Ferreira S.H. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur. J. Pharmacol. 251:1994;173-179.
34. Yamamoto T., Nozaki-Taguchi N. Analysis of the effects of cyclooxygenase COX-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non selective COX-1 inhibitor and NS 398, a COX-2 selective inhibitor. Brain Res. 739:1996;104-110.