Role of the serotonin transporter gene and family function in adolescent alcohol consumption

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 4, 2005, Pages 564-570

  Nilsson, Kent W ^a,b   Sjöberg, Rickard L ^a   Damberg, Mattias ^a   Alm, Per Olof ^a   Öhrvik, John ^a   Leppert, Jerzy ^a   Lindström, Leif ^a   Oreland, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b CENTRAL HOSPITAL   (Sweden)

Author keywords

Adolescent; Alcohol; Environment; Genes

Indexed keywords

ADOLESCENT; ADULT; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; FEMALE; FREQUENCY ANALYSIS; GENE; GENE FUNCTION; GENETIC POLYMORPHISM; HUMAN; INTOXICATION; MALE; MOLECULAR INTERACTION; MULTIGENE FAMILY; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; QUESTIONNAIRE; RANDOMIZATION; RISK ASSESSMENT; SEROTONIN TRANSPORTER GENE; SOCIAL PSYCHOLOGY; STATISTICAL MODEL; SWEDEN;

ADOLESCENT; ADOLESCENT BEHAVIOR; ADULT; ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; FAMILY; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 17444386305     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000159112.98941.B0     Document Type: Article

References (51)

1. Barr CS, Newman TK, Becker ML, Champoux M, Lesch KP, Suomi SJ, Goldman D, Higley JD (2003a) Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol Clin Exp Res 27:812-817.
2. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD (2003b) The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2:336-340.
3. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Champoux M, Suomi SJ, Linnoila MV, Higley JD (2002) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7:118-122.
4. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA (1995a) Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 52:42-52.
5. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA (1995b) Genetic-environmental interaction in the genesis of aggressivity and conduct disorders. Arch Gen Psychiatry 52:916-924.
6. Campanelli PC, Dielman TE, Shope JT (1987) Validity of adolescents' self-reports of alcohol use and misuse using a bogus pipeline procedure. Adolescence 22:7-22.
7. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297:851-854.
8. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389.
9. Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416.
10. Cloninger CR, Bohman M, Sigvardsson S (1981) Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry 38:861-868.
11. Collier DA, Stober G, Li T, Heils A, Catalane M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Muller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP (1996) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
12. Comings DE, MacMurray JP (2000) Molecular heterosis: a review. Mol Genet Metab 71:19-31.
13. Edenberg HJ, Reynolds J, Koller DL, Begleiter H, Bucholz KK, Conneally PM, Crowe R, Goate A, Hesselbrock V, Li TK, Nurnberger JI Jr, Porjesz B, Reich T, Rice JP, Schuckit M, Tischfield JA, Foroud T (1998) A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. Alcohol Clin Exp Res 22:1080-1085.
14. Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, Plomin R, Craig IW (2004) Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 9:908-915.
15. Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, Riley B (2004) Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch Gen Psychiatry 61:738-744.
16. Freud S (1949) An Outline of Psychoanalysis. W.W. Norton & Company, New York.
17. Hallikainen T, Saito T, Lachman HM, Volavka J, Pohjalainen T, Ryynanen OP, Kauhanen J, Syvalahti E, Hietala J, Tiihonen J (1999) Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. Mol Psychiatry 4:385-388.
18. Hammoumi S, Payen A, Favre JD, Balmes JL, Benard JY, Husson M, Ferrand JP, Martin JP, Daoust M (1999) Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? Alcohol 17:107-112.
19. Harrison L (1997) The validity of self-reported drug use in survey research: an overview and critique of research methods. NIDA Res Monogr 167:17-36.
20. Harrison L, Hughes A (1997) Introduction - the validity of self-reported drug use: improving the accuracy of survey estimates. NIDA Res Monogr 167:1-16.
21. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, Riederer P, Lesch KP (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 102:247-254.
22. Hibell B, Andersson B, Bjarnson B, Kokkevi A, Morgan M, Narusk A (1997) The 1995 ESPAD-Report: Alcohol and Other Drug Use Among Students in 26 European Countries, vol 1. The Swedish Council for Information on Alcohol and Other Drugs, Stockholm.
23. Hill SY, Steinhauer SR, Zubin J (1986) Biological markers for alcoholism: a vulnerability model conceptualization. Nebr Symp Motiv 34:207-256.
24. Ishiguro H, Saito T, Akazawa S, Mitushio H, Tada K, Enomoto M, Mifune H, Toru M, Shibuya H, Arinami T (1999) Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population. Alcohol Clin Exp Res 23:1281-1284.
25. Jessor R (1987) Problem-behavior theory, psychosocial development, and adolescent problem drinking. Br J Addict 82:331-342.
26. Kandel DB, Andrews K (1987) Processes of adolescent socialization by parents and peers. Int J Addict 22:319-342.
27. Kendler KS, Heath AC, Neale MC, Kessler RC, Eaves LJ (1992) A population-based twin study of alcoholism in women. JAMA 268:1877-1882.
28. Lang AR, Stritzke WG (1993) Children and alcohol. Recent Dev Alcohol 11:73-85.
29. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
30. Lorenz K (1966) On Aggression. 1st ed. Harcourt, Brace & World, New York.
31. Mazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D (1998) Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 55:936-940.
32. McGue M, Pickens RW, Svikis DS (1992) Sex and age effects on the inheritance of alcohol problems: a twin study. J Abnorm Psychol 101:3-17.
33. Midanik L (1982) The validity of self-reported alcohol consumption and alcohol problems: a literature review. Br J Addict 77:357-382.
34. Midanik LT (1988) Validity of self-reported alcohol use: a literature review and assessment. Br J Addict 83:1019-1030.
35. Oetting ER, Donnermeyer JF (1998) Primary socialization theory: the etiology of drug use and deviance. I. Subst Use Misuse 33:995-1026.
36. Offer D, Kaiz M, Howard KI, Bennett ES (2000) The altering of reported experiences. J Am Acad Child Adolesc Psychiatry 39:735-742.
37. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwim GM, Smith CA (1996) Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-733.
38. Öhrvik J (2002) Nonparametric methods in the two-way layout. Chiang Mai J Sci 29:103-115.
39. Parsian A, Cloninger CR (2001) Serotonergic pathway genes and subtypes of alcoholism: association studies. Psychiatr Genet 11:89-94.
40. Plant M, Miller P (2001) Young people and alcohol: an international insight. Alcohol Alcohol 36:513-515.
41. Rutter M (2002) The interplay of nature, nurture, and developmental influences: the challenge ahead for mental health. Arch Gen Psychiatry 59:996-1000.
42. Schinka JA, Busch RM, Robichaux-Keene N (2004) A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 9:197-202.
43. Sen S, Burmeister M, Ghosh D (2004) Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet 127B:85-89.
44. Sigvardsson S, Bohman M, Cloninger CR (1996) Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis. Arch Gen Psychiatry 53:681-687.
45. Silberg J, Rutter M, D'Onofrio B, Eaves L (2003) Genetic and environmental risk factors in adolescent substance use. J Child Psychol Psychiatry 44:664-676.
46. Sjoberg RL, Lindblad F (2002) Limited disclosure of sexual abuse in children whose experiences were documented by videotape. Am J Psychiatry 159:312-314.
47. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY (2002) Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
48. Van Gestel S, Van Broeckhoven C (2003) Genetics of personality: are we making progress? Mol Psychiatry 8:840-852.
49. Wagenaar AC, Komro KA, McGovern P, Williams CL, Perry CL (1993) Effects of a saliva test pipeline procedure on adolescent self-reported alcohol use. Addiction 88:199-208.
50. Widom CS, Weiler BL, Cottler LB (1999) Childhood victimization and drug abuse: a comparison of prospective and retrospective findings. J Consult Clin Psychol 67:867-680.
51. Wiers RW, Gunning WB, Sergeant JA (1998) Do young children of alcoholics hold more positive or negative alcohol-related expectancies than controls? Alcohol Clin Exp Res 22:1855-1863.