Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 5, 2003, Pages 812-817

  Barr, Christina S ^a,e   Newman, Timothy K ^a   Becker, Michelle L ^a   Champoux, Maribeth ^b   Lesch, Klaus Peter ^d   Suomi, Stephen J ^b   Goldman, David ^c   Higley, J Dee ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

^e NIH Animal Center   (United States)

Author keywords

Alcohol Sensitivity; Environment; Nonhuman Primate; Serotonin Transporter; Stress

Indexed keywords

ALCOHOL; SEROTONIN TRANSPORTER;

ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ALCOHOL TOLERANCE; ALLELISM; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTICLE; ATAXIA; COHORT ANALYSIS; FEMALE; GEL ELECTROPHORESIS; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; MALE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANK SUM TEST; REARING; RHESUS MONKEY; SEDATION; STRESS;

ALCOHOLIC INTOXICATION; ANIMALS; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; GENOTYPE; KINETICS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS; VARIATION (GENETICS);

ANIMALIA; MACACA; MACACA MULATTA; PRIMATES;

EID: 0038662872     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000067976.62827.ED     Document Type: Article

References (37)

1. Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW, Scaefer C, Lieber CS (2001) Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res 25:502-507.
2. Bennett AJ, Lesch K-P, Heils A, Long JC, Lorenz JG, Shoaf SE, Champoux M, Suomi SJ, Linnoila MV, Higley JD. (2002) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7:118-122.
3. Crabbe JC, Phillips TJ, Feller DJ, Hen R, Wenger CD, Lessov CN, Schafer GL (1996) Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat Genet 14:98-101.
4. Feller DJ, Young ER, Riggan JP, Stuart J, Crabbe JC (1993) Serotonin and genetic differences in sensitivity and tolerance to ethanol hypothermia. Psychopharmacology 112:331-338.
5. Fillmore MT, Vogel-Sprott M (1996) Social drinking history, behavioral tolerance and the expectation of alcohol. Psychopharmacology (Berlin) 127:359-364.
6. Heath AC, Martin NG (1992) Genetic differences in psychomotor performance decrement after alcohol: a multivariate analysis. J Stud Alcohol 53:262-271.
7. Heinz A, Mann K, Weinberger DR, Goldman D (2001) Serotonergic dysfunction, negative mood states, and response to alcohol. Alcohol Clin Exp Res 25:487-495.
8. Higley JD (1996) Primates in alcohol research. Alcohol Health Res World 19:213-216.
9. Higley JD, Hasert MF, Suomi SJ, Linnoila M (1991a) Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proc Natl Acad Sci USA 88:7261-7265.
10. Higley JD, King ST, Hasert MF, Champoux M, Suomi SJ, Linnoila M (1996a) Stability of interindividual differences in serotonin function and its relationship to aggressive wounding and competent social behavior in rhesus macaque females. Neuropsychopharmacology 14:67-76.
11. Higley JD, Suomi SJ, Linnoila M (1991b) CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology 103:551-556.
12. Higley JD, Suomi SJ, Linnoila M (1996b) A nonhuman primate model of type II excessive alcohol consumption? Part 1: low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcohol Clin Exp Res 20:629-642.
13. Higley JD, Suomi SJ, Linnoila M (1996c) A nonhuman primate model of type II alcoholism? Part 2: diminished social competence and excessive aggression correlates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Alcohol Clin Exp Res 20:643-650.
14. Hiltunen AJ (1997a) Acute alcohol tolerance in cognitive and psychomotor performance: influence of the alcohol dose and prior alcohol experience. Alcohol 14:125-130.
15. Hiltunen AJ (1997b) Acute alcohol tolerance in social drinkers: changes in subjective effects dependent on the alcohol dose and prior alcohol experience. Alcohol 14:373-378.
16. Hiltunen AJ, Saxon L, Skogerberg S, Borg J (2000) Acute tolerance during intravenous infusion of alcohol: comparison of performance during ascending and steady-state concentrations - a pilot study. Alcohol 22: 69-74.
17. Kurtz DL, Stewart RB, Zweifel M, Li TK, Froehlich JC (1996) Genetic differences in tolerance and sensitization to the sedative/hypnotic effects of alcohol. Pharmacol Biochem Behav 53:585-591.
18. Le AD, Kiianmaa K (1988) Characteristics of ethanol tolerance in alcohol drinking (AA) and alcohol avoiding (ANA) rats. Psychopharmacology (Berlin) 94:479-483.
19. Lesch K., Bengel D, Heils A, Sabol S, Greenberg B, Petri S, Benjamin J, Muller C, Hamer D, Murphy D (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
20. Lesch KP, Meyer J, Glatz K, Flügge G, Hinney A, Hebebrand J, Klauck S, Poustka F, Poutska A, Bonger D, Mossner R, Riederer P, Heils A (1997) The 5-HT transporter gene-linked polymorphic region (5-HTLPR) in evolutionary perpective: alternative biallolic variation in rhesus monkeys. J Neural Transm 104:1259-1266.
21. Li T-K, Lumeng L, Doolittle DP (1993) Selective breeding for alcohol preference and associated responses. Behav Genet 23:163-170.
22. MacPherson PS, Stewart SH, McWilliams LA (2001) Parental problem drinking and anxiety disorder symptoms in adult offspring: examining the mediating role of anxiety sensitivity components. Addict Behav 26:917-934.
23. Mazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D (1998) Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 55:936-940.
24. Schuckit MA (1993) Reaction to alcohol as a predictor of alcoholism. Alcohol Alcohol Suppl 2:91-94.
25. Schuckit MA (1994a) Alcohol sensitivity and dependence. Experientia 71:341-348.
26. Schuckit MA (1994b) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189.
27. Schuckit MA, Mazzanti C, Smith TL, Ahmed U, Radel M, Iwata N, Goldman D (1999) Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45:647-651.
28. Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53:202-210.
29. Schuckit MA, Tsuang JW, Anthenelli RM, Tipp JE, Nurnberger JI Jr (1996) Alcohol challenges in young men from alcoholic pedigrees and control families: a report from the COGA project. J Stud Alcohol 1996 57:368-377.
30. Serretti A, Lilli R, Mandelli L, Lorenzi C, Smeraldi E (2001) Serotonin transporter gene associated with lithium prophylaxis in mood disorders. Pharmacogenomics 1:71-77.
31. Sher KJ, Walitzer KS, Wood PK, Brent EE (1991) Characteristics of children of alcoholics: putative risk factors, substance use and abuse, and psychopathology. J Abnorm Psychol 100:427-448.
32. Sher KJ, Salitzer KS, Wood PK, Bredt EE (1997) The role of childhood stressors in the intergenerational transmission of alcohol use disorders. J Stud Alcohol 58:414-427.
33. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, Little KY (2002) Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 114:230-234.
34. Suomi SJ, Rasmussen KLR, Higley JD (1992) Primate models of behavioral and physiological change in adolescence, in Textbook of Adolescent Medicine (McAnarney K, Kreipe RE, Orr DP, Comerci GD eds), pp 135-140. W.B. Saunders, Philadelphia.
35. Thomasson HR (1995) Gender differences in alcohol metabolism. Physiological responses to ethanol. Recent Dev Alcohol 12:163-179.
36. Tsibulsky VL, Amit Z (1993) Tolerance to effects of high doses of ethanol: 1. Lethal effects in mice. Pharmacol Biochem Behav 45:465-472.
37. Turker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schutz H, Weiler G, Stober G (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248:14.