Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 7, 1999, Pages 1281-1284

  Ishiguro, H ^a   Saito, T ^d   Akazawa, S ^e   Mitushio, H ^f   Tada, K ^g   Enomoto, M ^h   Mifune, H ⁱ   Toru, M ^c   Shibuya, H ^b   Arinami, Tadao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b National Minamihanamala Hospital   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d University Sapporo   (Japan)

^e Funabashikita Hospital   (Japan)

^f National Center of Neurology and Psychiatry   (Japan)

^g Bungosou Hospital   (Japan)

^h Enomoto Clinic   (Japan)

ⁱ Hatsuishi Hospital   (Japan)

Author keywords

Alcoholism; Behavior; Polymorphism; Serotonin Transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGED; ALCOHOLISM; ANTISOCIAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0032812138     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04289.x     Document Type: Article

References (31)

1. Balldin J, Berggren U, Engel J, Eriksson M (1994a) Neuroendocrine evidence for reduced serotonergic neurotransmission during heavy drinking. Alcohol Clin Exp Res 18:822-825.
2. Balldin J, Berggren U, Engel J, Eriksson M, Hard E, Soderpalm B (1994b) Effect of citalopram on alcohol intake in heavy drinkers. Alcohol Clin Exp Res 18:1133-1136.
3. Balldin J, Berggren U, Bodstrom K, Eriksson M, Gottfries CG, Karlsson I, Walinder J (1994c) Six-month open trial with Zimelidine in alcohol-dependent patients: Reduction in days of alcohol intake. Drug Alcohol Depend 35:245-248.
4. Boismare F, Lhuintre JP, Daoust M, Moore N, Saligaut C, Hillemand B (1987) Platelet affinity for serotonin is increased in alcoholics and former alcoholics: A biological marker for dependence? Alcohol Alcohol 22:155-159.
5. Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236:410-416.
6. Crabbe JC, Belknap JK, Buck KJ (1994) Genetic animal models of alcohol and drug abuse. Science 264:1715-1723.
7. Edenberg HJ, Reynolds J, Koller DL, Begleiter H, Bucholz KK, Conneally PM, Crowe R, Goate A, Hesselbrock V, Li T-K, Nurnberger JI, Jr., Porjesz B, Reich T, Rice JP, Schuckit M, Tischfield JA, Foroud T (1998) A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. Alcohol Clin Exp Res 22:1080-1085.
8. Ernouf D, Compagnon P, Lothion P, Narcisse G, Benard JY, Daoust M (1993) Platelets 3H 5-HT uptake in descendants from alcoholic patients: A potential risk factor for alcohol dependence? Life Sci 52:989-995.
9. Faraj BA, Olkowski ZL, Jackson RT (1997) Prevalence of high serotonin uptake in lymphocytes of abstinent alcoholics. Biochem Pharmacol 53:53-57.
10. Gelernter J, Kranzler H, Cubells JF (1997) Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African-and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 101:243-246.
11. Hanna GL, Himle JA, Curtis GC, Koram DQ, Weele JV, Leventhal BL, Cook EH, Jr. (1998) Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacology 18:102-111.
12. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
13. Heinz A, Higley JD, Gorey JG, Saunders RC, Jones DW, Hommer D, Zajicek K, Suomi SJ, Lesch KP, Weinberger DR, Linnoila M (1998a) In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 155: 1023-1028.
14. Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB, Gorey JG, Doty L, Geyer C, Lee KS, Coppola R, Weinberger DR, Linnoila M (1998b) Reduced central serotonin transporters in alcoholism. Am J Psychiatry 155:1544-1549.
15. Jorm AF, Henderson AS, Jacomb PA, Christensen H, Korten AE, Rodgers B, Tan X, Easteal S (1998) An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms. Mol Psychiatry 3:449-451.
16. LeMarquand D, Pihl RO, Benkelfat C (1994a) Serotonin and alcohol intake, abuse, and dependence: Clinical evidence. Biol Psychiatry 36: 326-337.
17. LeMarquand D, Pihl RO, Benkelfat C (1994b) Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies. Biol Psychiatry 36:395-421.
18. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
19. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, DelProposto ZS, Hill E, Cassin BJ, Watson SJ, Cook EH (1998) Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-213.
20. Mazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D (1998) Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry 55:936-940.
21. Melo JA, Shendure J, Pociask K, Silver LM (1996) Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nat Genet 13:147-153.
22. Merikangas KR (1990) The genetic epidemiology of alcoholism. Psychol Med 20:11-22.
23. Murakami F, Shimomura T, Kotani K, Ikawa S, Nanba E, Adachi K (1999) Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese. J Hum Genet 44:15-17.
24. Naranjo C, Sellers E, Roach C, Woodley D, Sanchez-Craig M, Sykora K (1984) Zimelidine-induced variations in alcohol intake by nondepressed heavy drinkers. Clin Pharmacol Ther 35:374-381.
25. Naranjo C, Sellers E, Sullivan J, Woodley D, Kadlec K, Sykora K (1987) The serotonin uptake inhibitor citalopram attenuates ethanol intake. Clin Pharmacol Ther 41:266-274.
26. Ohara K, Nagai M, Suzuki Y, Ochiai M (1998) Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene. Psychiatry Res 81:277-279.
27. Risch S, Nemeroff C (1992) Neurochemical alternations of serotonergic neuronal systems in depression. J Clin Psychiatry 53:3-7.
28. Sander T, Harms H, Dufeu P, Kuhn S, Hoehe M, Lesch KP, Rommelspacher H, Schmidt LG (1998) Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry 43:908-912.
29. Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H, Schmidt LG (1997) Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 21:1356-1359.
30. Turker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schutz H, Weiler G, Stober G (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett 248:147-150.
31. Zhou FC, Bledsoe S. Lumeng L, Li T-K (1994) Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats. Alcohol Clin Exp Res 18:571-579.