Tumour targeting: Biological factors and formulation advances in injectable lipid nanoparticles

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 4, 2005, Pages 411-421

  Shenoy, V S ^a   Vijay, I K ^a   Murthy, R S R ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; BIOLOGICAL FACTOR; CISPLATIN; CYTOTOXIC AGENT; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; DOXORUBICINOL; FLUOROURACIL; INULIN; LIPID; METHOTREXATE; METHOXAMINE; MONOCLONAL ANTIBODY; NANOPARTICLE; PACLITAXEL; SMALL MOLECULE TRANSPORT AGENT; SUCROSE; THYMIDINE TRIPHOSPHATE; VASODILATOR AGENT; VINBLASTINE; ZINOSTATIN;

ANIMAL CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL DEATH; CELL DENSITY; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TARGETING; DRUG TRANSPORT; EXTRAVASATION; MACROMOLECULE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; REVIEW; SOLID TUMOR; TISSUE DISTRIBUTION; TUMOR BLOOD FLOW; TUMOR CELL CULTURE; TUMOR VASCULARIZATION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL FACTORS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HUMANS; INJECTIONS; LIPIDS; LIPOSOMES; NANOSTRUCTURES; NEOPLASMS; POLOXAMER;

EID: 17144420857     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357055894     Document Type: Review

References (98)

1. Adams, G. P. (1998) Improving the tumor specificity and retention of antibody-based molecules. In vivo 12: 11-12
2. Allemann, E., Gurny, R., Doelker, E. (1993) Drug loaded nanoparticles - preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. 39: 173-191
3. Beaney, R. P., Lammertsma, A. A., Jones, T., McKenzie, C. G., Halnan, K. E. (1984) In vivo measurement of regional blood flow, oxygen utilization and blood volume in patients with carcinoma of the breast using positron tomography. Lancet 1: 131-134
4. Cavalli, R., Caputo, O., Gasco, M. R. (1993) Solid lipospheres of doxorubicin and idarubicin. Int. J. Pharm. 89: R9-R12
5. Chen, D. B., Yang, T. Z., Lu, W. L., Zhang, Q. (2001) In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. Chem. Pharm. Bull. 49: 1444-1447
6. Collins, P. D., Connolly, D. T., Williams, T. J. (1993) Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo. Br. J. Pharmacol. 109: 195-199
7. Collin-Gold, L., Feiehtinger, N., Wamheim, T. (2000) Are lipid emulsions the drug delivery solutions? Mod. Drug. Discov. 3: 44-48
8. Cope, D. A., Dewhirst, M. W., Friedman, H. S., Bigner, D. D., Zalutsky, M. R. (1990) Enhanced delivery of a monoclonal antibody F(ab')2 fragments to subcutaneous human glioma xenografts using local hyperthermia. Cancer Res. 50: 1803-1809
9. Cortesi, R., Esposito, E., Luca, G., Nastruzzi, C. (2002) Production of lipospheres as carriers for bioactive compounds. Biomaterials 23: 2283-2294
10. Dellian, M., Witwer, B. P., Salehi, H. A., Yuan, F., Jain, R. K. (1996) Quantitative and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor/vascular permeability factor and host microenvironment. Am. J. Pathol. 149: 59-71
11. Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D. (1999) Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol. Rev. 51: 691-743
12. Edlich, R. F., Rogers, W., DeShazo, C. V., Aust, J. B. (1966) Effect of vasoactive drugs on tissue blood flow in the hamster melanoma. Cancer Res. 26: 1420-1424
13. Eldem, T., Speiser, P., Hincal, A. (1991) Optimization of spray dried and congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy. Pharm. Res. 8: 47-54
14. Endlich, B., Hammersen, F. (1986) Morphologic and hemodynamic alterations in capillaries during hyperthermia. In: Anghileri, L. J., Robert, J. (eds) Hyperthermia in cancer treatment. CRC Press, Boca Raton, FL, pp 17-47
15. Endrich, B., Reinhold, H. S., Gross, J. F., Intaglietta, M. (1979) Tissue perfusion inhomogeneity during early tumor growth in rats. J. Natl Cancer Inst. 62: 387-395
16. Erlanson, M., Daniel-Szolgay, E., Carlsson, J. (1992) Relations between the penetrations, binding and average concentration of cytostatic drugs in human tumour spheroids. Cancer Chemother. Pharmacol. 29: 343-353
17. Erlichman, C., Viogen, D. (1984) Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids and xenografts in immune-deprived mice. Cancer Res. 44: 5369-5375
18. Falk, P. (1982) Differences in vascular pattern between the spontaneous and the transplanted C3H mouse mammary carcinoma. Eur. J. Cancer Oncol. 18: 155-165
19. Folkman, J. (1990) What is the evidence that tumors are angiogenesis dependent? J. Natl Cancer Inst. 82: 4-6
20. Folkman, J. (1995) Tumor angiogenesis. In: Mendelsohn, P. M., Howley, M. A. P., Liotta, L. A. (eds) The molecular basis of cancer. W. B. Saunders, Philadelphia, PA, pp 206-232
21. Fundaro, A., Cavalli, R., Bargoni, A., Vighetto, D., Zara, G. P., Gasco, M. R. (2000) Non stealth and stealth solid lipid nanoparticles and tissue distribution alter IV administration of rats. Pharm. Res. 42: 337-343
22. Gasco, M. R. (1993) Method for producing solid lipid microspheres having a narrow size distribution. US Patent No 5250236
23. 111In-labeled hapten to bifunctional antibody in human colon tumor xenografts. Cancer Res. 51: 1515-1520
24. Griffon-Etienne, G., Boucher, Y., Brekken, C., Suit, H. D., Jain, R. K. (1999) Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res. 59: 3776-3782
25. Gullino, P. M., Grantham, F. H. (1963) The influence of the host and the neoplastic cell population on the collagen content of a tumor mass. Cancer Res. 23: 648-653
26. Harper, E., Dang, W., Lapidus, R. G., Garver, R. I. (1999) Enhanced efficacy of a novel controlled release paclitaxel formulation (PACLIMER delivery system) for local-regional therapy of lung cancer tumor nodules in mice. Clin. Cancer Res. 5: 4242-4248
27. Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., Jain, R. K. (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl Acad. Sci. USA 95: 4607-4612
28. Hori, K., Suzuki, M., Tanda, S., Saito, S. (1990) In vivo analysis of tumor vascularization in the rat. Jpn. J. Cancer Res. 81: 279-288
29. Hori, K., Suzuki, M., Tanda, S., Saito, S. (1991) Characterisation of heterogeneous distribution of tumor blood flow in rat. Jpn. J. Cancer Res. 82: 109-117
30. Hori, K., Zhang, Q. H., Saito, S., Tanda, S., Li, H. C., Suzuki, M. (1993) Microvascular mechanisms of change in tumor blood flow due to angiotensin II, epinephrine, and methoxamine: a functional morphometric study. Cancer. Res. 53: 5528-5534
31. Iwai, Y., Maeda, H., Konno, T. (1984) Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image. Cancer Res. 44: 2115-2121
32. Jain, R. K. (1989) Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl Cancer Inst. 81: 570-576
33. Jain, R. K. (1994) Transport phenomena in tumors. Adv. Chem. Eng. 19: 129-200
34. Jain, R. K., Ward-Hartley, K. A. (1984) Tumor blood flow - characterization, modification and role in hyperthermia. IEEE Trans. Sonics Ultrasonics 31: 504-524
35. Jang, S. H., Weintjes, M. G., Au, J. L.-S. (2001) Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J. Pharmacol. Exp. Ther. 296: 1035-1042
36. Kerbel, R. S. (2000) Tumor angiogenesis: past, present and the near future. Carcinogenesis 21: 505-515
37. Kinuya, S., Yokoyama, K., Hiramatsu, T., Tega, H., Tanaka, K., Konishi, S., Shuke, N., Aburano, T., Watanabe, N., Takayama, T., Michgishi, T., Tonami, N. (1999) Combination radioimmunotherapy with local hyperthermia: increased delivery of radioimmunoconjugate by vascular effect and its retention by increased antigen expression in colon cancer xenografts. Cancer Lett. 140: 209-218
38. Kuh, H. J., Jang, S. H., Wientjes, M. G., Weaver, J. R., Au, J. L.-S. (1999) Determinants of paclitaxel penetration and accumulation in human solid tumor. J. Pharmacol. Exp. Ther. 290: 871-880
39. Lasie, D. D. (1998) Novel applications of liposomes. Tibtech 16: 307-321
40. Lauk, S., Zeitman, A., Skates, S., Fabian, R., Suit, H. D. (1989) Comparative morphometric study of tumor vasculature in human squamous cell carcinomas and their xenotransplants in athymic nude mice. Cancer Res. 49: 4557-4561
41. Lim, S.-J., Kim, C.-K. (2002) Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid. Int. J. Pharm. 244: 135-146
42. Liotta, L. A., Rao C. N. (1985) Role of the extracellular matrix in cancer. Ann. NY Acad. Sci. 460: 333-344
43. Liotta, L. A., Kileinerman, J., Saide, G. M. (1974) Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer. Res. 34: 997-1004
44. 3] bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol. Chem. 263: 16051-16054
45. Matsumura, Y., Kimura, M., Yamamoto, T., Maeda, H. (1988) Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn. J. Cancer Res. 79: 1327-1334
46. Migiglitta, A., Cavalli, R., Bocca, C., Gabriel, L., Gasco, M. R. (2000) Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel. Int. J. Pharm. 210: 61-67
47. 131I anti-CEA monoclonal antibody and hyperthermia in patients with advanced colorectal adenocarcinoma. Cancer 78: 1861-1870
48. Monsky, W. L., Fukumura, D., Gohongi, T. (1999) Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factors. Cancer Res. 59: 4129-4135
49. Muggia, F. M. (1999) Doxorubicin-polymer conjugates: further demonstration of the concept of enhanced permeability and retention. Clin. Cancer Res. 5: 7-8
50. Muller, R. H., Maassen, S., Weyhers, H., Mehnert, W. (1996) Phagocytic uptake and cytotoxicity of solid lipid nanoparticles (SLN) sterically stabilized with poloxamine 908 and poloxamer 407. J. Drug Target. 4: 161-170
51. Muller, R. H., Mader, K., Gohla, S. (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur. J. Pharm. Biopharm. 50: 161-177
52. Nederman, T., Carlsson, J. (1984) Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids. Cancer Chemother. Pharmacol. 13: 131-135
53. Nederman, T., Carlsson, J., Kuoppa, K. (1988) Penetration of substances into tumour tissues. Model studies using saccharides, thymidine and thymidine-5′-triphosphate in cellular spheroids. Cancer Chemother. Pharmacol. 22: 21-25
54. Netti, P. A., Hamberg, L. M., Babich, J. W., Kierstead, D., Graham, W., Hunter, G. J., Wolf, G. L., Fischman, A., Boucher, Y., Jain, R. K. (1999) Enhancement of fluid filtration across tumor vessels: implications for delivery of macromolecules. Proc. Natl Acad. Sci. USA 96: 3137-3142
55. Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., Jain, R. K. (2000) Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res. 60: 2497-2503
56. Nicotera, P., Leist, M., Ferrando-May, E. (1999) Apoptosis and necrosis: different execution of the same death. Biochem. Soc. Symp. 66: 69-73
57. Noguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., Maeda, H. (1998) Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res. 89: 307-314
58. Nomura, T., Koreeda, N., Yamashita, F., Takakura, Y., Hashida, M. (1998) Effect of particles size and charge on the deposition of lipid carriers after intra-tumoral injection into tissue - isolated tumors. Pharm. Res. 15: 128-132
59. Northfelt, D. W., Martin, F. J., Working, P., Volberding, P. A., Russel, J., Newman, M., Amantea, M. A., Kaplan, L. D. (1996) Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol: pharmacokinetics, tumor localization, and safety in patients with AIDS-related Kaposi's sarcoma. J. Clin. Pharmacol. 36: 55-63
60. O'Driscoll, C. M. (1992) Anatomy and physiology of the lymphatics. In: Charman, W. N., Stella, V. J. (eds) Lymphatic transport of drugs. CRC Press, Boca Raton, FL, pp 1-36
61. th Int. Sym. Contolled Release Bioact. Mater. 519-520
62. Olbrich, C., Bakowsky, U., Lehr, C. M., Muller, R. H., Kneuer, C. (2001) Cationic solid lipid nanoparticles can efficiently bind and transfect plasmid DNA. J. Control. Release 13: 345-355
63. Pagnan, G., Stuart, D. D., Pastorino, F., Raffaghello, L., Montaldo, P. G., Allen, T. M., Calabretta, B., Ponzoni, M. (2000) Delivery of c-myb antisense oligodeoxynucleotide to human neuroblastoma cells via disialoganglioside GD(2)-targeted immunoliposomes: antitumor effects. J. Natl Cancer Inst. 92: 253-261
64. Peters, W., Teixeira, M., Intaglietta, M., Gross, I. F. (1980) Microcirculatory studies in a rat mammary carcinoma. I. Transparent chamber method, development of microvasculature and pressures in tumor vessels. J. Natl Cancer Inst. 65: 631-642
65. Pluen, A., Ramanujan, S., Boucher, Y., Unemori, E., Seed, B., Jain, R. K. (2000) Relacin increases the transport of large molecules in high collagen content tumors. Proc. Am. Assoc. Cancer. Res. 38: 604
66. Ranney, D. F. (2000) Biomimetic transport and rational drug delivery. Biochem. Pharmacol. 59: 105-114
67. Ranney, D., Antich, P., Cohen, J., Erdman, W., Kulkarni, P., Giovanella, B. (1988) Submillimeter monitoring of tumor treatment response by contrast-enhanced magnetic resonance imaging (MRI): implications for tumor access of antibodies lymphokines and macromolecular drugs. Proc. Am. Assoc. Cancer Res. 29: 495
68. Roberts, W. G., Palade, G. E. (1995) Increased micro-vascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell. Sci. 108: 2369-2379
69. Sasaki, T., Yamamoto, M., Yamaguchi, T., Sugiyama, S. (1984) Development of multicellular spheroids of HeLa cells co-cultured with fibroblasts and their response to X-irradiation. Cancer Res. 44: 345-351
70. Scholer, N., Hahn, H., Muller, R. H., Leiscufeld, O. (2001) Surfactant and not the size of Solid Lipid Nanoparticles (SLN) influences the viability and cytokine production of macrophages. Int. J. Pharm. 221: 57-67
71. Scholer, N., Hahn, H., Muller, R. H., Leiscufeld, O. (2002) Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on viability and cytokine production of macrophages. Int. J. Pharm. 231: 167-176
72. Schuster, J. M., Zalutsky, M. R., Noska, M. A., Dodge, R., Friedman, H. S., Bigner, D. D., Dewhirst, M. W. (1995) Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues. Int. J. Hyperthermia 11: 59-72
73. Schwarz, C., Mehnert, W., Lucks, J. S., Muller, R. H. (1994) Solid lipid nanoparticle (SLN) for controlled drug delivery: I production, characterization and steriliszation. J. Control. Release 30: 83-96
74. Schwarze, S. R., Ho, A., Vocero Akbani, A., Dowdy, S. F. (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285: 1569-1572
75. Seymour, L. W., Ulbrich, K., Steyger, P. S., Brereton, M., Subr, V., Strohalm, J., Duncan, R. (1994) Tumor tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma. Br. J. Cancer 70: 636-641
76. Shahgaldian, P., Da Silva, E., Coleman, A. W., Rather, B., Zaworotko, M. J. (2003) Para-acyl-calyx-arene based solid lipid nanoparticles (SLN): a detailed study of preparation and stability parameters. Int. J. Pharm. 253: 23-38
77. Sinn, H., Schrenk, H. H., Friedrich, E. A., Schilling, U., Mair-Borst, W. (1990) Design of compounds having an enhanced tumour uptake, using serum albumin as carrier. Part I. Int. J. Rad. Appl. Instrum B 17: 819-827
78. Sjostrom, B., Kaplon, A., Talmon, Y., Cabane, B. (1995) Structure of nanoparticles prepared from oil-in-water emulsions. Pharm. Res. 21: 39-48
79. Smith, A., Hunneyball, I. M. (1986) Evaluation of Polylactid as a biodegradable drug delivery system for parenteral administration. Int. J. Pharm. 30: 215-230
80. Straw, J., Hart, M., Klubes, P., Zaharko, D., Dedrick, R. L. (1974) Distribution of anticancer agents in spontaneous animal tumors. I Regional blood flow and methotrexate distribution in canine lymphosarcoma. J. Natl Cancer Inst. 52: 1327-1331
81. Suzuki, M., Hori, K., Abe, I., Saito, S., Sato, H. (1981) A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II. J. Natl Cancer Inst. 67: 663-669
82. Tannock, I. F., Steel, G. G. (1969) Quantitative techniques for study of the anatomy and function of small blood vessels in tumors. J. Natl Cancer Inst. 42: 771-782
83. Trotter, M. J., Chaplin, D. J., Olive, P. L. (1991) Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma. Eur. J. Cancer 27: 887-893
84. Vasey, P. A., Kaye, S. B., Morrison, R., Twelves, C., Wilson, P., Duncan, R., Thomson, A. H., Murray, L. S., Hilditch, T. E., Murray, T., Burtles, S., Fraier, D., Fringerio, E., Cassidy, J. (1999) Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: first member of new class of chemotherapeutic agents - drug-polymer conjugates. Clin. Cancer Res. 5: 83-94
85. Vaupel, P. (1977) Hypoxia in neoplastic tissue. Microvasc. Res. 13: 399-408
86. West, G. W., Weichselbaum, R., Little, J. B. (1980) Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. Cancer Res. 40: 3665-3668
87. Westensen, K. (1994) Novel lipid-based colloidal dispersions as potential drug administration systems - expectations and reality. Coll. Surf. Polym. Sci. 278: 609-618
88. Westensen, K., Bunjes, H., Koch, M. J. (1997) Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. J. Control. Release 48: 223-236
89. Weyhers, H., Ehlers, S., Mehnert, W., Hahn, H., Muller, R. H. (1995) Solid lipid nanoparticles - determination of an in vivo toxicity. Proceedings of first world Meeting APGI/APV, 489-490
90. Wilder, R. B., Langmuir, V. K., Mendonca, H. L., Goris, M. L., Knox, S. J. (1993) Local hyperthermia and SR 4233 enhance the anti-tumor effects of radioimmunotherapy in nude mice with human colonic adenocarcinoma xenografts. Cancer Res. 53: 3022-3027
91. Winlove, C. P., Parker, K. H. (1995) The physiological function of the extracellular matrix. In: Reed, R. K., Laine, G. A., Bert, J. L., Winlove, C. P., McHale, N. (eds) Interstitium, connective tissue and lymphatics. Portland Press, London, pp 137-165
92. Wolf, J. K., Mills, G. B., Bazzet, L., Bast, R. C., Roth, J. A., Gerhenson, D. M. (1999) Adenovirus-mediated p53 growth inhibition of ovarian cancer cell line is independent of endogenous p53 status. Gynecol. Oncol. 75: 261-266
93. Wretlind, A. (1981) Development of fat emulsions. J. Parenter. Enter. Nutr. 5: 230-235
94. Wu, N. Z., Da, D., Ruoll, T. L., Needham, D., Whorton, A. R., Dewhirst, M. W. (1993) Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissues. Cancer Res. 53: 3765-3770
95. Yamaura, H., Sato, H. (1974) Quantitative studies on the developing vascular system on rat hepatoma. J. Natl Cancer Inst. 53: 1229-1240
96. Yang, S. C., Lu, L. F., Cai, Y., Zhu, J. B., Liang, B. W., Yang, C. Z. (1999) Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release 59: 299-307
97. Zara, G. P., Cavalli, R., Fundaro, A., Bargoni, A., Caputo, O., Gasco, M. R. (1999) Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN). Pharm. Res. 42: 337-343
98. Zheng, J. H., Chen, C. T., Au, J. L.-S., Wientjes, M. G. (2001) Time and concentration-dependent penetration of doxorubicin in prostrate tumors. AAPS PharmSci. 3: article 15 (http://www.pharmsci.org/journal)