Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages

International Journal of Pharmaceutics

Volumn 231, Issue 2, 2002, Pages 167-176

  Scholer N ^a   Hahn, H ^a   Muller R H ^a   Liesenfeld, O ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cytokines; Cytotoxicity; Lipid matrix; Peritoneal macrophages; Size; Solid lipid nanoparticles (SLN)

Indexed keywords

CYTOKINE; DIMETHYLDIOCTADECYLAMMONIUM BROMIDE; DYNASAN 114; DYNASAN 118; ESTER DERIVATIVE; GLYCEROL BEHENATE; IMWITOR; LIPOFUNDIN; PALMITIC ACID CETYL ESTER; PARAFFIN; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; SOYBEAN OIL; STEARIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME DEGRADATION; MACROPHAGE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PARTICLE SIZE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN INDUCTION; PROTEIN SECRETION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LIPIDS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; PARTICLE SIZE;

EID: 0037074096     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00882-1     Document Type: Article

References (19)

1. The acute phase response
2. Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: Effect of size, concentration, and composition
3. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro
4. Solid lipid nanoparticles - Ein neuartiger wirkstoff-carrier für kosmetika und pharmazeutika, 2. Mitteilung: Wirkstoff-inkorporation, freisetzung und sterilisierbarkeit
5. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
6. Solid lipid nanoparticles (SLN) as potential carrier for human use: Interaction with human granulocytes
7. Solid lipid nanoparticles (SLN) - An alternative colloidal carrier system for controlled drug delivery
8. Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant
9. Biodegradation of solid lipid nanoparticles as a function of lipase incubation time
10. Effect of surfactant and lipid composition on the in vitro degradation time of solid lipid nanoparticles (SLN)
11. Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures
12. In vitro phagocytosis assay of nano- and microparticles by chemiluminscence. I. Effect of analytical parameters, particle size and particle concentration
13. Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages
14. Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages
15. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterisation and sterilisation
16. The mononuclear phagocyte system. A new classification of macrophages and their precursor cells
17. Solid lipid nanoparticles (SLN) for controlled drug delivery, drug release and release mechanism