Nucleotide specificity of HIV-1 reverse transcriptases with amino acid substitutions affecting Ala-114

Biochemical Journal

Volumn 387, Issue 1, 2005, Pages 221-229

  Cases González, Clara E ^a   Menéndez Arias, Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

DdNTPs; Drug resistance; Fidelity; HIV; Polymerase; Reverse transcriptase

Indexed keywords

AMINO ACIDS; BIOASSAY; ENZYMES; METABOLITES; MUTAGENESIS; NUCLEIC ACIDS; REACTION KINETICS; VAN DER WAALS FORCES;

GLYCINE; MUTATIONS; NUCLEOTIDES; SERINE;

VIRUSES;

3' AZIDO 3' DEOXYTHYMIDINE TRIPHOSPHATE; ALANINE; ASPARTIC ACID; BETA GALACTOSIDASE; DIDANOSINE; DNA POLYMERASE; GLUTAMINE; GLYCINE; MUTANT PROTEIN; NUCLEOTIDE; RIBONUCLEOTIDE; RNA DIRECTED DNA POLYMERASE; SERINE; THREONINE; THYMIDINE TRIPHOSPHATE; TYROSINE; UNCLASSIFIED DRUG; VALINE; ZALCITABINE; ZIDOVUDINE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS RESISTANCE; DNA SYNTHESIS; DRUG DISCRIMINATION; DRUG SENSITIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE INSERTION; GENETIC COMPLEMENTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEADY STATE; WILD TYPE;

ALANINE; AMINO ACID SUBSTITUTION; DIDEOXYNUCLEOSIDES; DINUCLEOSIDE PHOSPHATES; DNA; DNA, VIRAL; HIV-1 REVERSE TRANSCRIPTASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEOTIDES; THYMIDINE MONOPHOSPHATE; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 17144418899     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041056     Document Type: Article

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