Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 7, 2000, Pages 3056-3061

  Boyer, Paul L ^a   Sarafianos, Stefan G ^b   Arnold, Edward ^b   Hughes, Stephen H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE 5' TRIPHOSPHATE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; DNA STRAND; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION;

BINDING SITES; DEOXYRIBONUCLEOTIDES; DRUG RESISTANCE, MICROBIAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034724175     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.7.3056     Document Type: Article

References (34)

1. Coffin, J. M., Hughes, S. H. & Varmus, H. E. (1997) Retroviruses (Cold Spring Harbor Lab. Press, Plainview, NY).
2. De Clercq, E. (1994) Biochem. Pharmacol. 47, 155-169.
3. Mellors, J. W., Larder, B. A. & Sehinazi, R. G. (1995) Int. Antiviral News 3, 8-13.
4. Richman, D. D. (1993) Antimicrob. Agents Chemother. 37, 1207-1213.
5. Ding, J., Das, K., Hsiou, Y., Sarafianos, S. G., Clark, A. D., Jr., Jacobo-Molina, A., Tantillo, C., Hughes, S. H. & Arnold, E. (1998) J. Mol. Biol. 284, 1095-1111.
6. Huang, H., Chopra, R., Verdine, G. L. & Harrison, S. C. (1998) Science 282, 1669-1675.
7. Boyer, P. L., Ferris, A. L. & Hughes, S. H. (1992) J. Virol. 66, 1031-1039.
8. Boyer, P. L., Ferris, A. L., Clark, P., Whitmer, J., Frank, P., Tantillo, C., Arnold, E. & Hughes, S. H. (1994) J. Mol. Biol. 243, 472-483.
9. Larder, B. A., Kemp, S. D. & Purifoy, D. J. M. (1989) Proc. Natl. Acad. Sci. USA 86, 4803-4807.
10. Lowe, D. M., Parmar, V., Kemp. S. D. & Larder, B. A. (1991) FEBS Lett. 282, 231-234.
11. Martín-Hernández, A., Domingo, E. & Menèndez-Arias, L. (1996) EMBO J. 15, 4434-4442.
12. Martín-Hernández, A. M., Gutièrrez-Rivas, M., Domingo, E. & Menèndez-Arias, L. (1997) Nucleic Acids Res. 25, 1383-1389.
13. Wrobel, J. A., Chao, S.-F., Conrad, M. J., Merker, J. D., Swanstrom, R., Pielak, G. J. & Hutchison, C. A., III (1998) Proc. Natl. Acad. Sci. USA 95, 638-645.
14. Harris, D., Kaushik, N., Pandey, P. K., Yadav, P. N. S. & Pandey, V. N. (1998) J. Biol. Chem. 273, 33624-33634.
15. Vandamme, A.-M., Van Vaerenbergh, K. & De Clercq, E. (1998) Antiviral Chem. Chemother. 9, 187-203.
16. Tisdale, M., Alnadaf, T. & Cousens, D. (1997) Antimicrob. Agents Chemother. 41, 1094-1098.
17. Rezende, L. F., Curr, K., Ueno, T., Mitsuya, H. & Prasad, V. R. (1998) J. Virol. 72, 2890-2895.
18. Schafer, R. W., Kozal, M. J., Winters, M. A., Iverson, A. K. N., Katzenstein, D. A., Ragni, M. V., Meyer, W. A., III, Gupta, P., Rasheed, S., Coombs, R., et al. (1994) J. Infect. Dis. 169, 722-729.
19. Shirasaka, T., Kavlick, M. F., Ueno, T., Gao, W.-Y., Kojima, E., Alcaide, M. L., Chokekijchai, S., Roy, B. M., Arnold, E., Yarchoan, R. & Mitsuya, H. (1995) Proc. Natl. Acad. Sci. USA 92, 2398-2402.
20. Poch, O., Sauvaget, I., Delarue, M. & Tordo, N. (1989) EMBO J. 8, 3867-3874.
21. Gao, G., Orlova, M., Georgiadis, M. M., Hendrickson, W. A. & Goff, S. P. (1997) Proc. Natl. Acad. Sci. USA 94, 407-411.
22. Gao, G. & Goff, S. P. (1998) J. Virol. 72, 5905-5911.
23. Boyer, P. L., Ferris, A. L. & Hughes, S. H. (1992) J. Virol. 66, 7533-7537.
24. Boyer, P. L., Tantillo, C., Jacobo-Molina, A., Nanni, R. G., Ding, J., Arnold, E. & Hughes, S. H. (1994) Proc. Natl. Acad. Sci. USA 91, 4882-4886.
25. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Wiley, R. A., Rabson, A. & Martin, M. A. (1986) J. Virol. 59, 284-291.
26. Boyer, P. L., Liszienicz, J., Lori, F. & Hughes, S. H. (1999) J. Mol. Biol. 286, 995-1008.
27. Boyer, P. L. & Hughes, S. H. (1995) Antimicrob. Agents Chemother. 39, 1624-1628.
28. Boyer, P. L., Gao, H.-Q. & Hughes, S. H. (1998) Antimicrob. Agents Chemother. 42, 447-452.
29. Fuentes, G. M., Rodríguez, L., Palaniappan, C., Fay, P. J. & Bambara, R. A. (1996) J.. Biol. Chem. 271, 1966-1971.
30. Barber, A., Hizi, A., Maizel, J. V., Jr. & Hughes, S. H. (1990) AIDS Res. Human Retrovir. 6, 1061-1072.
31. Georgiadis, M. M., Jessen, S. M., Ogata, C. M., Telesnitsky, A., Goff, S. P. & Hendrickson, W. A. (1995) Structure (London) 3, 879-892.
32. Johnson, M. S., McClure, M. A., Feng, D. F., Gray, J. & Doolittle, R. (1986) Proc. Natl. Acad. Sci. USA 83, 7648-7652.
33. Joyce, C. M. (1997) Proc. Natl. Acad. Sci. USA 94, 1619-1622.
34. Das, A. T., Klaver, B., Klasens, B. I. F., van Wamel, J. L. B. & Berkhout, B. (1997) J. Virol. 71, 2346-2356.