A genetic approach for identifying critical residues in the fingers and palm subdomains of HIV-1 reverse transcriptase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 2, 1998, Pages 638-645

  Wrobel, John A ^a   Chao, Shih Fong ^a,d   Conrad, Michael J ^a   Merker, Jason D ^a   Swanstrom, Ronald ^a,c   Pielak, Gary J ^b   Hutchison III, Clyde A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE; RNA DIRECTED DNA POLYMERASE; ZINC FINGER PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVITY; GENE MAPPING; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; VIRUS GENOME; VIRUS REPLICATION;

AMINO ACID SEQUENCE; BINDING SITES; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVATION; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR SEQUENCE DATA;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031881696     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.2.638     Document Type: Article

References (29)

1. Hutchison, C. A., III, Phillips, S., Edgell, M. H., Gillam, S., Jahnke, P. & Smith, M. (1978) J. Biol. Chem. 253, 6551-6560.
2. Hutchison, C. A., III, Swanstrom, R. & Loeb, D. D. (1991) Methods Enzymol. 202, 356-390.
3. Hutchison, C. A., III, Nordeen, S. K., Vogt, K. & Edgell, M. H. (1986) Proc. Natl. Acad. Sci. USA 83, 710-714.
4. Loeb, D. D., Swanstrom, R., Everitt, L., Manchester, M., Stamper, S. E. & Hutchison, C. A., III (1989) Nature (London) 340, 397-400.
5. Farmerie, W. G., Loeb, D. D., Casavant, N. C., Hutchison, C. A., III, Edgell, M. H. & Swanstrom, R. (1987) Science 236, 305-308.
6. Loeb, D. D., Hutchison, C. A., III, Edgell, M. H., Farmerie, W. G. & Swanstrom, R. (1989) J. Virol. 63, 111-121.
7. Lattman, E. E. & Rose, G. D. (1993) Proc. Natl. Acad. Sci. USA 90, 439-441.
8. Chao, S. F., Chan, V. L., Juranka, P., Kaplan, A. H., Swanstrom, R. & Hutchison, C. A., III (1995) Nucleic Acids Res. 23, 803-810.
9. Chao, S. F. (1992) Ph.D. thesis (The University of North Carolina, Chapel Hill).
10. Vieira, J. & Messing, J. (1987) Methods Enzymol. 153, 3-11.
11. Wilson, R. K. (1993) Biotechniques 15, 414-422.
12. Richardson, D. C. & Richardson, J. S. (1994) Trends Biochem. Sci. 19, 135-138.
13. Carson, M. (1987) J. Mol. Graphics 5, 103-106.
14. Unge, T., Knight, S., Bhikhabhai, R., Lövgren, S., Dauter, Z., Wilson, K. & Strandberg, B. (1994) Structure (London) 2, 953-961.
15. Esnouf, R., Ren, J., Ross, C., Jones, Y., Stammers, D. & Stuart, D. (1995) Nat. Struct. Biol. 2, 303-308.
16. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H. & Arnold, E. (1993) Proc. Natl. Acad. Sci. USA 90, 6320-6324.
17. Georgiadis, M. M., Jessen, S. M., Ogata, C. M., Telesnitsky, A., Goff, S. P. & Hendrickson, W. A. (1995) Structure (London) 3, 879-892.
18. Xiong, Y. & Eickbush, T. H. (1990) EMBO J. 9, 3353-3362.
19. Wu, T. T. & Kabat, E. A. (1970) J. Exp. Med. 132, 211-250.
20. Silla, E., Tuñón, I. & Pascual-Ahuir, J. L. (1991) J. Comput. Chem. 12, 1077-1088.
21. Pascual-Ahuir, J. L., Silla, E. & Tuñon, I. (1992) GEPOL 92 (Quantum Chemistry Program Exchange, Department of Chemistry, Indiana University), Program 554.
22. Wrobel, J. A. (1996) Ph.D. thesis (The University of North Carolina, Chapel Hill).
23. Doyle, D. F. (1996) Ph.D. thesis (The University of North Carolina, Chapel Hill).
24. Wang, J., Smerdon, S. J., Jäger, J., Kohlstaedt, L. A., Rice, P. A., Friedman, J. M. & Steitz, T. A. (1994) Proc. Natl. Acad. Sci. USA 91, 7242-7246.
25. Dayhoff, M. O., Schwartz, R. M. & Orcutt, B. C. (1978) in Atlas of Protein Sequence and Structure, ed. Dayhoff, M. O. (Natl. Biomed. Res. Found., Silver Spring, MD), Vol. 5, pp. 345-352.
26. Sarafianos, S. G., Pandey, V. N., Kaushik, N. & Modak, M. J. (1995) Biochemistry 34, 7207-7216.
27. Boyer, P. L., Ferris, A. L., Clark, P., Whitmer, J., Frank, P., Tantillo, C., Arnold, E. & Hughes, S. H. (1994) J. Mol. Biol. 243, 472-483.
28. Byrnes, V. W., Sardana, V. V., Schleif, W. A., Condra, J. H., Waterbury, J. A., Wolfgang, J. A., Long, W. J., Schneider, C. L., Schlabach, A. J., Wolanski, B. S., Graham, D. J., Gotlib, L., Rhodes, A., Titus, D. L., Roth, E., Blahy, O. M., Quintero, J. C., Staszewski, S. & Emini, E. A. (1993) Antimicrob. Agents Chemother. 37, 1576-1579.
29. Boyer, P. L., Ding, J., Arnold, E. & Hughes, S. H. (1994) Antimicrob. Agents Chemother. 38, 1909-1914.