Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors

Journal of Chromatography A

Volumn 1072, Issue 2, 2005, Pages 159-168

  Chan, E C Y ^a,c   Tan, W L ^b   Ho, P C ^b   Fang, L J ^a  

^a S BIO Pte Ltd   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Waters Asia Limited   (Singapore)

Author keywords

IAM chromatography; Physicochemical descriptors

Indexed keywords

ABSORPTION; DRUG PRODUCTS; MATHEMATICAL MODELS; MEMBRANES; MOLECULAR WEIGHT; OPTIMIZATION; REGRESSION ANALYSIS;

CACO-2 PERMEABILITY; IMMOBILIZED ARTIFICIAL MEMBRANE (IAM) CHROMATOGRAPHY; PHYSIOCHEMICAL DESCRIPTORS; POLAR SURFACE AREA (PSA);

CHROMATOGRAPHIC ANALYSIS;

ACETYLSALICYLIC ACID; AMPICILLIN; ATENOLOL; CAPTOPRIL; CARBAMAZEPINE; CEFALEXIN; CHLORAMPHENICOL; CIMETIDINE; DICLOFENAC; DILTIAZEM; ETOPOSIDE; HYDROCORTISONE; IBUPROFEN; INDOMETACIN; KETOCONAZOLE; LABETALOL; MANNITOL; PARACETAMOL; PINDOLOL; PREDNISOLONE; PROCAINE; PROPRANOLOL; QUINIDINE; RANITIDINE; RIFAMPICIN; SALICYLIC ACID; TAMOXIFEN; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

ABSORPTION; ACCURACY; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL TRANSPORT; CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG PENETRATION; HUMAN; HUMAN CELL; HYDROGEN BOND; MODEL; MOLECULAR SIZE; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE PROPERTY RELATION; REGRESSION ANALYSIS; STATISTICAL SIGNIFICANCE; TECHNIQUE; VALIDATION PROCESS;

EID: 17044395483     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2005.03.006     Document Type: Article

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