Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: Application and significance to drug transport

Pharmaceutical Research

Volumn 15, Issue 9, 1998, Pages 1401-1406

  Stewart, Barbra H ^a   Chung, Francis Y ^a   Tait, Bradley ^a   John, C ^a   Chan, O Helen ^a  

^a PFIZER INC   (United States)

Author keywords

Caco 2 cell uptake; HIV protease inhibitors; Hydrophobicity; IAM; Immobilized artificial membrane; T cell uptake

Indexed keywords

PROTEINASE INHIBITOR;

ARTICLE; DRUG ABSORPTION; DRUG PENETRATION; DRUG STRUCTURE; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; INTESTINE MUCOSA PERMEABILITY; MOLECULAR WEIGHT; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEINASE INHIBITION; T LYMPHOCYTE;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHROMATOGRAPHY; FEASIBILITY STUDIES; HIV PROTEASE INHIBITORS; HUMANS; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; WATER;

EID: 0031782048     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011901605214     Document Type: Article

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