Advances in iron metabolism: A transition state;Données récentes sur le métabolisme du fer: Un état de transition

Revue de Medecine Interne

Volumn 26, Issue 4, 2005, Pages 315-324

  Cadet, E ^a,b   Gadenne, M ^a   Capron, D ^b,c   Rochette, J ^a,b  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^c AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Haemochromatosis; Hepcidin; Iron metabolism; Regulation

Indexed keywords

DNA MICROARRAY; GENE CONTROL; GENE EXPRESSION; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; IRON METABOLISM; IRON TRANSPORT; NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW;

EID: 17044369245     PISSN: 02488663     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.revmed.2004.09.024     Document Type: Short Survey

References (93)

1. T.H. Bothwell, R.W. Charlton, J.E. Cook, and C.A. Finch Iron Metabolism in Man 1979 Blackwell Scientific Publications Oxford
2. H.A. Goldenberg Regulation of mammalian iron metabolism: current state and need for further knowledge Crit. Rev. Clin. Lab. Sci. 51 1997 S4 S8
3. E.H. Morgan, and P.S. Oates Mechanisms and regulation of intestinal iron absorption Blood Cells Mol. Dis. 29 2002 384 399
4. M.E. Conrad, R.T. Parmley, and K. Osterloh Small intestinal regulation of ion absorption in the rat J. Lab. Clin. Med. 110 1987 418 426
5. M. Lombard, E. Chua, and P. O'Toole Regulation of intestinal non-haem iron absorption Gut 40 1997 435 439
6. R.T. Parmley, J.C. Barton, M.E. Conrad, R.L. Austin, and R.M. Holland Ultrastructural cytochemistry and radioautography of hemoglobin-iron absorption Exp. Mol. Pathol. 34 1981 131 144
7. M.D. Fleming, C.C. Trenor, M.A. Su, D. Foernzler, D.R. Beier, and W.F. Dietrich Microcytic anemia mice have a mutation in Nramp2; a candidate iron transporter gene Nat. Genet. 16 1997 383 386
8. H. Gunshin, B. Mackenzie, U.V. Berger, Y. Gunshin, M.G. Romera, and W.F. Boron Cloning and characterization of a mammalian proton-coupled-metal-iron transporter Nature 388 1997 482 488
9. K.B. Raja, R.J. Simpson, and T.J. Peters Investigation of a role for reduction in ferric iron uptake by mouse duodenum Biochim. Biophys. Acta. 1135 1992 141 146 Erratum in Biochim. Biophys. Acta. 1993;1176:197
10. A.T. McKie, D. Barrow, G.O. Latunde-Dada, A. Rolfs, G. Sager, and M. Mudaly An iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 2001 1755 1759
11. M.D. Fleming, M.A. Romano, M.A. Su, L.M. Garrick, M.D. Garrick, and N.C. Andrews Nramp2 is mutated in the anaemic Belgrade b rat: evidence of a role for Nramp2 in endosomal iron transport Proc. Natl. Acad. Sci. USA 95 1998 1148 1153
12. M.A. Su, C.C. Trenor, J.C. Fleming, M.D. Fleming, and N.C. Andrews The G185R mutation disrupts function of iron transporter Nramp2 Blood 92 1998 2157 2163
13. M.E. Conrad, and J.N. Umbreit Iron absorption - the mucin-mobilferrin- integrin pathway. A competitive pathway for metal absorption Am. J. Hematol. 42 1993 67 73
14. M.E. Conrad, J.N. Umbreit, E.G. Moore, R.D.A. Peterson, and M.B. Jones A newly identified iron binding protein in duodenal mucosa of rats: purification and characterization of mobilferrin J. Biol. Chem. 265 1990 5273 5279
15. M.E. Conrad, J.N. Umbreit, E.G. Moore, and C.R. Rodning Newly identified iron-binding protein in human duodenal mucosa Blood 79 1992 244 247
16. J.N. Umbreit, M.E. Conrad, E.G. Moore, M.P. Desai, and J. Turrens Paraferritin: a protein complex with ferrireductase activity is associated with iron absorption in rats Biochemistry 35 1996 6460 6469
17. G.J. Anderson, D.M. Frazer, A.T. McKie, and C.D. Vulpe The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption Blood Cells Mol. Dis. 29 2002 367 375
18. D.M. Frazer, and G.J. Anderson The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol. Dis. 30 2003 288 297
19. J.N. Umbreit, M.E. Conrad, E.G. Moore, and L.F. Latour Iron absorption and cellular transport: the mobilferrin/paraferritin paradigm Semin. Hematol. 35 1998 13 26
20. A. Donovan, A. Brownlie, Y. Zhou, J. Shepard, S.J. Pratt, and J. Moynihan Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter Nature 403 2000 776 781
21. A.T. McKie, P. Marciani, A. Rolfs, K. Brennan, K. Wehr, and D. Barrow A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol. Cell 5 2000 299 309
22. C.D. Vulpe, Y.M. Kuo, T.L. Murphy, L. Cowley, C. Askwith, and N. Libina Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse Nat. Genet. 21 1999 195 199
23. O.T. Njajou, N. Vaessen, M. Joosse, B. Berghuis, J.W. Van Dongen, and M.H. Breuning A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis Nat. Genet. 28 2001 213 214
24. G. Montosi, A. Donavan, A. Totaro, C. Garuti, E. Pignatti, and S. Cassanelli Autosomal dominant hemochromatosis with a mutation in the ferroportin (SLC11A3) gene J. Clin. Invest. 108 2001 619 623
25. D.F. Wallace, P. Pedersen, J.L. Dixon, P. Stephenson, J.W. Searle, and L.W. Powell Novel mutation in ferroportin 1 is associated with autosomal dominant hemochromatosis Blood 100 2002 692 694
26. A.M. Jouanolle, V. Douabin-Gicquel, C. Halimi, O. Loŕal, P. Fergelot, and T. Delacour Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload J. Hepatol. 39 2003 286 289
27. R.M. Bannerman, and P.H. Pinkerton X-linked hypochromic anaemia of mice Br. J. Haematol. 13 1967 1000 1013
28. J.A. Edwards, and R.M. Bannerman Hereditary defect of intestinal iron transport in mice with sex-linked anemia J. Clin. Invest. 49 1970 1869 1871
29. R.M. Bannerman, and R.G. Cooper Sex-linked anemia: a hypochromic anemia of mice Science 151 1966 581 582
30. N.C. Andrews Disorders of iron metabolism N. Engl. J. Med. 341 1999 1986 1995
31. P. Brissot, T.L. Wright, W.L. Ma, and R.A. Weisiger Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states J. Clin. Invest. 76 1985 1463 1470
32. J.M. Gutteridge, D.A. Rowley, E. Griffiths, and B. Halliwell Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis Clin Sci (Colch) 68 1985 463 467
33. M.W. Hentze, T.A. Rouault, S.W. Caughman, A. Dancis, J.B. Harford, and R.D. Klausner A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron Proc. Natl. Acad. Sci. USA 84 1987 6730 6734
34. M.E. Conrad, L.R. Weintraub, and W.H. Crosby The role of the intestine in iron kinetics J. Clin. Invest. 43 1964 963 974
35. S. Pollack, R.M. Kaufman, and W.H. Crosby Iron absorption: the effect of an iron deficient diet Science 144 1964 1015 1016
36. H. Cheng, and C.F. Leblond Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine Am. J. Anat. 141 1974 537 562
37. P.F. Hahn, W.F. Bale, J.F. Ross, W.M. Balfour, and G.H. Whipple Radioactive iron absorption by the gastro-intestinal tract: influence of anemia, anoxia, and antecedent feeding distribution in growing dogs J. Exp. Med. 78 1943 169 188
38. C. Finch Regulators of iron balance in humans Blood 84 1994 1697 1702
39. M.H. Sayers, G. English, and C. Finch Capacity of the store-regulator in maintaining iron balance Am. J. Hematol. 1994 194 197
40. H.N. Hunter, D.B. Fulton, T. Ganz, and H.J. Vogel The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis J. Biol. Chem. 277 2002 37597 37603
41. C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, and P. Brissot A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J. Biol. Chem. 276 2001 7811 7819
42. G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, and A. Kahn Lack of hepcidin gene expression and severe tissue iron overload in Upstream Stimulator Factor 2 (USF2) knockout mice Proc. Natl. Acad. Sci. USA 98 2001 8780 8785
43. G. Nicolas, M. Bennoun, A. Porteu, S. Mativet, C. Beaumont, and B. Grandchamp Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc. Natl. Acad. Sci. USA 99 2002 4596 4601
44. D.A. Weinstein, C.N. Roy, M.D. Fleming, M.F. Loda, J.I. Wolfsdorf, and N.C. Andrews Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease Blood 100 2002 3776 3781
45. A. Roetto, G. Papanikolaou, M. Politou, F. Alberti, D. Girelli, and J. Christakis Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis Nat. Genet. 33 2003 21 22
46. A.T. Merryweather-Clarke, E. Cadet, A. Bomford, D. Capron, V. Viprakasit, and A. Miller Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis Hum. Mol. Genet. 12 2003 2241 2247
47. R.E. Fleming, and W.S. Sly Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease Proc. Natl. Acad. Sci. USA 98 2001 8160 8162
48. D.M. Frazer, S.J. Wilkins, E.M. Becker, C.D. Vulpe, A.T. McKie, and D. Trinder Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 123 2002 835 844
49. K.J.H. Robson, A.T. Merryweather-Clarke, E. Cadet, V. Viprakasit, M.G. Zaahl, and J.J. Pointon Haemochromatosis and host defence J. Med. Genet. 2004 (sous presse)
50. G. Nicolas, L. Viatte, M. Bennoun, C. Beaumont, A. Kahn, and S. Vaulont Hepcidin, a new iron regulatory peptide Blood Cells Mol. Dis. 29 2002 327 335
51. G. Nicolas, C. Chauvet, L. Viatte, J.L. Danan, X. Bigard, and I. Devaux The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J. Clin. Invest. 110 2002 1037 1044
52. H. Shike, X. Lauth, M.E. Westerman, V.E. Ostland, J.M. Carlberg, and J.C. Van Olst Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge Eur. J. Biochem. 269 2002 2232 2237
53. E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461 2463
54. K.A. Ahmad, J.R. Ahmann, M.C. Migas, A. Waheed, R.S. Britton, and B.R. Bacon Decreased liver hepcidin expression in the Hfe knockout mouse Blood Cells Mol. Dis. 29 2002 361 366
55. G. Nicolas, L. Viatte, D.Q. Lou, M. Bennoun, C. Beaumont, and A. Kahn Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis Nat. Genet. 34 2003 97 101
56. K.R. Bridle, D.M. Frazer, S.J. Wilkins, J.L. Dixon, D.M. Purdie, and D.H.G. Crawford Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis Lancet 361 2003 669 673
57. M. Muckenthaler, C.N. Roy, A.O. Custodio, B. Minana, J. De Graaf, and L.K. Montross Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis Nat. Genet. 34 2003 102 107
58. N.C. Andrews A genetic view of iron homeostasis Semin. Hematol. 39 2002 227 234
59. G. Papanikolaou, M.E. Samuels, E.H. Ludwig, M.L.E. MacDonald, P.L. Franchini, and M.P. Dube Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat. Genet. 36 2004 77 82
60. J.A. Lebrón, M.J. Bennett, D.E. Vaughn, A.J. Chirino, P.M. Snow, and G.A. Mintier Crystal structure of the hemochromatosis protein HFE and characterisation of its interaction with transferrin receptor Cell 93 1998 111 123
61. J.N. Feder, Z. Tsuchihashi, A. Irrinki, V.K. Lee, F.A. Mapa, and E. Morikang The hemochromatosis founder mutation in HLA-H disrupts beta-2-microglobulin interaction and cell surface expression J. Biol. Chem. 272 1997 14025 14028
62. C.N. Gross, A. Irrinki, J.N. Feder, and C.A. Enns Co-trafficking of HFE, a non-classical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation J. Biol. Chem. 273 1998 22068 22074
63. A. Waheed, S. Parkkila, J. Saarnio, R.E. Fleming, X.Y. Zhou, and S. Tomatsu Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum Proc. Natl. Acad. Sci. USA 96 1999 1579 1584
64. R.S. Ajioka, J.E. Levy, N.C. Andrews, and J.P. Kushner Regulation of iron absorption in Hfe mutant mice Blood 100 2002 1465 1469
65. A.S. Zhang, S. Xiong, H. Tsukamoto, and C.A. Enns Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes Blood 103 2004 1509 1514
66. H. Kawabata, R. Yang, T. Hirama, P.T. Vuong, S. Kawano, and A.F. Gombart Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family J. Biol. Chem. 274 1999 20826 20832
67. R.E. Fleming, M.C. Migas, C.C. Holden, A. Waheed, R.S. Britton, and S. Tomatsu Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis Proc. Natl. Acad. Sci. USA 97 2000 2214 2219
68. H. Kawabata, R.S. Germain, P.T. Vuong, T. Nakamaki, J.W. Said, and H.P. Koeffler Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo J. Biol. Chem. 275 2000 16618 16625
69. A.P. West Jr., M.J. Bennett, V.M. Sellers, N.C. Andrews, C.A. Enns, and P.J. Bjorkman Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE J. Biol. Chem. 275 2000 38135 38138
70. C. Camaschella, A. Roetto, A. Cali, M. De Gobbi, G. Garozzo, and M. Carella The gene encoding transferrin receptor 2 is mutated in a new type of hemochromatosis mapping to 7q22 Nat. Genet. 25 2000 14 15
71. A. Roetto, A. Totaro, A. Piperno, A. Piga, F. Longo, and G. Garozzo New mutations inactivating transferrin receptor 2 in hemochromatosis type 3 Blood 97 2001 2555 2560
72. D. Girelli, C. Bozzini, A. Roetto, F. Alberti, F. Daraio, and R. Colombari Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene Gastroenterology 122 2002 1295 1302
73. S. Deaglio, A. Capobianco, A. Cali, F. Bellora, F. Alberti, and L. Righi Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum Blood 100 2002 3782 3789
74. A. Townsend, and H. Drakesmith Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload Lancet 359 2002 786 790
75. W.J.H. Griffiths, and T.M. Cox Colocalization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells J. Histochem. Cytochem. 51 2003 613 623
76. R.E. Fleming, J.R. Ahmann, M.C. Migas, A. Waheed, H.P. Koeffler, and H. Kawabata Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis Proc. Natl. Acad. Sci. USA 99 2002 10653 10658
77. N. Aziz, and H.N. Munro Iron regulates ferritin mRNA translation through a segment of its 5'untranslated region Proc. Natl. Acad. Sci. USA 87 1987 8478 8482
78. M.W. Hentze, S.W. Caughman, T.A. Rouault, J.G. Barriocanal, A. Dancis, and J.B. Harford Identification of the iron-responsive element for the translational regulation of human ferritin mRNA Science 238 1987 1570 1573
79. D. Owen, and L.C. Kühn Non-coding 3' sequences of the transferrin receptor gene are required for mRNA regulation by iron EMBO J. 6 1987 1287 1293
80. M.W. Hentze, and L.C. Kühn Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress Proc. Natl. Acad. Sci. USA 93 1996 8175 8182
81. T. Rouault, and R. Klausner Regulation of iron metabolism in eukaryotes Curr. Top. Cell. Regul. 35 1997 1 19
82. C.R. Bhasker, G. Burgiel, B. Neupert, A. Emery-Goodman, L.C. Kuhn, and B.K. May The putative iron-responsive element in the human erythroid 5-aminolevulinate synthase mRNA mediates translational control J. Biol. Chem. 268 1993 12699 12705
83. T.C. Cox, M.J. Bawden, A. Martin, and B.K. May Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA EMBO J. 10 1994 1891 1902
84. N.K. Gray, K. Pantopoulous, T. Dandekar, B.A. Ackrell, and M.W. Hentze Translational regulation of mammalian and drosophila citric acid cycle enzymes via iron-responsive elements Proc. Natl. Acad. Sci. USA 93 1996 4925 4930
85. H.Y. Kim, T. La Vaute, K. Iwai, R.D. Klausner, and T.A. Rouault Identification of a conserved and functional iron-responsive element in the 5' untranslated region of mammalian mitochondrial aconitase J. Biol. Chem. 271 1996 24226 24230
86. E.W. Mullner, and L.C. Kühn A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm Cell 53 1988 815 825
87. P. Lee, T. Gelbart, C. West, C. Halloran, and E. Beutler The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms Blood Cells Mol. Dis. 24 1998 199 215
88. A. Pietrangelo, E. Rocchi, G. Casalgrandi, G. Rigo, A. Ferrari, and M. Perini Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum Gastroenterology 102 1992 802 809
89. G. Cairo, S. Recalcati, G. Montosi, E. Castrusini, D. Conte, and A. Pietrangelo Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis Blood 89 1997 2546 2553
90. Z.L. Harris, A.P. Durley, T.K. Man, and J.D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proc. Natl. Acad. Sci. USA 96 1999 10812 10817
91. S. Abboud, and D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J. Biol. Chem. 26 2000 19906 19912
92. Z.L. Harris, Y. Takahashi, H. Miyajima, M. Serizawa, R.T. MacGillivray, and J. Gitlin Aceruloplasminemia: molecular characterization of this disorder of iron metabolism Proc. Natl. Acad. Sci. USA 92 1995 2539 2543
93. K. Yoshida, K. Furihata, S. Takeda, A. Nakamura, K. Yamamoto, and H. Morita A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans Nat. Genet. 9 1995 267 272