Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum

Blood

Volumn 100, Issue 10, 2002, Pages 3782-3789

  Deaglio, Silvia ^a,b   Capobianco, Andrea ^a,b   Calì, Angelita ^a,b   Bellora, Francesca ^a,b   Alberti, Federica ^a,b   Righi, Luisella ^a,b   Sapino, Anna ^a,b   Camaschella, Clara ^a,b   Malavasi, Fabio ^a,b  

^a Laboratory of Immunogenetics   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; IRON; MESSENGER RNA; MONOCLONAL ANTIBODY; POLYCLONAL ANTISERUM; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; ERYTHROID PRECURSOR CELL; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; UPREGULATION;

EID: 0037111572     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-01-0076     Document Type: Article

References (32)

1. Ponka P, Lok CN. The transferrin receptor: Role in health and disease. Int J Biochem Cell Biol. 1999;31:1111-1137.
2. Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997;1331:1-40.
3. Trinder D, Zak O, Aisen P. Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology. 1996;23:1512-1520.
4. Kawabata H, Yang R, Hirama T, et al. Molecular cloning of transferrin receptor 2: A new member of the transferrin receptor-like family. J Biol Chem. 1999;274:20826-20832.
5. Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood. 2001;98:2714-2719.
6. Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem. 2000;275:16618-16625.
7. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21:396-399.
8. Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of hemochromatosis mapping to 7q22. Nat Genet. 2000;25:14-15.
9. Roetto A, Totaro A, Piperno A, et al. New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood. 2001;97:2555-2560.
10. Girelli D, Bozzini C, Roetto A, et al. Clinical and histopathological findings in a family with hemochromatosis type 3, carrying a new mutation in transferrin receptor 2 gene. Gastroenterology. 2002;122:1295-1302.
11. Fleming RE, Migas MC, Holden CC, et al. Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2000;97:2214-2219.
12. Kawabata H, Germain RS, Ikezoe T, et al. Regulation of expression of murine transferrin receptor 2. Blood. 2001;98:1949-1954.
13. Deaglio S, Zubiaur M, Gregorini A, et al. Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. Blood. 2002;99:2490-2498.
14. Peruzzi L, Melioli G, De Monte LB, et al. Microplate selection technique (MPST): A new method for selecting mouse transfectants expressing human gene products. J Immunol Methods. 1989;123:113-121.
15. Funaro A, Spagnoli GC, Ausiello CM, et al. Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J Immunol. 1990;145:2390-2396.
16. Deaglio S, Dianzani U, Horenstein AL, et al. Human CD38 ligand: A 120-kDa protein predominantly expressed on endothelial cells. J Immunol. 1996;156:727-734.
17. Deaglio S, Morra M, Mallone R, et al. Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member. J Immunol. 1998;160:395-402.
18. DeMonte LB, Nistico P, Tecce R, et al. Gene transfer by retrovirus-derived shuttle vectors in the generation of murine bispecific monoclonal antibodies. Proc Natl Acad Sci U S A. 1990;87:2941-2945.
19. Zubiaur M, Fernandez O, Ferrero E, et al. CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-ζ immune receptor tyrosine-based activation motifs. J Biol Chem. 2002;277:13-22.
20. Sapino A, Bongiovanni M, Cassoni P, et al. Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast. J Pathol. 2001;194:254-261.
21. Fernandez JE, Deaglio S, Donati D, et al. Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues. J Biol Regul Homeost Agents. 1998;12:81-91.
22. West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000;275:38135-38138.
23. Taylor MR, Gatenby PB. Iron absorption in relation to transferrin saturation and other factors. Br J Haematol. 1966;12:747-753.
24. Andrews NC. Iron metabolism: Iron deficiency and iron overload. Annu Rev Genomics Hum Genet. 2000;1:75-98
25. Roy CN, Enns CA. Iron homeostasis: New tales from the crypt. Blood. 2000;96:4020-4027.
26. Trinder D, Olynyk JK, Sly WS, Morgan EH. Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci U S A. 2002;99:5622-5626.
27. Waheed A, Parkkila S, Saarnio J, et al. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci U S A. 1999;96:1579-1584.
28. Townsend A, Drakesmith H. Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload. Lancet. 2002;359:786-790.
29. Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut. 2000;46:270-276.
30. Canonne-Hergaux F, Levy JE, Fleming MD, Montross LK, Andrews NC, Gros P. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood. 2001;97:1138-1140.
31. Parkkila S, Waheed A, Britton RS, et al. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci U S A. 1997;94:2534-2539.
32. Moura IC, Centelles MN, Arcos-Fajardo M, et al. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J Exp Med. 2001;194:417-425.