Peroxisome proliferator-activated receptor-γ ligands inhibit α5 integrin gene transcription in non-small cell lung carcinoma cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 32, Issue 4, 2005, Pages 350-359

  Han, ShouWei ^a   Rivera, Hilda N ^b   Roman, Jesse ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

5 integrin; Erk; Human lung carcinoma; PPAR ; Transcription factors

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ALPHA5 INTEGRIN; ANTISENSE OLIGONUCLEOTIDE; DIMER; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; HETERODIMER; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PD 98095; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN J2; ROSIGLITAZONE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL CYCLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DNA PROTEIN COMPLEX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PROMOTER REGION; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BENZOPHENONES; BINDING SITES; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DNA, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; INTEGRIN ALPHA5; LIGANDS; PHOSPHORYLATION; PPAR GAMMA; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TYROSINE;

EID: 16644372667     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2004-0345OC     Document Type: Article

References (46)

1. Parise LV, Lee J, Juliano JL. New aspects of integrin signaling in cancer. Semin Cancer Biol 2000;10:407-414.
2. Kanwar YS, Wada J, Lin S, Danesh FR, Chugh SS, Yang Q, Banerjee T, Lomasney JW. Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am J Physiol Renal Physiol 2004;286:F202-F215.
3. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91-100.
4. Pignatelli M. Integrins, cadherins, and catenins: molecular cross-talk in cancer cells. J Pathol 1998;186:1-2.
5. Pellat-Deceunynck C, Barille S, Puthier D, Rapp MJ, Harousseau JL, Bataille R, Amiot M. Adhesion molecules on human myeloma cells: significant changes in expression related to malignancy, tumor spreading, and immortalization. Cancer Res 1995;55:3647-3653.
6. Adachi M, Taki T, Higashiyama M, Kohno N, Inufusa H, Miyake M. Significance of integrin alpha5 gene expression as a prognostic factor in node-negative non-small cell lung cancer. Clin Cancer Res 2000;6:96-101.
7. Han S, Sidell N, Roser-Pager S, Roman J. Fibronectin stimulates human lung cancer cell growth by inducing cyclooxygenase-2 (COX-2) gene expression. Int J Cancer 2004;111:322-331.
8. Cabrero A, Laguna JC, Vazquez M. Peroxisome proliferator-activated receptors and the control of inflammation. Curr Drug Targets Inflamm Allergy 2002;1:243-248.
9. Rocchi S, Auwerx J. Peroxisome proliferator-activated receptor-gamma: a versatile metabolic regulator. Ann Med 1999;31:342-351.
10. Keshamouni VG, Reddy RC, Arenberg DA, Joel B, Thannickal TJ, Kalemkerian GP, Standiford TJ. Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer. Oncogene 2004;23:100-108.
11. Vaidya S, Somers EP, Wright SD, Detmers PA, Bansal VS. 15-Deoxy-Delta12, 14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation. J Immunol 1999;163:6187-6192.
12. Han S, Roman J. Suppression of prostaglandin E (2) receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth. Biochem Biophys Res Commun 2004;314:1093-1099.
13. Lefevre G, Calipel A, Mouriaux F, Hecquet C, Malecaze F, Mascarelli F. Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells. Oncogene 2003;22:8813-8822.
14. Han SW, Lei ZM, Rao CV. Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into decidua. Endocrinology 1996;137:1791-1797.
15. Proulx S, Guerin SL, Salesse C. Effect of quiescence on integrin alpha5-beta1 expression in human retinal pigment epithelium. Mol Vis 2003;9:473-481.
16. Han S, Inoue H, Flowers LC, Sidell N. Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells. Clin Cancer Res 2003;9:4627-4635.
17. Boles BK, Ritzenthaler J, Birkenmeier T, Roman J. Phorbol ester-induced U-937 differentiation: effects on integrin alpha (5) gene transcription. Am J Physiol Lung Cell Mol Physiol 2000;278:L703-L712.
18. Han S, Wada RK, Sidell N. Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma. Cancer Res 2001;61:3998-4002.
19. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983;11:1475-1489.
20. Han S, Sidell N. RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappab signaling pathway. J Clin Endocrinol Metab 2003;88:713-719.
21. Corbi AL, Jensen UB, Watt FM. The alpha2 and alpha5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes. FEBS Lett 2001;474:201-217.
22. Han S, Sidell N, Fisher FB, Roman J. Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells. Clin Cancer Res 2004;10:1911-1919.
23. Motojima K. Peroxisome proliferator-activated receptor (PPAR)-dependent and -independent transcriptional modulation of several non-peroxisomal genes by peroxisome proliferators. Biochimie 1997;79:101-106.
24. Chen CW, Chang YH, Tsi CJ, Lin WW. Inhibition of fibronectin-gamma- mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma ligand, 15-deoxy-delta 12, 14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. J Immunol 2003;171:979-988.
25. Larouche K, Leclercm S, Salesse C, Guerin SL. Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. J Biol Chem 2000;275:39182-39192.
26. Gingras ME, Larouche K, Larouche N, Leclerc S, Salesse C, Guerin SL. Regulation of the integrin subunit alpha5 gene promoter by the transcription factors Sp1/Sp3 is influenced by the cell density in rabbit corneal epithelial cells. Invest Ophthalmol Vis Sci 2003;44:3742-3755.
27. Kuwada S, Li X. Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. Mol Biol Cell 2000;11:2485-2496.
28. Rintoul RC, Sethi T. Extracellular matrix regulation of drug resistance in small-cell lung carcinoma. Clin Sci (Lond) 2002;102:417-424.
29. Goetze S, Bungenstock A, Czupalla C, Eilers F, Stawowy P, Kintscher U, Spencer-Hansch C, Graf K, Nurnberg B, Law RE, et al. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands. Hypertension 2002;40:748-754.
30. Kim EJ, Park KS, Chung SY, Sheen YY, Moon DC, Song YS, Kim KS, Song S, Yun YP, Lee MK, et al. Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12, 14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. J Pharmacol Exp Ther 2003;307:505-517.
31. Takeda K, Ichiki T, Tokunou T, Iino N, Takeshita A. 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 2001;276:48950-48955.
32. Baek SJ, Wilson LC, His LC, Eling TE. Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma: a novel mechanism for its anti-tumorigenic activity. J Biol Chem 2003;278:5845-5853.
33. Okano H, Shiraki S, Inoue H, Yamanaka Y, Kawakita T, Saitou Y, Yamaguchi Y, Enokimura N, Yamamoto N, Sugimoto K, et al. 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. Lab Invest 2003;83:1529-1539.
34. Sawano H, Haneda M, Sugimoto T, Inoki K, Koya D, Kikkawa R. 15-Deoxy-Delta12, 14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. Kidney Int 2003;61:1957-1967.
35. Perez-Sala D, Cernuda-Morollon E, Canada FJ. Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2. J Biol Chem 2003;278:51251-51260.
36. Ren Z, Kar S, Wang Z, Wang M, Saavedra JE, Carr BIJS-K. A novel non-ionic diazeniumdiolate derivative inhibits Hep 3B hepatoma cell growth and induces c-Jun phosphorylation via multiple MAP kinase pathways. J Cell Physiol 2003;197:426-434.
37. 2-induced AP-1 activation and its effect on p21 (WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cell. Biochem Biophys Res Commun 2003;293:1248-1253.
38. Drobna Z, Jaspers I, Thomas DJ, Styblo M. Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J 2003;17:67-69.
39. Zhang J, Fu M, Zhao L, Chen YE. 15-Deoxy-prostaglandin J (2) inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR gamma. Biochem Biophys Res Commun 2002;298:128-132.
40. Sugawara A, Uruno A, Kudo M, Ikeda Y, Sato K, Taniyama Y, Ito S, Takeuchi K. Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem 2002;277:9676-9683.
41. Krey G, Mahfoudim A, Wahlim W. Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol Endocrinol 1995;9:219-231.
42. Wilmer WA, Dixon C, Lu L, Hilbelink T, Rovin BH. A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. Biochem Biophys Res Commun 2001;281:57-62.
43. Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu Rev Biochem 1987;56:881-914.
44. Camp HS, Tafuri SR. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem 1997;272:10811-10816.
45. Kitamura S, Miyazaki Y, Hiraoka S, Nagasawa Y, Toyota M, Takakura R, Kiyohara T, Shinomura Y, Matsuzawa Y. PPARgamma ligands inhibit cell growth and suppress the expression of cyclin D1 and EGF-like growth factors in ras-transformed rat intestinal epithelial cells. Int J Cancer 2001;94:335-342.
46. Danen EH, Yamada KM. Fibronectin, integrins, and growth control. J Cell Physiol 2001;189:1-13.