Integrin α5/β1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation

Molecular Biology of the Cell

Volumn 11, Issue 7, 2000, Pages 2485-2496

  Kuwada, Scott K ^a   Li, Xiufen ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; ALPHA5 INTEGRIN; FIBRONECTIN RECEPTOR; LEUKOCYTE ANTIGEN;

ARTICLE; CELL PROLIFERATION; CELL STRAIN CACO 2; ENZYME ACTIVATION; EPITHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CYTOLOGY; INTESTINE MUCOSA; METABOLISM;

ANTIGENS, CD; CELL DIVISION; FIBRONECTINS; HUMANS; INTEGRIN ALPHA5; INTEGRINS; INTESTINAL MUCOSA; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, FIBRONECTIN; TUMOR CELLS, CULTURED;

EID: 0033623969     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.7.2485     Document Type: Article

References (81)

1. Aliaga, J.C., Deschenes, C., Beaulieu, J.F., Calvo, E.L., and Rivard, N. (1999). Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells. Am. J. Physiol. 277, G631-G641.
2. Ben-Ze'ev, A., Robinson, G.S., Bucher, N.L., and Farmer, S.R. (1988). Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc. Natl. Acad. Sci. USA 85, 2161-2165.
3. Bishop, W.P., Lin, J., Stein, C.A., and Krieg, A.M. (1995). Interruption of a transforming growth factor alpha autocrine loop in Caco-2 cells by antisense oligodeoxynucleotides. Gastroenterology 109, 1882-1889.
4. Bishop, W.P., and Wen, J.T. (1994). Regulation of Caco-2 cell proliferation by basolateral membrane epidermal growth factor receptors. Am. J. Physiol. 267, G892-G900.
5. Bissell, D.M., Arenson, D.M., Maher, J.J., and Roll, F.J. (1987). Support of cultured hepatocytes by a laminin-rich gel: evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79, 801-812.
6. Bissell, D.M., and Guzelian, P.S. (1980). Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann. NY Acad. Sci 349, 85-98.
7. Bucci, B., D'Agnano, I., Botti, C., Mottolese, M., Carico, E., Zupi, G., and Vecchione, A. (1997). EGF-R expression in ductal breast cancer: proliferation and prognostic implications. Anticancer Res. 17, 769-774.
8. Cao, H., Lei, Z.M., Bian, L., and Rao, C.V. (1995). Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta. Endocrinology 136, 3163-3172.
9. Chen, Q., Kinch, M.S., Lin, T.H., Burridge, K., and Juliano, R.L. (1994). Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
10. Clark, E.A., and Brugge, J.S. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
11. Cook, P.W., Pittelkow, M.R., Keeble, W.W., Graves Deal, R., Coffey, R.J., Jr., and Shipley, G.D. (1992). Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res. 52, 3224-3227.
12. Cowley, S., Paterson, H., Kemp, P., and Marshall, C.J. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
13. Damstrup, L., Kuwada, S.K., Dempsey, P.J., Brown, C.L., Hawkey, C.J., Poulsen, H.S., Wiley, H.S., and Coffey, R.J., Jr. (1999). Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br. J. Cancer 80, 1012-1019.
14. Daub, H., Wallasch, C., Lankenau, A., Herrlich, A., and Ullrich, A. (1997). Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16, 7032-7044.
15. Daub, H., Weiss, F.U., Wallasch, C., and Ullrich, A. (1996). Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature 379, 557-560.
16. Ferriola, P.C., Earp, H.S., Di Augustine, R., and Nettesheim, P. (1991). Role of TGF alpha and its receptor in proliferation of immor-talized rat tracheal epithelial cells: studies with tyrphostin and TGF alpha antisera. J. Cell Physiol. 147, 166-175.
17. Ferriola, P.C., Robertson, A.T., Rusnak, D.W., Diaugustine, R., and Nettesheim, P. (1992). Epidermal growth factor dependence and TGF alpha autocrine growth regulation in primary rat tracheal epithelial cells. J. Cell Physiol. 152, 302-309.
18. Folkman, J., and Moscona, A. (1978). Role of cell shape in growth control. Nature 273, 345-349.
19. Gamett, D.C., Pearson, G., Cerione, R.A., and Friedberg, I. (1997). Secondary dimerization between members of the epidermal growth factor receptor family. J. Biol. Chem. 272, 12052-12056.
20. Garcia, A.J., Vega, M.D., and Boettiger, D. (1999). Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation. Mol. Biol. Cell 10, 785-798.
21. Gerosa, M.A., Talarico, D., Fognani, C., Raimondi, E., Colombatti, M., Tridente, G., De Carli, L., and Della Valle, G. (1989). Overexpression of N-ras oncogene and epidermal growth factor receptor gene in human glioblastomas. J. Natl. Cancer Inst. 81, 63-67.
22. Giancotti, F.G. (1997). Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr. Opin. Cell Biol. 9, 691-700.
23. Gill, G.N., Kawamoto, T., Cochet, C., Le, A., Sato, J.D., Masui, H., McLeod, C., and Mendelsohn, J. (1984). Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J. Biol. Chem. 259, 7755-7760.
24. Graus-Porta, D., Beerli, R.R., Daly, J.M., and Hynes, N.E. (1997). ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16, 1647-1655.
25. Hanks, S.K., and Polte, T.R. (1997). Signaling through focal adhesion kinase. Bioessays 19, 137-145.
26. Hemler, M.E. (1990). VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8, 365-400.
27. Hidalgo, I.J., Kato, A., and Borchardt, R.T. (1989a). Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayers. Biochem. Biophys. Res. Commun. 160, 317-324.
28. Hidalgo, I.J., Raub, T.J., and Borchardt, R.T. (1989b) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96, 736-749.
29. Hirono, Y., Tsugawa, K., Fushida, S., Ninomiya, I., Yonemura, Y., Miyazaki, I., Endou, Y., Tanaka, M., and Sasaki, T. (1995) Amplification of epidermal growth factor receptor gene and its relationship to survival in human gastric cancer. Oncology 52, 182-188.
30. Huang, T.S., Rauth, S., and Das Gupta, T.K. (1996). Overexpression of EGF receptor is associated with spontaneous metastases of a human melanoma cell line in nude mice. Anticancer Res. 16, 3557-3563.
31. Ingber, D.E. (1990). Fibronectin controls capillary endothelial cell growth by modulating cell shape. Proc. Natl. Acad. Sci. USA 87, 3579-3583.
32. lshitoya, J., Toriyama, M., Oguchi, N., Kitamura, K., Ohshima, M., Asano, K., and Yamamoto, T. (1989). Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck. Br. J. Cancer 59, 559-562.
33. Itakura, Y., Sasano, H., Shiga, C., Furukawa, Y., Shiga, K., Mori, S., and Nagura, H. (1994). Epidermal growth factor receptor overexpression in esophageal carcinoma: an immunohistochemical study correlated with clinicopathologic findings and DNA amplification. Cancer 74, 795-804.
34. Kelleher, M.D., Abe, M.K., Chao, T.S., Jain, M., Green, J.M., Solway, J., Rosner, M.R., and Hershenson, M.B. (1995). Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am. J. Physiol. 268, L894-L901.
35. Kennedy, T.G., Brown, K.D., and Vaughan, T.J. (1993). Expression of the genes for the epidermal growth factor receptor and its ligands in porcine corpora lutea. Endocrinology 132, 1857-1859.
36. Kuttan, N.A., and Bhakthan, N.M. (1997). Epidermal growth factor receptor (EGFR) in oral squamous cell carcinomas: overexpression, localization and therapeutic implications. Indian J. Dent. Res. 8, 9-18.
37. Kuwada, S.K., Li, X.F., Damstrup, L., Dempsey, P.J., Coffey, R.J., and Wiley, H.S. (1999). The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line. Growth Factors 17, 139-153.
38. Lange-Carter, C.A., and Johnson, G.L. (1994). Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265, 1458-1461.
39. Levy, P., Loreal, O., Munier, A., Yamada, Y., Picard, J., Cherqui, G., Clement, B., and Capeau, J. (1994). Enterocytic differentiation of the human Caco-2 cell line is correlated with down-regulation of fibronectin and laminin. FEBS Lett. 338, 272-276.
40. Li, J., Lin, M.L., Wiepz, G.J., Guadarrama, A.G., and Bertics, P.J. (1999). Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor. J. Biol. Chem. 274, 11209-11219.
41. Li, X., Lee, J.W., Graves, L.M., and Earp, H.S. (1998). Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway. EMBO J. 17, 2574-2583.
42. Mainiero, F., Murgia, C., Wary, K.K., Curatola, A.M., Pepe, A., Blumemberg, M., Westwick, J.K., Der, C.J., and Giancotti, F.G. (1997). The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J. 16, 2365-2375.
43. Mainiero, F., Pepe, A., Wary, K.K., Spinardi, L., Mohammadi, M., Schlessinger, J., and Giancotti, F.G. (1995). Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14, 4470-4481.
44. Mansour, S.J., Matten, W.T., Hermann, A.S., Candia, J.M., Rong, S., Fukasawa, K., Vande Woude, G.F., and Ahn, N.G. (1994). Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265, 966-970.
45. Miyamoto, S., Katz, B.Z., Lafrenie, R.M., and Yamada, K.M. (1998). Fibronectin and integrins in cell adhesion, signaling, and morphogenesis. Ann. NY Acad. Sci. 857, 119-129.
46. Miyamoto, S., Teramoto, H., Coso, O.A., Gutkind, J.S., Burbelo, P.D., Akiyama, S.K., and Yamada, K.M. (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol. 131, 791-805.
47. Miyamoto, S., Teramoto, H., Gutkind, J.S., and Yamada, K.M. (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol. 135, 1633-1642.
48. Morino, N., Mimura, T., Hamasaki, K., Tobe, K., Ueki, K., Kikuchi, K., Takehara, K., Kadowaki, T., Yazaki, Y., and Nojima, Y. (1995). Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J. Biol. Chem. 270, 269-273.
49. Moro, L., Venturino, M., Bozzo, C., Silengo, L., Altruda, F., Beguinot, L., Tarone, G., and Defilippi, P. (1998). Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17, 6622-6632.
50. Normanno, N., Selvam, M.P., Bianco, C., Damiano, V., de Angelis, E., Grassi, M., Magliulo, G., Tortora, G., Salomon, D.S., and Ciardiello, F. (1995). Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line. Int. J. Cancer 62, 762-766.
51. Pages, G., Lenormand, P., L'Allemain, G., Chambard, J.C., Meloche, S., and Pouyssegur, J. (1993). Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc. Natl. Acad. Sci. USA 90, 8319-8323.
52. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pawson, T., and Pelicci, P.C. (1992). A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70, 93-104.
53. Pignatelli, M., and Bodmer, W.F. (1989). Integrin-receptor-mediated differentiation and growth inhibition are enhanced by transforming growth factor-beta in colorectal tumor cells grown in collagen gel. Int. J. Cancer 44, 518-523.
54. Rajkumar, T., and Gullick, W.J. (1994). The type I growth factor receptors in human breast cancer. Breast Cancer Res. Treat. 29, 3-9.
55. Rosen, L.B., and Greenberg, M.E. (1996). Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc. Natl. Acad. Sci. USA 93, 1113-1118.
56. Roskelley, C.D., Desprez, P.Y., and Bissell, M.J. (1994). Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc. Natl. Acad. Sci. USA 91, 12378-12382.
57. Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T., and Bowtell, D. (1993). The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363, 83-85.
58. Ruff-Jamison, S., McGlade, J., Pawson, T., Chen, K., and Cohen, S. (1993). Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse. J. Biol. Chem. 268, 7610-7612.
59. Sachsenmaier, C., Radler-Pohl, A., Zinck, R., Nordheim, A., Herrlich, P., and Rahmsdorf, H.J. (1994). Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963-972.
60. Sasaoka, T., Langlois, W.J., Leitner, J.W., Draznin, B., and Olefsky, J.M. (1994). The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J. Biol. Chem. 269, 32621-32625.
61. Sastry, S.K., Lakonishok, M., Thomas, D.A., Muschler, J., and Horwitz, A.F. (1996). Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation. J. Cell Biol. 133, 169-184.
62. Schlaepfer, D.D., Hanks, S.K., Hunter, T., and van der Geer, P. (1994). Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
63. Schlaepfer, D.D., Jones, K.C., and Hunter, T. (1998). Multiple Grb2-mediated integrin-srimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol. 18, 2571-2585.
64. Schwartz, M.A., and Baron, V. (1999). Interactions between mitogenic stimuli, or, a thousand and one connections. Curr. Opin. Cell Biol. 11, 197-202.
65. Sekine, I., Takami, S., Guang, S.G., Yokose, T., Kodama, T., Nishiwaki, Y., Kinoshita, M., Matsumoto, H., Ogura, T., and Nagai, K. (1998). Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer. Oncol. Rep. 5, 351-354.
66. Simon-Assmann, P., Kedinger, M., and Haffen, K. (1986). Immunocytochemical localization of extracellular-matrix proteins in relation to rat intestinal morphogenesis. Differentiation 32, 59-66.
67. Somasiri, A., and Roskelley, C.D. (1999). Cell shape and integrin signaling regulate the differentiation state of mammary epithelial cells. Methods Mol. Biol. 129, 271-283.
68. Streuli, C.H., Bailey, N., and Bissell, M.J. (1991). Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. 115, 1383-1395.
69. Stumm, G., Eberwein, S., Rostock-Wolf, S., Stein, H., Pomer, S., Schlegel, J., and Waldherr, R. (1996). Concomitant overexpression of the EGFR and erbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis. Int. J. Cancer 69, 17-22.
70. Tong, W.M., Ellinger, A., Sheinin, Y., and Cross, H.S. (1998). Epidermal growth factor receptor expression in primary cultured human colorectal carcinoma cells. Br. J. Cancer 77, 1792-1798.
71. Vachon, P.H., Simoneau, A., Herring Gillam, F.E., and Beaulieu, J.F. (1995). Cellular fibronectin expression is down-regulated at the mRNA level in differentiating human intestinal epithelial cells. Exp. Cell Res. 216, 30-34.
72. Vadlamudi, R., Mandal, M., Adam, L., Steinbach, G., Mendelsohn, J., and Kumar, R. (1999). Regulation of cyclooxygenase-2 pathway by HER2 receptor. Oncogene 18, 305-314.
73. Varner, J.A., Emerson, D.A., and Juliano, R.L. (1995). Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol. Biol. Cell 6, 725-740.
74. Wang, D., Sun, L., Zborowska, E., Willson, J.K., Gong, J., Verraraghavan, J., and Brattain, M.G. (1999). Control of type II transforming growth factor-beta receptor expression by integrin ligation. J. Biol. Chem. 274, 12840-12847.
75. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., and Giancotti, F.G. (1996). The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 733-743.
76. Wary, K.K., Mariotti, A., Zurzolo, C., and Giancotti, F.G. (1998). A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94, 625-634.
77. Wiley, H.S., and Cunningham, D.D. (1981). A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands. Cell 25, 433-440.
78. Worthylake, R., Opresko, L.K., and Wiley, H.S. (1999). ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors. J. Biol. Chem. 274, 8865-8874.
79. Zhu, X., and Assoian, R.K. (1995). Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell 6, 273-282.
80. Zhu, X., and Assoian, R.K. (1996). Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol. Biol. Cell 7, 1001 (Errata).
81. Zwick, E., Daub, H., Aoki, N., Yamaguchi-Aoki, Y., Tinhofer, I., Maly, K., and Ullrich, A. (1997). Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J. Biol. Chem. 272, 24767-24770.