RNA polymerase as an antiviral target of hepatitis C virus

Antiviral Chemistry and Chemotherapy, Supplement

Volumn 12, Issue 1, 2001, Pages 143-147

  Lai, M M C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Antiviral target; HCV; Ribavirin; RNA polymerase

Indexed keywords

HELICASE; PROTEINASE INHIBITOR; RECOMBINANT ALPHA INTERFERON; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE; RNA POLYMERASE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; CHRONIC HEPATITIS; CONFERENCE PAPER; DRUG EFFICACY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; PREVALENCE; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; DNA-DIRECTED RNA POLYMERASES; HEPACIVIRUS; HUMANS; INTERFERON-ALPHA; RIBAVIRIN; SUBSTRATE SPECIFICITY;

HEPATITIS C VIRUS;

EID: 0034815528     PISSN: 13502816     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (35)

1. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation
2. The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation
3. Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli
4. Mechanism of the potentiating effect of ribavirin on the activity of 2′,3′-dideoxyinosine against human immunodeficiency virus
5. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
6. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial
7. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
8. Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs
9. Only a small fraction of purified hepatitis C RNA-dependent RNA polymerase is catalytically competent: Implications for viral replication and in vitro assays
10. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
11. Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes
12. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
13. A second hepatitis C virus-encoded proteinase
14. The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses
15. Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization
16. The 3′-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site
17. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
18. Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: The crystal structure provides insights into the mode of unwinding
19. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
20. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
21. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
22. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
23. Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
24. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
25. De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus
26. A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA
27. Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template
28. Molecular mechanisms of action of ribavirin
29. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
30. Structure of the 3′ terminus of the hepatitis C virus genome
31. Internal ribosome entry site within hepatitis C virus RNA
32. RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region
33. De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase