Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation

Tohoku Journal of Experimental Medicine

Volumn 201, Issue 4, 2003, Pages 251-259

  Guan, Jing Zhi ^a   Tamasawa, Naoki ^a   Murakami, Hiroshi ^a   Matsui, Jun ^a   Yamato, Kazumi ^a   Suda, Toshihiro ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

ATP binding cassette A1 (ABCA1); Clofibrate; Liver X receptor (LXR); Oxysterols; Peroxisome proliferator activated receptor (PPAR)

Indexed keywords

25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; ABC TRANSPORTER; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CLOFIBRATE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KETOCONAZOLE; LIVER X RECEPTOR ALPHA; MESSENGER RNA; OXYSTEROL; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENE EXPRESSION REGULATION; LIVER; LIVER LEVEL; LIVER MICROSOME; MALE; NONHUMAN; NORTHERN BLOTTING; PROTEIN INDUCTION; RAT; RECEPTOR UPREGULATION; RNA ANALYSIS; STEROL SYNTHESIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CLOFIBRATE; CYTOCHROME P-450 ENZYME SYSTEM; DNA-BINDING PROTEINS; DRUG THERAPY, COMBINATION; HYDROXYCHOLESTEROLS; KETOCONAZOLE; LIPID METABOLISM; LIPOPROTEINS; MALE; MICROSOMES, LIVER; PEROXISOME PROLIFERATORS; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA; RNA, MESSENGER; STEROIDS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 1642503920     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.201.251     Document Type: Article

References (35)

1. Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M.A., Salbert, G. & Pfahl, M. (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol., 14, 7025-7035.
2. Björkhem, I. & Diczfalusy, U. (2002) Oxysterols friends, foes, or just fellow passengers ? Arterioscler. Thromb. Vasc. Biol., 22, 734-742.
3. Boström, H. (1983) Binding of cholesterol to cytochromes P-450 from rabbit liver microsomes. J. Biol. Chem., 258, 15091-15094.
4. Chiang, J.Y.L., Kimmel, R. & Stroup, D. (2001) Regulation of cholesterol 7α- hydroxylase (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene, 262, 257-265.
5. Chinetti,G., Lestavel, S., Bocher, V., Remaley, A.T., Neve, B., Torra, I.P., Teissier, E., Minnicch, A., Jaye, M., Duverger, N., Brewer, H.B., Fruchart, J.C., Clavey, V. & Stael, B. (2001) PPARalpha and PPARgamma activators induce cholesterol removal from human macrophage foam cell through stimulation of the ABCA1 pathway. Nat. Med., 7, 53-58.
6. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
7. Dzeletovic, S., Breuer, O., Lund, E. & Diczfalusy, U. (1995) Determination of cholesterol oxidation products in human plasma by lsotope dilution-mass spectrometry. Anal. Biochem., 225, 73-80.
8. Eagling, V.A., Howe, J.L., Barry, M.J. & Back, D.J. (1994) The metabolism of zidovudine by human liver microsomes in vitro: formation of 3′-amino-3′-deoxythymidine. Biochem. Pharmacol., 48, 267-276.
9. Eagling, V.A., Tjia, J.F. & Back, D.J. (1998) Differential selectivity of cytochromeP450 inhibitors against probe substrate in human and rat liver microsomes. Br. J. Clin. Pharmacol., 45, 107-114.
10. Erickson, S.K., Cooper, A.D., Matsui, S.M. & Gould, G. (1977) 7-Ketocholesterol, its effects on hepatic cholesterogenesis and its hepatic metabolism in vivo and in vitro. J. Biol. Chem., 252, 5186-5193.
11. Forman, B.M., Ruan, B., Chen, J., Schroepfer, G.J. & Evans, R.M. (1997) The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proc. Natl. Acad. Sci. USA, 94, 10588-10593.
12. Gupta, A., Sexton, R.C. & Rudney, H. (1986) Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutary coenzyme A (HMG-CoA) reductase activity by ketoconazole. J. Biol. Chem., 261, 8348-8356.
13. Issemann, I. & Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
14. Janowski, B.A., Willy, P.J., Devi, T.R., Falck, J.R. & Mangelsdorf, D.J. (1996) An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature, 383, 728-731.
15. Janowski, B.A., Grogan, M.J., Jones, S.A., Wisely, G.B., Kliewer, S.A., Corey, E.J. & Mangelsdorf, D.J. (1999) Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ. Proc. Natl. Acad. Sci. USA, 96, 266-271.
16. Javitt, N.B. (2002) Cholesterol, hydroxycholesterols, and bile acids. Biochem. Biophys. Res., 292, 1147-1153.
17. Laffitte, B.A., Joseph, S.B., Walczak, R., Pei, L., Wilpitz, D.C., Collins, J.L. & Tontonoz, P. (2001) Autoregulation of the human liver X receptor alpha promoter. Mol. Cell Biol., 21, 7558-7568.
18. Lehmann, J.M., Kliewer, S.A., Moore, L.B., Smith-Oliver, T.A., Oliver, B.B., Su, J.L., Sundseth, S.S., Winegar, D.A., Blanchard, D.E., Spencer, T.A. & Willson, T.M. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem., 272, 3137-3140.
19. Marrapodi, M. & Chiang, J.Y.L. (2000) Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) Transcription. J. Lipid Res., 41, 514-520.
20. Milton, M.N., Elcombe, C.R. & Gibson, G.G. (1990) On the mechanism of induction microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate. Biochem. Pharmacol., 40, 2727-2732.
21. Murakami, H., Tamasawa, N., Matsui, J., Yasujima, M. & Suda, T. (2000) Plasma oxysterols and tocopherol in patients with diabetes mellitus and hyperlipidemia. Lipids, 35, 333-338.
22. Patel, D.D., Knight, B.L., Soutar, A.K., Gibbons, G.F. & Wade, D.P. (2000) The effect of peroxisome-proliferator-activated receptor-α on the activity of the cholesterol 7α-hydroxycholesterol gene. Biochem. J., 351, 747-753.
23. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.-M.A., Hammer, R.E. & Mangelsdorf, D.J. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell, 93, 693-704.
24. Repa, J.J., Turley, S.D., Lobaccaro, J.-M.A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R.A., Dietschy, J.M. & Mangelsdorf, D.J. (2000) Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science, 289, 1524-1529.
25. Sabine, M.P., Helene, D., Philippe, P.G., Bart, S., Folkert, K. & Hans, M.G.P. (2001) Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregularion of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression. Arterioscler. Thromb. Vasc. Biol., 21, 1840-1845.
26. Simpson, A.E. (1997) The cytochrome P450 4 (CYP4) family. Gen. Pharmacol., 28, 351-359.
27. Smith, L.L. (1981) Cholesterol autoxidation. Smith LL Plenum Press, New York, pp. 297-368.
28. Tamasawa, N., Tamasawa, A., Takebe, K. & Hayakari, M. (1994) The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7alpha-hydroxylase activity in rat. Biochim. Biophys. Acta, 1214, 20-26.
29. Tamasawa, N., Hayakari, M., Murakami, H., Matsui, J. & Suda, T. (1997) Reduction of oxysterol levels up-regulateds HMG-CoA reductase activity in rat liver. Atherosclerosis, 131, 237-242.
30. Tobin, K.A.R., Steineger, H.H., Alberti, S., Spydevold, O., Auwerx, J., Gustafsson, J.Å. & Nebb, H.I. (2000) Cross- talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α. Mol. Endocrinol., 14, 741-752.
31. Venkateswaren, A., Laffitte, B.A., Joseph, S.B., Mak, P.A., Wilpitz, D.C., Edwards, P.A. & Tontonoz, P. (2000) Control of cellular cholesterol efflux by the nuclearoxysterol receptor LXR alpha. Proc. Natl. Acad. Sci. USA, 97, 12097-12102.
32. Watts, G.F. & Dimmitt, S.B. (1999) Fibrate, dyslipoproteinemia and cardiovascular disease. Curr. Opin. Lipid., 10, 561-574.
33. Willy, P.J., Umesono, K., Ong, E.S., Evans, R.M., Heyman, R.A. & Mangelsdorf, D.J. (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Gene Dev., 9, 1033-1045.
34. Wortelboer, H.M., DE Kruif, C.A., VAN Iersel, A.A.J., Falke, H.E., Noordhoek, J. & Blaauboer, B.J. (1991) Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures: the effects of model inducers on apoproteins and biotransformation activities. Biochem. Pharmacol., 42, 381-390.
35. Yamoto, T., Ohashi, Y., Terannishi, M., Takaoka, M., Manabe, S., Matsunuma, N. & Makita, T. (1995) Age-elated changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver. Toxicol. Lett., 78, 141-145.