The Class II cytokine receptor (CRF2) family: Overview and patterns of receptor-ligand interactions

Cytokine and Growth Factor Reviews

Volumn 15, Issue 1, 2004, Pages 33-48

  Langer, Jerome A ^a   Cutrone, E Cali ^a,c   Kotenko, Sergei ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c DarPharma Inc   (United States)

Author keywords

Cytokine receptors; Cytokines; Interferons

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; INTERFERON; INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 22; INTERLEUKIN 24; RECEPTOR SUBTYPE; THROMBOPLASTIN;

AMINO ACID SEQUENCE; CYTOLOGY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SEQUENCE ALIGNMENT;

EID: 1642432084     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2003.10.001     Document Type: Review

References (102)

1. Bazan J.F. Haematopoietic receptors and helical cytokines. Immunol. Today. 11:1990;350-354.
2. Thoreau E., Petridou B., Kelly P.A., Mornon J.P. Structural symmetry of the extracellular domain of the cytokine/growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis. FEBS Lett. 282:1991;26-31.
3. Roberts R.M., Liu L., Guo Q., Leaman D., Bixby J. The evolution of the Type I interferons. J. Interferon Cytokine Res. 18:1998;805-816. [published erratum appears in J Interferon Cytokine Res 1999 April;19(4):427].
4. LaFleur D.W., Nardelli B., Tsareva T., Mather D., Feng P., Semenuk M.et al. Interferon-kappa, a novel Type I interferon expressed in human keratinocytes. J. Biol. Chem. 276:2001;39765-39771.
5. Roberts R.M., Ealy A.D., Alexenko A.P., Han C.S., Ezashi T. Trophoblast interferons. Placenta. 20:1999;259-264.
6. Oritani K., Medina K.L., Tomiyama Y., Ishikawa J., Okajima Y., Ogawa M. et al. An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat. Med. 6:2000;659-666.
7. Takahashi I., Kosaka H., Oritani K., Heath W.R., Ishikawa J., Okajima Y.et al. A new IFN-like cytokine, limitin, modulates the immune response without influencing thymocyte development. J. Immunol. 167:2001;3156-3163.
8. Oritani K., Kincade P.W., Tomiyama Y. Limitin: an interferon-like cytokine without myeloerythroid suppressive properties. J. Mol. Med. 79:2001;168-174.
9. Oritani K., Hirota S., Nakagawa T., Takahashi I., Kawamoto S., Yamada M.et al. T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein. Blood. 101:2003;178-185.
10. Biron C.A. Interferons alpha and beta as immune regulators - a new look. Immunity. 14:2001;661-664.
11. Bach E.A., Aguet M., Schreiber R.D. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15:1997;563-591.
12. Pestka S. The interferon receptors. Semin. Oncol. 24:1997;S9-18-S9-40.
13. Ikeda H., Old L.J., Schreiber R.D. The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13:2002;95-109.
14. Moore K.W., de Waal M.R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:2001;683-765.
15. Dumoutier L., Renauld J.C. Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions. Eur. Cytokine Netw. 13:2002;5-15.
16. Fickenscher H., Hor S., Kupers H., Knappe A., Wittmann S., Sticht H. The interleukin-10 family of cytokines. Trends Immunol. 23:2002;89-96.
17. Kotenko S.V. The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev. 13:2002;223-240.
18. Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S., Whitmore T.E.et al. IL-28, IL-29 and their Class II cytokine receptor IL-28R. Nat. Immunol. 4:2003;63-68.
19. Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K.et al. IFN-lambdas mediate antiviral protection through a distinct Class II cytokine receptor complex. Nat. Immunol. 4:2003;69-77.
20. Banner D.W., D'Arcy A., Chene C., Winkler F.K., Guha A., Konigsberg W.H.et al. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature. 380:1996;41-46.
21. Kossiakoff A.A., De Vos A.M. Structural basis for cytokine hormone-receptor recognition and receptor activation. Adv. Protein Chem. 52:1998;67-108.
22. Walter M.R. Crystal structures of alpha-helical cytokine-receptor complexes: we've only scratched the surface. Biotechniques. 33:2002;S46-S57.
23. Mogensen K.E., Lewerenz M., Reboul J., Lutfalla G., Uze G. The Type I interferon receptor: structure, function, and evolution of a family business. J. Interferon Cytokine Res. 19:1999;1069-1098.
24. Bazan J.F. Structural design and molecular evolution of a cytokine receptor. Proc. Natl. Acad. Sci. U.S.A. 87:1990;6934-6938.
25. Kotenko S.V., Izotova L.S., Pollack B.P., Muthukumaran G., Paukku K., Silvennoinen O.et al. Other kinases can substitute for Jak2 in signal transduction by interferon-gamma. J. Biol. Chem. 271:1996;17174-17182.
26. Kotenko S.V., Krause C.D., Izotova L.S., Pollack B.P., Wu W., Pestka S. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J. 16:1997;5894-5903.
27. Muthukumaran G., Kotenko S., Donnelly R., Ihle J.N., Pestka S. Chimeric erythropoietin-interferon gamma receptors reveal differences in functional architecture of intracellular domains for signal transduction. J. Biol. Chem. 272:1997;4993-4999.
28. Strobl B., Arulampalam V., Is'harc H., Newman S.J., Schlaak J.F., Watling D.et al. A completely foreign receptor can mediate an interferon-gamma-like response. EMBO J. 20:2001;5431-5442.
29. Chill J.H., Nivasch R., Levy R., Albeck S., Schreiber G., Anglister J. The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening. Biochemistry. 41:2002;3575-3585.
30. Reboul J., Gardiner K., Monneron D., Uze G., Lutfalla G. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. Genome Res. 9:1999;242-250.
31. Cheng S., Lutfalla G., Uze G., Chumakov I.M., Gardiner K. GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mammalian Genome. 4:1993;338-342.
32. Lutfalla G., Crollius H.R., Stange-Thomann N., Jaillon O., Mogensen K., Monneron D. Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the Class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 4:2003;29.
33. Moyle W.R., Campbell R.K., Myers R.V., Bernard M.P., Han Y., Wang X. Co-evolution of ligand-receptor pairs. Nature. 368:1994;251-255.
34. Novick D., Cohen B., Rubinstein M. Soluble interferon-alpha receptor molecules are present in body fluids. FEBS Lett. 314:1992;445-448.
35. Lutfalla G., Holland S.J., Cinato E., Monneron D., Reboul J., Rogers N.C.et al. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14:1995;5100-5108.
36. Novick D., Cohen B., Tal N., Rubinstein M. Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. J. Leukoc. Biol. 57:1995;712-718.
37. Owczarek C.M., Hwang S.Y., Holland K.A., Gulluyan L.M., Tavaria M., Weaver B.et al. Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine Type I interferon receptor, IFNAR 2. J. Biol. Chem. 272:1997;23865-23870.
38. Hardy M.P., Owczarek C.M., Trajanovska S., Liu X., Kola I., Hertzog P.J. The soluble murine Type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties. Blood. 97:2001;473-482.
39. Han C.S., Chen Y., Ezashi T., Roberts R.M. Antiviral activities of the soluble extracellular domains of Type I interferon receptors. Proc. Natl. Acad. Sci. U.S.A. 98:2001;6138-6143.
40. Cook J.R., Cleary C.M., Mariano T.M., Izotova L., Pestka S. Differential responsiveness of a splice variant of the human Type I interferon receptor to interferons. J. Biol. Chem. 271:1996;13448-13453.
41. Dumoutier L., Lejeune D., Hor S., Fickenscher H., Renauld J.C. Cloning of a new Type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Biochem. J. 370:2003;391-396.
42. Xu W., Presnell S.R., Parrish-Novak J., Kindsvogel W., Jaspers S., Chen Z.et al. A soluble Class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9511-9516.
43. Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P.et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166:2001;7096-7103.
44. Dumoutier L., Lejeune D., Colau D., Renauld J.C. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J. Immunol. 166:2001;7090-7095.
45. Kotenko S.V., Pestka S. Jak-Stat signal transduction pathway through the eyes of cytokine Class II receptor complexes. Oncogene. 19:2000;2557-2565.
46. Darnell J.E. Jr., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1994;1415-1421.
47. Schindler C.W. Series introduction. JAK-STAT signaling in human disease. J. Clin. Invest. 109:2002;1133-1137.
48. O'Shea J.J., Gadina M., Schreiber R.D. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 109(Suppl.):2002;S121-S131.
49. Brierley M.M., Fish E.N. Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry. J Interferon Cytokine Res. 22:2002;835-845.
50. David M. Signal transduction by Type I interferons. Biotechniques. 33:2002;S58-S65.
51. Krause C.D., Mei E., Xie J., Jia Y., Bopp M.A., Hochstrasser R.M.et al. Seeing the light: preassembly and ligand-induced changes of the interferon gamma receptor complex in cells. Mol. Cell Proteomics. 1:2002;805-815.
52. Takaoka A., Mitani Y., Suemori H., Sato M., Yokochi T., Noguchi S.et al. Cross-talk between interferon-gamma and interferon-alpha/beta signaling components in caveolar membrane domains. Science. 288:2000;2357-2360.
53. Sadir R., Lambert A., Lortat-Jacob H., Morel G. Caveolae and clathrin-coated vesicles: two possible internalization pathways for IFN-gamma and IFN-gamma receptor. Cytokine. 14:2001;19-26.
54. Subramaniam P.S., Johnson H.M. Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha. J. Immunol. 169:2002;1959-1969.
55. Walter M.R., Windsor W.T., Nagabhushan T.L., Lundell D.J., Lunn C.A., Zauodny P.J.et al. Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor [see comments]. Nature. 376:1995;230-235.
56. Thiel D.J., le Du M.H., Walter R.L., D'Arcy A., Chene C., Fountoulakis M., Garotta G.et al. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Struct. Fold Des. 8:2000;927-936.
57. Josephson K., Logsdon N.J., Walter M.R. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15:2001;35-46.
58. Jones B.C., Logsdon N.J., Josephson K., Cook J., Barry P.A., Walter M.R. Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc. Natl. Acad. Sci. U.S.A. 99:2002;9404-9409.
59. Harlos K., Martin D.M., O'Brien D.P., Jones E.Y., Stuart D.I., Polikarpov I.et al. Crystal structure of the extracellular region of human tissue factor. Nature. 370:1994;662-666. [published erratum appears in Nature 1994 October 20;371(6499):720].
60. Muller Y.A., Ultsch M.H., De Vos A.M. The crystal structure of the extracellular domain of human tissue factor refined to 1.7 Å resolution. J. Mol. Biol. 256:1996;144-159.
61. Chill J.H., Quadt S.R., Levy R., Schreiber G., Anglister J. The human Type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 11:2003;791-802.
62. Piehler J., Schreiber G. Mutational and structural analysis of the binding interface between Type I interferons and their receptor Ifnar2. J. Mol. Biol. 294:1999;223-237.
63. Cutrone E.C., Langer J.A. Identification of critical residues in bovine IFNAR-1 responsible for interferon binding. J. Biol. Chem. 276:2001;17140-17148.
64. Randal M., Kossiakoff A.A. The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure. 9:2001;155-163.
65. Goldman L.A., Cutrone E.C., Dang A., Hao X.M., Lim J.K., Langer J.A. Mapping human interferon-alpha (IFN-α2) binding determinants of the Type I interferon receptor subunit IFNAR-1 with human/bovine IFNAR-1 chimeras. Biochemistry. 37:1998;13003-13010.
66. Kumaran J., Colamonici O.R., Fish E.N. Structure-function study of the extracellular domain of the human Type I interferon receptor (IFNAR)-1 subunit. J. Interferon Cytokine Res. 20:2000;479-485.
67. Langer J.A., Yang J., Carmillo P., Ling L.E. Bovine Type I interferon receptor protein BoIFNAR-1 has high-affinity and broad specificity for human Type I interferons. FEBS Lett. 421:1998;131-135.
68. Lewerenz M., Mogensen K.E., Uze G. Shared receptor components but distinct complexes for alpha and beta interferons. J. Mol. Biol. 282:1998;585-599.
69. Mitsui Y., Senda T., Shimazu T., Matsuda S., Utsumi J. Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-β Pharmacol. Ther. 58:1993;93-132.
70. Karpusas M., Whitty A., Runkel L., Hochman P. The structure of human interferon-beta: implications for activity. Cell Mol. Life Sci. 54:1998;1203-1216.
71. Uzé G., Di Marco S., Mouchel-Vielh E., Monneron D., Bandu M.T., Horisberger M.A., Dorques A.et al. Domains of interaction between alpha interferon and its receptor components. J. Mol. Biol. 243:1994;245-257.
72. Runkel L., DeDios C., Karpusas M., Betzenhauser M., Muldowney C., Zafari M.et al. Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity. Biochemistry. 39:2000;2538-2551.
73. Piehler J., Roisman L.C., Schreiber G. New structural and functional aspects of the Type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface. J. Biol. Chem. 275:2000;40425-40433.
74. Roisman L.C., Piehler J., Trosset J.Y., Scheraga H.A., Schreiber G. Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking. Proc. Natl. Acad. Sci. U.S.A. 98:2001;13231-13236.
75. Vigers G.P., Anderson L.J., Caffes P., Brandhuber B.J. Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. Nature. 386:1997;190-194.
76. Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A.et al. A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. Nature. 386:1997;194-200.
77. Vigers G.P., Dripps D.J., Edwards C.K. III, Brandhuber B.J. X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. J. Biol. Chem. 275:2000;36927-36933.
78. Cutrone E.C., Langer J.A. Contributions of cloned Type I interferon receptor subunits to differential ligand binding. FEBS Lett. 404:1997;197-202.
79. Boulanger M.J., Chow D.C., Brevnova E.E., Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science. 300:2003;2101-2104.
80. Wells J.A., De Vos A.M. Structure and function of human growth hormone: implications for the hematopoietins. Annu. Rev. Biophys. Biomol. Struct. 22:1993;329-351.
81. Sali A, Blundell TL. Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. J Mol Biol 1990;212(20):403-28.
82. Mizuguchi K., Deane C.M., Blundell T.L., Johnson M.S., Overington J.P. JOY: protein sequence-structure representation and analysis. Bioinformatics. 14:1998;617-623.
83. Wells J.A. Binding in the growth hormone receptor complex. Proc. Natl. Acad. Sci. U.S.A. 93:1996;1-6.
84. Deonarain R., Chan D.C., Platanias L.C., Fish E.N. Interferon-alpha/beta- receptor interactions: a complex story unfolding. Curr. Pharm. Des. 8:2002;2131-2137.
85. Konigsberg W., Kirchhofer D., Riederer M.A., Nemerson Y. The TF:VIIa complex: clinical significance, structure-function relationships and its role in signaling and metastasis. Thromb. Haemost. 86:2001;757-771.
86. Aguet M., Dembic Z., Merlin G. Molecular cloning and expression of the human interferon-gamma receptor. Cell. 55:1988;273-280.
87. Soh J., Donnelly R.J., Kotenko S., Mariano T.M., Cook J.R., Wang N.et al. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell. 76:1994;793-802.
88. Hemmi S., Bohni R., Stark G., Di Marco F., Aguet M. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell. 76:1994;803-810.
89. Uzé G., Lutfalla G., Gresser I. Genetic transfer of a functional human interferon-α receptor into a mouse cells: cloning and expression of its cDNA. Cell. 60:1990;225-234.
90. Novick D., Cohen B., Rubinstein M. The human interferon alpha/beta receptor: characterization and molecular cloning. Cell. 77:1994;391-400.
91. Domanski P., Witte M., Kellum M., Rubinstein M., Hackett R., Pitha P.et al. Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J. Biol. Chem. 270:1995;21606-21611.
92. Cohen B., Novick D., Barak S., Rubinstein M. Ligand-induced association of the Type I interferon receptor components. Mol. Cell Biol. 15:1995;4208-4214.
93. Ho A.S., Liu Y., Khan T.A., Hsu D.H., Bazan J.F. A receptor for interleukin 10 is related to interferon receptors. Proc. Natl. Acad. Sci. U.S.A. 90:1993;11267-11271.
94. Liu Y., Wei S.H., Ho A.S., de Waal Malefyt R., Moore K.W. Expression cloning and characterization of a human IL-10 receptor. J. Immunol. 152:1994;1821-1829.
95. Spencer S.D., Di Marco F., Hooley J., Pitts-Meek S., Bauer M., Ryan A.M.et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 187:1998;571-578.
96. Xie M.H., Aggarwal S., Ho W.H., Foster J., Zhang Z., Stinson J.et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275:2000;31335- 31339.
97. Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P.et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J. Biol. Chem. 276:2001;2725-2732.
98. Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S.et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell. 104:2001;9-19.
99. Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.C.et al. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J. Immunol. 167:2001;3545-3549.
100. Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J. Biol. Chem. 277:2002;7341-7347.
101. Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J.et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J. Biol. Chem. 277:2002;47517-47523.
102. D.C. Conklin et al., US Patent 6,544,505 (2003).