The structure of human interferon-β: Implications for activity

Cellular and Molecular Life Sciences

Volumn 54, Issue 11, 1998, Pages 1203-1216

  Karpusas, M ^a   Whitty, A ^a   Runkel, L ^a   Hochman, P ^a  

^a BIOGEN   (United States)

Author keywords

Aggregation; Crystal structure; Cytokine; Glycosylation; Interferon; Multiple sclerosis

Indexed keywords

BETA INTERFERON;

CARBOHYDRATE ANALYSIS; CLINICAL PHARMACOLOGY; CRYSTAL STRUCTURE; GLYCOSYLATION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GLYCOSYLATION; HUMANS; INTERFERON-BETA; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, INTERFERON;

EID: 0031766727     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050248     Document Type: Review

References (72)

1. Stewart W. E. II (1981) The Interferon System, pp. 135-156, Springer, New York
2. Tyring S. K. (1995) Interferons: biochemistry and mechanisms of action. Am. J. Obstet. Gynecol. 172: 1350-1353
3. Duncan M. R. and Berman B. (1985) Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J. Exp. Med. 162: 516-527
4. Gutterman J. (1994) Cytokine therapeutics: lessons from interferon-alpha. Proc. Natl. Acad. Sci. USA 91: 1198-1205
5. Pestka S., Langer J. A. and Zoon K. C. (1987) Interferons and their actions. Annu. Rev. Biochem. 56: 727-777
6. Branca A. A. and Baglioni C. (1981) Evidence that types I and II interferons have different receptors. Nature 294: 768-770
7. Flores I., Mariano T. M. and Pestka S. (1991) Human interferon omega binds to the alpha beta receptor. J. Biol. Chem. 266: 19875-19877
8. Li J. and Roberts R. M. (1994) Interferon-tau and interferon-alpha interact with the same receptors in bovine endometruim. Use of a readily iodinatable form of recombinant interferon-tau for binding studies. J. Biol. Chem. 269: 13544-13550
9. Weissman C. and Weber H. (1986) The interferon genes. Prog. Nucleic Acid Res. Mol. Biol. 33: 251-300
10. Pestka S. (1997) The human interferon-alpha species and hybrid proteins. Semin Oncol 24 (3 Suppl. 9): S9-S4S917
11. Bazer F. W., Spencer T. E. and Ott T. L. (1997) Interferon tau: a novel pregnancy recognition signal. Am. J. Reprod. Immunol. 37: 412-420
12. Adolf G. R., Kalsner I., Ahorn H., Maurer-Fogy I. and Cantell K. (1991) Natural human interferon-alpha 2 is O-glycosylated. Biochem. J. 276: 511-518
13. Walter M. R., Windsor W. T., Nagabhushan T. L., Lundell D. J., Lunn C. A., Zauodny P. J. et al. (1995) Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. Nature 376: 230-235
14. Uzé G., Lutfalla G. and Gresser I. (1990) Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell 60: 225-234
15. Novick D., Cohen B. and Rubinstein M. (1994) The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77: 391-400
16. Bazan J. F. (1990) Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87: 6934-6938
17. Uzé G., Lutfalla G. and Mogensen K. E. (1995) Alpha and beta interferons and their receptor and their friends and relations. J. Interferon Cytokine Res. 15: 3-26
18. Baron S., Tyring S. K., Fleischmann R., Coppenhaver D. H., Niesel D. W., Klimpel G. R., Stanton G. J. et al. (1991) The interferons. Mechanisms of action and medical applications. JAMA 266: 1375-1383
19. Weinstock-Guttman B., Ransohoff R. M., Kinkel R. P. and Rudick R. A. (1995) The interferons: biological effects, mechanisms of action and use in multiple sclerosis. Ann. Neurol. 37: 7-15
20. Senda T., Saitoh S.-I. and Mitsui Y. (1995) Refined crystal structure of recombinant murine interferon-beta at 2.15 Å resolution. J. Mol. Biol. 253: 187-207
21. Radhakrishnan R., Walter L. J., Hruza A., Reichert P., Trotta P. P., Nagabhushan T. L. et al. (1996) Zinc mediated dimer of human interferon alpha 2b revealed by x-ray crystallography. Structure 4: 1453-1463
22. Karpusas M., Nolte M., Benton C. B., Meier W., Lipscomb W. N. and Goelz S. (1997) The crystal structure of human interferon beta at 2.2-Å resolution. Proc. Natl. Acad. Sci. USA 94: 11813-11818
23. Klaus W., Gsell B., Labhardt A. M., Wipf B. and Senn H. (1997) The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. J. Mol. Biol. 274: 661-675
24. Mitsui Y., Senda T., Shimazu T., Matsuda S. and Utsumi J. (1993) Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta. Pharmacol. Ther. 58: 93-132
25. Presnell S. R. and Cohen F. E. (1989) Topological distribution of four-α-helix bundles. Proc. Natl. Acad. Sci. USA 86: 6592-6596
26. Sprang S. R. and Bazan J. F. (1993) Cytokine structural taxonomy and mechanisms of receptor engagement. Curr. Opin. Struct. Biol. 3: 815-827
27. Colamonici O. R., D'Alessandro F., Diaz M. O., Gregory S. A., Neckers L. M. and Nordan R. (1990) Characterization of three monoclonal antibodies that recognize the interferon alpha 2 receptor. Proc. Natl. Acad. Sci. USA 87: 7230-7234
28. Colamonici O. R., Pfeffer L. M., D'Alessandro F., Platanias L. C., Gregory S. A., Rosolen A. et al. (1992) Multichain structure of the IFN-alpha receptor on hematopoietic cells. J. Immunol. 148: 2126-2132
29. Colamonici O. R. and Domanski P. (1993) Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21. J. Biol. Chem. 268: 10895-10899
30. Domanski P., Witte M., Kellum M., Rubinstein M., Hackett R., Pitha P. et al. (1995) Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J. Biol. Chem. 270: 21606-21611
31. Lutfalla G., Holland S. J., Cinato E., Monneron D., Reboul J., Rogers N. C. et al. (1995) Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14: 5100-5108
32. Heldin C.-H. (1995) Dimerization of cell surface receptors in signal transduction. Cell 80: 213-223
33. De Vos A. M., Ultsch M. and Kossiakoff A. A. (1992) Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255: 306-312
34. Ling L. E., Zafari M., Reardon D., Brickelmeier M., Goelz S. E. and Benjamin C. D. (1995) Human type I interferon receptor, IFNAR, is a heavily glycosylated 120 130 kD membrane protein. J. Interferon Cytokine Res. 15: 55-61
35. Lim J. K., Xiong J., Carrasco N. and Langer J. A. (1994) Intrinsic ligand binding properties of the human and bovine alpha-interferon receptors. FEBS Lett. 350: 281-286
36. Uzé G., Lutfalla G., Eid P., Maury C., Bandu M.-T. and Gresser I. (1991) Murine tumor cells expressing the gene for the human interferon alpha beta receptor elicit antibodies in syngeneic mice to the active form of the receptor. Eur. J. Immunol. 21: 447-451
37. Benoit P., Maguire D., Plavec I., Kocher H., Tovey M. and Meyer F. (1993) A monoclonal antibody to recombinant human IFN-alpha receptor inhibits biologic activity of several species of human IFN-alpha. IFN-beta and IFN-omega. Detection of heterogeneity of the cellular type I IFN receptor. J. Immunol. 150: 707-716
38. Cutrone E. C. and Langer J. A. (1997) Contributions of cloned type I interferon receptor subunits to differential ligand binding. FEBS Lett. 404: 197-202
39. Colamonici O. R., Uyttendaele H., Domanski P., Yan H. and Krolewski J. J. (1994) p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor. J. Biol. Chem. 269: 3518-3522
40. Darnell J. E. (1997) STATs and gene regulation. Science 277: 1630-1635
41. Yang C. H., Shi W., Basu L., Murti A., Constantinescu S. N., Blatt L. et al. (1996) Direct association of STAT3 with the IFNAR-1 chain of human type I interferon receptor. J. Biol. Chem. 271: 8057-8061
42. Li X., Leung S., Kerr I. M. and Stark G. R. (1997) Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. 17: 2048-2056
43. Petricoin E. F. III, Ito S., Williams B. L., Audet S., Stancato L. F., Gamero A. et al. (1997) Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling. Nature 390: 629-632
44. David M., Petricoin E. III, Benjamin C., Pine R., Weber M. J. and Larner A.C. (1995) Requirement for MAP Kinase (ERK2) activity in interferon alpha-and interferon beta-stimulated gene expression through STAT proteins. Science 269: 1721-1723
45. Kalvakolanu D. V. and Borden E. C. (1996) An overview of the interferon system: signal transduction and mechanisms of action. Cancer Invest. 14: 25-53
46. Pfeffer L. M., Basu L., Pfeffer S. R., Yang C. H., Murti A., Russell-Harde D. et al. (1997) The short form of the interferon alpha beta receptor chain 2 acts as a dominant negative for type I interferon action. J. Biol. Chem. 272: 11002-11005
47. Somers W., Ultsch M., De Vos A. M. and Kosslakoff A. A. (1994) The x-ray structure of a growth hormone-prolactin receptor complex. Nature 372: 478-481
48. Wells J. A. (1994) Structural and functional basis for hormone binding and receptor oligomerization. Curr. Opin. Cell. Biol. 6: 163-173
49. Day C., Schwartz B., Li B. L. and Pestka S. (1992) Engineered disulfide bond greatly increases specific activity of recombinant murine interferon-beta. J. Interferon Res. 12: 139-143
50. Uzé G., Di Marco S., Mouchel-Vielh E., Monneron D., Bandu M.-T., Horisberger M. A. et al. (1994) Domains of interaction between alpha interferon and its receptor components. J. Mol. Biol. 243: 245-257
51. Weber H., Valenzuela D., Lujber G., Gubler M. and Weissmann C. (1987) Single amino acid changes that render human IFN-alpha2 biologically active on mouse cells. EMBO J. 6: 591-598
52. Mouchel-Vielh E., Lutfalla G., Mogensen K. E. and Uzé G. (1992) Specific antiviral activities of the human alpha interferons are determined at the level of receptor (IFNAR) structure. FEBS Lett. 313: 255-259
53. Runkel L., Pfeffer L., Lewerenz M., Monneron D., Yang C. H., Murti A. et al. (1998) Differences in activity between alpha and beta type I interferons explored by mutational analysis. J. Biol. Chem. 273: 8003-8008
54. Platanias L. C., Uddin S. and Colamonici O. R. (1994) Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein. J. Biol. Chem. 269: 17761-17764
55. Abramovitch C., Shulman L., Ratovisky E., Harroch S., Tovey M., Eid P. et al. (1994) Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated protein in response to IFN-α and IFN-β. EMBO J. 13: 5817-5877
56. Constantinescu S. N., Croze E., Murti A., Wang C., Basu L., Hollander D. et al. (1995) Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex. Proc. Natl. Acad. Sci. USA 92: 10487-10491
57. Croze E., Russell-Harde D., Wagner T. C., Pu H., Pfeffer E. M. and Perez H. D. (1996) The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. J. Biol. Chem. 271: 33165-33168
58. John J., McKendry R., Pelligrini S., Flavell D., Kerr I. M. and Stark G. R. (1991) Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol. Cell. Biol. 11: 4189-4195
59. Velazquez L., Mogensen K. E., Barbieri G., Fellous M., Uzé G. and Pellegrini S. (1995) Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/ beta and for signal transduction J. Biol. Chem. 270: 3327-3334
60. Jarpe M. B., Knall C., Mitchell F. M., Buhl A. M., Duzic E. and Johnson G. L. (1998) [D-Arg1, D-Phe5, D-Trp7,9,Leul1] substance P acts as a biased agonist toward neuropeptide and chemokine receptors. J. Biol. Chem. 273: 3097-3104
61. Conradt H. S., Egge H, Peter-Katalinic J., Reiser W., Skilosi T. and Schaper K. (1987) Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line. J. Biol. Chem. 262: 14600-14605
62. Runkel L., Meier W., Pepinsky B., Karpusas M., Whitty A., Kimball K. et al. (1998) Structural and functional differences between glycosylated and nonglycosylated forms of human interferon-beta (IFN-beta). Pharm. Res. 15: 641-649
63. Mark D. F., Lu S. D., Creasey A. A., Yamamoto R. and Lin L. S. (1984) Site-specific mutagenesis of the human fibroblast interferon gene. Proc. Natl. Acad. Sci. USA 81: 5662-5666
64. Rudick R. A., Simonian N. A., Campion M., Scaramucci J. D., Jones W., Coats M. E. et al. (1998) Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group. Neurology 50:1266-1272
65. The IFNβ Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group (1996) Neutralizing antibodies during treatment of multiple sclerosis with interteron beta-1b: experience during the first three years. Neurology 47: 889-894
66. Antonelli G. (1997) In vivo development of antibody to interferons: an update to 1996. J. Interferon Cytokine Res. 17 (Suppl. 1): S39-S46
67. The IFNβ Multiple Sclerosis Study Group and the Univerity of British Columbia MS/MRI Analysis Group (1995) Interferon beta 1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 45: 1277-1285
68. Abdul-Ahad A. K., Galazka A. R., Revel M., Biddoni M. and Borden E. C. (1997) Incidence of antibodies to interferon-beta in patients treated with recombinant human interferon-β1a from mammalian cells. Cytokines Cell. Mol. Ther. 3: 27-32
69. REBIF® Package Insert, Serono Laboratories, Inc., Norwell MA
70. Palleroni A. V., Aglione A., Labow M., Brunda M. J., Pestka S., Sinigaglia F. et al. (1997) Interferon immunogenicity: preclinical evaluation of interferon-alpha2a. J. Interferon Cytokine Res. 17 (Suppl. 1): S23-S27
71. Alam J., McAllister A., Scaramucci J., Jones W. and Rogge M. (1997) Pharmacokinetics and pharmacodynamics of interferon beta-1a (IFNβ-1a) in healthy volunteers after intravenous, subcutaneous or intramuscular administration. Pharmacology 14: 35-43
72. Hochuli E. (1997) Interferon immunogenicity: technical evaluation of interferon-alpha2a. J. Interferon Cytokine Res. 17 (Suppl. 1): S15-S21