Isolation and characterization of two novel A20-like proteins

Biochemical Journal

Volumn 357, Issue 3, 2001, Pages 617-623

  Evans, P C ^a   Taylor, E R ^a   Coadwell, J ^a   Heyninck, K ^a   Beyaert, R ^a   Kilshaw, P J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Inflammation; Nuclear factor B; TRAF molecules

Indexed keywords

ADHESION; CYTOLOGY; GENES; ZINC;

INFLAMMATORY PROCESSES;

PROTEINS;

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE ISOLATION; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NUCLEAR PROTEINS; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTION, GENETIC;

EID: 0035423970     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570617     Document Type: Article

References (13)

1. Tumour necrosis factor receptor and Fas signaling mechanisms
2. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation
3. The Toll/interleukin-1 receptor domain: A molecular switch for inflammation and host defence
4. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
5. Antibody-induced transplant arteriosclerosis is prevented by expression of anti-oxidant and anti-apoptotic genes
6. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
7. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6
8. Interleukin-13 protects endothelial cells from apoptosis and activation: Association with the protective genes A20 and A1
9. Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by κB elements
10. 14-3-3 Proteins associate with A20 in an isoformspecific manner and function both as chaperone and adaptor molecules
11. The zinc finger protein A20 inhibits TNF-induced NF-κB-dependent gene expression by interfering with a RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-κB-inhibiting protein ABIN
12. Functional redundancy of the zinc fingers of A20 for inhibition of NF-κB activation and protein-protein interactions
13. The N-terminal domains target TNF receptor-associated factor-2 to the nucleus and display transcriptional regulatory activity