Effects of neuropeptide Y on the discriminative stimulus and antinociceptive properties of morphine

Pharmacology Biochemistry and Behavior

Volumn 64, Issue 1, 1999, Pages 161-164

  Picker, M J ^a   Allen, R M ^a   Morgan, D ^a   Levine, A S ^b   O'Hare, E ^b   Cleary, J P ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b VA MEDICAL CENTER   (United States)

Author keywords

Antinociception; Drug discrimination; Morphine; NPY; Opioids; Rats

Indexed keywords

MORPHINE; MU OPIATE RECEPTOR; NEUROPEPTIDE Y;

ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG DISCRIMINATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MORPHINE; NEUROPEPTIDE Y; PAIN MEASUREMENT; RATS; RATS, LONG-EVANS; REFLEX; REINFORCEMENT SCHEDULE;

EID: 0032859961     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(99)00110-0     Document Type: Article

References (21)

1. Broqua P., Wettstein J.G., Rocher M.N., Gauthier-Martin B., Riviere P.J., Junien J.L., Dahl S.G. Antinociceptive effects of neuropeptide Y and related peptides in mice. Brain Res. 724:1996;25-32.
2. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
3. Cleary J., Semotuk M., Levine A.S. Effects of neuropeptide Y on short-term memory. Brain Res. 653:1994;210-214.
4. Flood J.F., Baker M.L., Hernandez E.N., Morley J.E. Modulation of memory processing by neuropeptide Y varies with brain injection site. Brain Res. 503:1989;73-82.
5. Heiling M., Söderpalm B., Engel J.A., Wilderlöv E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology (Berlin). 98:1989;524-529.
6. Heilig M., Vecsei L., Widerlöv E. Opposite effects of centrally administered neuropeptide Y (NPY) on locomotor activity of spontaneously hypertensive (SH) and normal rats. Acta Physiol. Scand. 137:1989;243-248.
7. Hua X.Y., Boulik J.H., Spicer M.A., Rivier J.E., Brown M.R., Yaksh T.L. The antinociceptive effects of spinally administered neuropeptide Y in the rat. Systemic studies on structure-activity relationship J. Pharmacol. Exper. Ther. 258:1991;243-248.
8. Jaeger T.V., van der Kooy D. Morphine acts in the parabrachial nucleus, a pontine viscertosensory relay, to produce discriminative stimulus effects. Psychopharmacology (Berlin). 110:1993;76-84.
9. Kalra S.P., Clark J.T., Sahu A., Dube M.G., Kalra P.S. Control of feeding and sexual behaviors by neuropeptide Y. Physiological implications Synapse. 2:1988;254-257.
10. Koob G.F., Maldonado R., Stinus L. Neural substrates of opiate withdrawal. Trends in Neurosci. 15:1992;186-191.
11. Kotz C.M., Grace M.K., Billington C.J., Levine A.S. The effect of norbinaltorphimine, beta-funaltrexamine and naltrindole on NPY-induced feeding. Brain Res. 631:1993;325-328.
12. Kotz C.M., Grace M.K., Briggs J., Levine A.S., Billington C.J. Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action. J. Clin. Invest. 96:1995;163-170.
13. Levine A.S., Grace M., Billington C.J. The effect of centrally administered naloxone on deprivation and drug-induced feeding. Pharmacol. Biochem. Behav. 36:1990;409-412.
14. Levine A.S., Morley J.E. Neuropeptide Y. A potent inducer of consumatory behavior in rats Peptides. 5:1984;1025-1029.
15. Maldonado R., Stinus L., Gold L.H., Koob G.R. Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J. Pharmacol. Exp. Ther. 261:1992;669-677.
16. Morgan D., Picker M.J. Contribution of individual differences to the discriminative stimulus, antinociceptive, and rate-decreasing effects of opioids. Importance of the drug's relative intrinsic efficacy at the mu receptor Behav. Pharmacol. 7:1996;261-275.
17. O'Hare E., Cleary J., Weldon D.T., Pomonis J.D., Billington C.J., Levine A.S. Intrahypothalamic discriminative stimulus effects of neuropeptide Y. Pharmacol. Biochem. Behav. 59:1998;375-378.
18. Pages N., Orosco M., Fournier G., Rouch C., Hafi A., Gourch A., Comoy E., Bohuon C. The effects of chronic administration of morphine on the levels of brain and adrenal cateholamines and neuropeptide Y. Gen. Pharmacol. 22:1991;943-947.
19. Stanley B.G., Leibowitz S.F., Neuropeptide Y. Stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35:1984;2635-2642.
20. Woldbye D.P.D., Klemp K., Madsen T.M. Neuropeptide Y attenuates naloxone-precipitated morphine withdrawal via Y5-like receptors. J. Pharmacol. Exp. Ther. 284:1998;633-636.
21. Yaksh T.L. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesth. Scand. 41:1997;94-111.