Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement

Psychopharmacology

Volumn 153, Issue 2, 2001, Pages 203-209

  Duxon, M S ^a   Stretton, J ^a   Starr, K ^a   Jones, D N C ^a   Holland, V ^a   Riley, G ^a   Jerman, J ^a   Brough, S ^a   Smart, D ^a   Johns, Amanda ^b   Chan, Wai ^b   Porter, Rod A ^b   Upton, N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Department of Discovery Chemistry ^*  (United Kingdom)

Author keywords

5 HT2C receptor; 5 Hydroxytryptamine; Grooming; Orexin A; OX1 receptor

Indexed keywords

1 (2 METHYLBENZOXAZOL 6 YL) 3[1,5]NAPHTHYRIDIN 4 YLUREA; 1 (4 METHYLSULFANYLPHENYL) 3 QUINOLIN 4 YLUREA; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; NEUROPEPTIDE RECEPTOR; OREXIN; OREXIN A; OREXIN RECEPTOR; RECEPTOR SUBTYPE; SB 284422; SB 334867 A; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GROOMING; HUMAN; HUMAN CELL; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; CARRIER PROTEINS; CLONING, MOLECULAR; GROOMING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOTOR ACTIVITY; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PIPERAZINES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS;

EID: 0035142630     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000550     Document Type: Article

References (25)

1. 2C receptor-mediated corticosterone and prolactin but not oxytocin and penile erection responses
2. 2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations
3. Nonlinear regression using spreadsheets
4. Orexin-A excites dorsal raphe serotonergic neurons
5. The Cheng-Prusoff relationship: Something lost in the translation
6. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
7. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system
8. Orexin-A Activates locus coeruleus cell firing and increases arousal in the rat
9. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
10. Effects of centrally administered orexin-B and orexin-A: A role for orexin-1 receptors in orexin-B-induced hyperactivity
11. 1C receptors
12. 1C receptor antagonists
13. 2C receptor antagonist
14. 2B receptor agonist, causes hyperphagia and reduced grooming in rats
15. 2B receptor antagonist in rats
16. 2B receptor mediated
17. 2C receptor antagonist
18. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behaviour
19. Localization of receptors for the dipsogenic action of angiotensin II in the subfornical organ of the rat
20. Characterisation of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
21. i using the fluorimetric imaging plate reader (FLIPR)
22. Distribution of orexin receptor mRNA in the rat brain
23. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
24. Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus