Bipolar Disorder and Schizophrenia: Convergent Molecular Data

NeuroMolecular Medicine

Volumn 5, Issue 1, 2004, Pages 109-117

  Berrettini, Wade ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Association; Bipolar disorder; Genetics; Linkage; Schizophrenia

Indexed keywords

BIPOLAR DISORDER; CHROMOSOME 10P; CHROMOSOME 13Q; CHROMOSOME 18P; CHROMOSOME 22Q; CHROMOSOME 8P; DISEASE CLASSIFICATION; EPIDEMIOLOGICAL DATA; EVIDENCE BASED MEDICINE; FAMILIAL DISEASE; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

ANIMALS; BIPOLAR DISORDER; BRAIN CHEMISTRY; GENETIC PREDISPOSITION TO DISEASE; GENOME; HUMANS; LINKAGE (GENETICS); MUTATION; SCHIZOPHRENIA;

EID: 1642288039     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:5:1:109     Document Type: Review

References (76)

1. Akiskal, H. S. (2003) Validating hard and soft phenotypes within the bipolar spectrum: Continuity or discontinuity? J. Affect. Disord. 73, 1-5.
2. Angst, J., Gamma, A., Benazzi, F., Ajdacic, V., Eich, D., Rossler, W. (2003) Toward a redefinition of sub-threshold bipolarity: Epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J. Affect. Disord. 73, 133-146.
3. Badner, J., and Gershon, E. S. (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol. Psychiatry 7, 405-411.
4. Baron, M., Gruen, R., Anis, L., Kane, J. (1983) Schizo-affective illness, schizophrenia and affective disorders: Morbidity risk and genetic transmission. Acta. Psychiatrica Scand. 65, 253-262.
5. Baron, M., Gruen, D., Ranier, J. D., Kane, J., Asnis, L., Lord, A. (1985) A family study of schizophrenia and normal control probands: Implications for the spectrum concept of schizophrenia. Am. J. Psychiatry 142, 447-455.
6. Bennett, P., Segurado, R., Jones, I., et al. (2002) The Wellcome trust UK-Irish bipolar affective disorder sibling pair genome screen: First stage report. Mol. Psychiatry 7, 189-200.
7. Berrettini, W. H. Bipolar disorders: Review of molecular genetic studies. In KL Davis, D Charney, J. T. Coyle, C. Nemeroff (Eds.), Neuropsychopharmacology, The Fifth Generation of Progress, Lippincott, Philadelphia, 2002, pp. 1027-1038.
8. Berrettini, W., Ferraro, T., Goldin, L., et al. (1994) Chromosome 18 DNA markers and manic depressive illness: Evidence for a susceptibility gene. Proc. Natl. Acad. Sci. USA. 91, 5918-5921.
9. Berrettini, W., Ferraro, T., Choi, H., et al. (1997) Linkage studies of bipolar illness. Arch. Gen. Psychiatry 54, 32-39.
10. Blouin, J.-L., Dombroski, B., Nath, S. K., et al. (1998) Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat. Genet. 20, 70.
11. Brzustowicz, L. M., Honer, W. G., Chow, E. W. C., et al. (1999) Linkage of familial schizophrenia to chromosome 13q32. Am. J. Hum. Genet. 65, 1096-1103.
12. Carlson, C., Papolos, D., Pandita, R. K., et al. (1997) Molecular analysis of VCFS patients with psychiatric disorders. Am. J. Med. Genet. 60, 851-859.
13. Chen, Y.-S., Akula, N., DeTera-Wadleigh, S. D., et al. (2004) Findings in an independent sample support an association between bipolar affective disorder and the G22/G30 locus on chromosome 13q3. Mol. Psychiatry 9, 87-92.
14. Chumakov, I., Blumenfeld, M., Guerassimenko, O., et al. (2002) Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. USA. 99, 13675-12680.
15. Ciapparelli, A., Dell'Osso, L., Pini, S., et al. (2000) Clozapine for treatment-refractory schizophrenia, schizoaffective disorder and psychotic bipolar disorder: a 24-month naturalistic study. J. Clin. Psychiatry 61, 329-334.
16. Coryell, W., Zimmerman, M. (1988) The heritability of schizophrenia and schizoaffective disorder: A family study. Arch. Gen. Psychiatry 42, 770-779.
17. Detera-Wadleigh, S. D., Badner, J. A., Berrettini, W. H., et al. (1999) Evidence for a bipolar susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc. Natl. Acad. Sci. USA. 96, 5604-5609.
18. Edenberg, H., Foroud, T., Conneally, M., et al. (1997) Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22. Neuropsychiat Gen. 74, 238-246.
19. Egan, M.F., Goldberg, T. E., Kolachana, B. S., et al. (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad. Sci. USA. 98, 6917-6922.
20. Faraone, S. V, Matise, T., Svrakic, D., et al. (1998) Genome scan of European-American schizophrenia kindreds: Results of the NIMH Genetics Initiative and Millenium consortium. Am. J. Med. Genet. 81, 290-295.
21. Foroud, T., Castelluccio, P. F., Keller, D. L., et al. (2000) Suggestive evidence of a locus on chromosome 10p using the NIMH Genetics Initiative bipolar affective disorder pedigrees. Am. J. Med. Genet. 96, 18-23.
22. Gershon, E. S., DeLisi, L. E., Hamovit, J., et al. (1988) A controlled family study of chronic psychoses. Arch. Gen. Pscyhiatry 45, 328-336.
23. Gershon, E. S., Hamovit, J., Guroff, J. J., et al. (1982) A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch. Gen. Psychiatry 39, 1157-1167.
24. Gill, M., Vallada, H., Collier, D., et al. (1996) A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12. Am. J. Med. Genet. 67, 40-45.
25. Goldin, L. R., Gershon, E. S., Berrettini, W. H., et al. (1997) Description of the Genetic Analysis Workshop 10 bipolar disorder linkage data sets. Genet. Epidemiol. 14, 563-568.
26. Gurling, H. M. D., Kalsi, G., Blaveri, E., et al. (1999) Initial genome wide parametric genetic linkage analysis of schizophrenia and schizophrenia spectrum disorders finds LOD scores above 3.00 on four chromosomes at 1q22-23, 5q22-35, 8p21-23 and 11q14-24. Mol. Psychiatry 4(suppl), S4.
27. Hattori, E., Liu, C., Badner, J. A., et al. (2003) Polymorphisms at the G72/G30 gene locus on 13q33 are associated with bipolar disorder in two independent pedigree series. Am. J. Hum. Genet. 72, 1131-1140.
28. Helzer, J. E., and Winokur, G. (1974) A family interview study of male manic-depressives. Arch. Gen. Psychiatry 31, 73-77.
29. Horikawa, Y., Oda, N., Cox, N. J., Li X, et al. (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26, 163-175.
30. Hugot, J. P., Chamaillard, M., Zouali, H., et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's Disease. Nature 411, 599-603.
31. James, N. M., and Chapman, C. J. (1975) A genetic study of bipolar affective disorder. Br. J. Psychiatry 126, 449-456.
32. Johnson, G. F. S., and Leeman, M. M. (1977) Analysis of familial factors in bipolar affective illness. Arch. Gen. Psychiatry 34, 1074-1083.
33. Kelsoe, J. R., Spence, M. A., Loetscher, E., et al. (2001) A genome survey indicates a susceptibility locus for bipolar disorder on chromosome 22. Proc. Natl. Acad. Sci. USA. 98, 585-590.
34. Kendler, K. S, McGuire, M., Gruenberg, A. M., O'Hare, A., Spellman, M., Walsh, D. (1993) The Roscommon Family Study. IV. Affective illness, anxiety disorders, and alcoholism in relatives. Arch. Gen. Psychiatry 50, 952-960.
35. Lachman, H. M., Kelsoe, J. R., Remick, R. A., et al. (1996) Linkage studies support a possible locus for bipolar disorder in the velocardiofacial syndrome region on chromosome 22. Am. J. Med. Genet. 74, 121-128.
36. Lander, E., Kruglyak, L. (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat. Genet. 11, 241-247.
37. Levinson, D. F., and the Schizophrenia Linkage Collaborative Group. (1996) Additional support for schizophrenia linkage for chromosomes 6 and 8. A multicenter study. Am. J. Med. Genet. 67, 580-594.
38. Levinson, D. F., Levinson, M. D., Segurado, R., Lewis, C.M. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis. Am. J. Hum. Genet. 73, 17-33.
39. Lewis, C. M., Levinson, D. F., Wise, L. H. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am. J. Hum. Genet. 73, 34-48.
40. Lin, J. P., Bale, S. J. (1997) Parental transmission and D18S37 allele sharing in bipolar affective disorder. Genet. Epidemiol. 14, 665-668.
41. Liu, H., Abecasis, G. R., Health, S. C., et al. (2002) Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc. Natl. Acad. Sci. USA. 99, 16859-16864.
42. Maier, W., Lichtermann, D., Minges, J., et al. (1993) Continuity and discontinuity of affective disorders and schizophrenia, Results of a controlled family study. Arch. Gen. Psychiatry 50, 871-883.
43. Maier, W., Lichtermann, D., Franke, P., Heun, R., Falkai, P., Rietschel, M. (2002) The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophr. Res. 57, 259-266.
44. Maj, M., Starace, F., Pirozzi, R. (1991) A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and non-psychotic depression. Am. J. Psychiatry 148, 612-616.
45. Meltzer, H. Y., Alphs, L., Green, A. I., et al. and the International Suicide Prevention Trial Study Group. (2003) Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch. Gen. Psychiatry 60, 82-91.
46. Moises, H. W., Yang, L., Kristbjarnarson, H., et al. (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat. Genet. 11, 321-324.
47. Mujaheed, M., Corbex, M., Lichtenberg, P., Levinson, D. F., Deleuze, J. F., Mallet, J., Ebstein, R. P. (2000) Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a Palestinian Arab population. Am. J. Med. Genet. 96, 836-838.
48. Niculescu, A. B., 3rd, Segal, D. S., Kuczenski, R., Barrett, T., Hauger, R. L., Kelsoe, J. R. (2000) Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach. Physiol. Genomics 4, 83-91.
49. Nothen, M. M., Cichon, S., Rohleder, H., et al. (1999) Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families. Mol. Psychiatry 4, 76.
50. Nurnberger, J. L., Jr., and Berrettini, W. H. (1998) Psychiatric genetics. Chapman and Hall, London.
51. Ophoff, R. A., Escamilla, M. A., Service, S.K., et al. (2002) Genome-wide linkage disequilibrium mapping of severe bipolar disorder in a population isolate. Am. J. Hum. Genet. 71, 565-574
52. Papolos, D. F., Faedda, G. L., Veit, S., et al. (1996) Bipolar spectrum disorders in patients diagnoses with VCFS: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am. J. Psychiatry 153, 1541-1547.
53. Potash, J. B., Chiu, Y. F., MacKinnon, D. F., et al. (2003) Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees. Am. J. Med. Genet. 116B, 90-97.
54. Potash, J. B., Willour, V. L., Chiu, Y. F, et al. (2001) The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. Am. J. Psychiatry 158, 1258-1264.
55. Pulver, A. E., Karayiorgou, M., Wolyniec, P. S., et al. (1994) Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12- q13.1: Part 1. Am. J. Med. Genet. 54, 36-43.
56. Pulver, A. E., Nestadt, G., Goldberg, R., et al. (1994) Psychotic illness in patients diagnosed with velocardio-facial syndrome and their relatives. J. Nerv. Mental Dis. 182(8), 476-478.
57. Rioux, J. D., Daly, M. J, Silverberg, M. S, et al. (2001) Genetic variation in the 5q31 cytokine gene cluster confers susceptibility in Crohn's Disease. Nat. Genet. 29(2), 223-228.
58. Schwab, S. G., Hallmayer, J., Lerer, B., et al. (1998) Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis. Am. J. Hum. Genet. 63, 1139.
59. Schwab, S. G., Hallmayer, J., Albus, M., et al. (2000) A genome-wide autosomal screen for schizophrenia susceptibility loci in 71families with affected siblings: support for loci on chromosome 10p and 6. Mol. Psychiatry 5, 638-649.
60. Segurado, R., Detera-Wadleigh, S. D., Levinson, D. F., et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder part iii: Bipolar disorder. Am. J. Hum. Genet. 73, 49-62.
61. Shifman, S., Bronstein, M., Sternfeld, M., et al. (2002) A highly significant association between a COMT haplotype and schizophrenia. Am. J. Hum. Genet. 71, 1296-1302.
62. Somnath, C. P., Reddy, Y. C. J., Jain, S. (2002) Is there a familial overlap between schizophrenia and bipolar disorder? J. Affect. Disorders 72, 243-247.
63. Stefansson, H., Sigurdsson, E., Steinthorsdottir, V., et al. (2002) Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71, 877-892.
64. Stefansson, H., Sarginson, J., Kong, A., et al. (2003) Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am. J. Hum. Genet. 72, 83-87.
65. Stine, O. C., Xu, J., Koskela, R., et al. (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am. J. Hum. Genet. 57, 1384-1394.
66. Straub, R. E., MacLean, C. J., Martin, R. B., et al. (1998) A schizophrenia locus may be located in region 10p15-p11. Am. J. Med. Genet. 81, 296-301.
67. Straub, R. E., Jiang, Y., MacLean, C. J., et al. (2002) Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 71, 337-348.
68. Suppes, T., Webb, A., Paul, B., Carmody, T., Kraemer, H., Rush, A J. (1999) Clinical outcome in a randomzied 1-year trial of clozapine versus treatment as usual for patients with treatment-resistant illness and a history of mania. Am. J. Psychiatry 156, 1164-1169.
69. Tohen, M., Bowden, C., Calabrese, J., et al. Olanzapine versus placebo for relapse prevention in bipolar disorder. Presented at the Annual Meeting, American Psychiatric Association, San Francisco, CA, May 19, 2003.
70. Turecki, G., Grof, P., Cavazzoni, P., et al. Lithium responsive bipolar disorder, unilineality and chromosome 18: a linkage study. Am. J. Med. Genet. 88, 411-415.
71. Weissman, M. M., Gershon, E. S., Kidd, K. K., et al. (1984) Psychiatric disorders in the relatives of probands with affective disorder. Arch. Gen. Psychiatry 41, 13-21.
72. Winokur, G., Coryell, W., Keller, M., Endicott, J., Leon, A. (1995) A family study of manic-depressive (bipolar I) disease. Is it a distinct illness separable from primary unipolar depression? Arch. Gen. Psychiatry 52(5), 367-373.
73. Winokur, G., Tsuang, M. T., Crowe, R. R. (1982) The Iowa 500: Affective disorder in relatives of manic and depressed patients. Am. J. Psychiatry 139, 209-212.
74. Yang, J. Z., Si, T. M., Ruan, Y., et al. (2003) Association study of neurogulin 1 gene with schizophrenia. Mol. Psychiatry 8, 206-209.
75. Yoshikawa, T., Kikuchi, M., Saito, K., et al. (2001) Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples. Mol. Psychiatry 6, 202-210.
76. Zarate, C. A., Tohen, M., Banov, M. D., Weiss, M. K., Cole, J. O. (1999) Is clozapine a mood stabilizer? J. Clin. Psychiatry 60(suppl 12), 43-46.