Additional Support for Schizophrenia Linkage on Chromosomes 6 and 8: A Multicenter Study

American Journal of Medical Genetics

Volumn 67, Issue 6, 1996, Pages 580-594

  Wildenauer, Dieter B ^a   Schwab, Sibylle G ^a   Albus, Margot ^b   Hallmayer, Joachim ^c   Lerer, Bernard ^d   Maier, Wolfgang ^a   Blackwood, Douglas ^e   Muir, Walter ^e   St Clair, David ^e   Morris, Stewart ^e   Moises, Hans W ^f   Yang, Liu ^f   Kristbjarnarson, Helgi ^g   Helgason, Tomas ^g   Wiese, Claudia ^f   Collier, David A ^h   Holmans, Peter ⁱ   Daniels, Jo ⁱ   Rees, Mark ⁱ   Asherson, Philip ⁱ   Roberts, Queta ⁱ   Cardno, Alastair ⁱ   Arranz, Maria J ^h   Vallada, Homero ^h   Ball, David ^h   Kunugi, Hiroshi ^h   Murray, Robin M ^h   Powell, John F ^h   Nanko, Sin ^j   Sham, Pak ^h   Gill, Mike ^k   McGuffin, Peter ⁱ   Owen, Michael J ⁱ   Pulver, Ann E ^l   Antonarakis, Stylianos E ^m   Babb, Robert ⁿ   Blouin, Jean Louis ^m   DeMarchi, Nicola ^o   Dombroski, Beth ^p   Housman, David ^q   Karayiorgou, Maria ^r   Ott, Jurg ^r   Kasch, Laura ⁿ   Kazazian, Haig ^p   Lasseter, Virginia K ^l   Loetscher, Erika ^s   Luebbert, Hermann ^t   Nestadt, Gerald ^l   Ton, Carl ^q   Wolyniec, Paula S ^l   Laurent, Claudine ^u   de Chaldee, Michel ^u   Thibaut, Florence ^v   Jay, Maurice ^w   Samolyk, Daniele ^u   Petit, Michel ^v   Campion, Dominique ^v   Mallet, Jacques ^u   Straub, Richard E ^x   MacLean, Charles J ^x   Easter, Stephen M ^x   O'Neill, F Anthony ^y   Walsh, Dermot ^z   Kendler, Kenneth S ^x   Gejman, Pablo V ^aa   Cao, Qiuhe ^aa   Gershon, Elliot ^aa   Badner, Judith ^aa   Beshah, Ethiopia ^aa   Zhang, Jing ^aa   Riley, Brien P ^ab   Rajagopalan, Swarnageetha ^ab   Mogudi Carter, Mpala ^ac   Jenkins, Trefor ^ad   Williamson, Robert ^ab   DeLisi, Lynn E ^ae   Garner, Chad ^af   Kelly, Mary ^af   LeDuc, Carrie ^af   Cardon, Lon ^af   Lichter, Jay ^af   Harris, Tim ^af   Loftus, Josephine ^ag   Shields, Gail ^ae   Comasi, Margarite ^ah   Vita, Antonio ^ah   Smith, Angela ^ae   Dann, Jay ^ag   Joslyn, Geoff ^af   Gurling, Hugh ^ai   Kalsi, Gursharan ^ai   Brynjolfsson, Jon ^aj   Curtis, David ^ak   Sigmundsson, Thordur ^ai   Butler, Robert ^ai   Read, Tim ^ai   Murphy, Patrice ^ai   Chen, Andrew Chih Hui ^ai   Petursson, Hannes ^aj   Byerley, Bill ^al   Hoff, Mark ^al   Holik, John ^al   Coon, Hilary ^al   Levinson, Douglas F ^am   Nancarrow, Derek J ^an,ao   Crowe, Raymond R ^ap   Andreasen, Nancy ^ap   Silverman, Jeremy M ^aq   Mohs, Richard C ^aq   Siever, Larry J ^aq   Endicott, Jean ^ar   Sharpe, Lawrence ^ar   Walters, Marilyn K ^ao   Lennon, David P ^an   Hayward, Nicholas K ^ao   Sandkuijl, Lodewijk A ^as   Mowry, Bryan J ^an   Aschauer, Harald N ^at   Meszaros, Kurt ^at   Lenzinger, Elisabeth ^at   Fuchs, Karoline ^at   Heiden, Angela M ^at   Kruglyak, Leonid ^au   Daly, Mark J ^au   Matise, Tara C ^av   more..

^a UNIVERSITY OF BONN   (Germany)

^b KLINIKUM MÜNCHEN OST   (Germany)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e WESTERN GENERAL HOSPITAL   (United Kingdom)

^f UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^g LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ CARDIFF UNIVERSITY   (United Kingdom)

^j TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^k ST JAMES S HOSPITAL   (Ireland)

^l JOHNS HOPKINS UNIVERSITY   (United States)

^m UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

ⁿ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o SECOND UNIVERSITY OF NAPLES   (Italy)

^p HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^q MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^r ROCKEFELLER UNIVERSITY   (United States)

^s NOVARTIS PHARMA AG   (Switzerland)

^t Sandoz Pharma Ltd   (India)

^u PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^v CHS Sotteville les Rouen   (United Kingdom)

^w CHS Saint Paul   (France)

^x VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^y QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^z HEALTH RESEARCH BOARD   (Ireland)

^aa National Institutes of Health   (United Kingdom)

^ab IMPERIAL COLLEGE LONDON   (United Kingdom)

^ac UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^ad UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^ae STONY BROOK UNIVERSITY   (United States)

^af CELERA   (United States)

^ag WARNEFORD HOSPITAL   (United Kingdom)

^ah UNIVERSITY OF MILAN   (Italy)

^ai ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^aj UNIVERSITY OF ICELAND   (Iceland)

^ak QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^al UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^am DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^an UNIVERSITY OF QUEENSLAND   (Australia)

^ao QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^ap UNIVERSITY OF IOWA   (United States)

^aq MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ar NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^as ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^at MEDICAL UNIVERSITY OF VIENNA   (Austria)

^au WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^av NONE   (United States)

more..

Author keywords

Collaboration; Genetic linkage; Genotype levinson; Polymorphism; Schizophrenia

Indexed keywords

ARTICLE; CHROMOSOME 6; CHROMOSOME 8; CLINICAL TRIAL; GENE MAPPING; GENETIC LINKAGE; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA;

ADULT; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 6; CHROMOSOMES, HUMAN, PAIR 8; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; SCHIZOPHRENIA;

EID: 0029845435     PISSN: 01487299     EISSN: 10968628     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19961122)67:6<580::AID-AJMG11>3.0.CO;2-P     Document Type: Article

References (55)

1. Antonarakis SE, Blouin JL, Pulver AE, et al. (1995): Schizophrenia susceptibility and chromosome 6p24-22. Nature Genetics 11:235-6.
2. Aschauer HN, Fischer G, Isenberg KE, et al. (1993): No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region. Eur Arch Psychiatry Clin Neuroscience 243:193-8.
3. Baron, M (1995): Genes and psychosis: old wine in new bottles?. Acta Psychiatrica Scandinavica. 92:81-6.
4. Berrettini WH, Ferraro TN, Goldin LR, et al. (1994): Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Nat Acad Sci USA 91:5918-21.
5. Blackwood DH, He L, Morris SW, et al. (1996): A locus for bipolar affective disorder on chromosome 4p. Nature Genetics 12:427-30.
6. Campion D, d'Amato T, Bastard C, et al. (1994): Genetic study of dopamine Dl, D2, and D4 receptors in schizophrenia. Psychiatry Research 51:215-30.
7. Coon H, Jensen S, Holik J, et al. (1994): Genomic scan for genes predisposing to schizophrenia. American Journal of Medical Genetics. 54:59-71.
8. Cottingham RW Jr, Idury RM, Schaffer AA (1993): Faster sequential genetic linkage computations. American Journal of Human Genetics 53: 252-263.
9. Curtis D (1996): Genetic dissection of complex traits. Nature Genetics 12:356-357.
10. Davies JL, Kawaguchi Y, Bennett ST, et al. (1994): A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-6.
11. DeLisi LE, Devoto M, Lofthouse R, et al. (1994): Search for linkage to schizophrenia on the X and Y chromosomes. American Journal of Medical Genetics 54:113-21.
12. DeLisi LE, Goldin LR, Maxwell ME, et al. (1987): Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 44:891-6.
13. American Psychiatric Association (1987): Diagnostic and Statistical Manual (Third Edition - Revised). Washington, D.C.: American Psychiatric Press.
14. Easton DF, Bishop DT, Ford D, et al. (1993): Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. American Journal of Human Genetics. 52:678-701.
15. Faraway JJ (1993): Distribution of the admixture test for the detection of linkage under heterogeneity. Genetic Epidemiology 10:75-83.
16. Garner C, Kelly M, Cardon L, et al. (in press): Linkage analyses of schizophrenia to chromosome 6p24-p22: an attempt to replicate. American Journal of Medical Genetics.
17. Gejman PV, Martinez M, Cao Q, et al. (1993): Linkage analysis of fifty-seven microsatellite loci to bipolar disorder. Neuropsychopharmacology 9:31-40.
18. Gill M, McGuffin P, Parfitt E, et al. (1993): A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychological Medicine 23:27-44.
19. Gill M, Vallada H, Collier D, et al. (1996): A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. American Journal of Medical Genetics 67:40-5.
20. Gottesman II, Shields J (1967): A polygenic theory of schizophrenia. Proc Natl Acad Sci USA 58:199-205.
21. Gurling H, Kalsi G, Hui-Sui Chen A, et al. (1995): Schizophrenia susceptibility and chromosome 6p24-22. Nature Genetics 11:234-5.
22. Gyapay G, Morissette J, Vignal A, et al. (1994): The 1993-94 Genethon human genetic linkage map. Nature Genetics 7(2 Spec No):246-339.
23. Hauser ER, Boehnke M, Guo S-W, Risch N (1996): Affected sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genetic Epidemiology 13:117-138.
24. Holmans P (1993): Asymptotic properties of affected-sib-pair linkage analysis. American Journal of Human Genetics 52:362-74.
25. Holmans P, Clayton, D (1995): Efficiency of typing unaffected relatives in an affected sib-pair linkage study with single-locus and multiple tightly linked markers. Am J Hum Genet 57:1221-1232.
26. Kalsi G, Mankoo BS, Curtis D, et al. (1995): Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites. Psychological Medicine 25:531-7.
27. Karayiorgou M, Morris MA, Morrow B, et al. (1995): Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc Nat Acad Sci USA 92:7612-6.
28. Kendler, K.S., O'Neill A, Burke J, et al.. (1996): Irish Study of High-Density Schizophrenia Families: Field Methods and Power to Detect Linkage. American Journal of Medical Genetics 67:179-190.
29. Kendler, K.S., McGuire M, Gruenberg AM, et al. The Roscommon Family Study. II. The risk of nonschizophrenic nonaffective psychoses in relatives. Archives of General Psychiatry 50:645-52.
30. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996): Parametric and nonparametric linkage analysis: a unified multipoint approach. American Journal of Human Genetics. 58:1347-63, 1996 Jun.
31. Kruglyak L, Lander ES (1995): Complete multipoint sib-pair analysis of qualitative and quantitative traits. American Journal of Human Genetics 57:439-54.
32. Lander E, Kruglyak L (1995): Genetic dissection of complex traits: guidelines for interpreting and reporting linkage findings. Nature Genetics 11:241-247.
33. Lander E, Kruglyak L (1996): Genetic dissection of complex traits. Nature Genetics, 12, 357-358.
34. Lander ES (1988): Mapping complex genetic traits in humans. In Davies KE (ed), "Genome Analysis, A Practical Approach." Oxford: IRL Press, pp.171-189.
35. Lange K, Weeks D, Boehnke M (1988): Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genetic Epidemiology 5:471-2.
36. Lathrop GM, Lalouel JM, Julier C, et al. (1984): Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81, 3442-3446.
37. MacLean CJ, Ploughman LM, Diehl SR, Kendler KS (1992): A new test for linkage in the presence of locus heterogeneity. American Journal of Human Genetics 50:1259-66.
38. Maier W, Lichtermann D, Minges J, et al. (1993): Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Archives of General Psychiatry 50:871-83.
39. Moises HW, Yang L, Kristbjarnarson H, et al. (1995): An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genetics 11:321-4.
40. Mowry BJ, Nancarrow DJ, Lennon DP, et al. (1995): Schizophrenia susceptibility and chromosome 6p24-22. Nature Genetics 11:233-4.
41. Ott J (1991): "Analysis of human genetic linkage." Baltimore: Johns Hopkins Press.
42. Pulver AE, Karayiorgou M, Wolyniec PS, et al. (1994a): Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. American Journal of Medical Genetics 54:36-43.
43. Pulver AE, Karayiorgou M, Lasseter VK, et al. (1994b): Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. American Journal of Medical Genetics 54:44-50.
44. Pulver AE, Nestadt G, Goldberg R, et al. (1994c): Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis 182(8):476-8.
45. Pulver AE, Lasseter VK, Kasch L, et al. (1995): Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. American Journal of Medical Genetics 60:252-60.
46. Riley BP, Rajagopalan S, Mogudi-Carter M, et al. (in press): No evidence for linkage of chromosome 6p markers to schizophrenia in southern African Bantu-speaking families. Psychiatric Genetics,.
47. Schwab SG, Albus M, Hallmayer J, et al. (1995): Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genetics 11:325-7.
48. St.Clair DM, Blackwood DHR, Muir WJ, et al. (1989) No linkage of chromosome 5q11-13 markers to schizophrenia in Scottish families. Nature 339 305-309.
49. Straub RE, MacLean CJ, O'Neill FA, et al. (1995): A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genetics 11:287-93.
50. Suarez B, Hodge S (1979): A simple method to detect linkage for rare recessive diseases: an application to juvenile diabetes. Clinical Genetics 15:126-136.
51. Suarez B, Hampe CL, van Eerdewegh P (1995): Problems of replicating linkage claims in psychiatry. In Gershon ES, Cloninger CR (eds). "New Genetic Approaches to Mental Disorders." Washington, D.C.: American Psychiatric Press.
52. The Huntington's Disease Collaborative Research Group (1993): A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's Disease chromosomes. Cell 72:971-983.
53. Tsuang MT, Gilbertson MW, Faraone SV (1991): The genetics of schizophrenia: current knowledge and future directions. Schizophrenia Research 4:157-171.
54. Webb C, Levinson DF, Gladis M (1993): Schizotypal and paranoid personality in the relatives of patients with schizophrenia and affective disorders: A review. Schizophrenia Research 11:81-92.
55. Witte JS, Elston RC, Schork NJ (1996): Genetic dissection of complex traits. Nature Genetics 12:355-356.