Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples

Molecular Psychiatry

Volumn 6, Issue 2, 2001, Pages 202-210

  Yoshikawa, T ^a   Kikuchi, M ^a,b   Saito, K ^a   Watanabe, A ^a,b   Yamada, K ^a   Shibuya, H ^c   Nankai, M ^d   Kurumaji, A ^b   Hattori, E ^a   Ishiguro, H ^b   Shimizu, H ^b   Okubo, Y ^b   Toru, M ^b   Detera Wadleigh, S D ^e  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c National Hospital Organization Hanamaki Hospital   (Japan)

^d TOKYO METROPOLITAN POLICE HOSPITAL   (Japan)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Affective disorder; Chromosome 18; Haplotype; LightCycler; Linkage disequilibrium; Polymorphism

Indexed keywords

INOSITOL DERIVATIVE; MYOINOSITOL MONOPHOSPHATASE 2; PHOSPHATASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHROMOSOME 18; CONTROLLED STUDY; DNA FLANKING REGION; DNA POLYMORPHISM; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MOLECULAR CLONING; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 18; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HAPLOTYPES; HUMANS; JAPAN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MOOD DISORDERS; MUTATION, MISSENSE; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, GENETIC; RISK FACTORS; SCHIZOPHRENIA;

EID: 17744394881     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000835     Document Type: Article

References (22)

1. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
2. Do schizophrenia and affective disorder share susceptibility genes?
3. Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene
4. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect
5. Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
6. Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis
7. Isolation of chromosome 18-specific brain transcripts as positional candidates for bipolar disorder
8. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder
9. Inositol monophosphatase, the putative therapeutic target for lithium
10. Inositol levels are decreased in postmortem brain of schizophrenic patients
11. Genomic structure and novel variants of myoinositol monophosphatase 2 (IMPA2)
12. A bipolar pedigree series for genomic mapping of disease genes: Diagnostic and analytic considerations
13. Association study on the DUSP6 gene, an affective disorder candidate gene on 12q23, performed by using fluorescence resonance energy transfer-based melting curve analysis on the LightCycler
14. Monte-Carlo tests for association between disease and alleles at highly polymorphic loci
15. Test for linear trend in proportions and frequencies
16. A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: Genomic structure and polymorphism screening in manic-depressive patients
17. Mechanism of inositol monophosphatase, the putative target of lithium therapy
18. Analysis of association at single nucleotide polymorphisms in the APOE region
19. Genetic epidemiology of single-nucleotide polymorphisms
20. Predicting the range of linkage disequilibrium