Orchiectomy increases bone marrow interleukin-6 levels in mice

Calcified Tissue International

Volumn 62, Issue 3, 1998, Pages 219-226

  Zhang, J ^a   Pugh, T D ^b   Stebler, B ^a   Ershler, W B ^a   Keller, E T ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aging; Androgen; Cytokine; Osteoporosis

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; BONE TURNOVER; CONTROLLED STUDY; CYTOKINE RELEASE; ESTROGEN BLOOD LEVEL; GENE EXPRESSION; HORMONAL REGULATION; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; OSTEOPOROSIS; PRIORITY JOURNAL; SPLENOMEGALY;

ANIMALS; BONE MARROW CELLS; CELL COUNT; CELLS, CULTURED; DNA PRIMERS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; ORCHIECTOMY; ORGAN SIZE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN;

EID: 0031882145     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900421     Document Type: Article

References (54)

1. Manolagas SC (1995) Role of cytokines in bone resorption. Bone 17:63S-67S
2. Bellido T, Jilka RL, Boyce BF, Oirasolc G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC (1995) Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest 95: 2886-2895
3. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC (1992) Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91
4. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, Manolagas SC (1992) 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 89:883-891
5. Pottratz ST, Bellido T, Mocharla H, Crabb D, Manolagas SC (1994) 17β-estradiol inhibits expression of human promoterreporter constructs by a receptor-dependent mechanism. J Clin Invest 93:944-950
6. Ray A, Prefontaine KE, Ray P (1994) Down-modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J Biol Chem 269:12940-12946
7. Stein B, Yang MX (1995) Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/KBPβ. Mol Cell Biol 15:4971-4979
8. Anderson DC (1992) Osteoporosis in men. Br Med J 305:489-490
9. Stanley HL, Schmitt BP, Poses RM, Deiss WP (1991) Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 39:766-771
10. Stepan JJ, Lachman M, Zverina J, Pacovsky V, Baylink DJ (1989) Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab 69:523-527
11. Tenover JS (1994) Androgen administration to aging men. Endocrinol Metab Clin N Am 23:877-892
12. Foresta C, Ruzza G, Mioni R. Guarneri G, Gribaldo R, Meneghello A. Mastrogiacomo I (1984) Osteoporosis and decline of gonadal function in the elderly male. Hormone Res 19: 18-22
13. Ershler WB, Sun WH, Binkley N, Gravenstein S, Volk MJ, Kamoske G, Klopp RG, Roecker EB, Daynes RA, Weindruch R (1993) Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. LymphokineCytokine Res 12:225-230
14. Wei J. Xu H. Davies JL, Hemmings GP (1992) Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci 51:1953-1956
15. Vanhoenacker P, Fiers W, Haegeman G (1994) Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin. Eur Cytokine Network 5:283-291
16. Hager K, Machein U, Krieger S, Platt D, Seefried G, Bauer J (1994) Intcrleukin-6 and selected plasma proteins in healthy persons of different ages. Neurobiol Aging 15:771-772
17. Daynes RA, Araneo BA, Ershler WB, Maloney C. Li GZ, Ryu SY (1993) Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 150: 5219-5230
18. Lips P, Courpron P, Meunier P (1978) Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age. Calcif Tissue Int 26:13-17
19. Vanderschueren D. Van Herck E, Schot P, Rush E, Einhorn T. Geusens P, Bouillon R (1993) The aged male rate as a model for human osteoporosis: evaluation by nondestructive measurements and biomechanical testing. Calcif Tissue Int 53: 342-347
20. Wakley GK, Schutte HD Jr, Hannon KS, Turner RT (1991) Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res 6:325-330
21. Verhas M, Schoutens A, L'hermite-Baleriaux M, Dourov N, Verschaeren A, Mone M, Heilporn A (1986) The effect of orchidectomy on bone metabolism in aging rats. Calcif Tissue Int 39:74-77
22. Bismar H, Diel I, Ziegler R, Pfeilschifter J (1995) Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. J Clin Endocrinol Metab 80:3351-3355
23. Keller ET, Ershler WB (1995) Dihydrotestosterone (DHT) inhibits interleukin-6 (IL-6) promoter activity induced by NFκB (abstract). Gerontologist 35:96
24. Sun WH, Kreisle RA, Philips AW, Ershler WB (1992) In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells. Cancer Res 52:5412-5415
25. Hansen MB, Nielsen SE, Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210
26. Van Snick J, Cayphas S, Vink A, Uttenhove C, Coulie PG, Rubira MR, Simpson RJ (1986) Purification and NH2-terminal amino acid sequence of a new T-cell-derived lymphokine with growth factor activity for B cell hybridomas. Proc Natl Acad Sci USA 83:9679-9683
27. Chomezynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
28. Keller ET, Ershler WB (1995) Effect of IL-6 receptor antisense oligodeoxynucleotides on in vitro proliferation of myeloma cells. J Immunol 154:4091-4098
29. Suematsu S, Matsuda T, Aozasa K, Akira S, Nakano N, Ohno S. Miyazaki J, Yamamura K, Hirano T, Kishimoto T (1989) IgGI plamacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci USA 86:7547-7551
30. Manolagas SC, Jilka RL (1995) Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311
31. Keller ET, Chang C, Ershler WB (1996) Inhibition of NHκB through maintenance of IκBα levels contributes to dihydrotestosterone-mediated inhibition of the interleukin-6 promoter. J Biol Chem 271:26267-26275
32. Ray A, Prefontaine KE, Ray P (1994) Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA estrogen receptor. J Biol Chem 269:12940-12946
33. Littlewood AJ, Russell J, Harvery GR, Hughes DE, Russell RGG, Gowen M (1991) The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129:1513-1520
34. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303
35. Takahashi S, Reddy SV, Dallas M, Devlin R, Chou JY, Roodman GD (1995) Development and characterization of a human marrow that enhances osteoclast-like cell formation. Endocrinology 136:1441-1449
36. Chaudhary LR, Spelsberg TC, Riggs BL (1992) Production of various cytokines by normal human osteoblost-like cells in response to interleukin-Iβ and tumor necrosis factor-α: lack of regulation by 17β-estradiol. Endocrinology 130:2528-2534
37. Kassem M, Khosla S. Spelsberg TC, Riggs BL (1996) Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab 81:513-518
38. Kitazawa R, Kimble RB, Vannice JL, Kung VT, Pacificim R (1994) Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest 94:2397-2406
39. Rifas L, Kenney JS, Marcelli M, Pacifici R, Cheng S-L, Sawson LL, Avioli LV (1995) Production of interleukin-6 in human ostoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-a is not regulated by ovarian steroids. Endocrinology 136: 4056-4067
40. Rickard D, Russel G, Gowen M (1992) Oestradiol inhibits the release of tumor necrosis factor but nut interleukin 6 from adult human osteoblasts in vitro. Osteoporosis Int 2:94-102
41. Marie PJ, Hott M, Launay JM, Graulet AM, Gueris J (1993) In vitro production of cytokines by bone surface-derived ostcoblastic cells in normal and osteoporotic postmenopausal women: relationship with cell proliferation. J Clin Endocrinol Metab 77:824-830
42. Kania DM, Binkley N, Checovich M, Havighurst T. Schilling M. Ershler WB (1995) Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatr Soc 43:236-239
43. Vargas SJ. Kawaguchi H, Kalinowski J. Naprta A, Pilbeam C, Raisz L, Lorenzo JA (1995) Ovariectomy or estrogen treatment do not alter interleukin-6 mRNA expression in adult murine bone and bone marrow (abstract). J Bone Marrow Res 9:S388
44. Jablons CM, Mule JJ, McIntosh JK, Sehgal PB, May CT, Huang CM, Rosenberg SA, Lotze MT (1989) IL-6/IFN-B-2 as a circulating hormone: induction by cytokine administration in humans. J Immunol 142:1542-1547
45. McIntosh JK, Jablons DM, Mule JJ, Nordan RP, Rudikoff S, Lotze MT, Rosenberg SA (1989) In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice. J Immunol 143:162-167
46. Poli V, Balena R, Fattori E, Markatos A, Yamamoto M, Tanaka H, Ciliberto G, Rodan G, AC (1994) Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO 13:1189-1196
47. Kitamura H, Kawata H, Takahashi F, Higuchi Y, Furuichi T, Ohkawa H (1995) Bone marrow neutrophilia and suppressed bone turnover in human interleukin-6 transgenic mice. A cellular relationship among hematopoictic cells, osteoblasts. and osteoclasts mediated by stromal cells in bone marrow. Am J Pathol 147:1682-1692
48. Lorenzo J, Kalinowski J, McKinstry M, Cassarino D, Harrison J, Gronowicz G, Clark S, Lichtler A (1996) Targeted overexpression of imerleukin-6 in osteoblasts of transgenic mice produces a phenotype of hypercellularity and disorganized bone formation. J Bone Miner Res 11(suppl 1):S101
49. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ (1995) Catration alters peripheral immune function in normal male mice. Immunology 84:337-342
50. Wilson CA, Mrose SA, Thomas DW (1995) Enhanced production of B lymphocytes after castration. Blood 85:1535-1539
51. Olsen NJ, Watson MB. Kovacs WJ (1991) Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity due to other genetic factors. Immunology 73:52-57
52. Castro JE (1976) Orchidectomy and immune response. Ann R Coll Surg Engl 58:359-367
53. Peled A, Tzehoval E. Haran-Ghera N (1995) Role of cytokines in termination of the B cell lymphoma dormant state in AKR mice. Leukemia 9:1095-1101
54. Volk MJ, Pugh TD, Kim MJ, Frith CH, Daynes RA, Ershler WB, Weindruch R (1993) Dietary restriction from middle age attenuates age-associated lymphoma development and IL-6 dysregulation in C57BL/6 mice. Cancer Res 54:3054-3063