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Volumn 226, Issue 7, 2005, Pages 1079-1088

The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ASCORBIC ACID DERIVATIVE; CHONDROITIN SULFATE; GLUCOSAMINE; IBUPROFEN; MANGANESE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; NUTRACEUTICAL; PHENYLBUTAZONE;

EID: 16244411957     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2005.226.1079     Document Type: Review
Times cited : (53)

References (122)
  • 1
    • 0012178570 scopus 로고    scopus 로고
    • Diseases of joints, tendons, ligaments and related structures
    • Stashak TS, ed. Philadelphia: Lippincott Williams & Wilkins
    • McIlwraith CW. Diseases of joints, tendons, ligaments and related structures. In: Stashak TS, ed. Adams' lameness in horses. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2002;459-467.
    • (2002) Adams' Lameness in Horses. 5th Ed. , pp. 459-467
    • McIlwraith, C.W.1
  • 2
    • 0009071569 scopus 로고    scopus 로고
    • Anatomy and physiology of synovial joints
    • McIlwraith CW, Trotter GW, eds. Philadelphia: WB Saunders Co
    • Todhunter RJ. Anatomy and physiology of synovial joints. In: McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Co, 1996;1-28.
    • (1996) Joint Disease in the Horse , pp. 1-28
    • Todhunter, R.J.1
  • 3
    • 0347449738 scopus 로고    scopus 로고
    • Synovial joint fluid biology and pathobiology
    • Auer J, Stick J, eds. Philadelphia: WB Saunders Co
    • Caron JP. Synovial joint fluid biology and pathobiology. In: Auer J, Stick J, eds. Equine surgery. 2nd ed. Philadelphia: WB Saunders Co, 1999;665-678.
    • (1999) Equine Surgery. 2nd Ed. , pp. 665-678
    • Caron, J.P.1
  • 4
    • 0023049693 scopus 로고
    • Proteoglycans in health and disease: Structures and functions
    • Poole AR. Proteoglycans in health and disease: structures and functions. Biochem J 1986;236:1-14.
    • (1986) Biochem J , vol.236 , pp. 1-14
    • Poole, A.R.1
  • 5
    • 0025409848 scopus 로고
    • Pathologic findings and pathogenesis of racetrack injuries
    • Pool RR, Meagher DM. Pathologic findings and pathogenesis of racetrack injuries. Vet Clin North Am Equine Pract 1990;6:1-30.
    • (1990) Vet Clin North Am Equine Pract , vol.6 , pp. 1-30
    • Pool, R.R.1    Meagher, D.M.2
  • 6
    • 0001872493 scopus 로고    scopus 로고
    • General pathobiology of the joint and response to injury
    • McIlwraith CW, Trotter GW, eds. Philadelphia: WB Saunders Co
    • McIlwraith CW. General pathobiology of the joint and response to injury. In: McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Co, 1996;40-70.
    • (1996) Joint Disease in the Horse , pp. 40-70
    • McIlwraith, C.W.1
  • 7
    • 0005742450 scopus 로고    scopus 로고
    • Imaging techniques in the diagnosis of equine joint disease
    • McIlwraith CW, Trotter GW, eds. Philadelphia: WB Saunders Co
    • Park RD, Steyn PF, Wrigley RH. Imaging techniques in the diagnosis of equine joint disease. In: McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Co, 1996;145-164.
    • (1996) Joint Disease in the Horse , pp. 145-164
    • Park, R.D.1    Steyn, P.F.2    Wrigley, R.H.3
  • 9
    • 0033712395 scopus 로고    scopus 로고
    • The role of the chondrocyte in osteoarthritis
    • Goldring MB. The role of the chondrocyte in osteoarthritis. Arth Rheum 2000;43:1916-1926.
    • (2000) Arth Rheum , vol.43 , pp. 1916-1926
    • Goldring, M.B.1
  • 10
    • 0023239611 scopus 로고
    • Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage
    • Dean DD, Azzo W, Martel-Pelletier J, et al. Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage. J Rheumatol 1987;14:43-44.
    • (1987) J Rheumatol , vol.14 , pp. 43-44
    • Dean, D.D.1    Azzo, W.2    Martel-Pelletier, J.3
  • 11
    • 0025897125 scopus 로고
    • Proteinase-mediated cartilage degradation in osteoarthritis
    • Dean DD. Proteinase-mediated cartilage degradation in osteoarthritis. Semin Arthritis Rheum 1991;20:2-11.
    • (1991) Semin Arthritis Rheum , vol.20 , pp. 2-11
    • Dean, D.D.1
  • 12
    • 0028247201 scopus 로고
    • Excess of metalloproteases over tissue inhibitors of metalloproteases may contribute to cartilage degradation in OA and rheumatoid arthritis
    • Martel-Pelletier J, McCollum R, Fujimoto N, et al. Excess of metalloproteases over tissue inhibitors of metalloproteases may contribute to cartilage degradation in OA and rheumatoid arthritis. Lab Invest 1994;70:807-815.
    • (1994) Lab Invest , vol.70 , pp. 807-815
    • Martel-Pelletier, J.1    McCollum, R.2    Fujimoto, N.3
  • 13
    • 0030891983 scopus 로고    scopus 로고
    • Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
    • Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997;99:1534-1545.
    • (1997) J Clin Invest , vol.99 , pp. 1534-1545
    • Billinghurst, R.C.1    Dahlberg, L.2    Ionescu, M.3
  • 14
    • 0036159161 scopus 로고    scopus 로고
    • Matrix metalloproteinases as therapeutic targets in arthritic diseases: Bull's-eye or missing the mark?
    • Mengshol JA, Mix KS, Brinckerhoff CE. Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? Arthritis Rheum 2002;46:13-20.
    • (2002) Arthritis Rheum , vol.46 , pp. 13-20
    • Mengshol, J.A.1    Mix, K.S.2    Brinckerhoff, C.E.3
  • 15
    • 0029880393 scopus 로고    scopus 로고
    • The new collagenase, collagenase 3, is expressed and synthesized by human chondrocytes but not by synovial fibroblasts: A role in osteoarthritis
    • Reboul P, Pelletier JP, Tardif G, et al. The new collagenase, collagenase 3, is expressed and synthesized by human chondrocytes but not by synovial fibroblasts: a role in osteoarthritis. J Clin Invest 1996;97:2011-2019.
    • (1996) J Clin Invest , vol.97 , pp. 2011-2019
    • Reboul, P.1    Pelletier, J.P.2    Tardif, G.3
  • 16
    • 4143112912 scopus 로고    scopus 로고
    • A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: The ADAMTS family
    • Apte SS. A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family. Int J Biochem Cell Biol 2004;36:981-985.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 981-985
    • Apte, S.S.1
  • 17
    • 0035884605 scopus 로고    scopus 로고
    • Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo
    • Sandy JD, Verscharen C. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo. Biochem J 2001;358:615-626.
    • (2001) Biochem J , vol.358 , pp. 615-626
    • Sandy, J.D.1    Verscharen, C.2
  • 18
    • 0035918309 scopus 로고    scopus 로고
    • TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
    • Kashiwagi M, Tortorella M, Nagase H, et al. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem 2001;276:12501-12504.
    • (2001) J Biol Chem , vol.276 , pp. 12501-12504
    • Kashiwagi, M.1    Tortorella, M.2    Nagase, H.3
  • 19
  • 20
    • 0029986420 scopus 로고    scopus 로고
    • The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: Possible role in osteoarthritic cartilage degradation
    • Pelletier JP, Mineau F, Ranger P, et al. The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation. Osteoarthritis Cartilage 1996;4:77-84.
    • (1996) Osteoarthritis Cartilage , vol.4 , pp. 77-84
    • Pelletier, J.P.1    Mineau, F.2    Ranger, P.3
  • 21
    • 0031789159 scopus 로고    scopus 로고
    • Concurrent generation of nitric oxide and superoxide inhibits PG synthesis in bovine articular chondrocytes; involvement of peroxynitrite
    • Oh M, Fukuda K, Asada S, et al. Concurrent generation of nitric oxide and superoxide inhibits PG synthesis in bovine articular chondrocytes; involvement of peroxynitrite. J Rheumatol 1998;25:2169-2174.
    • (1998) J Rheumatol , vol.25 , pp. 2169-2174
    • Oh, M.1    Fukuda, K.2    Asada, S.3
  • 22
    • 0030964252 scopus 로고    scopus 로고
    • Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: Prolyl hydroxylase as a possible target
    • Cao M, Westerhausen-Larson A, Niyibizi C, et al. Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J 1997;324:305-310.
    • (1997) Biochem J , vol.324 , pp. 305-310
    • Cao, M.1    Westerhausen-Larson, A.2    Niyibizi, C.3
  • 23
    • 0030119634 scopus 로고    scopus 로고
    • Inflammatory mediators in equine synovial fluid
    • Gibson KT, Hodge H, Whitten T. Inflammatory mediators in equine synovial fluid. Aust Vet J 1996;73:148-151.
    • (1996) Aust Vet J , vol.73 , pp. 148-151
    • Gibson, K.T.1    Hodge, H.2    Whitten, T.3
  • 24
    • 0034199826 scopus 로고    scopus 로고
    • Concentrations of substance P and prostaglandin E2 in synovial fluid of normal and abnormal joints of horses
    • Kirker-Head CA, Chandna VK, Agarwal RK, et al. Concentrations of substance P and prostaglandin E2 in synovial fluid of normal and abnormal joints of horses. Am J Vet Res 2000;61:714-718.
    • (2000) Am J Vet Res , vol.61 , pp. 714-718
    • Kirker-Head, C.A.1    Chandna, V.K.2    Agarwal, R.K.3
  • 25
    • 0026912842 scopus 로고
    • Substance P in the synovial membrane and fluid of the equine middle carpal joint
    • Caron JP, Bowker RM, Abhold RH, et al. Substance P in the synovial membrane and fluid of the equine middle carpal joint. Equine Vet J 1992;24:364-366.
    • (1992) Equine Vet J , vol.24 , pp. 364-366
    • Caron, J.P.1    Bowker, R.M.2    Abhold, R.H.3
  • 27
    • 0028950175 scopus 로고
    • Synthesis of metalloproteases and interleukin 6 (IL6) in human osteoarthritic synovial membrane is an IL-1 mediated process
    • Pelletier JP, McCollum R, Cloutier JM, et al. Synthesis of metalloproteases and interleukin 6 (IL6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol 1995;22:109-114.
    • (1995) J Rheumatol , vol.22 , pp. 109-114
    • Pelletier, J.P.1    McCollum, R.2    Cloutier, J.M.3
  • 29
    • 0029085898 scopus 로고
    • Human synovial fibroblasts coexpress IL-1 receptor type I and II mRNA. The increased level of IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor
    • Sadouk MB, Pelletier JP, Tardif G et al. Human synovial fibroblasts coexpress IL-1 receptor type I and II mRNA. The increased level of IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. Lab Invest 1995;73:347-355.
    • (1995) Lab Invest , vol.73 , pp. 347-355
    • Sadouk, M.B.1    Pelletier, J.P.2    Tardif, G.3
  • 30
    • 0034220509 scopus 로고    scopus 로고
    • Effects of human recombinant interleukin-1β on canine articular chondrocytes in three-dimensional culture
    • Cook JL, Anderson C, Kreeger JM, et al. Effects of human recombinant interleukin-1β on canine articular chondrocytes in three-dimensional culture. Am J Vet Res 2000;61:766-770.
    • (2000) Am J Vet Res , vol.61 , pp. 766-770
    • Cook, J.L.1    Anderson, C.2    Kreeger, J.M.3
  • 31
    • 0036181747 scopus 로고    scopus 로고
    • Recombinant equine interleukin-1β induces putative mediators of articular cartilage degradation in equine chondrocytes
    • Tung JT, Fenton JI, Arnold C, et al. Recombinant equine interleukin-1β induces putative mediators of articular cartilage degradation in equine chondrocytes. Can J Vet Res 2002;66:19-25.
    • (2002) Can J Vet Res , vol.66 , pp. 19-25
    • Tung, J.T.1    Fenton, J.I.2    Arnold, C.3
  • 32
    • 0028210290 scopus 로고
    • Effect of interleukin 1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage
    • Morris EA, Treadwell BV. Effect of interleukin 1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage. Am J Vet Res 1994;55:138-146.
    • (1994) Am J Vet Res , vol.55 , pp. 138-146
    • Morris, E.A.1    Treadwell, B.V.2
  • 33
    • 0034199851 scopus 로고    scopus 로고
    • Effects of interleukin-1β and tumor necrosis factor-α on expression of matrix-related genes by cultured equine articular chondrocytes
    • Richardson D, Dodge GR. Effects of interleukin-1β and tumor necrosis factor-α on expression of matrix-related genes by cultured equine articular chondrocytes. Am J Vet Res 2000;61:624-630.
    • (2000) Am J Vet Res , vol.61 , pp. 624-630
    • Richardson, D.1    Dodge, G.R.2
  • 34
    • 0027064521 scopus 로고
    • Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1
    • MacDonald MH, Stover SM, Willits NH, et al. Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1. Am J Vet Res 1992;53:2278-2285.
    • (1992) Am J Vet Res , vol.53 , pp. 2278-2285
    • MacDonald, M.H.1    Stover, S.M.2    Willits, N.H.3
  • 35
    • 0028474718 scopus 로고
    • An investigation of the proteoglycan metabolism of mature equine articular cartilage and its regulation by interleukin-1
    • Platt D, Bayliss MT. An investigation of the proteoglycan metabolism of mature equine articular cartilage and its regulation by interleukin-1. Equine Vet J 1994;26:297-303.
    • (1994) Equine Vet J , vol.26 , pp. 297-303
    • Platt, D.1    Bayliss, M.T.2
  • 36
    • 0036731133 scopus 로고    scopus 로고
    • Effect of glucosamine on interleukin-1 conditioned articular cartilage
    • Fenton JI, Chlebek KA, Caron JP, et al. Effect of glucosamine on interleukin-1 conditioned articular cartil-age. Equine Vet J Suppl 2002;34:219-223.
    • (2002) Equine Vet J Suppl , vol.34 , pp. 219-223
    • Fenton, J.I.1    Chlebek, K.A.2    Caron, J.P.3
  • 37
    • 0037385065 scopus 로고    scopus 로고
    • Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes
    • Largo R, Alvarez-Soria MA, Diez-Ortego I, et al. Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2003;11:290-298.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 290-298
    • Largo, R.1    Alvarez-Soria, M.A.2    Diez-Ortego, I.3
  • 38
    • 0032211837 scopus 로고    scopus 로고
    • Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritis articular cartilage in vitro
    • Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritis articular cartilage in vitro. Osteoarthritis Cartilage 1998;6:427-434.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 427-434
    • Bassleer, C.1    Rovati, L.2    Franchimont, P.3
  • 39
    • 0036726363 scopus 로고    scopus 로고
    • Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate
    • Orth MW, Peters TL, Hawkins JN. Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate. Equine Vet J Suppl 2002;3:224-229.
    • (2002) Equine Vet J Suppl , vol.3 , pp. 224-229
    • Orth, M.W.1    Peters, T.L.2    Hawkins, J.N.3
  • 40
    • 0027076009 scopus 로고
    • In-vitro evaluation of drugs proposed as chondroprotective agents
    • Bassleer C, Henrotin Y, Franchimont P. In-vitro evaluation of drugs proposed as chondroprotective agents. Int J Tissue React 1992;14:231-241.
    • (1992) Int J Tissue React , vol.14 , pp. 231-241
    • Bassleer, C.1    Henrotin, Y.2    Franchimont, P.3
  • 41
    • 0033858339 scopus 로고    scopus 로고
    • Glucosamine HCl reduced equine articular cartilage degradation in explant culture
    • Fenton JI, Chlebek-Brown KA, Peters TL, et al. Glucosamine HCl reduced equine articular cartilage degradation in explant culture. Osteoarthritis Cartilage 2000;8:258-265.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 258-265
    • Fenton, J.I.1    Chlebek-Brown, K.A.2    Peters, T.L.3
  • 42
    • 16244382106 scopus 로고    scopus 로고
    • Effects of glucosamine and chondroitin sulfate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explants in vitro, in Proceedings
    • Dechant JE, Baxter GM, Frisbie DD, et al. Effects of glucosamine and chondroitin sulfate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explants in vitro, in Proceedings. 11th Annu Am Coll Vet Surg Symp 2001;491.
    • (2001) 11th Annu Am Coll Vet Surg Symp , pp. 491
    • Dechant, J.E.1    Baxter, G.M.2    Frisbie, D.D.3
  • 43
    • 0037501113 scopus 로고    scopus 로고
    • Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes
    • Byron CR, Orth MW, Venta PJ, et al. Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes. Am J Vet Res 2003;64:666-671.
    • (2003) Am J Vet Res , vol.64 , pp. 666-671
    • Byron, C.R.1    Orth, M.W.2    Venta, P.J.3
  • 44
    • 0032189902 scopus 로고    scopus 로고
    • Chondrocyte mediated catabolism of aggrecan: Aggrecanase dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine
    • Sandy JD, Gamett D, Thompson V, et al. Chondrocyte mediated catabolism of aggrecan: aggrecanase dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine. Biochem J 1998;335:59-66.
    • (1998) Biochem J , vol.335 , pp. 59-66
    • Sandy, J.D.1    Gamett, D.2    Thompson, V.3
  • 45
    • 0035871802 scopus 로고    scopus 로고
    • N-acetyl-glucosamine prevents IL-1β-mediated activation of human chondrocytes
    • Shikhman AR, Kuhn K, Alaaeddine N, et al. N-acetyl-glucosamine prevents IL-1β-mediated activation of human chondrocytes. J Immunol 2001;166:5155-5160.
    • (2001) J Immunol , vol.166 , pp. 5155-5160
    • Shikhman, A.R.1    Kuhn, K.2    Alaaeddine, N.3
  • 46
    • 0031747132 scopus 로고    scopus 로고
    • Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: A pilot study
    • Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(suppl A):37-38.
    • (1998) Osteoarthritis Cartilage , vol.6 , Issue.SUPPL. A , pp. 37-38
    • Uebelhart, D.1    Thonar, E.J.2    Delmas, P.D.3
  • 47
    • 0038344684 scopus 로고    scopus 로고
    • Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
    • Dodge GR, Jimenez SA. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage 2003;11:424-432.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 424-432
    • Dodge, G.R.1    Jimenez, S.A.2
  • 48
    • 0037116589 scopus 로고    scopus 로고
    • Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-κB pathway
    • Gouze JN, Bianchi A, Bécuwe P, et al. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-κB pathway. FEBS Lett 2002;510:166-170.
    • (2002) FEBS Lett , vol.510 , pp. 166-170
    • Gouze, J.N.1    Bianchi, A.2    Bécuwe, P.3
  • 49
    • 16244412376 scopus 로고    scopus 로고
    • The role of oral disease-modifying agents glucosamine and chondroitin sulphate in the management of equine degenerative joint disease
    • Platt D. The role of oral disease-modifying agents glucosamine and chondroitin sulphate in the management of equine degenerative joint disease. Equine Vet Educ 2001;3:262-272.
    • (2001) Equine Vet Educ , vol.3 , pp. 262-272
    • Platt, D.1
  • 50
    • 0031993983 scopus 로고    scopus 로고
    • The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease
    • Kelly GS. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Altern Med Rev 1998;3:27-39.
    • (1998) Altern Med Rev , vol.3 , pp. 27-39
    • Kelly, G.S.1
  • 51
    • 34250470934 scopus 로고
    • Intestinal absorption of glucosamine and N-acetylglucosamine
    • Tesoriere G, Dones F, Magistro D, et al. Intestinal absorption of glucosamine and N-acetylglucosamine. Experientia 1972;28:770-771.
    • (1972) Experientia , vol.28 , pp. 770-771
    • Tesoriere, G.1    Dones, F.2    Magistro, D.3
  • 53
    • 0034821815 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism and excretion of glucosamine sulfate
    • Setnikar I, Rovati LC. Absorption, distribution, metabolism and excretion of glucosamine sulfate. Arzneim-Forsch Drug Res 2001;51:699-725.
    • (2001) Arzneim-Forsch Drug Res , vol.51 , pp. 699-725
    • Setnikar, I.1    Rovati, L.C.2
  • 54
    • 0021366280 scopus 로고
    • Absorption, distribution and excretion of radioactivity after a single intravenous or oral administration of 14C glucosamine to the rat
    • Setnikar I, Giachetti C, Zanolo G. Absorption, distribution and excretion of radioactivity after a single intravenous or oral administration of 14C glucosamine to the rat. Pharmatherapeutica 1984;3:538-550.
    • (1984) Pharmatherapeutica , vol.3 , pp. 538-550
    • Setnikar, I.1    Giachetti, C.2    Zanolo, G.3
  • 56
    • 0032811925 scopus 로고    scopus 로고
    • Determination of the nutraceutical, glucosamine hydrochloride, in raw materials, dosage forms and plasma using pre-column derivatization with ultraviolet HPLC
    • Liang Z, Leslie J, Adebowale A, et al. Determination of the nutraceutical, glucosamine hydrochloride, in raw materials, dosage forms and plasma using pre-column derivatization with ultraviolet HPLC. J Pharm Biomed Anal 1999;20:807-814.
    • (1999) J Pharm Biomed Anal , vol.20 , pp. 807-814
    • Liang, Z.1    Leslie, J.2    Adebowale, A.3
  • 57
    • 3543122955 scopus 로고    scopus 로고
    • The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse
    • Du J, White N, Eddington ND. The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse. Biopharm Drug Dispos 2004;25:109-116.
    • (2004) Biopharm Drug Dispos , vol.25 , pp. 109-116
    • Du, J.1    White, N.2    Eddington, N.D.3
  • 58
    • 0032092920 scopus 로고    scopus 로고
    • Changes in sulfation patterns of chondroitin sulfate in equine articular cartilage and synovial fluid in response to ageing and osteoarthritis
    • Brown MP, West LA, Merritt KA, et al. Changes in sulfation patterns of chondroitin sulfate in equine articular cartilage and synovial fluid in response to ageing and osteoarthritis. Am J Vet Res 1998;59:786-791.
    • (1998) Am J Vet Res , vol.59 , pp. 786-791
    • Brown, M.P.1    West, L.A.2    Merritt, K.A.3
  • 59
    • 0037086301 scopus 로고    scopus 로고
    • Pretreatment procedure for the microdetermination of chondroitin sulfate in plasma and urine
    • Sakai S, Onose J, Nakamura H, et al. Pretreatment procedure for the microdetermination of chondroitin sulfate in plasma and urine. Anal Biochem 2002;302:169-174.
    • (2002) Anal Biochem , vol.302 , pp. 169-174
    • Sakai, S.1    Onose, J.2    Nakamura, H.3
  • 60
    • 0016269052 scopus 로고
    • Desulfation and depolymerization of chondroitin-4-sulfate and its degradation products by rat stomach, liver and small intestine
    • Liau YH, Horowitz MI. Desulfation and depolymerization of chondroitin-4-sulfate and its degradation products by rat stomach, liver and small intestine. Proc Soc Exp Biol Med 1974;146:1037-1043.
    • (1974) Proc Soc Exp Biol Med , vol.146 , pp. 1037-1043
    • Liau, Y.H.1    Horowitz, M.I.2
  • 61
    • 0347039397 scopus 로고    scopus 로고
    • Oral supplements in the treatment and prevention of joint diseases: A review of their potential application to the horse
    • Wright IM. Oral supplements in the treatment and prevention of joint diseases: a review of their potential application to the horse. Equine Vet Educ 2001;3:179-184.
    • (2001) Equine Vet Educ , vol.3 , pp. 179-184
    • Wright, I.M.1
  • 62
    • 0002330149 scopus 로고    scopus 로고
    • Analysis of glucosamine and chondroitin sulfate content in marketed products and the Caco-2 permeability of chondroitin sulfate raw materials
    • Adebowale AO, Cox DS, Liang Z, et al. Analysis of glucosamine and chondroitin sulfate content in marketed products and the Caco-2 permeability of chondroitin sulfate raw materials. J Am Nutraceutical Assoc 2000;3:33-44.
    • (2000) J Am Nutraceutical Assoc , vol.3 , pp. 33-44
    • Adebowale, A.O.1    Cox, D.S.2    Liang, Z.3
  • 63
    • 0036793123 scopus 로고    scopus 로고
    • Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers
    • Volpi N. Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers. Osteoarthritis Cartilage 2002;10:768-777.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 768-777
    • Volpi, N.1
  • 64
    • 0038344676 scopus 로고    scopus 로고
    • Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers
    • Volpi N. Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers. Osteoarthritis Cartilage 2003;11:433-441.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 433-441
    • Volpi, N.1
  • 65
    • 0026700373 scopus 로고
    • Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate
    • Baici A, Horler D, Moser B, et al. Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate. Rheumatol Int 1992;12:81-88.
    • (1992) Rheumatol Int , vol.12 , pp. 81-88
    • Baici, A.1    Horler, D.2    Moser, B.3
  • 66
    • 0028927919 scopus 로고
    • Determination of chondroitin sulfates in human whole blood, plasma and blood cells by high-performance liquid chromatography
    • Huang Y, Toyoda H, Toida T, et al. Determination of chondroitin sulfates in human whole blood, plasma and blood cells by high-performance liquid chromatography. Biomed Chromatogr 1995;9:102-105.
    • (1995) Biomed Chromatogr , vol.9 , pp. 102-105
    • Huang, Y.1    Toyoda, H.2    Toida, T.3
  • 67
    • 0031781240 scopus 로고    scopus 로고
    • Anti-inflammatory activity of chondroitin sulfate
    • Ronca F, Palmieri L, Panicucci P, et al. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 1998;6(suppl A):14-21.
    • (1998) Osteoarthritis Cartilage , vol.6 , Issue.SUPPL. A , pp. 14-21
    • Ronca, F.1    Palmieri, L.2    Panicucci, P.3
  • 68
    • 0029160101 scopus 로고
    • Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate
    • Conte A, Volpi N, Palmieri L, et al. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45:918-925.
    • (1995) Arzneimittelforschung , vol.45 , pp. 918-925
    • Conte, A.1    Volpi, N.2    Palmieri, L.3
  • 69
    • 0025274259 scopus 로고
    • Metabolic fate of exogenous chondroitin sulfate in the experimental animal
    • Palmierei L, Conte A, Giovannini L, et al. Metabolic fate of exogenous chondroitin sulfate in the experimental animal. Arzneimittelforschung 1990;40:319-323.
    • (1990) Arzneimittelforschung , vol.40 , pp. 319-323
    • Palmierei, L.1    Conte, A.2    Giovannini, L.3
  • 70
    • 0037099518 scopus 로고    scopus 로고
    • Determination of the chondroitin sulfate disaccharides in dog and horse plasma by HPLC using chondroitinase digestion, precolumn derivatization, and fluorescence detection
    • Du J, Eddington N. Determination of the chondroitin sulfate disaccharides in dog and horse plasma by HPLC using chondroitinase digestion, precolumn derivatization, and fluorescence detection. Analytical Biochem 2002;306:252-258.
    • (2002) Analytical Biochem , vol.306 , pp. 252-258
    • Du, J.1    Eddington, N.2
  • 71
    • 0036708636 scopus 로고    scopus 로고
    • The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs
    • Adebowale A, Du J, Liang Z, et al. The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs. Biopharm Drug Dispos 2002;23:217-225.
    • (2002) Biopharm Drug Dispos , vol.23 , pp. 217-225
    • Adebowale, A.1    Du, J.2    Liang, Z.3
  • 73
    • 0031750348 scopus 로고    scopus 로고
    • Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis
    • Busci L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(suppl A):31-36.
    • (1998) Osteoarthritis Cartilage , vol.6 , Issue.SUPPL. A , pp. 31-36
    • Busci, L.1    Poor, G.2
  • 74
    • 0028362757 scopus 로고
    • Glucosamine sulphate compared to ibuprofen in osteoarthritis of the knee
    • Muller-Fassbender H, Bach GL, Haase W, et al. Glucosamine sulphate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2:61-69.
    • (1994) Osteoarthritis Cartilage , vol.2 , pp. 61-69
    • Muller-Fassbender, H.1    Bach, G.L.2    Haase, W.3
  • 75
    • 21944439292 scopus 로고    scopus 로고
    • Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 Cases
    • Hanson R, Smalley LR, Huff GK, et al. Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 cases. Equine Pract 1997;19:16-22.
    • (1997) Equine Pract , vol.19 , pp. 16-22
    • Hanson, R.1    Smalley, L.R.2    Huff, G.K.3
  • 76
    • 85013783463 scopus 로고
    • The efficacy of orally administered sulfated glycosaminoglycan in chemically induced equine synovitis and degenerative joint disease
    • White GW, Jones EW, Hamm J, et al. The efficacy of orally administered sulfated glycosaminoglycan in chemically induced equine synovitis and degenerative joint disease. J Equine Vet Sci 1994;14:350-353.
    • (1994) J Equine Vet Sci , vol.14 , pp. 350-353
    • White, G.W.1    Jones, E.W.2    Hamm, J.3
  • 77
    • 0242316545 scopus 로고    scopus 로고
    • Oral glycosaminoglycans in treatment of degenerative joint disease in horses
    • Hanson RR. Oral glycosaminoglycans in treatment of degenerative joint disease in horses. Equine Pract 1996;18:18-22.
    • (1996) Equine Pract , vol.18 , pp. 18-22
    • Hanson, R.R.1
  • 78
    • 2442611339 scopus 로고    scopus 로고
    • Double blind study of the effects of an oral supplement intended to support joint health in horses with tarsal degenerative joint disease
    • Clayton HM, Almedia PE, Prades M, et al. Double blind study of the effects of an oral supplement intended to support joint health in horses with tarsal degenerative joint disease, in Proceedings. 48th Annu Conv Am Assoc Equine Pract 2002;314-317.
    • (2002) Proceedings. 48th Annu Conv Am Assoc Equine Pract , pp. 314-317
    • Clayton, H.M.1    Almedia, P.E.2    Prades, M.3
  • 79
    • 0035008921 scopus 로고    scopus 로고
    • Short-term glucosamine infusion does not affect insulin sensitivity in humans
    • Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J din Endocrinol Metab 2001;86:2099-2103.
    • (2001) J din Endocrinol Metab , vol.86 , pp. 2099-2103
    • Pouwels, M.J.1    Jacobs, J.R.2    Span, P.N.3
  • 80
    • 0038155452 scopus 로고    scopus 로고
    • The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: A placebo-controlled, double-blinded, randomized clinical trial
    • Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003;163:1587-1590.
    • (2003) Arch Intern Med , vol.163 , pp. 1587-1590
    • Scroggie, D.A.1    Albright, A.2    Harris, M.D.3
  • 81
    • 0030226659 scopus 로고    scopus 로고
    • Hematologic, hemostatic, and biochemical effects in dogs receiving an oral chondroprotective agent for thirty days
    • McNamara PS, Barr SC, Erb HN. Hematologic, hemostatic, and biochemical effects in dogs receiving an oral chondroprotective agent for thirty days. Am J Vet Res 1996;57:1390-1394.
    • (1996) Am J Vet Res , vol.57 , pp. 1390-1394
    • McNamara, P.S.1    Barr, S.C.2    Erb, H.N.3
  • 82
    • 0038355694 scopus 로고    scopus 로고
    • Hematological, hemostatic, and biochemical effects in cats receiving an oral chondroprotective agent for thirty days
    • McNamara PS, Barr SC, Erb HN, et al. Hematological, hemostatic, and biochemical effects in cats receiving an oral chondroprotective agent for thirty days. Vet Ther 2000;1:108-117.
    • (2000) Vet Ther , vol.1 , pp. 108-117
    • McNamara, P.S.1    Barr, S.C.2    Erb, H.N.3
  • 83
    • 0038017576 scopus 로고    scopus 로고
    • Safety of an oral chondroprotective agent in horses
    • Kirker-Head CA, Kirker-Head RP. Safety of an oral chondroprotective agent in horses. Vet Ther 2001;2:345-353.
    • (2001) Vet Ther , vol.2 , pp. 345-353
    • Kirker-Head, C.A.1    Kirker-Head, R.P.2
  • 84
    • 0033033607 scopus 로고    scopus 로고
    • Results of a survey of small animal practitioners on the perceived clinical efficacy and safety of an oral nutraceutical
    • Anderson MA, Slater MR, Hammad TA. Results of a survey of small animal practitioners on the perceived clinical efficacy and safety of an oral nutraceutical. Prev Vet Med 1999;38:65-73.
    • (1999) Prev Vet Med , vol.38 , pp. 65-73
    • Anderson, M.A.1    Slater, M.R.2    Hammad, T.A.3
  • 85
    • 0037442255 scopus 로고    scopus 로고
    • High-dose glucosamine associated with polyuria and polydipsia in a dog
    • McCoy SJ, Bryson JC. High-dose glucosamine associated with polyuria and polydipsia in a dog. J Am Vet Med Assoc 2003;222:431-432.
    • (2003) J Am Vet Med Assoc , vol.222 , pp. 431-432
    • McCoy, S.J.1    Bryson, J.C.2
  • 87
    • 23044518704 scopus 로고    scopus 로고
    • Glucosamine and chondroitin sulfate
    • Davidson G. Glucosamine and chondroitin sulfate. Campend Contin Educ Pract Vet 2000;22:454-458.
    • (2000) Campend Contin Educ Pract Vet , vol.22 , pp. 454-458
    • Davidson, G.1
  • 88
    • 0036843215 scopus 로고    scopus 로고
    • Active ingredient consistency of commercially available glucosamine sulfate products
    • Russell AS, Aghazadeh-Habashi A, Jamali F. Active ingredient consistency of commercially available glucosamine sulfate products. J Rheumatol 2002;29:2407-2409.
    • (2002) J Rheumatol , vol.29 , pp. 2407-2409
    • Russell, A.S.1    Aghazadeh-Habashi, A.2    Jamali, F.3
  • 90
    • 0036005002 scopus 로고    scopus 로고
    • An analysis of glucosamine and chondroitin sulfate content in oral joint supplement products
    • Ramey DW, Eddington N, Thonar E, et al. An analysis of glucosamine and chondroitin sulfate content in oral joint supplement products. J Equine Vet Sci 2002;22:125-127.
    • (2002) J Equine Vet Sci , vol.22 , pp. 125-127
    • Ramey, D.W.1    Eddington, N.2    Thonar, E.3
  • 91
    • 0033785299 scopus 로고    scopus 로고
    • Determination of glucosamine in nutritional supplements by reversed-phase ion-pairing HPLC
    • Way W, Gibson K, Breite A. Determination of glucosamine in nutritional supplements by reversed-phase ion-pairing HPLC. J Liquid Chrom Rel Tech 2000;23:2861-2871.
    • (2000) J Liquid Chrom Rel Tech , vol.23 , pp. 2861-2871
    • Way, W.1    Gibson, K.2    Breite, A.3
  • 92
    • 0033788379 scopus 로고    scopus 로고
    • Determination of chondroitin sulfate in nutritional supplements by liquid chromatography
    • Way W, Gibson K, Breite A. Determination of chondroitin sulfate in nutritional supplements by liquid chromatography. J Liquid Chrom Rel Tech 2000;23:807-814.
    • (2000) J Liquid Chrom Rel Tech , vol.23 , pp. 807-814
    • Way, W.1    Gibson, K.2    Breite, A.3
  • 93
    • 0037089926 scopus 로고    scopus 로고
    • Development and validation of a photometric titration method for the quantitation of sodium chondroitin sulfate (bovine) in Cosequin DS chewable tablet
    • Liang Z, Bonneville C, Senez T, et al. Development and validation of a photometric titration method for the quantitation of sodium chondroitin sulfate (bovine) in Cosequin DS chewable tablet. J Pharm Biomed Anal 2002;2:245-249.
    • (2002) J Pharm Biomed Anal , vol.2 , pp. 245-249
    • Liang, Z.1    Bonneville, C.2    Senez, T.3
  • 94
    • 0000361688 scopus 로고
    • Effect of hexosamines on the synthesis of chondroitin sulphuric acid in vitro
    • Roden L. Effect of hexosamines on the synthesis of chondroitin sulphuric acid in vitro. Arkiv Kemi 1956;10:345-352.
    • (1956) Arkiv Kemi , vol.10 , pp. 345-352
    • Roden, L.1
  • 95
    • 0347517752 scopus 로고    scopus 로고
    • 3H] chondroitin sulphate formation by cultured chondrocytes
    • 3H] chondroitin sulphate formation by cultured chondrocytes. Biochem J 2003;376:511-515.
    • (2003) Biochem J , vol.376 , pp. 511-515
    • Mroz, P.J.1    Silbert, J.E.2
  • 96
    • 0034533188 scopus 로고    scopus 로고
    • The effects of glucosamine derivatives on equine articular cartilage degradation in expiant culture
    • Fenton JI, Chlebek-Brown KA, Peters TL, et al. The effects of glucosamine derivatives on equine articular cartilage degradation in expiant culture. Osteoarthritis Cartilage 2000;8:444-451.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 444-451
    • Fenton, J.I.1    Chlebek-Brown, K.A.2    Peters, T.L.3
  • 97
    • 0034745403 scopus 로고    scopus 로고
    • Interleukin-1β down-regulates the expression of glucuronosyltransferase 1, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1β-medicated effects in rat chondrocytes
    • Gouze JN, Bordji K, Gulberti S, et al. Interleukin-1β down-regulates the expression of glucuronosyltransferase 1, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1β- medicated effects in rat chondrocytes. Arthritis Rheum 2001;44:351-360.
    • (2001) Arthritis Rheum , vol.44 , pp. 351-360
    • Gouze, J.N.1    Bordji, K.2    Gulberti, S.3
  • 98
    • 0034914603 scopus 로고    scopus 로고
    • Sulfate could mediate the therapeutic effect of glucosamine sulfate
    • Hoffer LJ, Kaplan LN, Hamadeh MT, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-770.
    • (2001) Metabolism , vol.50 , pp. 767-770
    • Hoffer, L.J.1    Kaplan, L.N.2    Hamadeh, M.T.3
  • 99
    • 0032725863 scopus 로고    scopus 로고
    • In vitro effects of glucosamine and acetylsalicylate on canine chondrocytes in three-dimensional culture
    • Anderson CC, Cook JL, Kreeger JM, et al. In vitro effects of glucosamine and acetylsalicylate on canine chondrocytes in three-dimensional culture. Am J Vet Res 1999;60:1546-1551.
    • (1999) Am J Vet Res , vol.60 , pp. 1546-1551
    • Anderson, C.C.1    Cook, J.L.2    Kreeger, J.M.3
  • 100
    • 0036793172 scopus 로고    scopus 로고
    • High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro
    • de Mattei M, Pellati A, Pasello M, et al. High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cartilage 2002;10:816-825.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 816-825
    • De Mattei, M.1    Pellati, A.2    Pasello, M.3
  • 101
    • 0043245006 scopus 로고    scopus 로고
    • Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage
    • Ilic MZ, Martinac B, Handley CJ. Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage. Osteoarthritis Cartilage 2003;11:613-622.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 613-622
    • Ilic, M.Z.1    Martinac, B.2    Handley, C.J.3
  • 102
    • 0031559584 scopus 로고    scopus 로고
    • Evidence for the involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta
    • Newton R, Kuitert LM, Bergmann M, et al. Evidence for the involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem Biophys Res Commun 1997;237:28-32.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 28-32
    • Newton, R.1    Kuitert, L.M.2    Bergmann, M.3
  • 103
    • 0033851463 scopus 로고    scopus 로고
    • Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-JUN N-terminal kinase and nuclear factor KB: Differential regulation of collagenase 1 and 3
    • Mengshol JA, Vincenti MP, Coon CI, et al. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-JUN N-terminal kinase and nuclear factor KB: differential regulation of collagenase 1 and 3. Arthritis Rheum 2000;43:801-811.
    • (2000) Arthritis Rheum , vol.43 , pp. 801-811
    • Mengshol, J.A.1    Vincenti, M.P.2    Coon, C.I.3
  • 104
    • 0035160307 scopus 로고    scopus 로고
    • Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1β
    • Vincenti MP, Brinckerhoff CE. Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1β. Arthritis Res 2001;3:381-388.
    • (2001) Arthritis Res , vol.3 , pp. 381-388
    • Vincenti, M.P.1    Brinckerhoff, C.E.2
  • 105
    • 0033854640 scopus 로고    scopus 로고
    • Effects of chondroitin sulfate and interleukin-1beta on human chondrocyte cultures exposed to pressurization: A biochemical and morphological study
    • Nerucci F, Fioravanti A, Cicero MR, et al. Effects of chondroitin sulfate and interleukin-1beta on human chondrocyte cultures exposed to pressurization: a biochemical and morphological study. Osteoarthritis Cartilage 2000;8:279-287.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 279-287
    • Nerucci, F.1    Fioravanti, A.2    Cicero, M.R.3
  • 106
    • 0033653572 scopus 로고    scopus 로고
    • In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate
    • Lippiello L, Woodward J, Karpman R, et al. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop 2000;381:229-240.
    • (2000) Clin Orthop , vol.381 , pp. 229-240
    • Lippiello, L.1    Woodward, J.2    Karpman, R.3
  • 107
    • 0035125650 scopus 로고    scopus 로고
    • Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis
    • Johnson KA, Hulse DA, Hart RC, et al. Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis. Osteoarthritis Cartilage 2001;9:14-21.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. 14-21
    • Johnson, K.A.1    Hulse, D.A.2    Hart, R.C.3
  • 108
    • 0037766040 scopus 로고    scopus 로고
    • Glucosamine and chondroitin sulfate: Biological response modifiers of chondrocytes under simulated conditions of joint stress
    • Lippiello L. Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stress. Osteoarthritis Cartilage 2003;11:335-342.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 335-342
    • Lippiello, L.1
  • 109
    • 0343698374 scopus 로고    scopus 로고
    • Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis
    • McAlindon TE, LaValley MP, Gulin JP, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000;283:1469-1475.
    • (2000) JAMA , vol.283 , pp. 1469-1475
    • McAlindon, T.E.1    LaValley, M.P.2    Gulin, J.P.3
  • 110
    • 0036111702 scopus 로고    scopus 로고
    • A randomized double blind, placebo controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee
    • Hughes R, Carr A. A randomized double blind, placebo controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology 2002;41:279-284.
    • (2002) Rheumatology , vol.41 , pp. 279-284
    • Hughes, R.1    Carr, A.2
  • 111
    • 0037078298 scopus 로고    scopus 로고
    • Glucosamine sulfate use and delay of progression of knee OA: A 3-year, randomized, placebo-controlled, double-blind study
    • Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee OA: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-2123.
    • (2002) Arch Intern Med , vol.162 , pp. 2113-2123
    • Pavelka, K.1    Gatterova, J.2    Olejarova, M.3
  • 112
    • 0035956653 scopus 로고    scopus 로고
    • Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomized, placebo-controlled clinical trial
    • Reginster JY, Deroisy R, Rovatti LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001;357:251-256.
    • (2001) Lancet , vol.357 , pp. 251-256
    • Reginster, J.Y.1    Deroisy, R.2    Rovatti, L.C.3
  • 113
    • 0037260646 scopus 로고    scopus 로고
    • Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate
    • Bruyere O, Honore A, Ethgen O, et al. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Osteoarthritis Cartilage 2003;11:1-5.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 1-5
    • Bruyere, O.1    Honore, A.2    Ethgen, O.3
  • 114
    • 0025826232 scopus 로고
    • Metabolic fate of exogenous chondroitin sulfate in man
    • Conte A, de Bernardi M, Palmieri L, et al. Metabolic fate of exogenous chondroitin sulfate in man. Arzneimittelforschung 1991;41:768-772.
    • (1991) Arzneimittelforschung , vol.41 , pp. 768-772
    • Conte, A.1    De Bernardi, M.2    Palmieri, L.3
  • 115
    • 0033834443 scopus 로고    scopus 로고
    • Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis
    • Das A, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage 2000;8:343-350.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 343-350
    • Das, A.1    Hammad, T.A.2
  • 116
    • 0034986046 scopus 로고    scopus 로고
    • Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: A randomized double blind controlled 3-month clinical trial
    • Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3-month clinical trial. J Rheumatol 2001;28:1347-1355.
    • (2001) J Rheumatol , vol.28 , pp. 1347-1355
    • Thie, N.M.1    Prasad, N.G.2    Major, P.W.3
  • 117
    • 0029758948 scopus 로고    scopus 로고
    • Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis
    • Morreale P, Manopulo R, Galati M, et al. Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-1391.
    • (1996) J Rheumatol , vol.23 , pp. 1385-1391
    • Morreale, P.1    Manopulo, R.2    Galati, M.3
  • 118
    • 0742323757 scopus 로고    scopus 로고
    • Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats
    • Beale BS. Use of nutraceuticals and chondroprotectants in osteoarthritic dogs and cats. Vet Clin North Am Small Anim Pract 2004;34:271-289.
    • (2004) Vet Clin North Am Small Anim Pract , vol.34 , pp. 271-289
    • Beale, B.S.1
  • 119
    • 0001856242 scopus 로고    scopus 로고
    • The effect of Cosequin in cranial cruciate deficient and reconstructed stifle joints in dogs
    • Hulse DS, Hart D, Slatter M, et al. The effect of Cosequin in cranial cruciate deficient and reconstructed stifle joints in dogs, in Proceedings. 25th Annu Conf Vet Orthop Soc 1998;64.
    • (1998) Proceedings. 25th Annu Conf Vet Orthop Soc , pp. 64
    • Hulse, D.S.1    Hart, D.2    Slatter, M.3
  • 120
    • 0344240121 scopus 로고    scopus 로고
    • Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate
    • Canapp SO, McLaughlin RM Jr, Hoskinson JJ, et al. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate. Am J Vet Res 1999;60:1552-1557.
    • (1999) Am J Vet Res , vol.60 , pp. 1552-1557
    • Canapp, S.O.1    McLaughlin Jr., R.M.2    Hoskinson, J.J.3
  • 121
    • 0031750838 scopus 로고    scopus 로고
    • Chondroitin sulfate and joint disease
    • Hardingham T. Chondroitin sulfate and joint disease. Osteoarthritis Cartilage 1998;6(suppl A):3-5.
    • (1998) Osteoarthritis Cartilage , vol.6 , Issue.SUPPL. A , pp. 3-5
    • Hardingham, T.1
  • 122
    • 0032387180 scopus 로고    scopus 로고
    • Effects of oral and intramuscular use of chondroitin sulphate in induced equine aseptic arthritis
    • Dorna VJ, Guerrero RC. Effects of oral and intramuscular use of chondroitin sulphate in induced equine aseptic arthritis. J Equine Vet Sci 1998;18:548-555.
    • (1998) J Equine Vet Sci , vol.18 , pp. 548-555
    • Dorna, V.J.1    Guerrero, R.C.2


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