Absorption, distribution, metabolism and excretion of glucosamine sulfate: A review

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 9, 2001, Pages 699-725

  Setnikar, I ^a   Rovati, L C ^a  

^a Rotta Research Laboratorium   (Italy)

Author keywords

CAS 29031 19 4; CAS 3416 24 8; Dona packets; Dona tablets; Glucosamine, pharmacokinetics

Indexed keywords

CARBON 14; CARBON DIOXIDE; GLOBULIN; GLUCOSAMINE SULFATE; GLUCOSE; GLYCOSAMINOGLYCAN;

AREA UNDER THE CURVE; ARTICULAR CARTILAGE; BIOEQUIVALENCE; BOLUS INJECTION; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG URINE LEVEL; EXPIRED AIR; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; HUMAN; ION EXCHANGE CHROMATOGRAPHY; KIDNEY; NONHUMAN; REVIEW; SEX DIFFERENCE; STEADY STATE;

EID: 0034821815     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300105     Document Type: Review

References (50)

1. Hype about glucosamine
2. Glucosamine metabolism in regenerating rat liver
3. Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle
4. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic cartilage in vitro
5. Glutamine fructose-6-phosphate aminotransferase activity in cultured human skeletal muscle cells: Relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin
6. 13C-labeling in the dog
7. The effect of intravenous N-acetyl-D-glucosamine on the blood and urine sugar concentrations of normal subjects
8. 14C-labeled quaternary ammonium-glucosamine Conjugates
9. The biology of osteoarthritis
10. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin
11. Glucosamine-induced insulin resistance in 3T3-L 1 adipocytes is caused by depletion of intracellular ATP
12. Effect of D-glucosamine concentration on the kinetics of mucopolysaccharide biosynthesis in cultured chick embryo vertebral cartilage
13. Glucosamine and acetylglucosamine tolerance in man
14. Determination of the nutraceutical, glucosamine hydrochloride, in raw materials, dosage forms and plasma using pre-column derivatization with ultraviolet HPCL
15. Biosynthesis of plasma lipoproteins
16. Effects of glucosamine infusion on insulin secretion and insulin action in humans
17. A new system of automatic amino acid analysis. II
18. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee
19. Uptake of tritiated glucosamine by femur and mandible of 7-day old and adult mice
20. Determination of hexosamines in conjunction with electrophoresis on starch
21. Glucosamine sulfate in osteoarthritis of the knee
22. Preferential uptake and incorporation of glucosamine into proteoglycan in articular cartilage explants
23. A long-term, randomized, placebo-controlled, confirmatory trial on the effects of glucosamine sulfate on knee osteoarthritis progression
24. Short-term glucosamine infusion does not affect insulin sensitivity in humans
25. Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomized, placebo-controlled clinical trial
26. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee
27. Effects of hexosamines on the synthesis of chondroitin sulphuric acid in vitro
28. The clinical profile of glucosamine sulfate as a selective symptom modifying drug in osteoarthritis: Current data and perspectives
29. 14C]-glucosamine to the rat
30. Pharmacokinetics of glucosamine in the dog and in man
31. Pharmacokinetics of glucosamine in man
32. 14C] glucose to the rat
33. Assay of hexosamine pathway intermediates (uridine diphosphate-N-acetyl aminosugars) in small samples of human muscle tissues
34. 14C] glucosamine incorporation into intestinal glycoproproteins by calf intestinal epithelium in organ culture
35. Intestinal absorption of glucosamine and of N-acetylglucosamine
36. 11C]D-glucosamine and evaluation of its in vivo distribution in rat with PET
37. Coordinated regulation of glutamine fructose-6-phosphate amidotransferase activity by insulin, glucose and glutamine
38. Studies on bone matrix glycoproteins
39. The fate of glucosamine hydrochloride injected intravenously in man
40. Serum hexosamine levels in healthdisease
41. Glucosamine sulfate does not crossreact with the antibodies of patients with heparin-induced thrombocytopenia