The bioavailability and pharmacokinetic of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 6, 2002, Pages 217-225

  Adebowale, Abi ^a   Du, Jianpin ^b   Liang, Zhonming ^c   Leslie, James L ^b   Eddington, Natalie D ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Bioavailability; Chondroitin sulfate; Disaccharides; Glucosamine

Indexed keywords

CHONDROITIN SULFATE; COSAMIN; COSEQUIN; DISACCHARIDE; FCHG 49; GLUCOSAMINE; LOW MOLECULAR WEIGHT CHONDROITIN SULFATE; TRH 122; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; MALE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; ANIMAL; BIOAVAILABILITY; BLOOD; DRUG COMBINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; TIME;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHONDROITIN SULFATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG COMBINATIONS; GLUCOSAMINE; INJECTIONS, INTRAVENOUS; MOLECULAR WEIGHT; TIME FACTORS;

EID: 0036708636     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.315     Document Type: Article

References (25)

1. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999; 340: 1888-1899.
2. Moskowitz RW, Davis W, Sammarco J. Experimentally induced corticosteroid arthropathy. Arthritis Rheum 1996; 13: S-74.
3. Dingle JT. The effect of nonsteroidal andinflammatory drugs on human articular cartilage glycosaminoglycan synthesis. Osteoarthritis Cart 1999; 7: 313-314.
4. Lippiello L, Woodward J, Karpman R, Hammad A. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res 2000; 381: 229-240.
5. Johnson KA, Hulse DA, Hart RC, Kochevar D, Chu Q. Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis. Osteoarthritis Cartl 2001; 9: 14-21.
6. McAlindon TE, LaValley MP, Felson DT. Efficacy of glucosamine and chondroitin for treatment of osteoarthritis. JAMA 2000; 284: 1241.
7. Das A, Hammad TA. Efficacy of a combination of FCHG49™ glucosamine hydrochloride, TRH122™ low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cart 2000; 8: 343-350.
8. Canapp SO, McLaughlin RM, Hoskinson JJ, Roush JK, Butine MD. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate. Am J Vet Res 1999; 60: 1552-1557.
9. Orth MW, Peters TL, Hawkins JN. Glucosamine HCl and chondroitin sulfate inhibit the catabolic response of articular cartilage explants cultured with lipopolysaccharide. Osteoarthritis Cartl 2001; 9(Suppl. B): S54.
10. Setnikar I, Palumbo C, Zanolo G. Pharmacokinetics of glucosamine in man. Arzneim-Forsch/Drug Res 1993; 43: 1109-1113.
11. Setnikar I, Giacchetti C, Zanolo G. Pharmacokinetics of glucosamine in dog and in man. Arzneim-Forsch/Drug Res 1986; 36: 729-735.
12. Setnikar I, Pacini MA, Revel L. Antiarthritic effects of glucosamine sulfate studied in animal models. Arzneim-Forsch/Drug Res 1991; 41: 542-545.
13. Conte A, Volpi N, Palmieri L, Bahous I, Ronca G. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneim-Forsch./Drug Res 1995; 45: 918-925.
14. Volpi N. Fastmoving, and slow moving heparins, dermatan sulfate and chondroitin sulfate: Qualitative and quantitative analysis by agarose-gel electrophoresis. Charbohydr Res. 1993; 247: 263-278.
15. DuSouich P, Verges J. Simple approach to predict the maximal effect elicited by a drug when plasma concentrations are not available or are dissociated from the effect, as illustrated with chondroitin sulfate data. Clin Pharmacol Ther 2001; 70: 5-9.
16. Liau YH, Galicki N, Horowitz MI. Degradation of chondroitin 4-sulfate by rat stomach exoglycosidases, sulfohydrolase and hyaluronidase-like enzymes. Digestion 1981; 21: 117-124.
17. Liang Z, Leslie J, Adebowale A, Ashraf M, Eddington N. Determination of the nutraceutical, glucosamine hydrochloride, in raw materials, dosage forms and plasma using pre-column derivatization with ultraviolet HPLC. J Pharmaceut Biomed Anal 1999; 20: 807-814.
18. Volpi N.Disaccharide and analysis, molecular mass determination to microgram level of single sulfated glycosaminoglycan species in mixtures following agarose-gel electrophoresis. Anal Biochem 1999; 273: 229-239.
19. Huang Y, Toyoda H, Toida T, Imanari T. Determination of chondroitin sulphates in human whole blood, plasma and blood cells by high performance chromatography. Biomed Chrom 1995; 9: 102-105.
20. Okazaki J, Kamada A, Matsukawa F, Sakaki T, Gonda Y Disaccharide analysis of chondroitin sulphate in human gingival crevicular fluid using high-performance liquid chromatography. Archs Oral Biol 1995; 40: 777-779.
21. Adebowale AO, Cox DS, Liang Z, Eddington ND. Analysis of glucosamine and chondroitin sulfate content in marketed products and the Caco-2 permeability of chondroitin sulfate raw materials. J Am Nutrac Assoc 2000; 3: 37-44.
22. Du Jianping, Gao A, Eddington ND. Determination of the dissacharides of chondroitin sulfate in dog and horse plasma. in preparation.
23. Mazieres B, Combe B, Phan Van A, Tondut J, Grynfeltt M. Chondroitin sulfate in osteoarthritis of the knee: A prospective, double blind, placebo controlled multicenter clinical study J Rheumatol 2001; 28: 173-181.
24. Bassleer CT, Combal JP, Bougaret S, Malaise M. Effects of chondroitin sulfate and interleukin-1 beta on human articular chondrocytes cultivated in clusters. Osteoarthritis Cart 1998; 6: 196-204.
25. Morreale, P, Manopulo R, Galati M, Boccanera L, Saponati G, Bocchi. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac socium in patients with knee osteoarthritis. J Rheumatol 1996; 23: 1385-1391.