Recombinant equine interleukin-1β induces putative mediators of articular cartilage degradation in equine chondrocytes

Canadian Journal of Veterinary Research

Volumn 66, Issue 1, 2002, Pages 19-25

  Tung, J T ^a   Fenton, J I ^a   Arnold, C ^a   Alexander, L ^a   Yuzbasiyan Gurkan, V ^a   Venta, P J ^a   Peters, T L ^a   Orth, M W ^a   Richardson, D W ^a   Caron, J P ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; CYCLOOXYGENASE 2; GELATINASE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; NICKEL; NITRITE; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT PROTEIN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CELL CULTURE; CELL HYBRIDIZATION; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DNA PROBE; ENZYME ACTIVITY; ESCHERICHIA COLI; EXPLANT; EXPRESSION VECTOR; GENE AMPLIFICATION; GENE EXPRESSION; HORSE; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; OSTEOARTHRITIS; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PURIFICATION;

ANIMALS; BLOTTING, NORTHERN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HORSE DISEASES; HORSES; INTERLEUKIN-1; ISOENZYMES; MATRIX METALLOPROTEINASES; OSTEOARTHRITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; ESCHERICHIA COLI; VECTORS;

EID: 0036181747     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Cytokines and their role in the pathophysiology of osteoarthritis
2. The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis
3. Cytokines and inflammation in cartilage degradation
4. Proteinases and matrix degradation
5. 2 production by recombinant human interleukin-1 and tumor necrosis factor
6. Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression
7. Interleukin-1-like activity in synovial fluids and sera of horses with arthritis
8. Identification of interleukin-1 in equine osteoarthritic joint effusions
9. Effect of interleukin 1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage
10. Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by IL-1 and corticosteroids
11. Effects of interleukin-1 beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes
12. Regulation of matrix metabolism in equine cartilage explant cultures by interleukin 1
13. Metabolic and mitogenic activities of insulin-like growth factor-1 in interleukin-1-conditioned equine cartilage
14. Influence of interleukin-1beta and hyaluronan on proteoglycan release from equine navicular hyaline cartilage and fibrocartilage
15. Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage
16. Molecular cloning of equine interleukin-1 alpha and -beta cDNAs
17. Cloning of equine interleukin 1 alpha and equine interleukin 1 beta and determination of their full-length cDNA sequences
18. The interleukin-1 receptor in normal and osteoarthritic human articular chondroctes is the Type-1 receptor: Binding kinetics and biological function
19. Interleukin 1 receptors on rabbit articular chondrocytes: Relationship between biological activity and receptor binding kinetics
20. Prostaglandins E2 and E1 inhibit cytokine induced metalloprotease expression in human synovial fibroblasts
21. Interleukin-1 stimulation of equine articular cells
22. Species restrictions demonstrated by the stimulation of equine cells with recombinant human interleukin-1
23. Measurement of DNA length by gel electrophoresis
24. Molecular characteristics of equine stromelysin and the tissue inhibitor of metalloproteinase 1
25. Glucosamine reduces equine articular cartilage degradation in explant culture
26. Assaying proteinases with azocoll
27. 15N] nitrate in biological fluids
28. Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors
29. A common class of receptors for the two types of porcine interleukin-1 on articular chondrocytes
30. Recombinant human interleukin-1 alpha and recombinant human interleukin-1 beta stimulate cartilage matrix degradation and inhibit glycosaminoglycan synthesis
31. Effects of indomethacin on the production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by human articular chondrocytes
32. Vitro effects of interleukin-1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors inhuman articular cartilage
33. The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells
34. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
35. Some molecular mechanisms of glucocorticoid action
36. Dose-dependent effects of corticosteroids on the expression of matrix related genes in normal and cytokine treated articular chondrocytes
37. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide
38. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: A potential mechanism for inflammatory angiogenesis
39. Evidence for the involvement of interleukin-1 in human osteoarthritic cartilage degradation: Protective effect of NSAID
40. Modulation of osteoclast differentiation by local factors
41. Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage
42. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: Evidence for an inducible "neuronal-like" nitric oxide synthase
43. Nitric oxide production by equine articular cells in vitro
44. Nitric oxide activated metalloprotease enzymes in articular cartilage
45. The increased synthesis of inducible nitric oxide inhibits IL-1Ra synthesis by human articular chondrocytes; possible role in osteoarthritis cartilage degradation
46. Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: Involvement of peroxynitrite
47. Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: Prolyl hydroxylase as a possible target