Managing chronic arthritis

Veterinary Clinics of North America - Equine Practice

Volumn 18, Issue 3, 2002, Pages 411-437

  Malone, Erin D ^a  

^a 225K Veterinary Teaching Hospitals ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; EQUIDAE;

ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

AGING; ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ARTHRITIS; FEMALE; HORSE; HORSE DISEASE; MALE; OSTEOARTHRITIS; PAIN; PHYSIOLOGY; REVIEW;

AGING; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS; FEMALE; HORSE DISEASES; HORSES; MALE; OSTEOARTHRITIS; PAIN; PHYSICAL CONDITIONING, ANIMAL;

EID: 0036982204     PISSN: 07490739     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0749-0739(02)00024-X     Document Type: Review

References (184)

1. Kyles A.E., and Ruslander D. Chronic pain: osteoarthritis and cancer. Semin Vet Med Surg 12 (1997) 122-132
2. Muir W.W., and Woolf C.J. Mechanisms of pain and their therapeutic implications. JAVMA 219 (2001) 1346-1356
3. Todhunter R.J., and Lust G. Pathophysiology of synovitis: clinical signs and examination in horses. Compend Contin Educ Pract Vet 12 (1990) 980-991
4. Caron J.P. Neurogenic factors in joint pain and disease pathogenesis. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 71-80
5. McIlwraith C.W., and Vachon A. Review of pathogenesis and treatment of degenerative joint disease. Equine Vet J Suppl 6 (1988) 3-11
6. McIlwraith C.W., and Bramlage L.R. Surgical treatment of joint injury. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 292-317
7. Theoret C.L., Barber S.M., Moyana T.N., Townsend H.G.G., and Archer J. Repair and function of synovium after total arthroscopic synovectomy of the equine antebrachiocarpal joint. Vet Surg 23 (1994) 418 [abstract]
8. Palmer J.L., Bertone A.L., Malemud C.J., and Mansour J. Changes in third carpal bone articular cartilage after synovectomy in normal and inflamed joints. Vet Surg 27 (1998) 321-330
9. Kampen W.U., Brenner W., Kroeger S., Sawula J.A., Bohuslavizki K.H., and Henze E. Long-term results of radiation synovectomy: a clinical follow-up study. Nucl Med Commun 22 (2001) 239-246
10. Rodriguez-Merchan E.C., and Goddard N.J. The technique of synoviorthosis. Haemophilia 7 Suppl 2 (2001) 11-15
11. Yarbrough T.B., Lee M.R., Hornof W.J., Koblik P.D., Brodack J., Troup C., et al. Samarium 153-labeled hydroxyapatite microspheres for radiation synovectomy in the horse: a study of the biokinetics, dosimetry, clinical, and morphologic response in normal metacarpophalangeal and metatarsophalangeal joints. Vet Surg 29 (2000) 191-199
12. Auer J.A. Arthrodesis techniques. In: Auer J.A., and Stick J.A. (Eds). Equine surgery. 2nd edition (1999), WB Saunders, Philadelphia 696-704
13. Caron J.P., Fretz P.B., Bailey J.V., and Barber S.M. Proximal interphalangeal arthrodesis in the horse: a retrospective study and a modified screw technique. Vet Surg 19 (1990) 196-202
14. Schaer T., Bramlage L., Embertson R., and Hance S. Proximal interphalangeal arthrodesis in 22 horses. Vet Surg 27 (1998) 516 [abstract]
15. Adams O.R. Surgical arthrodesis for the treatment of bone spavin. JAVMA 157 (1970) 1480-1485
16. Trotter G.W. Management of bone spavin. Proceedings of the 18th Annual Veterinary Surgical Forum (Large Animal), Chicago (1990), American College of Veterinary Surgeons, Bethesda (MD) 283-284
17. Wyn-Jones G., and May S.A. Surgical arthrodesis for the treatment of osteoarthrosis of the proximal intertarsal, distal intertarsal and tarsometatarsal joints in 30 horses: a comparison of four different techniques. Equine Vet J 18 (1986) 59-64
18. Archer R.M., Schneider R.K., Lindsay W.A., and Wilson J.W. Arthrodesis of the equine distal tarsal joints by perforated stainless steel cylinders. Equine Vet J Suppl 6 (1988) 125-130
19. Sonnichsen H.V., and Svalastoga E. Surgical treatment of bone spavin in the horse. Equine Pract 7 (1985) 6-9
20. Bohanon T.C. Tarsal arthrodesis. In: White N.A., and Moore J.N. (Eds). Current techniques in equine surgery and lameness. 2nd edition (1998), WB Saunders, Philadelphia 433-439
21. Arighi M., Miller C.R., and Pennock P.W. Arthrodesis of the scapulohumeral joint in a miniature horse. JAVMA 191 (1987) 713-714
22. Felson D.T., Lawrence R.C., Hochberg M.C., McAlinson T., Dieppe P.A., Minor M.A., et al. Osteoarthritis: new insights;. part 2. Treatment approaches. Ann Intern Med 133 (2000) 726-737
23. Hurtig M.B., Fretz P.B., Doige C.E., and Schnurr D. Effects of lesion size and location on equine articular cartilage repair. Can J Vet Res 52 (1988) 137-146
24. Ramey D.W. Horseshoeing and its effects on joints. Concise guide to arthritis in the horse (1998), Howell Book House, NewYork 99-102
25. Xie H. Treating equine lameness with acupuncture. Compend Contin Educ Pract Vet 23 (2001) 838-841
26. Ezzo J., Hadhazy V., Birch S., Lao L., Kaplan G., Hochberg M., et al. Acupuncture for osteoarthritis of the knee: a systematic review. Arthritis Rheum 44 (2001) 819-825
27. Berman B.M., Singh B.B., Lao L., Langenberg P., Li H., Hadhazy V., et al. A randomized trial of acupuncture as an adjunctive therapy in osteoarthritis of the knee. Rheumatology 38 (1999) 346-354
28. Puett D.W., and Griffin M.R. Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis. Ann Intern Med 121 (1994) 133-140
29. Ramey D.W. Magnetic and electromagnetic therapy in horses. Compend Contin Educ Pract Vet 21 (1999) 553-560
30. Jacobson J.I., Gorman R., Yamanashi W.S., Saxena B.B., and Clayton L. Low-amplitude, extremely low frequency magnetic fields for the treatment of osteoarthritic knees: a double-blind clinical study. Altern Ther Health Med 7 (2001) 54-64
31. Weinberger A., Nyska A., and Giler S. Treatment of experimental inflammatory synovitis with continuous magnetic field. Isr J Med Sci 32 (1996) 1197-1201
32. Millis D.L., and Levine D. The role of exercise and physical modalities in the treatment of osteoarthritis. Vet Clin North Am Small Anim Pract 27 (1997) 913-930
33. Carroll D., Moore R.A., McQuay H.J., Fairman F., Tramer M., and Leijon G. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev 3 (2001) CD003222
34. Osiri M., Welch V., Brosseau L., Shea B., McGowan J., Tugwell P., et al. Transcutaneous electrical nerve stimulation for knee osteoarthritis. Cochrane Database Syst Rev 4 (2000) CD002823
35. Steiss J.E. Physical therapy modalities: therapeutic ultrasound and phonophoresis. Compend Contin Educ Pract Vet 22 (2000) 690-693
36. Brosseau L., Welch V., Wells G., Tugwell P., de Bie R., Gam A., et al. Low level laser therapy for osteoarthritis and rheumatoid arthritis: a meta-analysis. J Rheumatol 27 (2000) 1961-1969
37. Zhang W.Y., and Li Wan Po A. The effectiveness of topically applied capsaicin. A meta-analysis. Eur J Clin Pharmacol 46 (1994) 517-522
38. McCleane G. The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: a randomized, double blind, placebo controlled study. Eur J Pain 4 (2000) 355-360
39. Weinberger T., and Nolting B. Focused extracorporeal shockwave therapy in sport horses. Proceedings of the Fourth Congress of the International Society for Musculoskeletal Shockwave Therapy, Berlin (2001), International Society for Musculoskeletal Shockwave Therapy, Vienna [abstract 35]
40. McClure S., Van Sickle D., and McCarroll D. Equine applications of extracorporeal shockwave therapy. Proceedings of the Fourth Congress of the International Society for Musculoskeletal Shockwave Therapy, Berlin (2001), International Society for Musculoskeletal Shockwave Therapy, Vienna [abstract 34]
41. Boddeker R., Schafer H., and Haake M. Extracorporeal shockwave therapy (ESWT) in the treatment of plantar fasciitis-a biometrical review. Clin Rheumatol 20 (2001) 324-330
42. Natalini C.C., and Robinson E.P. Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol and U0488H in horses. Am J Vet Res 61 (2000) 1579-1586
43. Liu S.S., Hodgson P.S., Carpenter R.I., and Fricke Jr. J.R. ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia. Clin Pharmacol Ther 69 (2001) 66-71
44. Curatolo M., and Bogduk N. Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects. Clin J Pain 17 (2001) 25-32
45. Lamont L.A., Tranquilli W.J., and Mathews K.A. Adjunctive analgesic therapy. Vet Clin North Am Small Anim Pract 30 (2000) 805-813
46. 4 receptor antagonist, MK-571, in mice: possible involvement of opioidergic mechanism. Eur J Pharmacol 386 (1999) 195-200
47. Chan W.H., Lin C.J., Sun W.Z., Tsai S.P., Tsai S.K., and Hsieh C.Y. Comparison of subcutaneous hydromorphone with intramuscular meperidine for immediate postoperative analgesia. Kaohsiung J Med Sci 15 (1999) 419-427
48. Lesser G.J., Grossman S.A., Leong K.W., Lo H., and Eller S. In vitro and in vivo studies of subcutaneous hydromorphone implants designed for the treatment of cancer pain. Pain 65 (1996) 265-272
49. Matthews N.S., Peck K.E., and Mealy K.L. Transdermal fentanyl: absorption and plasma levels in horses. Proceedings of the Sixth International Congress of Veterinary Anesthesiology, Thessaloniki, Greece (1997), American College of Veterinary Anesthesiologists, Knoxville (TN) 116
50. Barry B.W. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 14 (2001) 101-114
51. Langerman L., Grant G.J., Zakowski M., Golomb E., Ramanathan S., and Turndorf H. Prolongation of epidural anesthesia using a lipid drug carrier with procaine, lidocaine, and tetracaine. Anesth Analg 75 (1992) 900-905
52. Masters D.B., Berde C.B., Dutta S., Turek T., and Langer R. Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia. Pharm Res 10 (1993) 1527-1532
53. Palmer J.L., and Bertone A.L. Joint structure, biochemistry and biochemical disequilibrium in synovitis and equine joint disease. Equine Vet J 26 (1994) 263-277
54. Todhunter R.J. Anatomy and physiology of synovial joints. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 1-28
55. MacDonald M.H., and Benton H.P. Cellular responses and receptor mechanisms in joint disease: a bacterial lipopolysaccharide-induced model of articular damage. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 447-467
56. Kawcak C.E. New thinking about chondroprotection. Compend Contin Educ Pract Vet 22 Suppl 5A (2000) 14-16
57. Collins L.G., and Tyler D.E. Phenylbutazone toxicosis in the horse: a clinical study. JAVMA 184 (1984) 699-703
58. Owens J.G., Kamerling S.G., Stanton S.R., Keowen M.L., and Prescott-Matthews J.S. Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses. Am J Vet Res 57 (1996) 866-874
59. Owens J.G., Kamerling S.G., Stanton S.R., and Keowen M.L. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. Equine Vet J 27 (1995) 296-300
60. Houdeshell J.W., and Hennessey P.W. A new non-steroidal, anti-inflammatory analgesic for horses. J Equine Med Surg 1 (1977) 57-63
61. MacAllister C.G., Morgan S.J., Borne A.T., and Pollet R.A. Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. JAVMA 202 (1993) 71-77
62. Gregoricka M.J., Sutherland S.F., Dedrickson B.J., and Busch K.R. Assessment of the intramuscular administration of ketoprofen. Equine Pract 12 (1990) 15-22
63. Breuhaus B.A., DeGraves F.J., Honore E.K., and Papich M.G. Pharmacokinetics of ibuprofen after intravenous and oral administration and assessment of safety of administration to healthy foals. Am J Vet Res 60 (1999) 1066-1073
64. Hamm D., Turchi P., Johnson J.C., Lockwood P.W., Thompson K.C., and Katz T. Determination of an effective dose of eltenac and its comparison with that of flunixin meglumine in horses after experimentally induced carpitis. Am J Vet Res 58 (1997) 298-302
65. Prugner W., Huber R., and Luhmann R. Eltenac, a new anti-inflammatory and analgesic drug for horses: clinical aspects. J Vet Pharmacol Ther 14 (1991) 193-199
66. Lees P., and Higgins A.J. Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 17 (1985) 83-96
67. Jaraiz M.V., Rodriguez C., San Andres M.D., Gonzalez F., and San Andres M.I. Disposition and tolerance of suxibuzone in horses. Equine Vet J 31 (1999) 411-416
68. Jones E.W., and Hamm D. Comparative efficacy of phenylbutazone and naproxen in induced equine myositis. J Equine Med Surg 2 (1978) 341-347
69. McKellar Q.A., Bogan J.A., von Fellenberg R.L., Ludwig B., and Cawley G.D. Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse. Equine Vet J 23 (1991) 280-284
70. Soma L.R., Uboh C.E., Rudy J.A., and Smith M.S. Disposition and excretion of 6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone in horses. Am J Vet Res 57 (1996) 517-521
71. Day R.O., McLachlan A.J., Graham G.G., and Williams K.M. Pharmacokinetics of nonsteroidal anti-inflammatory drugs in synovial fluid. Clin Pharmacokinet 36 (1999) 191-210
72. Papich M.G. Pharmacologic considerations for opiate analgesic and nonsteroidal anti-inflammatory drugs. Vet Clin North Am Small Anim Pract 30 (2000) 815-837
73. Rose R.J., Kohnke J.R., and Baggot J.D. Bioavailability of phenylbutazone preparations in the horse. Equine Vet J 14 (1982) 234-237
74. Vandenbossche G.M.R., Bouckaert S., De Muynck C., Mommens G., Van Zeveren A., and Remon J.-P. Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies. Am J Vet Res 53 (1992) 528-531
75. 2 in mares. Am J Vet Res 54 (1993) 1901-1905
76. Lees P., Maitho T.E., and Taylor J.B. Pharmacokinetics of phenylbutazone in two age groups of ponies: a preliminary study. Vet Rec 116 (1985) 229-232
77. Landoni M.F., Foot R., Frean S., and Lees P. Effects of flunixin, tolfenamic acid, R(-) and S(+) ketoprofen on the response of equine synoviocytes to lipopolysaccharide stimulation. Equine Vet J 28 (1996) 468-475
78. Beluche L.A., Bertone A.L., Anderson D.E., and Rohde C. Effects of oral administration of phenylbutazone to horses on in vitro articular cartilage metabolism. Am J Vet Res 62 (2001) 1916-1921
79. May S.A., and Lees P. Nonsteroidal anti-inflammatory drugs. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 223-237
80. Trotter G.W. Intra-articular corticosteroids. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 237-256
81. Black J.B. Management of equine joint disease and lameness. Compend Contin Educ Pract Vet 22 Suppl 5A (2000) 10-13
82. Murphy D.J., Todhunter R.J., Fubini S.L., Vernier-Singer M., Straubinger R.K., and Lust G. The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses. Vet Surg 29 (2000) 546-557
83. Moses V.S., Hardy J., Bertone A.L., and Weisbrode S.E. Effects of anti-inflammatory drugs on lipopolysaccharide-challenged and -unchallenged equine synovial explants. Am J Vet Res 62 (2001) 54-60
84. Carter B.G., Bertone A.L., Weisbrode S.E., Bailey M.Q., Andrews J.M., and Palmer J.L. Influence of methylprednisolone acetate on osteochondral healing in exercised tarsocrural joints of horses. Am J Vet Res 57 (1996) 914-922
85. Frisbie D.D., Kawcak C.E., Baxter G.M., Trotter G.W., Powers B.E., Lassen E.D., et al. Effects of 6α-methylprednisolone acetate on an equine osteochondral fragment exercise model. Am J Vet Res 59 (1998) 1619-1628
86. Fubini S.L., Boatwright C.E., Todhunter R.J., and Lust G. Effect of intramuscularly administered polysulfated glycosaminoglycan on articular cartilage from equine joints injected with methylprednisolone acetate. Am J Vet Res 54 (1993) 1359-1365
87. Todhunter R.J., Fubini S.L., Vernier-Singer M., Wootton J.A.M., Lust G., Freeman K.P., et al. Acute synovitis and intra-articular methylprednisolone acetate in ponies. Osteoarthritis Cartilage 6 (1998) 94-105
88. Foland J.W., McIlwraith C.W., Trotter G.W., Powers B.E., and Lamar C.H. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 23 (1994) 369-376
89. Frisbie D.D., Kawcak C.E., Trotter C.W., Powers B.E., Walton R.M., and McIlwraith C.W. Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model. Equine Vet J 29 (1997) 349-359
90. Kawcak C.K., Norrdin R.W., and Trotter G.W. Effects of osteochondral fragmentation and intra-articular triamcinolone acetonide treatment on subchondral bone in the equine carpus. Equine Vet J 30 (1998) 66-71
91. Smith C.L., Macdonald M.H., Tesch A.M., and Willits N.H. In vitro evaluation of the effect of dimethyl sulfoxide on equine articular cartilage matrix metabolism. Vet Surg 29 (2000) 347-357
92. Adair H.S., Goble D.O., Vanhooser S., Blackford J.T., and Rohrbach B.W. Evaluation of use of dimethyl sulfoxide for intra-articular lavage in clinically normal horses. Am J Vet Res 52 (1991) 333-336
93. Welch R.D., Watkins J.P., DeBowes R.M., and Leipold H.W. Effect of intra-articular administration of dimethyl sulfoxide on chemically induced synovitis in immature horses. Am J Vet Res 52 (1991) 934-939
94. Smith G., Bertone A.L., Kaeding C., Simmons E.J., and Apostoles S. Anti-inflammatory effects of topically applied dimethyl sulfoxide gel on endotoxin-induced synovitis in horses. Am J Vet Res 59 (1998) 1149-1152
95. Ahlengard S., Tufvesson G., Pettersson H., and Andersson T. Treatment of traumatic arthritis in the horse with intra-articular orgotein (Palosein). Equine Vet J 10 (1978) 122-124
96. McIlwain H., Silverfield J.C., Cheatum D.E., Poiley J., Taborn J., Ignaczak T., et al. Intra-articular orgotein in osteoarthritis of the knee: a placebo-controlled efficacy, safety and dosage comparison. Am J Med 87 (1989) 295-300
97. Tiku M.L., Gupta S., and Deshmukh D.R. Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants. Free Radic Res 30 (1999) 395-405
98. Giri S.N., and Misra H.P. Fate of superoxide dismutase in mice following oral administration. Med Biol 62 (1984) 285-289
99. Beale B.S. Evaluation of active enzyme activity in six oral superoxide dismutase products. Proceedings of the 25th Annual Conference of the Veterinary Orthopedic Society, Snowmass (1998), Veterinary Orthopedic Society, Newmarket (NH) 65
100. Brand C., Snaddon J., Bailey M., and Cicuttini F. Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study. Ann Rheum Dis 60 (2001) 946-949
101. Hill J., and Bird H.A. Failure of selenium-ACE to improve osteoarthritis. Br J Rheumatol 29 (1990) 211-213
102. Schwartz E.R., Leveille C., and Oh W.H. Experimentally-induced osteoarthritis in guinea pigs: effect of surgical procedure and dietary intake of vitamin C. Lab Anim Sci 31 (1981) 683-687
103. Howard R.D., and McIlwraith C.W. Hyaluronan and its use in the treatment of equine joint disease. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 257-269
104. Tulamo R.M., Heiskanen T., and Salonen M. Concentration and molecular weight distribution of hyaluronate in synovial fluid from clinically normal horses and horses with diseased joints. Am J Vet Res 55 (1994) 710-715
105. 2 production by cultured equine synoviocytes. Am J Vet Res 61 (2000) 499-505
106. Lynch T.M., Caron J.P., Arnoczky S.P., Lloyd J.W., Stick J.A., and Render J.A. Influence of exogenous hyaluronan on synthesis of hyaluronan and collagenase by equine synoviocytes. Am J Vet Res 59 (1998) 888-892
107. Gaustad G., and Larsen S. Comparison of polysulphated glycosaminoglycan and sodium hyaluronate with placebo in treatment of traumatic arthritis in horses. Equine Vet J 27 (1995) 356-362
108. Peloso J.G., Stick J.A., Caron J.P., Peloso P.M., and Soutas-Little R.W. Effects of hylan on amphotericin-induced carpal lameness in equids. Am J Vet Res 54 (1993) 1527-1534
109. Rydell N.W., Butler J., and Balazs E.A. Hyaluronic acid in synovial fluid. VI. Effect of intra-articular injection of hyaluronic acid on the clinical symptoms of arthritis in track horses. Acta Vet Scand 11 (1970) 139-155
110. Roneus B., Lindblad A., Lindholm A., and Jones B. Effects of intraarticular corticosteroid and sodium hyaluronate injections on synovial fluid production and synovial fluid content of sodium hyaluronate and proteoglycans in normal equine joints. Zentralbl Veterinarmed A 40 (1993) 10-16
111. Barr A.R.S., Duance V.C., Wotton S.F., and Waterman A.E. Influence of intra-articular sodium hyaluronate and polysulphated glycosaminoglycans on the biochemical composition of equine articular surface repair tissue. Equine Vet J 26 (1994) 40-42
112. Kawcak C.E., Frisbie D.D., Trotter G.W., McIlwraith C.W., Gillette S.M., Powers B.E., et al. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. Am J Vet Res 58 (1997) 1132-1140
113. Calder P.C., and Zurier R.B. Polyunsaturated fatty acids and rheumatoid arthritis. Curr Opin Clin Nutr Metab Care 4 (2001) 115-121
114. Fortin P.R., Lew R.A., Liang M.H., Wright E.A., Beckett L.A., Chalmers T.C., et al. Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol 48 (1995) 1379-1390
115. Anderson M.A. Oral chondroprotective agents. Part II. Evaluation of products. Compend Contin Educ Pract Vet 21 (1999) 861-865
116. McCann M.E., and Carrick J.B. Potential uses of ω-3 fatty acids in equine diseases. Compend Contin Educ Pract Vet 20 (1998) 637-641
117. Halpern G.M. Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol 32 (2000) 272-278
118. Canapp S.O., McLaughlin R.M., Hoskinson J.J., Roush J.K., and Butine M.D. Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate. Am J Vet Res 60 (1999) 1552-1557
119. DiPadova C. S-adenosylmethionine in the treatment of osteoarthritis, review of the clinical studies. Am J Med 83 (1987) 60-65
120. Konig B. A long-term (2 year) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 83 (1987) 89-94
121. Bradley J.D., Flusser D., Katz B.P., Schumacher Jr. H.R., Brandt K.D., Chambers M.A., et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 21 (1994) 905-911
122. Brandt K.D. Second-line drug therapy for osteoarthritis. Clin Med 1 (2001) 110-114
123. Fernandes J.C., Martel-Pelletier J., Jovanovic D., Tardif G., DiBattista J.A., Lascau-Coman V., et al. The effects of tenidap on canine experimental osteoarthritis:. II. Study of the expression of collagenase-1 and interleukin 1β by in situ hybridization. J Rheumatol 25 (1998) 951-958
124. Pelletier J.P., Jovanovic D.V., Lascau-Coman V., Fernandes J.C., Manning P.T., Connor J.R., et al. Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum 43 (2000) 1290-1299
125. Jauering S., Schweighauser A., Reist M., Von Rechenberg B., Schawalder P., and Spreng D. The effects of doxycycline on nitric oxide and stromelysin production in dogs with cranial cruciate ligament rupture. Vet Surg 30 (2001) 132-139
126. Shlopov B.V., Stuart J.M., Gumanovskaya M.L., and Hasty K.A. Regulation of cartilage collagenase by doxycycline. J Rheumatol 28 (2001) 835-842
127. Tilley B.C., Alarcon G.S., Heyse S.P., Trentham D.E., Neuner R., Kaplan D.A., et al. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. Ann Intern Med 15 (1995) 81-89
128. Herrmann G., Steeger D., Klasser M., Wirbitzky J., Furst M., Venbrocks R., et al. Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac. Clin Rheumatol 19 (2000) 99-104
129. Veihelmann A., Hofbauer A., Refior H.J., and Messmer K. Oxaceprol, an atypical inhibitor of inflammation, reduces leukocyte adherence in mouse antigen-induced arthritis. Acta Orthop Scand 72 (2001) 293-298
130. Altman R.D., and Marcussen K.C. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 44 (2001) 2531-2538
131. Appleboom T., Schuermans J., Verbruggen G., Henrotin Y., and Reginster J.Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. Scand J Rheumatol 30 (2001) 242-247
132. Little C.V., and Parsons T. Herbal therapy for treating osteoarthritis. Cochrane Database Syst Rev 1 (2001) CD002947
133. Mardjuadi A., and Dequeker J. Double-blind trial comparing bufexamac infiltrations with triamcinolone acetonide infiltrations in patients with peri-arthritis of the shoulder. Curr Med Res Opin 5 (1978) 401-406
134. Suominen M.M., Tulamo R.-M., Puupponen L.M., and Sankari S.M. Effects of intra-articular injections of bufexamac suspension on amphotericin B-induced aseptic arthritis in horses. Am J Vet Res 60 (1999) 1467-1473
135. Suominen M.M., Tulamo R.-M., Anttila M.O., Sankari S.M., Kiraly K., Lapvetelainen T., et al. Effects of intra-articular injections of bufexamac suspension in healthy horses. Am J Vet Res 62 (2001) 1629-1635
136. Kranke B., Szolar-Platzer C., Komericki P., Derhaschnig J., and Aberer W. Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer. Contact Dermatitis 36 (1997) 212-215
137. Bragdon B., Bertone A.L., Hardy J., and Simmons E.J. Use of an isolated joint model to detect early changes induced by intra-articular injection of paclitaxel-impregnated polymeric microspheres. J Invest Surg 14 (2001) 169-182
138. Cordero J.A., Alarcon L., Escribano E., Obach R., and Domenech J. A comparative study of the transdermal penetration of a series of nonsteroidal antiinflammatory drugs. J Pharm Sci 86 (1997) 503-508
139. Li L.C., Scudds R.A., Heck C.S., and Harth M. The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: a pilot study. Arthritis Care Res 9 (1996) 126-132
140. Moore R.A., Tramèr M.R., Carroll D., Wiffen P.J., and McQuay H.J. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 316 (1998) 333-338
141. Trotter G.W. Polysulfated glycosaminoglycan (Adequan). In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 270-280
142. Burba D.J., Collier M.A., Default L.E., Hanson-Painton O., Thompson Jr. H.C., and Holder C.L. In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articular cartilage in an osteochondral defect model. J Equine Vet Sci 13 (1993) 696-703
143. Sevalla K., Todhunter R.J., Vernier-Singer M., and Budsberg S.C. Effect of polysulfated glycosaminoglycan on DNA content and proteoglycan metabolism in normal and osteoarthritic canine articular cartilage explants. Vet Surg 29 (2000) 407-414
144. Glade M.J. Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes. Am J Vet Res 51 (1990) 779-785
145. Yovich J.V., Trotter G.W., McIlwraith C.W., and Norrdin R.W. Effects of polysulfated glycosaminoglycan on chemical and physical defects in equine articular cartilage. Am J Vet Res 48 (1987) 1407-1414
146. Todhunter R.J., Yeager A.E., Freeman K.P., Parente E.J., and Lust G. Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in ponies. Am J Vet Res 54 (1993) 1007-1016
147. Todhunter R.J., Minor R.R., Wootton J.A.M., Krook L., Burton-Wurster N., and Lust G. Effects of exercise and polysulfated glycosaminoglycan on the repair of articular cartilage defects in the equine carpus. J Orthop Res 11 (1993) 782-795
148. Todhunter R.J., and Lust G. Polysulfated glycosaminoglycan in the treatment of osteoarthritis. JAVMA 204 (1994) 1245-1251
149. Todhunter R.J., Freeman K.P., Yeager A.E., and Lust G. Effects of exercise and polysulfated glycosaminoglycan on the development of osteoarthritis in equine carpal joints with osteochondral defects. Vet Surg 22 (1993) 330-342
150. Crisman M., Furr M., Ley W., Flynn D.V., and Kenney J.E. Evaluation of polysulfated glycosaminoglycan for the treatment of navicular disease: a double blind study. Proceedings of the 39th Annual Convention of the American Association of Equine Practitioners, San Antonio (1993), American Association of Equine Practitioners, Lexington (KY) 219-220
151. Caron J.P., Kaneene J.B., and Miller R. Results of a survey of equine practitioners on the use and perceived efficacy of polysulfated glycosaminoglycan. JAVMA 209 (1996) 1564-1568
152. Little C., and Ghosh P. Potential use of pentosan polysulfate for the treatment of equine joint disease. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 281-292
153. Deal C.L., and Moskowitz R.W. Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am 25 (1999) 379-395
154. Karzel K., and Domenjoz R. Effects of hexosamine derivatives and uronic acid derivatives on glycosaminoglycan metabolism of fibroblast cultures. Pharmacology 5 (1971) 337-345
155. Anderson C.C., Cook J.L., Kreeger J.M., Tomlinson J.L., and Wagner-Mann C.C. In vitro effects of glucosamine and acetylsalicylate on canine chondrocytes in three-dimensional culture. Am J Vet Res 60 (1999) 1546-1551
156. Anderson M.A. Oral chondroprotective agents. Part I. Common compounds. Compend Contin Educ Pract Vet 21 (1999) 601-609
157. Conte A. Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzniemttelforschung 45 (1995) 918-925
158. Davidson G. Glucosamine and chondroitin sulfate. Compend Contin Educ Pract Vet 22 (2000) 454-458
159. Dorna V., and Guerrero R.C. Effects of oral and intramuscular use of chondroitin sulfate in induced equine aseptic arthritis. J Equine Vet Sci 19 Suppl 1 (1999) 14-18
160. ®) for ameliorating signs of navicular syndrome in horses. Vet Ther 2 (2001) 148-159
161. Hanson R.R., Smalley L.R., Huff G.K., White S., and Hammad T.A. Oral treatment with a glucosamine-chondroitin sulfate compound for degenerative joint disease in horses: 25 cases. Equine Pract 19 (1997) 16-22
162. White G.W., Jones E.W., Hamm J., and Sanders T. The efficacy of orally administered sulfated glycosaminoglycan in chemically induced equine synovitis and degenerative joint disease. J Equine Vet Sci 14 (1994) 350-353
163. Anderson M.A., Slater M.R., and Hammad T.A. Results of a survey of small-animal practitioners on the perceived clinical efficacy and safety of an oral nutraceutical. Prev Vet Med 38 (1999) 65-73
164. McNamara P.S., Barr S.C., Erb H., and Barlow L.L. Hematologic, hemostatic, and biochemical effects in cats receiving an oral chondroprotective agent for 30 days. Vet Ther 1 (2000) 108-117
165. Kirker-Head C.A., and Kirker-Head R.P. Safety of an oral chondroprotective agent in horses. Vet Ther 2 (2001) 345-353
166. Rejholec V. Long-term studies of antiosteoarthritic drugs: an assessment. Semin Arthritis Rheum 17 Suppl 1 (1987) 35-53
167. Boothe D.M. Nutraceuticals in veterinary medicine. Part II. Safety and efficacy. Compend Contin Educ Pract Vet 20 (1998) 15-21
168. Horstman J. The arthritis foundation's guide to alternative therapies (1999), The Arthritis Foundation, Atlanta p. 179-180
169. Hwa S.Y., Burkhardt D., Little C., and Ghosh P. The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. J Rheumatol 28 (2001) 825-834
170. Tamura T., Kosaka N., Ishiwa J., Sato T., Nagase H., and Ito A. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis Cartilage 9 (2001) 257-263
171. Tamura T., and Ohmori K. Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis. Eur J Pharmacol 419 (2001) 269-274
172. Dougados M., Nguyen M., Berdah L., Mazieres B., Vignon E., and Lequesne M. Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the chondromodulating effect of diacerein in OA of the hip. Arthritis Rheum 44 (2001) 2539-2547
173. Nicholas P., Tod M., Padoin C., and Petitjean O. Clinical pharmacokinetics of diacerein. Clin Pharmacokinet 35 (1998) 347-359
174. Frisbie D.D., Trotter G.W., Powers B.E., Rodkey W.G., Steadman J.R., Howard R.D., et al. Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses. Vet Surg 28 (1999) 242-255
175. Hurtig M., Pearce S., Warren S., Kalra M., and Miniaci A. Arthroscopic mosaic arthroplasty in the equine third carpal bone. Vet Surg 30 (2001) 228-239
176. McIlwraith C.W., and Nixon A.J. Joint resurfacing: attempts at repairing articular cartilage defects. In: McIlwraith C.W., and Trotter G.W. (Eds). Joint disease in the horse (1996), WB Saunders, Philadelphia 317-334
177. Frisbie D.D., and McIlwraith C.W. Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis. Clin Orthop 379 Suppl (2000) S273-S287
178. Harman J.C. Complementary (alternative) therapies for poor performance, back problems and lameness. In: Robinson N.E. (Ed). Current therapy in equine medicine. 4th edition (1997), WB Saunders, Philadelphia 131-137
179. Blake D.J., Maisiak R., Koplan A., Alarcon G.S., and Brown S. Sexual dysfunction among patients with arthritis. Clin Rheumatol 7 (1988) 50-60
180. Smilack J.D. The tetracyclines. Mayo Clin Proc 74 (1999) 727-729
181. Crisman M.V., Wilcke J.R., Sams R.A., and Gerken D.F. Concentrations of phenylbutazone and oxyphenbutazone in post-parturient mares and their neonatal foals. J Vet Pharmacol Ther 14 (1991) 330-334
182. Clark J.O., and Clark T.P. Analgesia. Vet Clin North Am Equine Pract 15 (1999) 705-723
183. Crisman M.V., Sams R.A., and Irby M.H. The disposition of phenylbutazone in lactating mares and its effect on nursing foals. Proceedings of the 35th Annual Convention of the American Association of Equine Practitioners, Boston (1989), American Association of Equine Practitioners, Lexington (KY) 127-131
184. Dubois R.N., Abramson S.B., Crofford L., Gupta R.A., Simm L.S., Van De Putte L.B., et al. Cyclooxygenase in biology and disease. FASEB J 12 (1998) 1063-1073