The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria

Free Radical Biology and Medicine

Volumn 25, Issue 4-5, 1998, Pages 480-492

  Shivaram, Kalugotla N ^a,b   Winklhofer Roob, Brigitte M ^a,b   Straka, Michael S ^a,b   Devereaux, Michael W ^a,b   Everson, Gregory ^b   Mierau, Gary W ^a   Sokol, Ronald J ^a,b  

^a CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Chenodeoxycholic acid; Cholestasis; Free radicals; Lipid peroxidation; Liver injury; Reactive oxygen species; Ubiquinone

Indexed keywords

BILE ACID; FLUORESCEIN DERIVATIVE; GLYCOCHENODEOXYCHOLIC ACID; IDEBENONE; LACTATE DEHYDROGENASE; SUCCINIC ACID; TAUROCHENODEOXYCHOLIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UBIQUINONE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; HYDROPHOBICITY; LIVER CELL DAMAGE; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; BENZOQUINONES; BILE ACIDS AND SALTS; GLYCOCHENODEOXYCHOLIC ACID; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUCCINIC ACID; TAUROCHENODEOXYCHOLIC ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA;

EID: 0032171253     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00077-X     Document Type: Article

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