GHRH and IL1β increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons

Brain Research

Volumn 949, Issue 1-2, 2002, Pages 209-212

  De, Alok ^a   Churchill, Lynn ^a   Obal Jr, Ferenc ^b   Simasko, Steven M ^a   Krueger, James M ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cytokines; GABA; GAD; Sleep

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CALCIUM ION; GROWTH HORMONE RELEASING FACTOR; INTERLEUKIN 1BETA; 4 AMINOBUTYRIC ACID; CALCIUM; INTERLEUKIN 1;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; DESENSITIZATION; FETUS; HYPOTHALAMUS; IMMUNOREACTIVITY; MEASUREMENT; NERVE CELL CULTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SLEEP; ANIMAL; CULTURE TECHNIQUE; CYTOLOGY; CYTOPLASM; DRUG EFFECT; METABOLISM; NERVE CELL;

ANIMALS; CALCIUM; CELL CULTURE TECHNIQUES; CYTOPLASM; GAMMA-AMINOBUTYRIC ACID; GROWTH HORMONE-RELEASING HORMONE; HYPOTHALAMUS; INTERLEUKIN-1; NEURONS; RATS;

EID: 0037072476     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03157-8     Document Type: Article

References (26)

1. Alam N., McGinty D., Imeri L., Opp M., Szymusiak R. Effects of interleukin-1beta on sleep- and wake-related preoptic anterior hypothalamic neurons in unrestrained rats. Sleep. 24:2001;A59.
2. Chen C., Zhang J., Vincent J.D., Israel J.M. Sodium and calcium currents in action potentials of rat somatotrophs: their possible functions in growth hormone secretion. Life Sci. 46:1990;983-989.
3. + channels in pituitary somatotrophs. Immunol. Cell Biol. 78:2000;356-368.
4. Farrar W.L., Kilian P.L., Ruff M.R., Hill J.M., Pert C.B. Visualization and characterization of interleukin 1 receptors in brain. J. Immunol. 139:1987;459-463.
5. Fry C., Gunter D.R., McMahon C.D., Steele B., Sartin J.L. Cytokine-mediated hormone release from cultured ovine pituitary cells. Neuroendocrinology. 68:1998;192-200.
6. Gallopin T., Fort P., Eggermann E., Caull B., Luppi P.-H., Rossier J., Audinat E., Mühlethaler M., Serafin M. Identification of sleep-promoting neurons in vitro. Nature. 404:2000;992-995.
7. Goghari V., Franciosi S., Kim S.U., Lee Y.B., McLarnon J.G. Acute application of interleukin-1beta induces Ca(2+) responses in human microglia. Neurosci. Lett. 281:2000;83-86.
8. Gong H., Szymusiak R., King J., Steininger T., McGinty D. Sleep-related c-fos protein expression in the preoptic hypothalamus: Effect of ambient warming. Am. J. Physiol. 279:2000;R2079-R2088.
9. Holliday J., Gruol D.L. Cytokine stimulation increases intracellular calcium and alters the response to quisqualate in cultured cortical astrocytes. Brain Res. 621:1993;233-241.
10. Krueger J.M., Obal F. Jr., Fang J., Kubota T., Taishi P. The role of cytokines in sleep regulation. Ann. NY Acad. Sci. 933:2001;211-221.
11. Lin J.S., Sakai K., Vanni-Mercier G., Jouvet M. A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats. Brain Res. 479:1989;225-240.
12. 2+ concentration and growth hormone (GH) release from purified rat somatotrophs. III. Mechanism of action of GH-releasing factor and somatostatin. Endocrinology. 128:1991;592-603.
13. McGinty D., Alam M.N., Szymusiak R., Nakao M., Yamamoto M. Hypothalamic sleep-promoting mechanisms: coupling to thermoregulation. Arch. Ital. Biol. 139:2001;63-75.
14. Mugnaini E., Oertel W.H. An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunocytochemistry. Bjorklund A., Hokfelt T., Handbook of Chemical Neuroanatomy. Vol. 4:1985;436-608 Elsevier, New York. Part 1.
15. Naumov A.P., Herrington J., Hille B. Actions of growth-hormone-releasing hormone on rat pituitary cells: intracellular calcium and ionic currents. Pfluger's Arch. 427:1994;414-421.
16. Sallanon M., Denoyer M., Kitahama K., Aubert C., Gay N., Jouvet M. Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat. Neuroscience. 32:1989;669-683.
17. Sherin J.E., Shiromani P.J., McCarley R.W., Saper C.B. Activation of ventrolateral preoptic neurons during sleep. Science. 271:1996;216-219.
18. Simasko S.M., Boyadjieva N., De A., Sarkar D.K. Effect of ethanol on calcium regulation in rat fetal hypothalamic cells in culture. Brain Res. 824:1999;89-96.
19. Steininger T.L., Gong H., McGinty D., Szymusiak R. Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups. J. Comp. Neurol. 429:2001;638-653.
20. Szymusiak R., Alam N., Steininger T.L., McGinty D. Sleep-waking discharge of ventrolateral/anterior hypothalamic neurons in rats. Brain Res. 803:1998;178-188.
21. Szymusiak R., Steininger T., Alam N., McGinty D. Preoptic area sleep-regulating mechanisms. Arch. Ital. Biol. 139:2001;77-92.
22. Takahashi T., Okimura Y., Yoshimura K., Shigeyoshi Y., Kaji H., Abe H., Chihara K. Regional distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in the rat brain. Endocrinology. 136:1995;4721-4724.
23. Terao A., Matsumura H., Saito M. Interleukin-1 induces slow wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. J. Neurosci. 18:1998;6599-6607.
24. Twery M.J., Moss R.L. Sensitivity of rat forebrain neurons to growth hormone-releasing hormone. Peptides. 6:1985;609-613.
25. Xu R., Clarke I.J., Chen S., Chen C. Growth hormone-releasing hormone decreases voltage-gated potassium currents in GH4C1 cells. J. Neuroendocrinol. 12:2000;147-157.
26. Zhang J., Obál F. Jr., Zheng T., Fang J., Taishi P., Krueger J.M. Intrapreoptic microinjection of GHRH or its antagonist alters sleep in rats. J. Neurosci. 19:1999;2187-2194.