Sleep deprivation increases somatostatin and growth hormone-releasing hormone messenger RNA in the rat hypothalamus

Journal of Sleep Research

Volumn 6, Issue 3, 1997, Pages 171-178

  Toppila, Jussi ^a   Alanko, Lauri ^a   Asikainen, Marjut ^a   Tobler, Irene ^b   Stenberg, Dag ^a   Porkka Heiskanen, Tarja ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Growth hormone releasing hormone; Hypothalamus; mRNA; Rat; Sleep deprivation; Somatostatin

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; MESSENGER RNA; SOMATOSTATIN;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP DEPRIVATION; SLOW WAVE SLEEP; THALAMUS MIDLINE NUCLEUS;

EID: 0030881174     PISSN: 09621105     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2869.1997.00049.x     Document Type: Article

References (30)

1. Aguila, M.C. and McCann, S.M. Growth hormone increases somatostatin release and messenger ribonucleic acid levels in the rat hypothalamus. Brain Res., 1993, 623: 89-94.
2. Benyassi, A., Gavaldà, A., Armario, A. and Arancibia, S. Role of somatostatin in the acute immobilization stress-induced GH decrease in rat. Life Sci. 1992, 52: 361-370.
3. Benyassi, A., Roussel, J.P., Rougeot, C., Gavaldà, A., Astier, H. and Arancibia, S. Chronic stress a affects in vivo hypothalamic somatostatin release but not in vitro GH responsiveness to somatostatin in rats. Neurosci. Lett., 1993, 159: 166-170.
4. Bertherat, J., Bluet-Pajot, M.T. and Epelbaum, J. Neuroendocrine regulation of growth hormone. Eur. J. Endocrinol., 1995, 132: 12-24.
5. Bredow, S., Taishi, P., Obál, F., Guha-Thakurta, N. and Krueger, J.M. Hypothalamic growth hormone-releasing hormone mRNA varies across the day in rats. NeuroReport, 1996, 7: 2501-2505.
6. Chihara, K., Uchiyama, T., Shakutsui, S., Kaji, H., Okimura, Y. and Abe, H. Molecular genetics of growth hormone-releasing factors. Horm. Res., 1994, 42: 182-188.
7. Danguir, J. Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats. Brain Res., 1986, 367: 26-30.
8. Franken, P., Dijk, D.-J., Tobler, I. and Borbély, A.A. Sleep deprivation in rats effects on EEG power spectra, vigilance states, and cortical temperature. Am. J. Physiol., 1991, 261: R198-R208.
9. Franken, P., Tobler, I. and Borbély, A.A. Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat. Physiol. Behav., 1993, 54: 885-894.
10. Holl, R.W., Hartman, M.L., Veldhuis, J.D., Taylor, W.M. and Thorner, M.O. Thirty-second sampling of plasma growth hormone in man: correlation with sleep stages. J. Clin. Endocrinol. Metab., 1991, 72: 854-861.
11. Kerkhofs, M., Van Cauter, E., Van Onderbergen, A., Caufriez, A., Thorner, M.O. and Copinschi, G. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am. J. Physiol., 1993, 264: E594-E598.
12. Kimura, F. and Tsai, C. Ultradian rhythm of growth hormone secretion and sleep in adult male rat. J. Physiol., 1984, 353: 305-315.
13. Liposits, Z. Ultrastructure of hypothalamic paraventricular neurons. Crit. Rev. Neurobiol., 1993, 7: 89-162.
14. Marshall, L., Mölle, M., Böschen, G., Steiger, A., Fehm, H. L. and Born, J. Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J. Clin. Endocrinol. Metab., 1996, 81: 1009-1013.
15. Mitsugi, N. and Kimura, F. Simultaneous determination of blood levels of corticosterone and growth hormone in the male rat: relation to sleep-wakefulness cycle. Neuroendocrinology, 1985, 41: 125-130.
16. Murison, R., Ursin, R., Coover, G.D., Lien, W. and Ursin, H. Sleep deprivation procedure produces stomach lesions in rats. Physiol. Behav., 1982, 29: 693-694.
17. Obál, F.J., Alföldi, P., Cady, A.B., Johannsen, L., Sáry, G. and Krueger, J.M. Growth hormone-releasing factor enhances sleep in rats and rabbits. Am. J. Physiol., 1988, 255: R310-R316.
18. Obál, F.J., Floyd, R., Kapás, L., Bodosi, B. and Krueger, J. M. Effects of systemic GHRH on sleep in intact and hypophysectomized rats. Am. J. Physiol., 1996, 270: E230-E237.
19. Obál, F.J., Payne, L., Opp, M., Alföldi, P., Kapás, L. and Krueger, J.M. Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation. Am. J. Physiol., 1992, 263: R1078-R1085.
20. Obál, F., Payne, L., Kapás, L., Opp, M. and Krueger, J.M. Inhibition of growth hormone-releasing factor suppresses both sleep and growth hormone secretion in the rat. Brain Res., 1991, 557: 149-153.
21. Porkka-Heiskanen, T., Smith, S.E., Taira, T., Urban, J.H., Levine, J.E., Turek, F.W. and Stenberg, D. Noradrenergic activity in the rat brain during REM sleep deprivation and rebound sleep. Am. J. Physiol., 1995, 268: R1456-R1463.
22. Sassin, J.F., Parker, D.C., Mace, J.F., Gotin, R.W., Johnson, L.C. and Rossman, L.G. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science, 1969, 165: 513-515.
23. Sawchenko, P.E., Swanson, L.W., Rivier, J. and Vale, W.W. The distribution of growth hormone-releasing factor (GRF) immunoreactivity in the central nervous system of the rat: an immunohistochemical study using antisera directed against rat hypothalamic GRF. J. Comp. Neurol., 1985, 237: 100-115.
24. Takahashi, Y., Kipnis, D. M. and Daughaday, W. H. Growth hormone secretion during sleep. J. Clin. Invest., 1968, 47: 2079-2090.
25. Tobler, I. and Borbély, A.A. The effect of 3-h and 6-h sleep deprivation on sleep and EEG spectra of the rat. Behav. Brain Res., 1990, 36: 73-78.
26. Toppila, J., Asikainen, M., Alanko, L., Turek, F.W., Stenberg, D. and Porkka-Heiskanen, T. The effect of REM sleep deprivation on somatostatin and growth hormone-releasing hormone gene expression in the rat hypothalamus. J. Sleep Res., 1996, 5: 115-122.
27. Van Cauter, E. and Plat, L. Physiology of growth hormone secretion during sleep. J. Pediatr., 1996, 128: S32-S37.
28. Zeitler, P., Tannenbaum, G.S., Clifton, D.K. and Steiner, R.A. Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats. Proc. Natl. Acad. Sci. USA, 1991, 88: 8920-8924.
29. Zeitler, P., Vician, L., Chowen-Breed, J.A., Argente, J., Tannenbaum, G.S., Clifton, D.K. and Steiner, R.A. Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain. Metabolism, 1990, 9 (Suppl. 2): 46-49.
30. Zhang, J., Obál, F.J., Fang, J., Collins, B.J. and Krueger, J.M. Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurosci. Lett., 1996, 220: 97-100.