Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-x(L)-overexpressing chemotherapy-resistant tumor cells

Cancer Research

Volumn 60, Issue 11, 2000, Pages 3051-3057

  Walczak, Henning ^a   Bouchon, Axel ^a,b   Stahl, Heiko ^a   Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; ETOPOSIDE; PROTEIN BCL 2; PROTEIN BCL X; TUMOR NECROSIS FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; GENE ACTIVATION; GENE INACTIVATION; GENE INDUCTION; GENE OVEREXPRESSION; GENETIC RESISTANCE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; TUMOR CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL SURVIVAL; CYTOCHROME C GROUP; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; ETOPOSIDE; FLOW CYTOMETRY; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; MITOCHONDRIA; PHOSPHATIDYLSERINES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034213248     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, J. K., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C. T., Smith, G. A., and Goodwin, R. G. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 3: 673-682, 1995.
2. Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., and Ashkenazi, A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem., 271: 12687-12690, 1996.
3. Peter, M. E., Scaffidi, C., Medema, J. P., Kischkel, F., and Krammer, P. H. The death receptors. In: S. Kumar (ed.), Apoptosis, Problems and Diseases, pp. 25-63. Heidelberg, Germany: Springer, 1998.
4. Krammer, P. H. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol., 99: 163-210, 1999.
5. Brouckaert, P. G., Leroux-Roels, G. G., Guisez, Y., Tavernier, J., and Fiers, W. In vivo anti-tumor activity of recombinant human and murine TNF, alone and in combination with murine IFN, on a syngenic murine melanoma. Int. J. Cancer, 38: 763-769, 1986.
6. Havell, E. A., Fiers, W., and North, R. J. The antilumor function of tumor necrosis factor (TNF). 1. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited to severe toxicity. J. Exp. Med., 167: 1067-1085, 1988.
7. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.), 364: 806-809, 1993.
8. Tanaka, M., Suda, T., Yatomi, T., Nakamura, N., and Nagata, S. Lethal effect of recombinant human Fas ligand in mice pretreated with Prapionibacterium acnes. J. Immunol., 158: 2303-2309, 1997.
9. Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., and Rauch, C. T. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J., 16: 5386-5397, 1997.
10. Griffith, T. S., Chin, W. A., Jackson, G. C., Lynch, D. H., and Kubin, M. Z. Intracellular regulation of TRAIL-induced apoplosis in human melanoma cells. J. Immunol., 161: 2833-2840, 1998.
11. Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., Smith, C. A., Smolak, P. J., Goodwin, R. G., and Lynch, D. H. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med., 5: 157-163, 1999.
12. Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., DeForge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., and Schwall, R. H. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Investig., 104: 155-162, 1999.
13. Roth, W., Isenmann, S., Naumann, U., Kugler, S., Bahr, M., Dichgans, J., Ashkenazi, A., and Weller, M. Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity. Biochem. Biophys. Res. Commun., 265: 479-483, 1999.
14. Griffith, T. S., Wiley, S. R., Kubin, M. Z., Sedger, L. M., Maliszewski, C. R., and Fanger, N. A. Monocyte-mediated tumoricidal activity via tumor necrosis factor-related cytokine, TRAIL. J. Exp. Med., 189: 1343-1353, 1999.
15. Kayagaki, N., Yamaguchi, N., Nakayama, M., Eto, H., Okumura, K., and Yagita, H. Type I interferons (INFs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: a novel mechanism for the antitumor effects of type I INFs. J. Exp. Med., 189: 1451-1460, 1999.
16. Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., and Dixit, V. M. The receptor for the cytotoxic ligand TRAIL. Science (Washington, DC), 276: 111-113, 1997.
17. Sheridan, J. P., Marsters, S. A., Pitti, R. M., Gurney, A., Skubatch, M., Baldwin, D., Ramakrishnan, L., Gray, C. L., Baker, K., Wood, W. I., Goddard, A. D., Godowski, P., and Ashkenazi, A. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Science (Washington DC), 277: 818-821, 1997.
18. Schneider, P., Bodmer, J. L., Thome, M., Hofmann, K., Holler, N., and Tschopp, J. Characterization of two receptors for TRAIL. FEBS Lett., 416: 329-334, 1997.
19. Pan, G., Ni, J., Wie, Y. F., Yu, G., Gentz, R., and Dixit, V. M. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science (Washington DC). 277: 815-817, 1997.
20. Wu, G. S., Burns, T. F., McDonald, E. R., Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D. D., Zhou, J-Y., Muschel, R., Hamilton, S. R., Spinner, N. B., Markowitz, S., Wu, G., and El-Deiry, W. S. Killer/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat. Genet., 17: 141-143, 1997.
21. Degli-Esposti, M. A., Smolak, P. J., Walczak, H., Waugh, J., Huang, C-P., DuBose, R. F., Goodwin, R. G., and Smith, C. A. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med., 186: 1165-1170, 1997.
22. Degli-Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J., Smith, C. A., and Goodwin, R. G. The novel receptor TRAIL-R4 induces NFκB and protects against TRAIL-induced apoptosis, yet retains an incomplete death domain. Immunity, 7: 813-820, 1997.
23. Emery, J. G., MacDonnell, P., Brgham Burke, M., Deen, K. C., Lyn, S., Silverman, C., Dul, E., Appelbaum, E. R., DiPrinzipio, R., Dodds, D. A., James, I. E., Rosenberg, M., Lee, J. C., and Young, P. R. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem., 273: 14363-14367, 1998.
24. Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., and Ashkenazi, A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol., 7: 1003-1006, 1997.
25. Adams, M. A., and Cory, S. The Bcl-2 protein family: arbiters of cell death. Science (Washington DC), 281: 322-326, 1998.
26. L can differentially block chemotherapy-induced cell death. Blood, 90: 1208-1216, 1997.
27. L antagonize the mitochondrial dysfunction proceeding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res., 57: 62-67, 1997.
28. Decaudin, D., Marzo, I., Brenner, C., and Kroemer, G. Mitochondria in chemotherapy-induced apoptosis: a prospect novel target of cancer therapy. Int. J. Oncol., 12: 141-152, 1998.
29. Fulda, S., Scaffidi, C., Susin, S. A., Krammer, P. H., Kroemer, G., Peter, M. E., and Debatin, K. M. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J. Biol. Chem., 273: 33942-33948, 1998.
30. Bantel, H., Engels, I. H., Voelter, W., Schulze-Osthoff, K., and Wesselborg, S. Misteltoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res., 59: 2083-2090, 1999.
31. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
32. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Washington DC), 275: 1132-1136, 1997.
33. Mancini, M., Nicholson, D. W., Roy, S., Thornberry, N. A., Peterson, E. P., Casciola-Rosen, L. A., and Rosen, A. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J. Cell. Biol., 140: 1485-1495, 1998.
34. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Brenner, C., Lacochette, N., Prevost, M-C., Alzari, P. M., and Kroemer, G. 189: Mitochondrial release of caspase-2 and -9 during the apoptotic process. J. Exp. Med., 189: 381-393, 1999.
35. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (Lond.), 397: 441-446, 1999.
36. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.
37. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997.
38. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerizalion. Mol. Cell, 1: 949-957, 1998.
39. Yang, X., Chang, H. Y., and Baltimore, D. Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell, 1: 319-325, 1998.
40. Cleary, M. L., Smith, S. D., and Sklar, J. Cloning and structural analysis of cDNA for bcl-2 and hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell. 47: 19-28, 1986.
41. Pepper, C., Hoy, T., and Bentley, D. P. Bcl-2/Bax ratio in chronic lymphocytic leukemia and their correlation with in vitro apoptosis and clinical resistance. Br. J. Cancer, 76: 935-938, 1997.
42. Campana, D., Coustan-Smith, E., Manabe, A., Buschle, M., Raimondi, S. C., Behm, F. G., Ashum, R., Arico, M., Biondi, A., and Pui, C. H. Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein. Blood, 81: 1025-1031, 1993.
43. L and Bax correlates with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood, 89: 2986-2993, 1997.
44. Laytragoon-Lewin, N., Kashuba, V., Mellstedt, H., and Klein, G. Bcl-2 rearrangement detected by pulsed-field gel electrophoresis (PFGF) in B-chronic lymphocytic leukemia (B-CLL) cells. Int. J. Cancer, 76: 909-912, 1998.
45. Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K-M., Krammer, P. H., and Peter, M. E. Two CD95 (APO-1/Fas) signaling pathways. EMBO J., 17: 1675-1687, 1998.
46. Marchetti, P., Decaudin, D., Macho, A., Zamzami, N., Hirsch, T., Susin, S. A., and Kroemer, G. Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. Eur. J. Immunol., 27: 289-296, 1997.
47. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139: 271-279, 1991.
48. Griffith, T. S., Rauch, C. T., Smolak, P. J., Waugh, J. Y., Boiani, N., Lynch, D. H., Smith, C. A., Goodwin, R. G., and Kubin, M. Z. Functional analysis of TRAIL receptors using monoclonal antibodies. J. Immunol., 162: 2597-2605, 1999.
49. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., and Vogelstein, B. A model for p53-induced apoptosis. Nature (Lond.), 389: 300-304, 1997.
50. Kroemer, G., Dallaporta, B., and Resche-Rigon, M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol., 60: 619-642, 1998.