Solar ultraviolet radiation as a trigger of cell signal transduction

Toxicology and Applied Pharmacology

Volumn 195, Issue 3, 2004, Pages 288-297

  Heck, Diane E ^a   Gerecke, Donald R ^a   Vetrano, Anna M ^a   Laskin, Jeffrey D ^b  

^a RUTGERS UNIVERSITY   (United States)

^b University of Medicine and Dentistry   (United States)

Author keywords

Activator protein 1; AP 1; COX 2; Cyclooxygenase 2; EGF; Epidermal growth factor; ERK; Extracellular signal regulated kinase; Glutathione; GSH; ICAM 1; IL 1; IL 6; Interleukin 1; Intracellular adhesion molecule 1; MAP kinase; Melanoma; Skin cancer; UVA; UVB

Indexed keywords

EMETINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXYNITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; PROTEIN C JUN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UROCANIC ACID;

DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION; GENE FUNCTION; HUMAN; NONHUMAN; OXIDATION REDUCTION REACTION; RADIATION EXPOSURE; RADIATION RESPONSE; REVIEW; SIGNAL TRANSDUCTION; SKIN INFLAMMATION; SKIN TOXICITY; SOLAR RADIATION; TRANSCRIPTION INITIATION;

GENE EXPRESSION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; SIGNAL TRANSDUCTION; SKIN; SUNLIGHT; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS;

EID: 1542407665     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.09.028     Document Type: Review

References (150)

1. Aboussekhra A., Biggerstaff M., Shivji M.K., Vilpo J.A., Moncollin V., Podust V.N., Protic M., Hubscher U., Egly J.M., Wood R.D. Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell. 80:1995;859-868.
2. Abts H.F., Breuhahn K., Michel G., Kohrer K., Esser P., Ruzicka T. Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction. Photochem. Photobiol. 66:1997;363-367.
3. Abts H.F., Welss T., Breuhahn K., Ruzicka T. UVB-regulated gene expression in human keratinocytes. Analysis by differential display. Methods Mol. Biol. 99:2000;347-366.
4. Adler V., Polotskaya A., Kim J., Dolan L., Davis R., Pincus M., Ronai Z. Dose rate and mode of exposure are key factors in JNK activation by UV irradiation. Carcinogenesis. 17:1996;2073-2076.
5. Afaq F., Adhami V.M., Ahmad N., Mukhtar H. Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea constituent (-)-epigallocatechin-3-gallate. Oncogene. 22:2003;1035-1044.
6. Aragane Y., Kulms D., Metze D., Wilkes G., Poppelmann B., Luger T.A., Schwarz T. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J. Cell Biol. 140:1998;171-182.
7. Barber L.A., Spandau D.F., Rathman S.C., Murphy R.C., Johnson C.A., Kelley S.W., Hurwitz S.A., Travers J.B. Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. J. Biol. Chem. 273:1998;18891-18897.
8. Black H.S. Potential involvement of free radical reactions in ultraviolet light-mediated cutaneous damage. Photochem. Photobiol. 46:1987;213-221.
9. Bode A.M., Dong Z. Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci. STKE. 167:2003;RE2.
10. Cadet J., Douki T., Pouget J.P., Ravanat J.L., Sauvaigo S. Effects of UV and visible radiations on cellular DNA. Curr. Probl. Dermatol. 29:2001;62-73.
11. Cole C.A., Forbes P.D., Davies R.E. An action spectrum for UV photocarcinogenesis. Photochem. Photobiol. 43:1986;275-284.
12. Connor M.J., Wheeler L.A. Depletion of cutaneous glutathione by ultraviolet radiation. Photochem. Photobiol. 46:1987;239-245.
13. Cooke C.L., Davidge S.T. Peroxynitrite increases iNOS through NF-κB and decreases prostacyclin synthase in endothelial cells. Am. J. Physiol.: Cell Physiol. 282:2002;C395-C402.
14. Cornelius L.A., Sepp N., Li L.J., Degitz K., Swerlick R.A., Lawley T.J., Caughman S.W. Selective upregulation of intercellular adhesion molecule (ICAM-1) by ultraviolet B in human dermal microvascular endothelial cells. J. Invest. Dermatol. 103:1994;23-28.
15. Danielsen A.J., Maihle N.J. The EGF/ErbB receptor family and apoptosis. Growth Factors. 20:2002;1-15.
16. Dazard J.E., Gal H., Amariglio N., Rechavi G., Domany E., Givol D. Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. Oncogene. 22:2003;2993-3006.
17. de Gruijl F.R., Sterenborg H.J.C.M., Forbes P.D., Davies R.E., Cole C., Kelfkens G., van Weelden H., Slaper H., van der Leun J.C. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res. 53:1993;53-60.
18. 2 receptor and redox-transducer in gene activation. Cell. 111:2002;471-481.
19. Dhanwada K.R., Dickens M., Neades R., Davis R., Pelling J.C. Differential effects of UV-B and UV-C components of solar radiation on MAP kinase signal transduction pathways in epidermal keratinocytes. Oncogene. 11:1995;1947-1953.
20. Douki T., Reynaud-Angelin A., Cadet J., Sage E. Bipyrimidine photoproducts rather than oxidative lesions are the main type of DNA damage involved in the genotoxic effect of solar UVA radiation. Biochemistry. 42:2003;9221-9226.
21. Enk C.D., Sredni D., Blauvelt A., Katz S.I. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J. Immunol. 154:1995;4851-4856.
22. Finch P.W., Murphy F., Cardinale I., Krueger J.G. Altered expression of keratinocyte growth factor and its receptor in psoriasis. Am. J. Pathol. 151:1997;1619-1628.
23. Fisher G.J., Talwar H.S., Lin J., Lin P., McPhillips F., Wang Z., Li X., Wan Y., Kang S., Voorhees J.J. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J. Clin. Invest. 101:1998;1432-1440.
24. Fisher G.J., Choi H.C., Bata-Csorgo Z., Shao Y., Datta S., Wang Z.Q., Kang S., Voorhees J.J. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. J. Invest. Dermatol. 117:2001;219-226.
25. Foote C.S. Mechanisms of photosensitized oxidation. Science. 162:1968;963-970.
26. Foote C.S. Light, oxygen, and toxicity. Autor A. Pathology of Oxygen. 1982;21-44 Academic Press, New York.
27. Gonzalez S., Pathak M.A. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos. Photodermatol., Photoimmunol. Photomed. 12:1996;45-56.
28. Goodman M.F. Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu. Rev. Biochem. 71:2002;17-50.
29. Hadari Y.R., Gotoh N., Kouhara H., Lax I., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8578-8583.
30. Halliwell B., Gutteridge J. The chemistry of oxygen radicals and other oxygen derived species. Halliwell B., Gutteridge J. Free Radicals in Biology and Medicine. 1990;22-85 Oxford Univ. Press, New York.
31. Haralampus-Grynaviski N., Ransom C., Ye T., Rozanowska M., Wrona M., Sarna T., Simon J.D. Photogeneration and quenching of reactive oxygen species by urocanic acid. J. Am. Chem. Soc. 124:2002;3461-3468.
32. Hauser C., Saurat J.H., Schmitt A., Jaunin F., Dayer J.M. Interleukin 1 is present in normal human epidermis. J. Immunol. 136:1986;3317-3323.
33. He Y.Y., Huang J.L., Gentry J.B., Chignell C.F. Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity. J. Biol. Chem. 278:2003;42457-42465.
34. Heck D.E., Laskin D.L., Gardner C.R., Laskin J.D. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. 267:1992;21277-21280.
35. Heck D.E., Vetrano A.M., Mariano T.M., Laskin J.D. UVB light stimulates production of reactive oxygen species: unexpected role for catalase. J. Biol. Chem. 278:2003;22432-22436.
36. Holbrook N.J., Fornace A.J. Jr. Response to adversity: molecular control of gene activation following genotoxic stress. New Biol. 3:1991;825-833.
37. Huang C., Ma W., Bowden G.T., Dong Z. Ultraviolet B-induced activated protein-1 activation does not require epidermal growth factor receptor but is blocked by a dominant negative PKCλ/I. J. Biol. Chem. 271:1996;31262-31268.
38. Huang R.P., Fan Y., Boynton A.L. UV irradiation upregulates Egr-1 expression at transcription level. J. Cell. Biochem. 73:1999;227-236.
39. Huang C., Mattjus P., Ma W.Y., Rincon M., Chen N.Y., Brown R.E., Dong Z. Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice. J. Biol. Chem. 275:2000;9143-9149.
40. Hurks M., Garssen J., Van Loveren H., Vermeer B.J. General aspects of UV-irradiation on the immune system. Jori G. Photobiology in Medicine. vol. 161:1994;61-85 Plenum Press, New York.
41. Ichihashi M., Ueda M., Budiyanto A., Bito T., Oka M., Fukunaga M., Tsuru K., Horikawa T. UV-induced skin damage. Toxicology. 189:2003;21-39.
42. Iordanov M.S., Magun B.E. Different mechanisms of c-Jun NH(2)-terminal kinase-1 (JNK1) activation by ultraviolet-B radiation and by oxidative stressors. J. Biol. Chem. 274:1999;25801-25806.
43. Iordanov M.S., Pribnow D., Magun J.L., Dinh T.H., Pearson J.A., Chen S.L., Magun B.E. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA. Mol. Cell. Biol. 17:1997;3373-3381.
44. Iordanov M.S., Pribnow D., Magun J.L., Dinh T.H., Pearson J.A., Magun B.E. Ultraviolet radiation triggers the ribotoxic stress response in mammalian cells. J. Biol. Chem. 273:1998;15794-15803.
45. Iordanov M.S., Choi R.J., Ryabinina O.P., Dinh T.H., Bright R.K., Magun B.E. The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol. Cell. Biol. 22:2002;5380-5394.
46. Isoherranen K., Punnonen K., Jansen C., Uotila P. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. Br. J. Dermatol. 140:1999;1017-1022.
47. Isoherranen K., Sauroja I., Jansen C., Punnonen K. UV irradiation induces deownregulation of bcl-2 expression in vitro and in vivo. Arch. Dermatol. Res. 291:1999;212-216.
48. Janssens S., Beyaert R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell. 11:2003;293-302.
49. Jo S.H., Lee S.H., Chun H.S., Lee S.M., Koh H.J., Lee S.E., Chun J.S., Park J.W., Huh T.L. Cellular defense against UVB-induced phototoxicity by cytosolic NADP(+)-dependent isocitrate dehydrogenase. Biochem. Biophys. Res. Commun. 292:2002;542-549.
50. Jones S.A., McArdle F., Jack C.I.A., Jackson M.J. Effect of antioxidant supplementation on the adaptive response of human skin fibroblasts to UV-induced oxidative stress. Redox Rep. 4:1999;291-299.
51. Kang K.W., Choi S.H., Kim S.G. Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction. Nitric Oxide. 7:2002;244-253.
52. Katiyar S.K., Afaq F., Azizuddin K., Mukhtar H. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol. Appl. Pharmacol. 176:2001;110-117.
53. Klotz L.O., Schroeder P., Sies H. Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways. Free Radical Biol. Med. 33:2002;737-743.
54. Köck A., Schwarz T., Kirnbauer R., Urbanski A., Perry P., Ansel J.C., Luger T.A. Human keratinocytes are a source for tumor necrosis factor: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med. 172:1990;1609-1614.
55. Kondo S., Kono T., Sauder D.N., McKenzie R.C. IL-8 gene expression and production in human keratinocytes and their modulation by UVB. J. Invest. Dermatol. 101:1993;690-694.
56. Kondo S., Sauder D.N., Kono T.A., Galley K.A., McKenzie R.C. Differential modulation of interleukin-1α (IL-1α) and interleukin-1β (IL-1β) in human epidermal keratinocytes by UVB. Exp. Dermatol. 3:1994;29-39.
57. Kondo S., Yoneta A., Yazawa H., Kamada A., Jimbow K. Downregulation of CXCR-2 but not CXCR-1 expression by human keratinocytes by UVB. J. Cell. Physiol. 182:2000;366-370.
58. Kuhn A., Fehsel K., Lehmann P., Krutmann J., Ruzicka T., Kolb-Bachofen V. Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous Lupus erythematosus. J. Invest. Dermatol. 111:1998;149-153.
59. Laskin J.D., Lee E., Yurkow E.J., Laskin D.L., Gallo M.A. A possible mechanism of psoralen phototoxicity not involving direct interaction with DNA. Proc. Natl. Acad. Sci. U.S.A. 82:1985;6158-6162.
60. Laskin J.D., Lee E., Laskin D.L., Gallo M.A. Psoralens potentiate ultraviolet light-induced inhibition of epidermal growth factor binding. Proc. Natl. Acad. Sci. U.S.A. 83:1986;8211-8215.
61. Laskin D.L., Gardner C.R., Laskin J.D. Induction of chemotaxis in mouse peritoneal macrophages by activators of protein kinase C. J. Leukocyte Biol. 41:1987;474-480.
62. Laskin J.D., Heck D.E., Laskin D.L. The ribotoxic stress response as a potential mechanism for MAP kinase activation in xenobiotic toxicity. Toxicol. Sci. 69:2002;289-291.
63. Lauber K., Bohn E., Krober S.M., Xiao Y.J., Blumenthal S.G., Lindemann R.K., Marini P., Wiedig C., Zobywalski A., Baksh S., Xu Y., Autenrieth I.B., Schulze-Osthoff K., Belka C., Stuhler G., Wesselborg S. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell. 113:2003;717-730.
64. Lee H.S., Kooshesh F., Sauder D.N., Kondo S. Modulation of TGF-β1 production from human keratinocytes by UVB. Exp. Dermatol. 6:1997;105-110.
65. Lopez-Torres M., Thiele J.J., Shindo Y., Han D., Packer L. Topical application of α-tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. Br. J. Dermatol. 138:1998;207-215.
66. Lu Y.P., Lou Y.R., Yen P., Mitchell D., Huang M.T., Conney A.H. Time course for early adaptive responses to ultraviolet B light in the epidermis of SKH-1 mice. Cancer Res. 59:1999;4591-4602.
67. Magnoni C., Euclidi E., Benassi L., Bertazzoni G., Cossarizza A., Seidenari S., Giannetti A. Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes. Toxicol. In Vitro. 16:2002;349-355.
68. Marchese C., Maresca V., Cardinali G., Belleudi F., Ceccarelli S., Bellocci M., Frati L., Torrisi M.R., Picardo M. UVB-induced activation and internalization of keratinocyte growth factor receptor. Oncogene. 22:2003;2422-2431.
69. Marschall C., Lengyel E., Nobutoh T., Braungart E., Douwes K., Simon A., Magdolen V., Reuning U., Degitz K. UVB increases urokinase-type plasminogen activator receptor (uPAR) expression. J. Invest. Dermatol. 113:1999;69-76.
70. Matata B.M., Galinanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-κB DNA binding activity. J. Biol. Chem. 277:2002;2330-2335.
71. Matsui M.S., DeLeo V.A. Induction of protein kinase C activity by ultraviolet radiation. Carcinogenesis. 11:1990;229-234.
72. Matsui M.S., Laufer L., Scheide S., DeLeo V. Ultraviolet-B (290-320 nm)-irradiation inhibits epidermal growth-factor binding to mammalian cells. J. Invest. Dermatol. 92:1989;617-622.
73. Matsui M.S., Wang N., DeLeo V.A. Ultraviolet radiation B induces differentiation and protein kinase C in normal human epidermal keratinocytes. Photodermatol., Photoimmunol. Photomed. 12:1996;103-108.
74. Maytin E.V. Differential effects of heat shock and UVB light upon stress protein expression in epidermal keratinocytes. J. Biol. Chem. 267:1992;23189-23196.
75. McArdle F., Rhodes L.E., Parslew R., Jack C.I., Friedmann P.S., Jackson M.J. UVR-induced oxidative stress in human skin in vivo: effects of oral vitamin C supplementation. Free Radical Biol. Med. 33:2002;1355-1362.
76. Menon E.L., Morrison H. Formation of singlet oxygen by urocanic acid by UVA irradiation and some consequences thereof. Photochem. Photobiol. 75:2002;565-569.
77. Mermelstein F.H., Abidi T.F., Laskin J.D. Inhibition of epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid cells following psoralen/ultraviolet light treatment. Mol. Pharmacol. 36:1989;848-855.
78. Miller C.C., Hale P., Pentland A.P. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. J. Biol. Chem. 269:1994;3529-3533.
79. Mittler R., Berkowitz G. Hydrogen peroxide, a messenger with too many roles? Redox Rep. 6:2001;69-72.
80. Miyachi Y. Reactive oxygen species in photodermatology. Hayashi O., Imamura S., Miyachi Y. The Biological Role of Reactive Oxygen Species in Skin. 1987;37-41 Elsevier Science, New York.
81. Molloy C.J., Laskin J.D. Specific alterations in keratin biosynthesis in mouse epidermis in vivo and in explant culture following a single exposure to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 47:1987;4674-4680.
82. Molloy C.J., Laskin J.D. Keratin polypeptide expression in mouse epidermis and cultured epidermal cells. Differentiation. 37:1988;86-97.
83. Molloy C.J., Laskin J.D. Altered expression of a mouse epidermal cytoskeletal protein is a sensitive marker for proliferation induced by tumor promoters. Carcinogenesis. 13:1992;963-968.
84. Molloy C.J., Gallo M.A., Laskin J.D. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis. 8:1987;1193-1199.
85. Moncada S. Nitric oxide: discovery and impact on clinical medicine. J. R. Soc. Med. 92:1999;164-169.
86. Moysan A., Marquis I., Gaboriau F., Santus R., Dubertret L., Morliere P. Ultraviolet A-induced lipid peroxidation and antioxidant defense systems in cultured human skin fibroblasts. J. Invest. Dermatol. 100:1993;692-698.
87. Murakami T., Fujimoto M., Ohtsuki M., Nakagawa H. Expression profiling of cancer-related genes in human keratinocytes following non-lethal ultraviolet B irradiation. J. Dermatol. Sci. 27:2001;121-129.
88. Murphy G.M., Dowd P.M., Hudspith B.N., Brostoff J., Greaves M.W. Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo. Photodermatology. 6:1989;268-274.
89. Nabeyrat E., Jones G.E., Fenwick P.S., Barnes P.J., Donnelly L.E. Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:2003;L1112-L1120.
90. Niizeki H., Naruse T., Hecker K.H., Taylor J.R., Kurimoto I., Shimizu T., Yamasaki Y., Inoko H., Streilein J.W. Polymorphisms in the tumor necrosis factor (TNF) genes are associated with susceptibility to effects of ultraviolet-B radiation on induction of contact hypersensitivity. Tissue Antigens. 58:2001;369-378.
91. Niizeki H., Inoko H., Streilein W.J. Polymorphisms in the TNF region confer susceptibility to UVB-induced impairment of contact hypersensitivity induction in mice and humans. Methods. 28:2002;46-54.
92. Nolan T.M., DiGirolamo N., Sachdev N.H., Hampartzoumian T., Coroneo M.T. The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygium. Am. J. Pathol. 162:2003;567-574.
93. Nomura M., Kaji A., Ma W.Y., Zhong S., Liu G., Bowden G.T., Miyamoto K.I., Dong Z. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem. 276:2001;25558-25567.
94. Norval M., El-Ghorr A.A. Studies to determine the immunomodulating effects of cis-urocanic acid. Methods. 28:2002;63-70.
95. Pelle E., Huang X., Mammone T., Marenus K., Maes D., Frenkel K. Ultraviolet-B-induced oxidative DNA base damage in primary normal human epidermal keratinocytes and inhibition by a hydroxyl radical scavenger. J. Invest. Dermatol. 121:2003;177-183.
96. Peter M.E., Krammer P.H. The CD95 (APO-1/Fas) DISC and beyond. Cell Death Differ. 10:2003;26-35.
97. Peus D., Pittelkow M.R. Reactive oxygen species as mediators of UVB-induced mitogen-activated protein kinase activation in keratinocytes. Curr. Probl. Dermatol. 29:2001;114-127.
98. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J. Invest. Dermatol. 110:1998;966-971.
99. Peus D., Vasa R.A., Meves A., Beyerle A., Pittelkow M.R. UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival. Photochem. Photobiol. 72:2000;135-140.
100. Piepkorn M., Pittelkow M.R., Cook P.W. Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors. J. Invest. Dermatol. 111:1998;715-721.
101. Ponten F., Lindman H., Bostrom A., Berne B., Bergh J. Induction of p53 expression in skin by radiotherapy and UV radiation: a randomized study. J. Natl. Cancer Inst. 93:2001;82-83.
102. Potter T., Gohde W., Wedemeyer N., Kohnlein W. Keratinocytes exposed to ultraviolet radiation reveal three down-regulated genes with potential function in differentiation and cell cycle control. Radiat. Res. 154:2000;151-158.
103. Punnonen K., Yuspa S.H. Ultraviolet light irradiation increases cellular diacylglycerol and induces translocation of diacylglycerol kinase in murine keratinocytes. J. Invest. Dermatol. 99:1992;221-226.
104. Pupe A., Degreef H., Garmyn M. Induction of tumor necrosis factor-alpha by UVB: a role for reactive oxygen intermediates and eicosanoids. Photochem. Photobiol. 78:2003;68-74.
105. Quan T., He T., Voorhees J.J., Fisher G.J. Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its type-II receptor and inducing Smad7. J. Biol. Chem. 276:2001;26349-26356.
106. Quan T., He T., Kang S., Voorhees J.J., Fisher G.J. Ultraviolet irradiation alters transforming growth factor β/smad pathway in human skin in vivo. J. Invest. Dermatol. 119:2002;499-506.
107. Quan T., He T., Kang S., Voorhees J.J., Fisher G.J. Connective tissue growth factor: expression in human skin in vivo and inhibition by ultraviolet irradiation. J. Invest. Dermatol. 118:2002;402-408.
108. Ramaswamy N.T., Ronai Z., Pelling J.C. Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes. Oncogene. 16:1998;1501-1505.
109. Ravanat J.L., Douki T., Cadet J. Direct and indirect effects of UV radiation on DNA and its components. J. Photochem. Photobiol., B. 63:2001;88-102.
110. Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat. Immun. 3:2002;1129-1134.
111. Rhee S.G., Bae Y.S., Lee S.R., Kwon J. Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci. STKE. 10:2000;PE1.
112. Rosen C.F., Gajic D., Drucker D.J. Ultraviolet radiation induction of ornithine decarboxylase in rat keratinocytes. Cancer Res. 50:1990;2631-2635.
113. Rosen C.F., Poon R., Drucker D.J. UVB radiation-activated genes induced by transcriptional and posttranscriptional mechanisms in rat keratinocytes. Am. J. Physiol. 268:1995;C846-C855.
114. Rosenstein B.S., Mitchell D.L. Action spectra for the induction of pyrimidine photoproducts and cyclobutane pyrimidine dimers in normal human skin fibroblasts. Photochem. Photobiol. 45:1987;775-780.
115. Rosette C., Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 274:1996;1194-1197.
116. Ryter S.W., Tyrrell R.M. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radical Biol. Med. 28:2000;289-309.
117. Sachi Y., Hirota K., Masutani H., Toda K., Okamoto T., Takigawa M., Yodoi J. Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells. Immunol. Lett. 44:1995;189-193.
118. Schallreuter K.U., Wood J.M. Thioredoxin reductase - Its role in epidermal redox status. J. Photochem. Photobiol., B. 64:2001;179-184.
119. Sesto A., Navarro M., Burslem F., Jorcano J.L. Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays. Proc. Natl. Acad. Sci. U.S.A. 99:2002;2965-2970.
120. Shaoul E., Reich-Slotky R., Berman B., Ron D. Fibroblast growth factor receptors display both common and distinct signaling pathways. Oncogene. 10:1995;357-366.
121. She Q.B., Chen N., Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J. Biol. Chem. 275:2000;20444-20449.
122. She Q.B., Ma W.Y., Dong Z. Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20. Oncogene. 21:2002;1580-1589.
123. Shindo Y., Witt E., Han D., Packer L. Dose-response effects of acute ultraviolet, irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis. J. Invest. Dermatol. 102:1994;470-475.
124. Sleijffers A., Yucesoy B., Kashon M., Garssen J., De Gruijl F.R., Boland G.J., Van Hattum J., Luster M.I., Van Loveren H. Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination. J. Immunol. 170:2003;3423-3428.
125. Soriani M., Hejmadi V., Tyrrell R.M. Modulation of c-jun and c-fos transcription by UVB and UVA radiations in human dermal fibroblasts and KB cells. Photochem. Photobiol. 71:2000;551-558.
126. Spikes J. Photosensitization. Smith K.C. The Science of Photobiology. 1989;79-110 Plenum Press, New York.
127. Stone J.R., Collins T. The role of hydrogen peroxide in endothelial proliferative responses. Endothelium. 9:2002;231-238.
128. Sur R., Heck D.E., Mariano T.M., Jin Y., Murphy W.J., Laskin J.D. UVB light suppresses nitric oxide production by murine keratinocytes and macrophages. Biochem. Pharmacol. 64:2002;1469-1481.
129. Suzuki Y.J., Forman H.J., Sevanian A. Oxidants as stimulators of signal transduction. Free Radical Biol. Med. 22:1997;269-285.
130. Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 11:2003;105-112.
131. Takao J., Ariizumi K., Dougherty I., Cruz P.D. Jr. Genomic scale analysis of the human keratinocyte response to broad-band ultraviolet-B irradiation. Photodermatol., Photoimmunol. Photomed. 18:2002;5-13.
132. Tobin D., van Hogerlinden M., Toftgard R. UVB-induced association of tumor necrosis factor (TNF) receptor 1/TNF receptor-associated factor-2 mediates activation of Rel proteins. Proc. Natl. Acad. Sci. U.S.A. 95:1998;565-569.
133. Tyrrell R.M. The molecular and cellular pathology of solar ultraviolet radiation. Baum H. Molecular Aspects of Medicine. 1994;1-77 Elsevier, Oxford, UK.
134. Tyrrell R.M. Ultraviolet radiation and free radical damage to skin. Biochem. Soc. Trans. 61:1996;47-53.
135. Tyrrell R.M., Pidoux M. Correlation between endogenous glutathione content and the sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar UV range. Photochem. Photobiol. 47:1988;405-412.
136. Urbanski A., Schwarz T., Neuner P., Krutmann J., Kirnbauer R., Kock A., Luger T.A. Ultraviolet light induces increased circulating interleukin-6 in humans. J. Invest. Dermatol. 94:1990;808-811.
137. Vincek V., Kurimoto I., Medema J.P., Prieto E., Streilein J.W. Tumor necrosis factor alpha polymorphism correlates with deleterious effects of ultraviolet B light on cutaneous immunity. Cancer Res. 53:1993;728-732.
138. Virag L., Szabo E., Bakondi E., Bai P., Gergely P., Hunyadi J., Szabo C. Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin. Exp. Dermatol. 11:2002;189-202.
139. Wan Y.S., Wang Z.Q., Voorhees J., Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes. Cell. Signalling. 13:2001;139-144.
140. Wang H.Q., Quan T., He T., Franke T.F., Voorhees J.J., Fisher G.J. EGF receptor-dependent, NF-κB independent activation of PI-3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases 3, 8, and 9 in human keratinocytes. J. Biol. Chem. 278:2003;45737-45745.
141. Warmuth I., Harth Y., Matsui M.S., Wang N., DeLeo V.A. Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res. 54:1994;374-376.
142. Wood R.D. Nucleotide excision repair in mammalian cells. J. Biol. Chem. 272:1997;23465-23468.
143. Zhang Y., Zhong S., Dong Z., Chen N., Bode A.M., Ma W., Dong Z. UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J. Biol. Chem. 276:2001;14572-14580.
144. Zhang Y., Liu G., Dong Z. MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J. Biol. Chem. 276:2001;42534- 42542.
145. Zhang Y., Dong Z., Nomura M., Zhong S., Chen N., Bode A.M., Dong Z. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J. Biol. Chem. 276:2001;20913-20923.
146. Zhang Y., Mattjus P., Schmid P.C., Dong Z., Zhong S., Ma W.Y., Brown R.E., Bode A.M., Schmid H.H., Dong Z. Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis. J. Biol. Chem. 276:2001;11775-11782.
147. Zhang Y., Ma W.Y., Kaji A., Bode A.M., Dong Z. Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem. 277:2002;3124-3131.
148. Zheng Z.S., Chen R.Z., Prystowsky J.H. UVB radiation induces phosphorylation of the epidermal growth factor receptor, decreases EGF binding and blocks EGF induction of ornithine decarboxylase gene expression in SV40-transformed human keratinocytes. Exp. Dermatol. 2:1993;257-265.
149. Zhong S.P., Ma W.Y., Dong Z. ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J. Biol. Chem. 275:2000;20980-20984.
150. Zhong S., Zhang Y., Jansen C., Goto H., Inagaki M., Dong Z. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J. Biol. Chem. 276:2001;12932-12937.