Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by Polypodium leucotomos

Photodermatology Photoimmunology and Photomedicine

Volumn 12, Issue 2, 1996, Pages 45-56

  Gonzalez S ^a   Pathak, M A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Erythema; Lipid peroxidation; Photosensitization; Polypodium leucotomos; Reactive oxygen species; Ultraviolet radiation

Indexed keywords

LIPID PEROXIDE; METHOXSALEN; PLANT EXTRACT; POLYPODIUM LEUCOTOMOS EXTRACT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ERYTHEMA; GUINEA PIG; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; NONHUMAN; NORMAL HUMAN; PHOTOTOXICITY; PRIORITY JOURNAL; SKIN INFLAMMATION; SUNBURN; ULTRAVIOLET RADIATION;

POLYPODIUM LEUCOTOMOS;

EID: 0029808330     PISSN: 09054383     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0781.1996.tb00175.x     Document Type: Article

References (38)

1. Soter NA. Acute effects of ultraviolet radiation on the skin. Semin Dermatol 1990: 9(1): 11-15.
2. Kupper TS. Role of epidermal cytokines. In: Oppenheim JJ, Shervach GM, ed. Immunophysiology. New York: Oxford University Press, 1990: 285-305.
3. Norris PG, Gange RW, Hawk JLM. Acute effects of ultraviolet radiation on the skin. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, ed. Dermatology in general medicine. I (Chapter 133). New York: McGrawHill, Inc., 1993: 1651-1658.
4. Black AK. Fireham N, Greaves MW, Hensby CN. Time course changes in levels of arachidonic acid and prostaglandins D2, E2, and F2 alpha in human skin following ultraviolet B irradiation. Br J Clin Pharmcol 1980: 10: 453-457.
5. Pentland AP, Jacobs SC Bradykinin-induced prostaglandin synthesis is enhanced in keratinocytes and fibroblasts by UV injury. Am J Physiol 1991: 261: R543-R547.
6. Hawk JLM, Black AK, Jaenicke KF, Barr RM, Soter NA, Mallet AI, Gilchrest BA, Hensby CN, Parrish JA, Greaves MW. Increased concentration of arachidonic acid, prostaglandins E2, D2, and 6-oxo-Flalpha, and histamine in skin following UVA irradiation. J Invest Dermatol 1983: 80: 496-499.
7. Epstein JH. Photocarcinogenesis, skin cancer, and aging. J Am Acad Dermatol 1983: 9: 487-502.
8. Frederich JE, Snell HE, Haywood EK. Solar ultraviolet radiation at the earth's surface. Photochem Photobiol 1989: 50: 443-450.
9. Peak MJ, Peak JG. Solar ultraviolet-induced damage to DNA. Photodermatol Photoimmunol Photomed 1989: 6: 1-15.
10. Peak MJ, Peak JG, Churchill ME. Cellular and molecular effects of UVA radiation and visible light in mammalian cells. In: Urbach F, ed. Biological response to ultraviolet A radiation. Overland Park, KS: Valdenmer Publishing Co., 1992: 39-46.
11. Carbonare MD, Pathak MA. Skin photosensitizing agents and the role of reactive oxygen species in photoaging. J Photochem Photobiol B Biol 1992: 14: 105-124.
12. Pathak MA, Stratton K. Free radicals in human skin before and after exposure to light. Arch Biochem Biophys 1968: 39: 445-48.
13. Darr D, Combs S, Dunston S, Manning T, Pinnell S. Topical vitamin C protects skin from ultraviolet radiation-induced damage. Br J Dermatol 1992: 127: 247-253.
14. Carraro C, Pathak MA, Studies on the nature of in vitro and in vivo photosensitization reaction by psoralens and porphyrins. J Invest Dermatol 1988: 90: 267-275.
15. Fuchs J, Freisleben HJ, Packer L. Antioxidants in the skin. In: Mukhtar H, ed. Pharmacology of the skin. Boca Raton, FL: CRC Press Inc.. 1992: 247-267.
16. Athar M, Agarwal R, Bickers DR, Mukhtar H. Role of reactive oxygen species. In: Mukhtar H, ed. Pharmacology of the skin. Boca Raton, FL: CRC Press Inc., 1992: 269-279.
17. Hruza LA, Pentland AP. Mechanisms of UV-induced inflammation. J Invest Dermatol 1993: 100: 35s-41s.
18. Halliwell B, Gutteridge JMC, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992: 119: 598-620.
19. Horvarth A, Alvarado F, Szöcs J, Ney de Alvarado Z, Padilla G. Metabolic effects of calagualine. and antitumoral saponine of Polypodium leucotomos. Nature 1967: 214: 1256-1258.
20. Vargas J, Muñoz C, Osorio C, Garcia-Olivares E. Anapsos, an antipsoriatic drug which increases the proportion of suppressor cells in human peripheral blood. Ann Immunol (Inst. Pasteur) 1983: 134C: 393-400.
21. Tuominen M, Bohlin I, Lindbom L-O, Rolfsen W. Enhancing effect of extract of Polypodium leucotomos on the prevention of rejection on skin transplants in mice. Phytother Res 1991: 5: 234-236.
22. Antón-Alvarez X, Franco A, Fernández-Nova L, Cacabelos R. Effects of anapsos on behaviour and brain citokincs in rats. Ann Psychiatry 1992: 3: 329-341.
23. Rayward J, Villarrubia VG, Gonzalez S, Sada G, Alvarez-Mon M. A methanolic extract of the fern Polypodium leucotomos inhibits proliferative responses of human T-lymphotyes to several polyclonal mitogens. Int J Immunopharmacol (in press).
24. Tuominen M, Bohlin I, Rolfsen W. Effects of calaguala and an active principle, adenosine, on platelet activating factor. Planta Med 1992: 58: 306-310.
25. Corrales-Padilla H, Laínez HN, Pacheco JA. A new agent (hydrophilic fraction of Polypodium leucotomos) for man-agement of psoriasis. Int J Dermatol 1974: 13: 276-282.
26. Jiménez D, Naranjo R, Doblaré E, Munoz C, Vargas JF. Anapsos, an antipsoriatic drug, in atopic dermatitis. Allergol Immunopathol 1987: 15: 185-189.
27. Padilla HC, Pathak MA, Fitzpatrick TB, Gonzalez S. The use of oral and topical Polypodium leucotomos (DIFUR) in the therapy of vitiligo (abstract). Unpublished data presented in a scientific exhibit in the American Academy of Dermatology, San Francisco, 1994.
28. 2') by psoralens and ultraviolet radiation (320-400 nm). Biochim Biophys Acta 1984: 798: 115-126.
29. Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gel. Anal Biochem 1971: 44: 276-287.
30. Kraljic I, El Mohsni S. A new method for the detection of singlet oxygen in aqueous solution. Photochem Photobiol 1978: 28: 577-581.
31. Pathak MA, Carraro C. Reactive oxygen species in cutaneous photosensitivity reactions in porphyrias and PUVA photochemotherapy and melanin pigmentation. In: Hayaishi O, Imamura S, Miyachi Y, ed. The biological role of reactive oxygen species in skin. Tokyo: University of Tokyo Press, 1988: 75-94.
32. Osihi N, Ohkawa H, Miike A, Tatano T, Yagi K. A new assay method for lipid peroxide using a methylene blue derivative. Biochem Int 1985: 10: 205-211.
33. Pathak MA. Mechanisms of psoralen photosensitization reactions. In: Pathak MA, Dunnick JA, ed. Photobiologic. toxicologic and pharmacologic aspects of psoralens. NCI monograph no. 66 Bethesda, MD: NIH, 1984: 41-46.
34. Black AK, Greaves MW, Hensby CN, Plummer NA, Warin AP. The effects of indomethacin on arachidonic acid and prostaglandins E2, F2a levels in human skin 24 hours after UVB and UVC irradiation. Br J Clin Pharmacol 1978: 6: 261-266.
35. Snyder DS. Effects of topical indomethacin on UVR-induced redness and prostaglandin E levels in guinea pig skin. Prostaglandin 1976: 11: 631-643.
36. Pentland AP, Mahoney MY, Jacobs SC, Holtzman MJ. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. J Clin Invest 1990: 56: 566-574.
37. Morison WL, Paul BS, Parrish JA. The effects of indomethacin on long wave ultraviolet-induced delayed erythema. J Invest Dermatol 1977: 68: 120-133.
38. Stern RS, Thibodeau LA, Kleinerman RA et al. Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy of psoriasis. N Engl J Med 1979: 300: 809-813.